Drug & supplement interaction

Sweet Orange + Ziprasidone

Ziprasidone brand name: Geodon.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Sweet Orange and Ziprasidone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Ziprasidone states a food rule worth keeping to.

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Interaction report

Sweet Orange and Ziprasidone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ziprasidone and Sweet Orange in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Sweet Orange safety at a glance

Sweet Orange overall Generally safe Sweet orange fruit and juice are safe as food for most people; concentrated oils and extracts call for more caution.
Pregnancy Likely Safe When sweet orange juice or fruit is used orally in amounts commonly found in foods. Read the full pregnancy detail
Breastfeeding Likely Safe When sweet orange juice or fruit is used orally in amounts commonly found in foods. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ziprasidone and Sweet Orange? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Ziprasidone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Ziprasidone is filed under 8 classifications — including antipsychotic drugs, qt interval-prolonging drugs, serotonergic drugs. Sweet Orange has documented interactions with 7 drug classes — the most serious being celiprolol (celicard) (major), ivermectin (stromectol, others) (major) and organic anion-transporting polypeptide substrates (oatp) (major) — and none of Ziprasidone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Sweet Orange Does Interact With Other Medications

Sweet Orange has 48 major, 198 moderate known drug interactions in our database — Ziprasidone isn’t one of them. If you take anything else, check it against the full list below.

Major 48 Moderate 198 No known interaction 2,584 (incl. Ziprasidone)
Taking anything else?

Check Another of Your Medications Against Sweet Orange

Covers the 2,830 medications we’ve checked against Sweet Orange. Pick one to open its full report.

What to actually watch for

What Ziprasidone’s Own FDA Label Lists

This is not an interaction — none of it involves Sweet Orange. These are the most notable effects listed in the ADVERSE REACTIONS section of Ziprasidone’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Mania or an unusually elevated mood Worth acting on
  • Serotonin syndrome Worth acting on
  • Trouble swallowing Worth acting on
  • Hallucinations Worth acting on
  • An irregular heartbeat Worth acting on
  • Seizures Worth acting on
  • Chest pain Worth acting on
  • Shortness of breath Worth acting on
  • A low white blood cell count Worth acting on
  • A higher chance of infection Worth acting on

Showing the 10 most notable of 29 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Ziprasidone. Read the label on DailyMed › Where a percentage is shown, it is the share of 19,927 voluntary FDA FAERS reports for Ziprasidone that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Sweet Orange’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Sweet Orange side to compare — that is a limit of the record, not a statement that Sweet Orange has no side effects.

Special populations

Sweet Orange in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When sweet orange juice or fruit is used orally in amounts commonly found in foods.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Ziprasidone Products Have a Food Rule — Sweet Orange Should Not Break It

At least one FDA label for a product containing Ziprasidone says to take it with food. If you take Sweet Orange on an empty stomach out of habit, keep them separate — and take Ziprasidone with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Ziprasidone products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.4 ) 2.1 Administration Information for GEODON Capsules Administer GEODON capsules orally with food.

From the Dosage and Administration section of the FDA label we read for Ziprasidone — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Overlapping uses

What Ziprasidone Is Prescribed For, and What Sweet Orange Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Ziprasidone is a prescription medicine with approved uses on its FDA label. Sweet Orange is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Ziprasidone is prescribed for: Ziprasidone is prescribed for adults with schizophrenia and for adults experiencing manic or mixed episodes of bipolar I disorder. It can be used on its own for acute manic or mixed episodes, or added to lithium or valproate to help maintain stability in bipolar I disorder long-term. An injectable form is also available for rapid control of agitation in people with schizophrenia who need quick relief. Prescribers are advised to weigh ziprasidone's potential effect on heart rhythm when choosing among treatment options.

