Pareira + Benzocaine, Dextromethorphan
Benzocaine, Dextromethorphan brand name: Tetra-Formula.
We found no known interaction between Pareira and Benzocaine, Dextromethorphan in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Pareira and Benzocaine, Dextromethorphan
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Benzocaine, Dextromethorphan and Pareira in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Pareira at all — not against Benzocaine, Dextromethorphan, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Pareira safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Pareira in Pregnancy & Breastfeeding
When used orally. Pareira may promote menstruation.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
See Every Supplement That Interacts With Benzocaine, Dextromethorphan
This page covers Pareira only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Benzocaine, Dextromethorphan page lists 24 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Lithium (major), 5-htp (moderate), Acetyl-l-carnitine (moderate), Ayahuasca (moderate) and Black Cohosh (moderate).
By severity: 1 major · 20 moderate · 3 minor.
From our pharmacist’s overview on the Benzocaine, Dextromethorphan page
“Tetra-Formula pairs benzocaine, a throat-numbing agent, with dextromethorphan, a cough suppressant that raises serotonin activity, and that second ingredient explains why 21 of the 24 supplement interactions on file share one theme, pushing serotonin higher and raising the risk of serotonin syndrome (agitation, racing heart, fever, con…”
Reviewed by 2 · Jul 18, 2026
Where Pareira and Benzocaine, Dextromethorphan Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,350 of 1,452 supplements looked up here in the last 7 days
#1,509 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pareira reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Pareira and Benzocaine, Dextromethorphan records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Pareira
What is Pareira?
- Urinary tract complaints
- Bladder irritation and inflammation
- Kidney stones
- Fluid retention (diuretic use)
- Digestive upset
Pareira is a traditional plant remedy, mainly from the South American vine Chondrodendron tomentosum, that has long been used for urinary and bladder complaints. Modern scientific evidence in humans is very limited, and some related plants in this group contain powerful muscle-relaxing compounds, so it should be used cautiously and only under professional guidance.
Chondrodendron tomentosum · Menispermaceae · Root and woody stem (bark) · Dried root, tincture, fluid extract, homeopathic preparations
An interaction check asks whether these two react with each other — it does not ask whether Pareira is a good idea for someone in your situation. Here is what our Pareira record says about it on its own.
Pareira: dosing
There is no established standardized dose for pareira, and products vary widely in strength and form. Because of this, it is not possible to recommend a specific safe and effective amount.If you choose to use a pareira product, follow the directions on the label and do not exceed the recommended amount.
From our Pareira monograph — the full record covers uses, side effects and every documented interaction.
Other Drugs & Pareira
Browse every other medication we’ve checked against Pareira — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Pareira against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Pareira list.
Pareira References
The 1 references that drive our Pareira monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Pareira and Benzocaine, Dextromethorphan Together: Common Questions
Is it safe to take Pareira with Benzocaine, Dextromethorphan?
Does Benzocaine, Dextromethorphan interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Benzocaine, Dextromethorphan and Pareira?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.