Agave + Quetiapine
Quetiapine brand names: Seroquel, Dopaquel.
We found no known interaction between Agave and Quetiapine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Quetiapine states a food rule worth keeping to.
Agave and Quetiapine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Quetiapine and Agave in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Agave at all — not against Quetiapine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Agave safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Agave in Pregnancy & Breastfeeding
When used orally. Agave contains constituents that may be uterine stimulants, and it has traditionally been used to induce labor.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Quetiapine Products Have a Food Rule — Agave Should Not Break It
At least one FDA label for a product containing Quetiapine says to take it on an empty stomach. Most supplements — Agave included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Quetiapine on its own and move Agave to a meal later in the day.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Quetiapine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
It is recommended that SEROQUEL XR be taken without food or with a light meal (approximately 300 calories) [see Clinical Pharmacology (12.3) ].
From the Dosage and Administration section of the FDA label we read for Quetiapine — where that label names a specific product, the instruction is that product's. See the Quetiapine drug page ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
Questions About Agave or Quetiapine
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Agave or Quetiapine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Can You Split Seroquel Tablets? ›
- Accidentally Took Two Seroquel During The Day Instead Of One ›
- Seroquel - Mirapex Interaction Details ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Quetiapine
This page covers Agave only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Quetiapine page lists 199 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).
By severity: 11 major · 147 moderate · 41 minor.
From our pharmacist’s overview on the Quetiapine page
“Quetiapine (Seroquel) treats schizophrenia and bipolar disorder, illnesses where an unplanned swing in the drug's blood level has real consequences, and that is why these 199 supplement interactions deserve a careful read rather than a shrug. Most of the risk runs through CYP3A4, the liver enzyme that clears quetiapine: grapefruit bloc…”
Reviewed by 2 · Jul 18, 2026
Taking Agave as Part of a Dietary Supplement Product? Check It for Interactions
We hold 88 real supplement products containing Agave, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Agave. Even though Agave itself has no known interaction with Quetiapine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Agave and Quetiapine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,102 of 1,452 supplements looked up here in the last 7 days
#38 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Agave reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Agave and Quetiapine records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Agave
What is Agave?
- Natural sweetener (agave nectar)
- Digestive complaints
- Wound and skin care (topical)
- Mild antimicrobial
- Traditional remedy for inflammation
Agave is a succulent plant best known as the source of agave nectar, a popular sweetener, and the base for tequila and mezcal. While it has a long history of folk use for digestion, skin care, and minor infections, there is very little solid human research to support medicinal benefits, and the raw sap can irritate skin and may be unsafe to take internally in large amounts. Talk to your pharmacist or doctor before using agave as a supplement.
Agave americana · Asparagaceae · Leaves, sap (used to make agave nectar/syrup), and roots · Agave nectar/syrup (sweetener), dried leaf, topical sap preparations, and occasionally capsules or extracts
An interaction check asks whether these two react with each other — it does not ask whether Agave is a good idea for someone in your situation. Here is what our Agave record says about it on its own.
Agave: dosing
There is no established standardized medicinal dose for agave. Most people only encounter it as agave nectar used to sweeten food and drinks, where the "dose" is simply how much sweetener you choose to use.For any supplement product containing agave extract, follow the directions on the product label and do not exceed the recommended amount.
From our Agave monograph — the full record covers uses, side effects and every documented interaction.
About Quetiapine
What Is Quetiapine Used For?
Brand names: Seroquel, Dopaquel
Quetiapine treats schizophrenia and bipolar disorder in adults and certain age groups of children and adolescents. For bipolar disorder, it is approved for manic episodes (both as a stand-alone treatment and alongside lithium or divalproex) and for depressive episodes.
The extended-release form of quetiapine is also approved as add-on therapy for major depressive disorder (MDD) in adults who are already taking an antidepressant. The regular tablet form is not approved for this use.
Other Drugs & Agave
Browse every other medication we’ve checked against Agave — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Agave against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Omeprazole ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
- Bisoprolol ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Agave list.
Agave References
The 8 references that drive our Agave monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Golan H, Landau M, Goldberg I, et al. [Dermatitis from contact with Agave americana]. Harefuah 2000;139(7-8):276-8, 326.
- Brenner S, Landau M, Goldberg I. Contact dermatitis with systemic symptoms from Agave americana. Dermatology 1998;196(4):408-411.
- High WA. Agave contact dermatitis. Am J Contact Dermat 2003;14(4):213-214. DOI
- Brazzelli V, Romano E, Balduzzi A, et al. Acute irritant contact dermatitis from Agave americana L. Contact Dermatitis 1995;33(1):60-61.
- Ricks MR, Vogel PS, Elston DM, et al. Purpuric agave dermatitis. J Am Acad Dermatol 1999;40(2 Pt 2):356-358. PubMed
- Kerner J, Mitchell J, Maibach HI. Irritant contact dermatitis from Agave americana L. Incorrect use of sap as "hair restorer". Arch Dermatol 1973;108(1):102-103. DOI
- Basilio CM, Seyler L, Bernstein J, et al. Isolation and characterization of an utero-active compound from Agave americana. P R Health Sci J 1989;8(3):295-299.
- Cherpelis BS, Fenske NA. Purpuric irritant contact dermatitis induced by Agave americana. Cutis 2000;66(4):287-8.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Agave and Quetiapine Together: Common Questions
Is it safe to take Agave with Quetiapine?
Should I take Agave and Quetiapine at the same time of day?
Does Quetiapine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.