Drug & supplement interaction

Orris + Sulindac

Sulindac brand names: Sundac, Sulin, Clinoril.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Orris and Sulindac in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Sulindac states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Orris and Sulindac

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sulindac and Orris in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Orris at all — not against Sulindac, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Orris safety at a glance

Orris overall Use caution Mostly used as a fragrance; the fresh root can irritate the skin and gut and human safety data for internal use are limited.
Pregnancy Avoid Not enough safety information; avoid medicinal use during pregnancy.
Breastfeeding Avoid Not enough safety information; avoid medicinal use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sulindac and Orris? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Orris and Sulindac May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Diarrhea / Vomiting reported in 4.4% of FDA reports for Sulindac Additional detail

    Orris

    “Orally, the fresh plant juice or root can cause severe mucosal irritation, abdominal pain, vomiting, and bloody diarrhea (18).”

    Orris · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Sulindac

    Listed in the ADVERSE REACTIONS section of the FDA label for Sulindac, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • A skin rash Additional detail

    Orris

    “Topically, the fresh plant juice or root can cause severe skin and mucosal irritation (12,18). A case of allergic contact dermatitis has been reported in a 45-year-old atopic patient using a facial cream containing an extract of orris root.”

    Orris · Natural Medicines adverse-effect record, reported in dermatitis.

    3 sources cited
    1. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    3. 106685. Baudy A, Samaran Q, Dereure O, Raison-Peyron N. Allergic contact dermatitis to Iris germanica root in a "natural" cosmetic. Contact Dermatitis 2021;85(1):111-112.

    Sulindac

    Listed in the ADVERSE REACTIONS section of the FDA label for Sulindac. Read the label on DailyMed ›

Reported for Orris but not commonly for Sulindac: stomach pain.

Effects for Sulindac come from the ADVERSE REACTIONS section of its FDA label; effects for Orris come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 2,392 voluntary FDA FAERS reports for Sulindac that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Sulindac Products Have a Food Rule — Orris Should Not Break It

At least one FDA label for a product containing Sulindac says to take it with food. If you take Orris on an empty stomach out of habit, keep them separate — and take Sulindac with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Sulindac products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Sulindac tablets should be administered orally twice a day with food.

From the Dosage and Administration section of the FDA label we read for Sulindac — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Overlapping uses

What Sulindac Is Prescribed For, and What Orris Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Sulindac is a prescription medicine with approved uses on its FDA label. Orris is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Sulindac is prescribed for: Sulindac is used to treat pain and inflammation in several conditions. These include osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis (a type of spinal arthritis) for both short-term and long-term use. It is also used short-term for acute painful shoulder (subacromial bursitis or supraspinatus tendinitis) and acute gouty arthritis. Note that sulindac's safety and effectiveness have not been established in the most severely disabled rheumatoid arthritis patients (those classified as Functional Class IV).

Orris has been studied for:

  • Joint pain studied, not established Orris has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Orris for joint pain

    Although there has been interest in oral orris root for joint pain, there is insufficient reliable information about the clinical effects of orris for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Sulindac on your own; if you are taking Orris for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Orris or Sulindac

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Orris or Sulindac, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Sulindac

This page covers Orris only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sulindac page lists 34 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Siberian Cocklebur (major) and Wine (major).

By severity: 5 major · 18 moderate · 11 minor.

From our pharmacist’s overview on the Sulindac page

“Sulindac (Clinoril) is an NSAID, and like all NSAIDs it already strains the stomach lining and the kidneys. That is exactly where most of its 34 known supplement interactions land, so the five rated major warrant genuine caution rather than a quick skim.”

Reviewed by 2 · Jul 18, 2026

Open the Sulindac interaction page

One more smart check

Taking Orris as Part of a Dietary Supplement Product? Check It for Interactions

We hold 36 real supplement products containing Orris, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Orris. Even though Orris itself has no known interaction with Sulindac, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Orris and Sulindac Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Orris
Top half

#722 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sulindac
Steady interest

#1,599 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Orris reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Orris and Sulindac records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Orris

What is Orris?

  • Fragrance and flavoring (perfumes, gin, cosmetics)
  • Traditional remedy for coughs and congestion
  • Skin and breath freshening
  • Teething soothers for infants (traditional, not recommended)
  • Digestive complaints (traditional use)

Orris is the dried, aged rhizome of certain iris species, valued mainly for its violet-like scent in perfumes, cosmetics, and flavorings rather than for proven health benefits. There is very little reliable human evidence that it treats any medical condition, and the fresh root can be irritating, so it is best thought of as a fragrance ingredient rather than a remedy. Talk to your pharmacist or doctor before using it for any health purpose.

Iris germanica · Iridaceae · Dried rhizome (orris root) and its essential oil/extract (orris butter) · Dried root pieces, powder, essential oil (orris butter), tinctures, and as a flavoring or fragrance ingredient

An interaction check asks whether these two react with each other — it does not ask whether Orris is a good idea for someone in your situation. Here is what our Orris record says about it on its own.

Orris: dosing

There is no established or standardized medicinal dose for orris root. Its main everyday uses—as a perfume ingredient or a flavoring—involve very small amounts and are not the same as taking it as a supplement.If you are considering a product that contains orris, follow the directions on the label and do not exceed them.

From our Orris monograph — the full record covers uses, side effects and every documented interaction.

Read the full Orris monograph & all interactions
Medication

About Sulindac

What Is Sulindac Used For?

Brand names: Sundac, Sulin, Clinoril

Sulindac is used to treat pain and inflammation in several conditions. These include osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis (a type of spinal arthritis) for both short-term and long-term use.

It is also used short-term for acute painful shoulder (subacromial bursitis or supraspinatus tendinitis) and acute gouty arthritis. Note that sulindac's safety and effectiveness have not been established in the most severely disabled rheumatoid arthritis patients (those classified as Functional Class IV).

See full Sulindac drug information
Keep checking

Other Drugs & Orris

Browse every other medication we’ve checked against Orris — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Orris against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Orris list.

See the full Orris interactions page
See every supplement checked against Sulindac, ranked by severity
Evidence & sources

Orris References

The 3 references that drive our Orris monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Baudy A, Samaran Q, Dereure O, Raison-Peyron N. Allergic contact dermatitis to Iris germanica root in a "natural" cosmetic. Contact Dermatitis 2021;85(1):111-112.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Orris and Sulindac Together: Common Questions

Is it safe to take Orris with Sulindac?
We do not list a known interaction between Orris and Sulindac. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Orris and Sulindac have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Orris and Sulindac at the same time of day?
At least one FDA label for a product containing Sulindac says to take it with food. If you take Orris on an empty stomach out of habit, keep them separate and take Sulindac with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Sulindac products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Are Orris and Sulindac used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Orris in each. That is a conversation for your prescriber, especially if Sulindac is being adjusted to a target.
Does Sulindac interact with any supplements?
Yes. Sulindac has documented interactions with 34 supplements in our database — Orris is not one of them. The Sulindac interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Orris monograph Uses, safety profile, and every drug interaction in one place Sulindac drug information The full plain-English guide to this medication Sulindac supplement interactions Every supplement checked against Sulindac, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Sulindac and Orris?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.