1,4-butanediol + Quetiapine
Quetiapine brand names: Seroquel, Dopaquel.
We found no known interaction between 1,4-butanediol and Quetiapine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Quetiapine states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
1,4-butanediol and Quetiapine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Quetiapine and 1,4-butanediol in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
1,4-butanediol safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Quetiapine
Interactions in our licensed database are recorded against drug classes, not just single drug names. Quetiapine is filed under 10 classifications — including antipsychotic drugs, qt interval-prolonging drugs, serotonergic drugs. 1,4-butanediol has documented interactions with 10 drug classes — the most serious being alcohol (ethanol) (major), cns depressants (major) and narcotic drugs (major) — and none of Quetiapine’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
1,4-butanediol Does Interact With Other Medications
1,4-butanediol has 250 major, 21 moderate known drug interactions in our database — Quetiapine isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against 1,4-butanediol
We haven’t checked that one against 1,4-butanediol yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against 1,4-butanediol. Pick one to open its full report.
1,4-butanediol in Pregnancy & Breastfeeding
When used orally.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Quetiapine Products Have a Food Rule — 1,4-butanediol Should Not Break It
At least one FDA label for a product containing Quetiapine says to take it on an empty stomach. Most supplements — 1,4-butanediol included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Quetiapine on its own and move 1,4-butanediol to a meal later in the day.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Quetiapine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
It is recommended that SEROQUEL XR be taken without food or with a light meal (approximately 300 calories) [see Clinical Pharmacology (12.3) ].
From the Dosage and Administration section of the FDA label we read for Quetiapine — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
What Quetiapine Is Prescribed For, and What 1,4-butanediol Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Quetiapine is a prescription medicine with approved uses on its FDA label. 1,4-butanediol is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Quetiapine is prescribed for: Quetiapine treats schizophrenia and bipolar disorder in adults and certain age groups of children and adolescents. For bipolar disorder, it is approved for manic episodes (both as a stand-alone treatment and alongside lithium or divalproex) and for depressive episodes. The extended-release form of quetiapine is also approved as add-on therapy for major depressive disorder (MDD) in adults who are already taking an antidepressant. The regular tablet form is not approved for this use.
1,4-butanediol has been studied for:
-
Depression studied, not established 1,4-butanediol has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
1,4-butanediol for depression
Although there has been interest in using oral 1,4-butanediol for depression, there is insufficient reliable information about the clinical effects of 1,4-butanediol for this purpose.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Quetiapine on your own; if you are taking 1,4-butanediol for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
Questions About 1,4-butanediol or Quetiapine
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers 1,4-butanediol or Quetiapine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Can You Split Seroquel Tablets? ›
- Accidentally Took Two Seroquel During The Day Instead Of One ›
- Seroquel - Mirapex Interaction Details ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Quetiapine
This page covers 1,4-butanediol only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Quetiapine page lists 199 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).
By severity: 11 major · 147 moderate · 41 minor.
From our pharmacist’s overview on the Quetiapine page
“Quetiapine (Seroquel) treats schizophrenia and bipolar disorder, illnesses where an unplanned swing in the drug's blood level has real consequences, and that is why these 199 supplement interactions deserve a careful read rather than a shrug. Most of the risk runs through CYP3A4, the liver enzyme that clears quetiapine: grapefruit bloc…”
Reviewed by 2 · Jul 18, 2026
Where 1,4-butanediol and Quetiapine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#708 of 1,452 supplements looked up here in the last 7 days
#38 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every 1,4-butanediol reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The 1,4-butanediol and Quetiapine records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About 1,4-butanediol
What is 1,4-butanediol?
- Marketed illegally as a 'recreational' or party substance
- Falsely sold as a sleep aid
- Falsely promoted for bodybuilding or muscle growth
- Industrial solvent and chemical manufacturing
1,4-butanediol is a toxic industrial chemical, not a safe dietary supplement. Once swallowed, the body converts it into GHB, a powerful central nervous system depressant that can cause coma, dangerous breathing problems, addiction, and death. It should never be taken as a supplement or recreational substance.
Synthetic industrial chemical (not a plant) · Liquid solvent (sometimes sold illegally as a 'supplement,' cleaner, or party drug)
An interaction check asks whether these two react with each other — it does not ask whether 1,4-butanediol is a good idea for someone in your situation. Here is what our 1,4-butanediol record says about it on its own.