Sweet Orange has been studied for:

  • Depression studied, not established Sweet Orange has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Sweet Orange for depression

    It is unclear if drinking sweet orange juice or using sweet orange essential oil as aromatherapy is beneficial for depression.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Ziprasidone on your own; if you are taking Sweet Orange for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Ziprasidone

This page covers Sweet Orange only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ziprasidone page lists 188 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 11 major · 136 moderate · 41 minor.

From our pharmacist’s overview on the Ziprasidone page

“Ziprasidone (Geodon) is an antipsychotic that already carries a warning about disturbing the heart's electrical rhythm, so a list with 11 major-rated interactions calls for real care before mixing in supplements. Most of the 188 ingredients on file touch the liver enzyme, CYP3A4, that clears ziprasidone from the body.”

Reviewed by 2 · Jul 18, 2026

Open the Ziprasidone interaction page

One more smart check

Taking Sweet Orange as Part of a Dietary Supplement Product? Check It for Interactions

We hold 678 real supplement products containing Sweet Orange, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Sweet Orange. Even though Sweet Orange itself has no known interaction with Ziprasidone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Sweet Orange and Ziprasidone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Sweet Orange
Top 25%

#256 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ziprasidone
Top half

#1,063 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Sweet Orange reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Sweet Orange and Ziprasidone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Sweet Orange

What is Sweet Orange?

Sweet Orange
  • Vitamin C source
  • Digestive upset
  • Stress and relaxation (aromatherapy)
  • Cold and respiratory support
  • Antioxidant support

Sweet orange is a common citrus fruit that is a good source of vitamin C, fiber, and antioxidants, and is enjoyed as a food worldwide. Its peel and essential oil are used in aromatherapy and traditional remedies, but strong scientific proof for most medicinal claims is limited. The fruit and juice are safe for most people as food, while concentrated oils and extracts deserve more caution.

Citrus sinensis · Rutaceae · Fruit, peel, and essential oil · Fresh fruit, juice, capsules, essential oil, peel extract, aromatherapy oil

An interaction check asks whether these two react with each other — it does not ask whether Sweet Orange is a good idea for someone in your situation. Here is what our Sweet Orange record says about it on its own.

Sweet Orange: dosing

There is no standardized medicinal dose for sweet orange. As a food, oranges and orange juice are enjoyed in normal serving sizes.For supplements, peel extracts, or essential oils, follow the directions on the product label, since products vary widely in strength.

From our Sweet Orange monograph — the full record covers uses, side effects and every documented interaction.

Read the full Sweet Orange monograph & all interactions
Medication

About Ziprasidone

What Is Ziprasidone Used For?

Brand name: Geodon

Ziprasidone is prescribed for adults with schizophrenia and for adults experiencing manic or mixed episodes of bipolar I disorder. It can be used on its own for acute manic or mixed episodes, or added to lithium or valproate to help maintain stability in bipolar I disorder long-term.

An injectable form is also available for rapid control of agitation in people with schizophrenia who need quick relief. Prescribers are advised to weigh ziprasidone's potential effect on heart rhythm when choosing among treatment options.

See full Ziprasidone drug information
Keep checking

Other Drugs & Sweet Orange

Browse every other medication we’ve checked against Sweet Orange — both the ones with a known interaction and the ones without. Select any drug for the full detail.

48Major
198Moderate
0Minor
2,583No known interaction
48 Major 198 Moderate 2,583 No interaction
Major

48 interactions

Moderate

198 interactions

Showing 60 of 198 moderate interactions — see all 198 on the Sweet Orange page.

No interaction 2,583 drugs checked — show the list

We also checked Sweet Orange against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,583 medications checked with no known interaction — see the full Sweet Orange list.

