Medication interaction hub

What Supplements Interact with Ziprasidone?

Ziprasidone brand name: Geodon. Every interaction below applies to the brands too.

188 Interactions 11 Major 136 Moderate 41 Minor
Curated & coded by · Clinical Pharmacist · Updated September 21, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Ziprasidone? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Ziprasidone against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Ziprasidone (Geodon) is an antipsychotic that already carries a warning about disturbing the heart's electrical rhythm, so a list with 11 major-rated interactions calls for real care before mixing in supplements. Most of the 188 ingredients on file touch the liver enzyme, CYP3A4, that clears ziprasidone from the body. Grapefruit can push the drug's level up, while St. John's wort can drain it low enough for symptoms to creep back. Thirteen more ingredients can add to that heart rhythm risk.

Twenty entries raise serotonin, which combined with ziprasidone can build toward agitation, fever, and a racing heart, and another 20 add to sun sensitivity. Seventeen, mostly charcoal and thick fibers, can keep an oral dose from absorbing fully, so space those well apart from your tablet. The 136 moderate and 41 minor entries are worth a scan, but the 11 majors are where I would start reading.

— , Clinical Pharmacist · July 18, 2026

Major 11 Moderate 136 Minor 41 No known interaction 1,264

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Ziprasidone: Top Interactions at a Glance

The Ziprasidone supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 188 interacting ingredients — plus 1,264 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Ziprasidone Combinations Today

The Ziprasidone + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Horny Goat Weed + Ziprasidonei

Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Bitter Orange + Ziprasidonei

Theoretically, bitter orange might have an additive effect when combined with drugs that prolong the QT interval, potentially increasing the risk of ventricular...

Read the full interaction Minor Likelihood Possible Vitamin D + Ziprasidonei

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Licorice + Ziprasidonei

Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Black Pepper + Ziprasidonei

Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Bacopa + Ziprasidonei

Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.

Read the full interaction
The complete list

Every Supplement Checked Against Ziprasidone

All 1,452 ingredients in our database, ranked by severity — 188 with a Ziprasidone interaction on file and 1,264 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Ziprasidone?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Horny Goat Weed with Ziprasidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.

Full Horny Goat Weed + Ziprasidone answer

Can you take Bitter Orange with Ziprasidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bitter orange might have an additive effect when combined with drugs that prolong the QT interval, potentially increasing the...

Full Bitter Orange + Ziprasidone answer

Can you take Vitamin D with Ziprasidone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.

Full Vitamin D + Ziprasidone answer

Can you take Licorice with Ziprasidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.

Full Licorice + Ziprasidone answer

Can you take Black Pepper with Ziprasidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Full Black Pepper + Ziprasidone answer

Can you take Lime with Ziprasidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of lime oil with photosensitizing drugs may increase the risk of phototoxicity.

Full Lime + Ziprasidone answer

Can you take Manganese with Ziprasidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the risk for manganese toxicity might increase when taken with antipsychotic drugs.

Full Manganese + Ziprasidone answer

Can you take Melatonin with Ziprasidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.

Full Melatonin + Ziprasidone answer

Can you take Methoxylated Flavones with Ziprasidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence suggests that methoxylated flavones might inhibit cytochrome P450 3A4 (CYP3A4).

Full Methoxylated Flavones + Ziprasidone answer

Can you take Methylene Blue with Ziprasidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Combining serotonergic drugs with methylene blue can cause additive serotonergic effects, including serotonin syndrome.

Full Methylene Blue + Ziprasidone answer

Can you take Moringa with Ziprasidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.

Full Moringa + Ziprasidone answer

Can you take Neem with Ziprasidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, neem leaf extract might increase the levels and clinical effects of CYP3A4 substrates.

Full Neem + Ziprasidone answer

Can you take Oregon Grape with Ziprasidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP3A4.

Full Oregon Grape + Ziprasidone answer

Can you take Padang Cassia with Ziprasidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that a methanol extract of Padang cassia inhibits cytochrome P450 3A4 (CYP3A4) activity.

Full Padang Cassia + Ziprasidone answer

Can you take Panax Ginseng with Ziprasidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Panax ginseng has an additive effect with drugs that prolong the QT interval and potentially increase the risk of ventricular...

Full Panax Ginseng + Ziprasidone answer

Can you take Peony with Ziprasidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Peony + Ziprasidone answer

Can you take Peppermint with Ziprasidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Full Peppermint + Ziprasidone answer

Can you take Phellodendron with Ziprasidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.

Full Phellodendron + Ziprasidone answer

Can you take Phenethylamine (pea) with Ziprasidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining serotonergic drugs with phenethylamine might increase the risk of serotonergic adverse effects.

Full Phenethylamine (pea) + Ziprasidone answer

Can you take Propolis with Ziprasidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.

Full Propolis + Ziprasidone answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Ziprasidone is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Ziprasidone, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Ziprasidone sits in 8 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Ziprasidone through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Ziprasidone through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Ziprasidone through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Ziprasidone through this category.

Qt Interval-Prolonging Drugs 13 ingredients

Medications that can affect the heart's electrical rhythm (the QT interval). Supplements with similar effects can add to that risk.

13 of the supplement ingredients on this page reach Ziprasidone through this category.

Antipsychotic Drugs 8 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

8 of the supplement ingredients on this page reach Ziprasidone through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Ziprasidone through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Ziprasidone through this category.

About Ziprasidone

Ziprasidone (Geodon) is an atypical antipsychotic used to treat schizophrenia and bipolar I disorder.

Generic name: Ziprasidone  ·  Brand name: Geodon.

See the full Ziprasidone drug information
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Take a Supplement Product? Check the Whole Bottle Against Ziprasidone

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Pharmacist Counseling Corner

Ziprasidone & Supplements: Common Questions

What supplements interact with Ziprasidone?
More than you might expect — 188 in total, though they are far from equal: 11 are rated major, 136 moderate, and 41 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Grapefruit, Activated Charcoal, Arsenic.
Which Ziprasidone supplement interactions are the most serious?
The 11 major-rated combinations — led by Grapefruit, Activated Charcoal, Arsenic, Cesium and Ephedra — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Ziprasidone?
Usually yes — most people on Ziprasidone can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Geodon have the same supplement interactions as Ziprasidone?
Yes — Geodon all contain Ziprasidone, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Ziprasidone and my other medications?
This page covers Ziprasidone against supplements and herbal ingredients. Checking Ziprasidone against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Ziprasidone drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 21, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.