1,4-butanediol: dosing
There is no established or recommended dose of 1,4-butanediol, because it is not a legitimate supplement or medicine. It should not be taken in any amount.If you have encountered a product that contains or is suspected to contain 1,4-butanediol, do not use it. In the U.S., you can reach Poison Control at 1-800-222-1222.
From our 1,4-butanediol monograph — the full record covers uses, side effects and every documented interaction.
About Quetiapine
What Is Quetiapine Used For?
Brand names: Seroquel, Dopaquel
Quetiapine treats schizophrenia and bipolar disorder in adults and certain age groups of children and adolescents. For bipolar disorder, it is approved for manic episodes (both as a stand-alone treatment and alongside lithium or divalproex) and for depressive episodes.
The extended-release form of quetiapine is also approved as add-on therapy for major depressive disorder (MDD) in adults who are already taking an antidepressant. The regular tablet form is not approved for this use.
Other Drugs & 1,4-butanediol
Browse every other medication we’ve checked against 1,4-butanediol — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
250 interactions
- Diphenhydramine ›
- Flurazepam ›
- Triazolam ›
- Zopiclone ›
- Fentanyl ›
- Oxycodone ›
- Phenytoin ›
- Temazepam ›
- Carbamazepine ›
- Morphine Sulfate ›
- Nitrazepam ›
- Buprenorphine ›
- Diazepam ›
- Lofepramine ›
- Meprobamate ›
- Oxymorphone ›
- Propoxyphene ›
- Topiramate ›
- Aripiprazole ›
- Cetirizine ›
- Clobazam ›
- Clonazepam ›
- Clorazepate ›
- Desipramine ›
- Doxepin ›
- Hydromorphone ›
- Levetiracetam ›
- Metoclopramide ›
- Midazolam ›
- Phenobarbital ›
- Tramadol ›
- Valproic Acid ›
- Zolpidem ›
- Acetazolamide ›
- Alprazolam ›
- Aripiprazole Lauroxil ›
- Buprenorphine Hydrochloride ›
- Butabarbital Sodium ›
- Chlorpromazine ›
- Dexmedetomidine ›
- Gabapentin ›
- Hexobarbital ›
- Hydrocodone ›
- Hydrocodone Bitartrate ›
- Lithium Carbonate (prescription Drug) ›
- Loxapine ›
- Magnesium Sulfate (prescription Drug) ›
- Meperidine ›
- Oxcarbazepine ›
- Oxycodone Hydrochloride ›
- Pregabalin ›
- Tasimelteon ›
- Zaleplon ›
- Zonisamide ›
- Acepromazine ›
- Alfentanil ›
- Aminoglutethimide ›
- Amitriptyline ›
- Amobarbital ›
- Brexanolone ›
Showing 60 of 250 major interactions — see all 250 on the 1,4-butanediol page.
21 interactions
- Amphetamine ›
- Naloxone ›
- Amphetamine Sulfate ›
- Naloxone Hydrochloride ›
- Saquinavir ›
- Dexamfetamine ›
- Dextroamphetamine ›
- Dextroamphetamine (patch) ›
- Dextroamphetamine Sulphate ›
- Hethylphenidate Hcl ›
- Lisdexamfetamine ›
- Methamphetamine ›
- Methoxyamphetamine ›
- Ritonavir ›
- Amphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate ›
- Darunavir, Ritonavir ›
- Dasabuvir Sodium, Ombitasvir, Paritaprevir, Ritonavir ›
- Lopinavir, Ritonavir ›
- Nirmatrelvir, Ritonavir ›
- Ombitasvir, Paritaprevir Ritonavir ›
- Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir ›
No interaction 2,558 drugs checked — show the list
We also checked 1,4-butanediol against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Doxycycline ›
- Fluoxetine ›
- Methotrexate ›
- Isotretinoin ›
- Azithromycin ›
- Omeprazole ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
- Dapsone ›
- Cyclopentolate ›
- Candesartan Cilexetil ›
- Mannitol ›
- Cephalexin ›
- Roxithromycin ›
- Pegunigalsidase Alfa-iwxj ›
- Atorvastatin Calcium ›
- Daptomycin ›
Showing the 60 most looked-up of 2,558 medications checked with no known interaction — see the full 1,4-butanediol list.
1,4-butanediol References
The 20 references that drive our 1,4-butanediol monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Smith SW, Zvosec DL. Death and central nervous system depression after ingestion of 1.4-butanediol, a gamma-hydroxybutyrate-related dietary supplement. Ann Emerg Med 2000;36:S85.