See the full Sweet Orange interactions page
See every supplement checked against Ziprasidone, ranked by severity
Evidence & sources

Sweet Orange References

The 17 references that drive our Sweet Orange monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. FDA, CFSAN. FDA-approved potassium health claim notification for potassium containing foods. 2000. Available at: www.cfsan.fda.gov/~dms/hclm-k.html.
  3. Kurowska EM, Spence JD, Jordan J, et al. HDL-cholesterol-raising effect of orange juice in subjects with hypercholesterolemia. Am J Clin Nutr 2000;72:1095-100. PubMed
  4. Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
  5. Bailey DG, Dresser GK, Munoz C, et al. Reduction of fexofenadine bioavailability by fruit juices. Clin Pharmacol Ther 2001;69:P21.
  6. Pletz MW, Petzold P, Allen A, et al. Effect of calcium carbonate on bioavailability of orally administered gemifloxacin. Antimicrob Agents Chemother 2003;47:2158-60.. PubMed
  7. Lilja JJ, Juntti-Patinen L, Neuvonen PJ. Orange juice substantially reduces the bioavailability of the beta-adrenergic-blocking agent celiprolol. Clin Pharmacol Ther 2004;75:184-90.
  8. Tian R, Koyabu N, Takanaga H, et al. Effects of grapefruit juice and orange juice on the intestinal efflux of P-glycoprotein substrates. Pharm Res 2002;19:802-9. PubMed
  9. Vanapalli SR, Chen Y, Ellingrod VL, et al. Orange juice decreases the oral bioavailability of ivermectin in health volunteers. Clin Pharmacol Ther 2003;73 (Abstract PDII-A-10):P94.
  10. Huang SM, Lesko LJ. Drug-drug, drug-dietary supplement, and drug-citrus fruit and other food interactions: what have we learned? J Clin Pharmacol 2004;44:559-69. PubMed
  11. Koitabashi Y, Kumai T, Matsumoto N, et al. Orange juice increased the bioavailability of pravastatin, 3-hydroxy-3-methylglutaryl CoA reductase inhibitor, in rats and healthy human subjects. Life Sci 2006;78:2852-9. PubMed
  12. Takanaga H, Ohnishi A, Yamada S, et al. Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not cytochrome P450 3A4. J Pharmacol Exp Ther 2000;293:230-6. DOI
  13. Greenblatt DJ. Analysis of drug interactions involving fruit beverages and organic anion-transporting polypeptides. J Clin Pharmacol 2009;49:1403-7. PubMed
  14. Bailey DG. Fruit juice inhibition of uptake transport: a new type of food-drug interaction. Br J Clin Pharmacol 2010;70:645-55. PubMed
  15. Kamath AV, Yao M, Zhang Y, Chong S. Effect of fruit juices on the oral bioavailability of fexofenadine in rats. J Pharm Sci 2005;94:233-9. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Sweet Orange and Ziprasidone Together: Common Questions

Is it safe to take Sweet Orange with Ziprasidone?
We do not list a known interaction between Sweet Orange and Ziprasidone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Sweet Orange and Ziprasidone at the same time of day?
At least one FDA label for a product containing Ziprasidone says to take it with food. If you take Sweet Orange on an empty stomach out of habit, keep them separate and take Ziprasidone with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Ziprasidone products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Are Sweet Orange and Ziprasidone used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Sweet Orange in each. That is a conversation for your prescriber, especially if Ziprasidone is being adjusted to a target.
How was the Sweet Orange and Ziprasidone combination checked?
Interactions in our licensed database are recorded against drug classes. Ziprasidone is filed under 8 classifications, and Sweet Orange has documented interactions with 7 drug classes — none of Ziprasidone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Sweet Orange interact with any other medications?
Yes. Sweet Orange has 246 documented drug interactions in our database — Ziprasidone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Ziprasidone interact with any supplements?
Yes. Ziprasidone has documented interactions with 188 supplements in our database — Sweet Orange is not one of them. The Ziprasidone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Sweet Orange monograph Uses, safety profile, and every drug interaction in one place Ziprasidone drug information The full plain-English guide to this medication Ziprasidone supplement interactions Every supplement checked against Ziprasidone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 17 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ziprasidone and Sweet Orange?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.