Drug & supplement interaction

Sweet Orange + Quetiapine

Quetiapine brand names: Seroquel, Dopaquel.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Sweet Orange and Quetiapine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Quetiapine states a food rule worth keeping to.

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Interaction report

Sweet Orange and Quetiapine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Quetiapine and Sweet Orange in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Sweet Orange safety at a glance

Sweet Orange overall Generally safe Sweet orange fruit and juice are safe as food for most people; concentrated oils and extracts call for more caution.
Pregnancy Likely Safe When sweet orange juice or fruit is used orally in amounts commonly found in foods. Read the full pregnancy detail
Breastfeeding Likely Safe When sweet orange juice or fruit is used orally in amounts commonly found in foods. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Quetiapine and Sweet Orange? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Quetiapine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Quetiapine is filed under 10 classifications — including antipsychotic drugs, qt interval-prolonging drugs, serotonergic drugs. Sweet Orange has documented interactions with 7 drug classes — the most serious being celiprolol (celicard) (major), ivermectin (stromectol, others) (major) and organic anion-transporting polypeptide substrates (oatp) (major) — and none of Quetiapine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Sweet Orange Does Interact With Other Medications

Sweet Orange has 48 major, 198 moderate known drug interactions in our database — Quetiapine isn’t one of them. If you take anything else, check it against the full list below.

Major 48 Moderate 198 No known interaction 2,584 (incl. Quetiapine)
Taking anything else?

Check Another of Your Medications Against Sweet Orange

Covers the 2,830 medications we’ve checked against Sweet Orange. Pick one to open its full report.

What to actually watch for

What Quetiapine’s Own FDA Label Lists

This is not an interaction — none of it involves Sweet Orange. These are the most notable effects listed in the ADVERSE REACTIONS section of Quetiapine’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Mania or an unusually elevated mood Worth acting on
  • A change in thyroid levels Worth acting on
  • Thoughts of self-harm Worth acting on
  • A bowel blockage Worth acting on
  • Severe muscle breakdown Worth acting on
  • Memory problems Worth acting on
  • High blood sugar Worth acting on mentioned in 4.4% of FDA reports for Quetiapine
  • Trouble swallowing Worth acting on
  • Trouble passing urine Worth acting on
  • Low sodium Worth acting on

Showing the 10 most notable of 63 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Quetiapine. Read the label on DailyMed › Where a percentage is shown, it is the share of 188,604 voluntary FDA FAERS reports for Quetiapine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Sweet Orange’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Sweet Orange side to compare — that is a limit of the record, not a statement that Sweet Orange has no side effects.

Special populations

Sweet Orange in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When sweet orange juice or fruit is used orally in amounts commonly found in foods.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Quetiapine Products Have a Food Rule — Sweet Orange Should Not Break It

At least one FDA label for a product containing Quetiapine says to take it on an empty stomach. Most supplements — Sweet Orange included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Quetiapine on its own and move Sweet Orange to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Quetiapine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

It is recommended that SEROQUEL XR be taken without food or with a light meal (approximately 300 calories) [see Clinical Pharmacology (12.3) ].

From the Dosage and Administration section of the FDA label we read for Quetiapine — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Overlapping uses

What Quetiapine Is Prescribed For, and What Sweet Orange Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Quetiapine is a prescription medicine with approved uses on its FDA label. Sweet Orange is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Quetiapine is prescribed for: Quetiapine treats schizophrenia and bipolar disorder in adults and certain age groups of children and adolescents. For bipolar disorder, it is approved for manic episodes (both as a stand-alone treatment and alongside lithium or divalproex) and for depressive episodes. The extended-release form of quetiapine is also approved as add-on therapy for major depressive disorder (MDD) in adults who are already taking an antidepressant. The regular tablet form is not approved for this use.