- Anon. Adverse events associated with ingestion of gamma-butyrolactone--Minnesota, New Mexico, and Texas, 1998-1999. MMWR Morb Mortal Wkly Rep 1999;48:137-40.
- Harrington RD, Woodward JA, Hooton TM, et al. Life-threatening interactions between HIV-1 protease inhibitors and the illicit drugs MDMA and gamma-hydroxybutyrate. Arch Intern Med 1999;159:2221-4.
- Anon. FDA alert on misuse of consumer products containing GHB, GBL and BD. Food and Drug Administration, Rockville, MD. June 15, 1999.
- Anon. Important message for health professionals: Report serious adverse events associated with dietary supplements containing GBL, GHB or BD. Food and Drug Administration, Rockville, MD. August 25, 1999. Available at: http://vm.cfsan.fda.gov/~dms/mwg
- Anon. Multistate outbreak of poisonings associated with illicit use of gamma hydroxy butyrate. JAMA 1991;265:447-8. DOI
- Carotenuto A, De Feo V, Fattorusso E, et al. The flavonoids of Allium ursinum. Phytochem 1996;41:531-6. PubMed
- Ferrara SD, Tedeschi L, Frison G, Rossi A. Fatality due to gamma-hydroxybutyric acid (GHB) and heroin intoxication. J Forensic Sci 1995;40:501-4. DOI
- Timby N, Eriksson A. Gamma-Hydroxybutyrate-Associated Deaths. Am J Med 2000;108:518. PubMed
- Schneir AB, Ly BT, Clark RF. A case of withdrawal from the GHB precursors gamma-butyrolactone and 1,4-butanediol. J Emerg Med 2001;21:31-3.. PubMed
- Zvosec DL, Smith SW, McCutcheon JR, et al. Adverse events, including death, associated with the use of 1,4-butanediol. N Engl J Med. 2001;344:87-94.. PubMed
- Mason P, Kerns II W. Gamma Hydroxybutyric Acid (GHB) Intoxication. Acad Emerg Med 2002;9:730-39.. DOI
- Poldrugo, F., Barker, S., Basa, M., Mallardi, F., and Snead, O. C. Ethanol potentiates the toxic effects of 1,4-butanediol. Alcohol Clin.Exp.Res 1985;9(6):493-497. PubMed
- Thai, D., Dyer, J. E., Jacob, P., and Haller, C. A. Clinical pharmacology of 1,4-butanediol and gamma-hydroxybutyrate after oral 1,4-butanediol administration to healthy volunteers. Clin.Pharmacol Ther. 2007;81(2):178-184. PubMed
- Boscolo-Berto R, Viel G, Montagnese S, Raduazzo DI, Ferrara SD, Dauvilliers Y. Narcolepsy and effectiveness of gamma-hydroxybutyrate (GHB): a systematic review and meta-analysis of randomized controlled trials. Sleep Med Rev. 2012 Oct;16(5):431-43. PubMed
- Thai D, Dyer JE, Benowitz NL, Haller CA. Gamma-hydroxybutyrate and ethanol effects and interactions in humans. J Clin Psychopharmacol. 2006 Oct;26(5):524-9. PubMed
- Weiss T, Müller D, Marti I, Happold C, Russmann S. Gamma-hydroxybutyrate (GHB) and topiramate--clinically relevant drug interaction suggested by a case of coma and increased plasma GHB concentration. Eur J Clin Pharmacol. 2013 May;69(5):1193-4. PubMed
- Product information for Xyrem. Jazz Pharmaceuticals, Inc. Palo Alto, CA. March 2022.
- Liakoni E, Gugelmann H, Dempsey DA, et al. Butanediol conversion to gamma-hydroxybutyrate markedly reduced by the alcohol dehydrogenase blocker fomepizole. Clin Pharmacol Ther 2019;105(5):1196-203. doi: 10.1002/cpt.1306. PubMed
- Stefani M, Roberts DM. 1,4-Butanediol overdose mimicking toxic alcohol exposure. Clin Toxicol (Phila) 2020;58(3):204-7. doi: 10.1080/15563650.2019.1617419. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking 1,4-butanediol and Quetiapine Together: Common Questions
Is it safe to take 1,4-butanediol with Quetiapine?
Do 1,4-butanediol and Quetiapine have any of the same side effects?
Should I take 1,4-butanediol and Quetiapine at the same time of day?
Are 1,4-butanediol and Quetiapine used for the same thing?
How was the 1,4-butanediol and Quetiapine combination checked?
Does 1,4-butanediol interact with any other medications?
Does Quetiapine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.