Drug & supplement interaction

Pimpinella + Afatinib Dimaleate

Afatinib Dimaleate brand name: Gilotrif.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Pimpinella and Afatinib Dimaleate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Pimpinella and Afatinib Dimaleate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Afatinib Dimaleate and Pimpinella in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Pimpinella at all — not against Afatinib Dimaleate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Pimpinella safety at a glance

Pimpinella overall Use caution Generally well tolerated in food amounts, but concentrated supplements and essential oil need more caution.
Pregnancy Avoid Avoid medicinal or concentrated amounts during pregnancy because safety is not established.
Breastfeeding Use caution Safety of medicinal doses while breastfeeding is unclear, so use caution.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Afatinib Dimaleate and Pimpinella? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Afatinib Dimaleate’s Own FDA Label Lists

This is not an interaction — none of it involves Pimpinella. These are the most notable effects listed in the ADVERSE REACTIONS section of Afatinib Dimaleate’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Dehydration Worth acting on
  • Low potassium Worth acting on
  • Pancreatitis Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • A severe skin reaction Worth acting on
  • Kidney problems Worth acting on
  • Shortness of breath Worth acting on
  • Liver problems Worth acting on
  • Bleeding or bruising Worth acting on
  • A higher chance of infection Worth acting on

Showing the 10 most notable of 22 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Afatinib Dimaleate. Read the label on DailyMed › Where a percentage is shown, it is the share of 6,587 voluntary FDA FAERS reports for Afatinib Dimaleate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Pimpinella’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Pimpinella side to compare — that is a limit of the record, not a statement that Pimpinella has no side effects.

Everything else you take

See Every Supplement That Interacts With Afatinib Dimaleate

This page covers Pimpinella only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Afatinib Dimaleate page lists 54 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), St. John's Wort (major), Bitter Melon (moderate), Black Pepper (moderate) and Bulbine Natalensis (moderate).

By severity: 2 major · 35 moderate · 17 minor.

From our pharmacist’s overview on the Afatinib Dimaleate page

“Afatinib (Gilotrif) is a targeted lung cancer therapy, and because its effectiveness depends on keeping a steady blood level, this list deserves genuine care. Most of the 54 supplements here either change how much of the drug the gut absorbs or interfere with P-glycoprotein, a pump that moves afatinib across cell walls, pushing its lev…”

Reviewed by 2 · Jul 18, 2026

Open the Afatinib Dimaleate interaction page

One more smart check

Taking Pimpinella as Part of a Dietary Supplement Product? Check It for Interactions

We hold 5 real supplement products containing Pimpinella, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Pimpinella. Even though Pimpinella itself has no known interaction with Afatinib Dimaleate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Pimpinella and Afatinib Dimaleate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pimpinella
Steady interest

#1,125 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Afatinib Dimaleate
Top half

#862 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources.
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Pimpinella and Afatinib Dimaleate records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Pimpinella

What is Pimpinella?

  • Digestive upset and bloating
  • Gas (flatulence)
  • Cough and congestion
  • Menstrual discomfort
  • Flavoring agent

Pimpinella anisum, commonly known as anise, is a seed-bearing herb long used in traditional medicine for digestive complaints and as a flavoring. Human evidence for most health uses is limited, though it is widely consumed in foods and teas. Talk to your pharmacist or doctor before using it as a supplement, especially if you are pregnant, breastfeeding, or have a hormone-sensitive condition.

Pimpinella anisum · Apiaceae · Seeds (fruit) and essential oil · Tea, dried seeds, capsules, extracts, essential oil

An interaction check asks whether these two react with each other — it does not ask whether Pimpinella is a good idea for someone in your situation. Here is what our Pimpinella record says about it on its own.

Pimpinella: dosing

There is no official, standardized dose of anise for any health condition. Traditional use as a tea involves steeping crushed seeds in hot water, and amounts vary widely between products.If you choose to use an anise supplement, follow the directions on the product label and do not exceed the recommended amount.

From our Pimpinella monograph — the full record covers uses, side effects and every documented interaction.

Read the full Pimpinella monograph & all interactions
Medication

About Afatinib

What Is Afatinib Used For?

Brand name: Gilotrif

Gilotrif (afatinib) is used to treat metastatic non-small cell lung cancer (NSCLC) — cancer that has spread and cannot be removed by surgery. It has two specific approved uses.

First, Gilotrif is used as an initial treatment for metastatic NSCLC when the tumor carries certain EGFR mutations (gene changes in the cancer cells) confirmed by an FDA-approved test — specifically non-resistant mutations. Second, Gilotrif is used to treat metastatic squamous NSCLC (a particular cell type of lung cancer) in patients whose cancer progressed during or after platinum-based chemotherapy.

See full Afatinib drug information
Keep checking

Other Drugs & Pimpinella

Browse every other medication we’ve checked against Pimpinella — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Pimpinella against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Pimpinella list.

See the full Pimpinella interactions page
See every supplement checked against Afatinib Dimaleate, ranked by severity
Sources

Sources & How We Checked

We checked Pimpinella against Afatinib Dimaleate in the Natural Medicines interaction database and found no documented interaction on file. The medication overview comes from MedlinePlus, and supplement label details from the NIH Dietary Supplement Label Database.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Pimpinella monograph › Uses, safety, and every drug interaction in one place Afatinib Dimaleate supplement interactions › Every supplement checked against Afatinib Dimaleate, ranked by severity Afatinib drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Pimpinella and Afatinib Dimaleate Together: Common Questions

Is it safe to take Pimpinella with Afatinib Dimaleate?
We do not list a known interaction between Pimpinella and Afatinib Dimaleate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Afatinib Dimaleate interact with any supplements?
Yes. Afatinib Dimaleate has documented interactions with 54 supplements in our database — Pimpinella is not one of them. The Afatinib Dimaleate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Afatinib Dimaleate and Pimpinella?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.