Sweet Orange has been studied for:

  • Depression studied, not established Sweet Orange has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Sweet Orange for depression

    It is unclear if drinking sweet orange juice or using sweet orange essential oil as aromatherapy is beneficial for depression.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Quetiapine on your own; if you are taking Sweet Orange for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Sweet Orange or Quetiapine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Sweet Orange or Quetiapine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Quetiapine

This page covers Sweet Orange only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Quetiapine page lists 199 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 11 major · 147 moderate · 41 minor.

From our pharmacist’s overview on the Quetiapine page

“Quetiapine (Seroquel) treats schizophrenia and bipolar disorder, illnesses where an unplanned swing in the drug's blood level has real consequences, and that is why these 199 supplement interactions deserve a careful read rather than a shrug. Most of the risk runs through CYP3A4, the liver enzyme that clears quetiapine: grapefruit bloc…”

Reviewed by 2 · Jul 18, 2026

Open the Quetiapine interaction page

One more smart check

Taking Sweet Orange as Part of a Dietary Supplement Product? Check It for Interactions

We hold 678 real supplement products containing Sweet Orange, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Sweet Orange. Even though Sweet Orange itself has no known interaction with Quetiapine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Sweet Orange and Quetiapine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Sweet Orange
Top 25%

#267 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Quetiapine
Top 5%

#54 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Sweet Orange reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Sweet Orange and Quetiapine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Sweet Orange

What is Sweet Orange?

Sweet Orange
  • Vitamin C source
  • Digestive upset
  • Stress and relaxation (aromatherapy)
  • Cold and respiratory support
  • Antioxidant support

Sweet orange is a common citrus fruit that is a good source of vitamin C, fiber, and antioxidants, and is enjoyed as a food worldwide. Its peel and essential oil are used in aromatherapy and traditional remedies, but strong scientific proof for most medicinal claims is limited. The fruit and juice are safe for most people as food, while concentrated oils and extracts deserve more caution.

Citrus sinensis · Rutaceae · Fruit, peel, and essential oil · Fresh fruit, juice, capsules, essential oil, peel extract, aromatherapy oil

An interaction check asks whether these two react with each other — it does not ask whether Sweet Orange is a good idea for someone in your situation. Here is what our Sweet Orange record says about it on its own.

Sweet Orange: dosing

There is no standardized medicinal dose for sweet orange. As a food, oranges and orange juice are enjoyed in normal serving sizes.For supplements, peel extracts, or essential oils, follow the directions on the product label, since products vary widely in strength.

From our Sweet Orange monograph — the full record covers uses, side effects and every documented interaction.

Read the full Sweet Orange monograph & all interactions
Medication

About Quetiapine

What Is Quetiapine Used For?

Brand names: Seroquel, Dopaquel

Quetiapine treats schizophrenia and bipolar disorder in adults and certain age groups of children and adolescents. For bipolar disorder, it is approved for manic episodes (both as a stand-alone treatment and alongside lithium or divalproex) and for depressive episodes.

The extended-release form of quetiapine is also approved as add-on therapy for major depressive disorder (MDD) in adults who are already taking an antidepressant. The regular tablet form is not approved for this use.

See full Quetiapine drug information
Keep checking

Other Drugs & Sweet Orange

Browse every other medication we’ve checked against Sweet Orange — both the ones with a known interaction and the ones without. Select any drug for the full detail.

48Major
198Moderate
0Minor
2,583No known interaction
48 Major 198 Moderate 2,583 No interaction
Major

48 interactions

Moderate

198 interactions

Showing 60 of 198 moderate interactions — see all 198 on the Sweet Orange page.

No interaction 2,583 drugs checked — show the list

We also checked Sweet Orange against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,583 medications checked with no known interaction — see the full Sweet Orange list.

