Drug & supplement interaction

Pedunculate Oak + Naltrexone

Naltrexone brand names: Trexan, Depade, Vivitrol.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Pedunculate Oak and Naltrexone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Pedunculate Oak and Naltrexone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Naltrexone and Pedunculate Oak in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Pedunculate Oak at all — not against Naltrexone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Pedunculate Oak safety at a glance

Pedunculate Oak overall Use caution Generally used short-term for minor complaints, but the high tannin content can irritate the stomach and is not meant for long-term use.
Pregnancy Avoid There is not enough reliable safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid use unless advised by your doctor.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Naltrexone and Pedunculate Oak? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Naltrexone’s Own FDA Label Lists

This is not an interaction — none of it involves Pedunculate Oak. These are the most notable effects listed in the ADVERSE REACTIONS section of Naltrexone’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Dependence or withdrawal symptoms Worth acting on
  • A stroke or mini-stroke Worth acting on
  • A bowel blockage Worth acting on
  • Dehydration Worth acting on
  • A heart attack Worth acting on
  • Blood clots Worth acting on
  • Pancreatitis Worth acting on
  • Heart failure Worth acting on
  • Fainting Worth acting on
  • An irregular heartbeat Worth acting on

Showing the 10 most notable of 62 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Naltrexone. Read the label on DailyMed › Where a percentage is shown, it is the share of 40,504 voluntary FDA FAERS reports for Naltrexone that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Pedunculate Oak’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Pedunculate Oak side to compare — that is a limit of the record, not a statement that Pedunculate Oak has no side effects.

Everything else you take

See Every Supplement That Interacts With Naltrexone

This page covers Pedunculate Oak only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Naltrexone page lists 56 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Ashwagandha (moderate).

By severity: 4 major · 43 moderate · 9 minor.

From our pharmacist’s overview on the Naltrexone page

“The single biggest risk on this page is to your liver. Naltrexone (Vivitrol, Depade), prescribed for alcohol and opioid dependence, carries its own warnings about liver stress at higher doses, and 38 of the 56 supplements here share that liability, led by Siberian cocklebur, a major-rated entry tied to outright liver failure.”

Reviewed by 2 · Jul 18, 2026

Open the Naltrexone interaction page

How much people look this up

Where Pedunculate Oak and Naltrexone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pedunculate Oak
Steady interest

#1,373 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Naltrexone
Top 5%

#122 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pedunculate Oak reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Pedunculate Oak and Naltrexone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Pedunculate Oak

What is Pedunculate Oak?

  • Diarrhea
  • Sore throat and mouth inflammation
  • Skin irritation and minor wounds
  • Hemorrhoids
  • Excessive sweating

Pedunculate oak bark is a traditional astringent remedy used mainly for mild diarrhea, sore throat, and skin or anal irritation, thanks to its high tannin content. Evidence comes mostly from tradition and laboratory studies rather than strong human trials, so use it short-term and check with a pharmacist or doctor before trying it.

Quercus robur · Fagaceae · Bark, and sometimes the galls and acorns · Dried bark for tea or decoction, liquid extracts, and bark powder for compresses, baths, or gargles

An interaction check asks whether these two react with each other — it does not ask whether Pedunculate Oak is a good idea for someone in your situation. Here is what our Pedunculate Oak record says about it on its own.

Pedunculate Oak: dosing

There is no single standardized dose of pedunculate oak bark that applies to everyone, and amounts vary by product and how it is used (tea, gargle, wash, or bath).The best approach is to follow the directions on the product label and not exceed them. Traditional use generally limits internal use to a few days only.

From our Pedunculate Oak monograph — the full record covers uses, side effects and every documented interaction.

Read the full Pedunculate Oak monograph & all interactions
Medication

About Naltrexone

What Is Naltrexone Used For?

Brand names: Trexan, Depade, Vivitrol

Naltrexone Hydrochloride tablets are used to treat alcohol dependence and to block the effects of opioids in people with opioid dependence. The extended-release injectable suspension — sold as Vivitrol and also available as a generic injectable — is used to treat alcohol dependence and to prevent relapse to opioid dependence after a person has completed opioid detoxification.

All formulations are meant to be part of a broader treatment plan that includes counseling and other support — naltrexone works best when it is not used alone.

Most-Reported Side Effects for Naltrexone

From FAERS, the FDA’s public side-effect reporting system (40,504 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Injection site reaction 4,417 reports
Nausea 4,208 reports
Injection site pain 3,192 reports
Headache 2,685 reports
Fatigue 2,479 reports
See full Naltrexone drug information
Keep checking

Other Drugs & Pedunculate Oak

Browse every other medication we’ve checked against Pedunculate Oak — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Pedunculate Oak against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Pedunculate Oak list.

See the full Pedunculate Oak interactions page
See every supplement checked against Naltrexone, ranked by severity
Evidence & sources

Pedunculate Oak References

The 1 references that drive our Pedunculate Oak monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Weber RW. Allergen of the Month--English Oak. Ann Allergy Asthma Immunol. 2015 Nov;115(5):A13. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Pedunculate Oak and Naltrexone Together: Common Questions

Is it safe to take Pedunculate Oak with Naltrexone?
We do not list a known interaction between Pedunculate Oak and Naltrexone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Naltrexone interact with any supplements?
Yes. Naltrexone has documented interactions with 56 supplements in our database — Pedunculate Oak is not one of them. The Naltrexone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Pedunculate Oak monograph Uses, safety profile, and every drug interaction in one place Naltrexone drug information The full plain-English guide to this medication Naltrexone supplement interactions Every supplement checked against Naltrexone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Naltrexone and Pedunculate Oak?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.