Drug & supplement interaction

Pellitory + Levoleucovorin

Levoleucovorin brand name: Khapzory.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Pellitory and Levoleucovorin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Pellitory and Levoleucovorin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Levoleucovorin and Pellitory in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Pellitory at all — not against Levoleucovorin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Pellitory safety at a glance

Pellitory overall Use caution Limited safety data exist, and it may cause mouth irritation or allergic reactions.
Pregnancy Avoid Not enough safety information is available, so it is best avoided.
Breastfeeding Avoid There is no reliable safety data during breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Levoleucovorin and Pellitory? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Levoleucovorin’s Own FDA Label Lists

This is not an interaction — none of it involves Pellitory. These are the most notable effects listed in the ADVERSE REACTIONS section of Levoleucovorin’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 5 of them are worth acting on rather than waiting out — marked below.

  • A low white blood cell count Worth acting on mentioned in 6.8% of FDA reports for Levoleucovorin
  • Confusion Worth acting on
  • A low platelet count Worth acting on
  • Shortness of breath Worth acting on
  • An allergic reaction Worth acting on
  • Mouth irritation or sores
  • Hair loss
  • Reduced appetite mentioned in 5.0% of FDA reports for Levoleucovorin
  • Stomach upset
  • Itching

Showing the 10 most notable of 16 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Levoleucovorin. Read the label on DailyMed › Where a percentage is shown, it is the share of 3,706 voluntary FDA FAERS reports for Levoleucovorin that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Pellitory’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Pellitory side to compare — that is a limit of the record, not a statement that Pellitory has no side effects.

One more smart check

Taking Pellitory as Part of a Dietary Supplement Product? Check It for Interactions

We hold 36 real supplement products containing Pellitory, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Pellitory. Even though Pellitory itself has no known interaction with Levoleucovorin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Pellitory and Levoleucovorin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pellitory
Top half

#599 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Levoleucovorin
Steady interest

#2,748 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pellitory reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Pellitory and Levoleucovorin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Pellitory

What is Pellitory?

  • Toothache and oral discomfort
  • Increasing saliva flow
  • Sluggish digestion
  • Traditional tonic in some folk medicine systems

Pellitory (often Anacyclus pyrethrum, the root traditionally called 'pellitory of Spain') is an herb chiefly known in folk and traditional medicine for numbing toothache and stimulating saliva. Human evidence for its benefits is very limited, so it should be viewed as a traditional remedy rather than a proven treatment. Talk to your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Anacyclus pyrethrum · Asteraceae · Root · Powder, root extract, tinctures, tooth powders and mouthwashes

An interaction check asks whether these two react with each other — it does not ask whether Pellitory is a good idea for someone in your situation. Here is what our Pellitory record says about it on its own.

Pellitory: dosing

There is no well-established, standardized dose for pellitory, and product strengths vary widely.

From our Pellitory monograph — the full record covers uses, side effects and every documented interaction.

Read the full Pellitory monograph & all interactions
Medication

About Levoleucovorin Injection

What Is Levoleucovorin Injection Used For?

Brand name: Khapzory

Levoleucovorin injection (brands: Fusilev, Khapzory) is used intravenously in three main situations. First, it is given as a "rescue" treatment after high-dose methotrexate chemotherapy in osteosarcoma (bone cancer) — helping to limit the toxic effects methotrexate can have on healthy cells. Second, it is used when methotrexate is not clearing the body fast enough, or when there has been an accidental overdose of methotrexate or similar drugs called folic acid antagonists.

Third, levoleucovorin injection is used alongside the chemotherapy drug 5-fluorouracil (5-FU) for the palliative treatment of advanced metastatic colorectal cancer — meaning it helps make 5-FU work better, though the goal is disease control rather than cure. It is not approved for pernicious anemia or megaloblastic anemias related to vitamin B12 deficiency.

Most-Reported Side Effects for Levoleucovorin

From FAERS, the FDA’s public side-effect reporting system (3,706 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 288 reports
Neutropenia 251 reports
Diarrhea 246 reports
Decreased appetite 187 reports
Vomiting 171 reports
See full Levoleucovorin Injection drug information
Keep checking

Other Drugs & Pellitory

Browse every other medication we’ve checked against Pellitory — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Pellitory against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Pellitory list.

See the full Pellitory interactions page
See every supplement checked against Levoleucovorin, ranked by severity
Evidence & sources

Pellitory References

The 1 references that drive our Pellitory monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Pellitory and Levoleucovorin Together: Common Questions

Is it safe to take Pellitory with Levoleucovorin?
We do not list a known interaction between Pellitory and Levoleucovorin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Pellitory monograph Uses, safety profile, and every drug interaction in one place Levoleucovorin Injection drug information The full plain-English guide to this medication Levoleucovorin supplement interactions Every supplement checked against Levoleucovorin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Levoleucovorin and Pellitory?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.