See the full Sweet Orange interactions page
See every supplement checked against Quetiapine, ranked by severity
Evidence & sources

Sweet Orange References

The 17 references that drive our Sweet Orange monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. FDA, CFSAN. FDA-approved potassium health claim notification for potassium containing foods. 2000. Available at: www.cfsan.fda.gov/~dms/hclm-k.html.
  3. Kurowska EM, Spence JD, Jordan J, et al. HDL-cholesterol-raising effect of orange juice in subjects with hypercholesterolemia. Am J Clin Nutr 2000;72:1095-100. PubMed
  4. Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
  5. Bailey DG, Dresser GK, Munoz C, et al. Reduction of fexofenadine bioavailability by fruit juices. Clin Pharmacol Ther 2001;69:P21.
  6. Pletz MW, Petzold P, Allen A, et al. Effect of calcium carbonate on bioavailability of orally administered gemifloxacin. Antimicrob Agents Chemother 2003;47:2158-60.. PubMed
  7. Lilja JJ, Juntti-Patinen L, Neuvonen PJ. Orange juice substantially reduces the bioavailability of the beta-adrenergic-blocking agent celiprolol. Clin Pharmacol Ther 2004;75:184-90.
  8. Tian R, Koyabu N, Takanaga H, et al. Effects of grapefruit juice and orange juice on the intestinal efflux of P-glycoprotein substrates. Pharm Res 2002;19:802-9. PubMed
  9. Vanapalli SR, Chen Y, Ellingrod VL, et al. Orange juice decreases the oral bioavailability of ivermectin in health volunteers. Clin Pharmacol Ther 2003;73 (Abstract PDII-A-10):P94.
  10. Huang SM, Lesko LJ. Drug-drug, drug-dietary supplement, and drug-citrus fruit and other food interactions: what have we learned? J Clin Pharmacol 2004;44:559-69. PubMed
  11. Koitabashi Y, Kumai T, Matsumoto N, et al. Orange juice increased the bioavailability of pravastatin, 3-hydroxy-3-methylglutaryl CoA reductase inhibitor, in rats and healthy human subjects. Life Sci 2006;78:2852-9. PubMed
  12. Takanaga H, Ohnishi A, Yamada S, et al. Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not cytochrome P450 3A4. J Pharmacol Exp Ther 2000;293:230-6. DOI
  13. Greenblatt DJ. Analysis of drug interactions involving fruit beverages and organic anion-transporting polypeptides. J Clin Pharmacol 2009;49:1403-7. PubMed
  14. Bailey DG. Fruit juice inhibition of uptake transport: a new type of food-drug interaction. Br J Clin Pharmacol 2010;70:645-55. PubMed
  15. Kamath AV, Yao M, Zhang Y, Chong S. Effect of fruit juices on the oral bioavailability of fexofenadine in rats. J Pharm Sci 2005;94:233-9. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Sweet Orange and Quetiapine Together: Common Questions

Is it safe to take Sweet Orange with Quetiapine?
We do not list a known interaction between Sweet Orange and Quetiapine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Sweet Orange and Quetiapine at the same time of day?
At least one FDA label for a product containing Quetiapine says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Quetiapine on its own and move Sweet Orange to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
Are Sweet Orange and Quetiapine used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Sweet Orange in each. That is a conversation for your prescriber, especially if Quetiapine is being adjusted to a target.
How was the Sweet Orange and Quetiapine combination checked?
Interactions in our licensed database are recorded against drug classes. Quetiapine is filed under 10 classifications, and Sweet Orange has documented interactions with 7 drug classes — none of Quetiapine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Sweet Orange interact with any other medications?
Yes. Sweet Orange has 246 documented drug interactions in our database — Quetiapine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Quetiapine interact with any supplements?
Yes. Quetiapine has documented interactions with 199 supplements in our database — Sweet Orange is not one of them. The Quetiapine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Sweet Orange monograph Uses, safety profile, and every drug interaction in one place Quetiapine drug information The full plain-English guide to this medication Quetiapine supplement interactions Every supplement checked against Quetiapine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 17 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Quetiapine and Sweet Orange?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.