Agave + Levothyroxine

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

At least one FDA label for a product containing Levothyroxine says to take it on an empty stomach. Most supplements — Agave included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Levothyroxine on its own and move Agave to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Levothyroxine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

These two come up together because they touch the same health topic — not because they do the same job. Levothyroxine is a prescription medicine with approved uses on its FDA label. Agave is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Levothyroxine is prescribed for: Levothyroxine replaces or supplements the thyroid hormone your body isn't making enough of. It's used for hypothyroidism — an underactive thyroid — in adults, children, and even newborns, whether the cause is the thyroid gland itself, the pituitary gland, or the hypothalamus in the brain. It's also used alongside surgery and radioiodine treatment in people with certain types of thyroid cancer, to help suppress the hormone that can stimulate cancer growth. It is not meant for weight loss, treating benign thyroid nodules in people who have enough iodine, or for hypothyroidism during recovery from a temporary condition called subacute thyroiditis.

Agave has been studied for:

• Cancer studied, not established Agave has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

  Agave for cancer

  Although there has been interest in using oral agave for cancer, there is insufficient reliable information about the clinical effects of agave for this purpose.

• Constipation studied, not established Agave has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

  Agave for constipation

  Although there has been interest in using oral agave for cancer, there is insufficient reliable information about the clinical effects of agave for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Levothyroxine on your own; if you are taking Agave for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Agave or Levothyroxine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

• Black Currant Oil With Levothyroxine, Methotrexate, and a Statin Answered by Dr. Brian Staiger, PharmD · August 2026 ›
• Provitalize With Levothyroxine, Valacyclovir, and Citalopram Answered by Dr. Brian Staiger, PharmD · July 2026 ›
• Can I Drink Essiac Tea With My Blood Pressure and Thyroid Meds? Answered by Dr. Brian Staiger, PharmD · July 2026 ›

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

This page covers Agave only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Levothyroxine page lists 50 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Tiratricol (major), Acetyl-l-carnitine (moderate), Alpha-lipoic Acid (moderate) and Ascophyllum Nodosum (moderate).

By severity: 2 major · 39 moderate · 9 minor.

Open the Levothyroxine interaction page ›

We hold 88 real supplement products containing Agave, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Agave. Even though Agave itself has no known interaction with Levothyroxine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.