Drug & supplement interaction

Patchouli Oil + Bupropion

Bupropion brand names: Wellbutrin, Wellbutrin SR, Zyban, Wellbutrin XL, Aplenzin, and others.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Patchouli Oil and Bupropion in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Patchouli Oil and Bupropion

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Bupropion and Patchouli Oil in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Patchouli Oil at all — not against Bupropion, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Patchouli Oil safety at a glance

Patchouli Oil overall Use caution Generally considered safe for topical and aromatherapy use when diluted, but can irritate skin and should not be swallowed.
Pregnancy Avoid Safety is not established, so avoid use during pregnancy unless cleared by your doctor.
Breastfeeding Avoid Not enough safety information exists, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Bupropion and Patchouli Oil? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Bupropion’s Own FDA Label Lists

This is not an interaction — none of it involves Patchouli Oil. These are the most notable effects listed in the ADVERSE REACTIONS section of Bupropion’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Mania or an unusually elevated mood Worth acting on
  • Thoughts of self-harm Worth acting on
  • Trouble swallowing Worth acting on
  • Hallucinations Worth acting on
  • An irregular heartbeat Worth acting on
  • Confusion Worth acting on
  • Seizures Worth acting on
  • Chest pain Worth acting on
  • Raised blood pressure Worth acting on
  • Hives Worth acting on

Showing the 10 most notable of 43 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Bupropion. Read the label on DailyMed › Where a percentage is shown, it is the share of 152,137 voluntary FDA FAERS reports for Bupropion that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Patchouli Oil’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Patchouli Oil side to compare — that is a limit of the record, not a statement that Patchouli Oil has no side effects.

From our Q&A

Questions About Patchouli Oil or Bupropion

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Patchouli Oil or Bupropion, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Bupropion

This page covers Patchouli Oil only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Bupropion page lists 46 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Adrafinil (moderate), African Wild Potato (moderate), Artichoke (moderate) and Astaxanthin (moderate).

By severity: 1 major · 33 moderate · 12 minor.

From our pharmacist’s overview on the Bupropion page

“Bupropion (Wellbutrin, Zyban) deserves genuine care around supplements, and the entry to understand first is activated charcoal, the only major-rated interaction on this list. Charcoal and similar bulk products can soak up the drug in the gut and blunt its effect, so space them well apart from your dose.”

Reviewed by 2 · Jul 18, 2026

Open the Bupropion interaction page

How much people look this up

Where Patchouli Oil and Bupropion Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Patchouli Oil
Steady interest

#1,394 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Bupropion
Top 1%

#23 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Patchouli Oil reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Patchouli Oil and Bupropion records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Patchouli Oil

What is Patchouli Oil?

  • Aromatherapy and relaxation
  • Skin care
  • Insect repellent
  • Fragrance and perfume
  • Antimicrobial use
  • Mood support

Patchouli oil is an essential oil pressed from the leaves of the patchouli plant, used mainly for its strong, earthy scent in aromatherapy, skin products, and perfumes. Most claimed health benefits come from laboratory studies rather than solid human trials, so its real-world value remains unproven. Like all essential oils, it should be diluted before skin use and never swallowed unless directed by a qualified professional.

Pogostemon cablin · Lamiaceae · Leaves (dried and steam-distilled essential oil) · Essential oil, diluted oil blends, soaps, lotions, perfumes, incense

An interaction check asks whether these two react with each other — it does not ask whether Patchouli Oil is a good idea for someone in your situation. Here is what our Patchouli Oil record says about it on its own.

Patchouli Oil: dosing

There is no established standard dose for patchouli oil, and it is not meant to be taken by mouth. For topical use, it is typically diluted to a small percentage in a carrier oil before being applied to the skin.For aromatherapy, a few drops may be added to a diffuser according to the product directions.

From our Patchouli Oil monograph — the full record covers uses, side effects and every documented interaction.

Read the full Patchouli Oil monograph & all interactions
Medication

About Bupropion

What Is Bupropion Used For?

Brand names: Wellbutrin, Wellbutrin SR, Zyban, Wellbutrin XL, Aplenzin, Forfivo XL

Bupropion is FDA-approved to treat major depressive disorder (MDD) — a form of clinical depression. Extended-release formulations (XL and hydrobromide versions, including Aplenzin) are also approved for the prevention of seasonal affective disorder (SAD), the pattern of depression that tends to arrive in autumn and winter.

Not all formulations share every indication. Aplenzin (bupropion hydrobromide extended-release) and bupropion hydrochloride extended-release tablets (XL) are indicated for both MDD and SAD. Bupropion hydrochloride extended-release tablets (SR) and bupropion hydrochloride immediate-release tablets are indicated for MDD only.

Most-Reported Side Effects for Bupropion

From FAERS, the FDA’s public side-effect reporting system (152,137 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 11,909 reports
Fatigue 10,076 reports
Headache 10,053 reports
Depression 8,639 reports
Dizziness 7,786 reports
See full Bupropion drug information
Keep checking

Other Drugs & Patchouli Oil

Browse every other medication we’ve checked against Patchouli Oil — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Patchouli Oil against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Patchouli Oil list.

See the full Patchouli Oil interactions page
See every supplement checked against Bupropion, ranked by severity
Evidence & sources

Patchouli Oil References

The 2 references that drive our Patchouli Oil monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Das NG, Dhiman S, Talukdar PK, Rabha B, Goswami D, Veer V. Synergistic mosquito-repellent activity of Curcuma longa, Pogostemon heyneanus and Zanthoxylum limonella essential oils. J Infect Public Health. 2015 Jul-Aug;8(4):323-8. PubMed
  2. Shin YK, Lee SY, Lee JM, Kang P, Seol GH. Effects of short-term inhalation of patchouli oil on professional quality of life and stress levels in emergency nurses: A randomized controlled trial. J Altern Complement Med. 2020 Nov;26(11):1032-1038. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Patchouli Oil and Bupropion Together: Common Questions

Is it safe to take Patchouli Oil with Bupropion?
We do not list a known interaction between Patchouli Oil and Bupropion. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Bupropion interact with any supplements?
Yes. Bupropion has documented interactions with 46 supplements in our database — Patchouli Oil is not one of them. The Bupropion interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Patchouli Oil monograph Uses, safety profile, and every drug interaction in one place Bupropion drug information The full plain-English guide to this medication Bupropion supplement interactions Every supplement checked against Bupropion, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Bupropion and Patchouli Oil?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.