Drug & supplement interaction

Pareira + Tridihexethyl Chloride

Tridihexethyl Chloride brand name: Pathilon.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Pareira and Tridihexethyl Chloride in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Pareira and Tridihexethyl Chloride

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tridihexethyl Chloride and Pareira in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Pareira at all — not against Tridihexethyl Chloride, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Pareira safety at a glance

Pareira overall Use caution Human safety data are limited and related plants contain potent alkaloids, so use cautiously.
Pregnancy Unsafe When used orally. Pareira may promote menstruation. Read the full pregnancy detail
Breastfeeding Avoid There is no reliable safety data, so avoid use while breastfeeding.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tridihexethyl Chloride and Pareira? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Special populations

Pareira in Pregnancy & Breastfeeding

Pregnancy Unsafe

When used orally. Pareira may promote menstruation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Tridihexethyl Chloride

This page covers Pareira only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tridihexethyl Chloride page lists 46 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Henbane (major), Scopolia (major), Angel's Trumpet (moderate) and Bacopa (moderate).

By severity: 3 major · 32 moderate · 11 minor.

From our pharmacist’s overview on the Tridihexethyl Chloride page

“This one calls for real care. Tridihexethyl chloride (Pathilon) is itself an anticholinergic, prescribed to quiet stomach acid and gut spasms, and most of its 46 documented supplement interactions cut one of two ways.”

Reviewed by 2 · Jul 18, 2026

Open the Tridihexethyl Chloride interaction page

How much people look this up

Where Pareira and Tridihexethyl Chloride Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pareira
Steady interest

#1,354 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tridihexethyl Chloride
Steady interest

#1,432 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pareira reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Pareira and Tridihexethyl Chloride records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Pareira

What is Pareira?

  • Urinary tract complaints
  • Bladder irritation and inflammation
  • Kidney stones
  • Fluid retention (diuretic use)
  • Digestive upset

Pareira is a traditional plant remedy, mainly from the South American vine Chondrodendron tomentosum, that has long been used for urinary and bladder complaints. Modern scientific evidence in humans is very limited, and some related plants in this group contain powerful muscle-relaxing compounds, so it should be used cautiously and only under professional guidance.

Chondrodendron tomentosum · Menispermaceae · Root and woody stem (bark) · Dried root, tincture, fluid extract, homeopathic preparations

An interaction check asks whether these two react with each other — it does not ask whether Pareira is a good idea for someone in your situation. Here is what our Pareira record says about it on its own.

Pareira: dosing

There is no established standardized dose for pareira, and products vary widely in strength and form. Because of this, it is not possible to recommend a specific safe and effective amount.If you choose to use a pareira product, follow the directions on the label and do not exceed the recommended amount.

From our Pareira monograph — the full record covers uses, side effects and every documented interaction.

Read the full Pareira monograph & all interactions
Keep checking

Other Drugs & Pareira

Browse every other medication we’ve checked against Pareira — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Pareira References

The 1 references that drive our Pareira monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Pareira and Tridihexethyl Chloride Together: Common Questions

Is it safe to take Pareira with Tridihexethyl Chloride?
We do not list a known interaction between Pareira and Tridihexethyl Chloride. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Tridihexethyl Chloride interact with any supplements?
Yes. Tridihexethyl Chloride has documented interactions with 46 supplements in our database — Pareira is not one of them. The Tridihexethyl Chloride interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Tridihexethyl Chloride and Pareira?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.