Drug & supplement interaction

Plum + Tenapanor Hydrochloride

Tenapanor Hydrochloride brand name: Ibsrela.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Plum and Tenapanor Hydrochloride in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Plum and Tenapanor Hydrochloride

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tenapanor Hydrochloride and Plum in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Plum safety at a glance

Plum overall Generally safe Plums and prunes are widely eaten as food and are generally safe in normal amounts.

Pregnancy Use caution Plum as a food is generally fine, but concentrated supplements are not well studied in pregnancy.

Breastfeeding Use caution Eating plums is generally considered fine, but concentrated supplement forms lack safety data.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tenapanor Hydrochloride and Plum? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Tenapanor Hydrochloride

Interactions in our licensed database are recorded against drug classes, not just single drug names. Tenapanor Hydrochloride is filed under 2 classifications — cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Plum has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Tenapanor Hydrochloride’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Plum Does Interact With Other Medications

Plum has 122 moderate known drug interactions in our database — Tenapanor Hydrochloride isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Tenapanor Hydrochloride)

Taking anything else?

Check Another of Your Medications Against Plum

Covers the 2,830 medications we’ve checked against Plum. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Plum and Tenapanor Hydrochloride May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

Bloating or gas / Diarrhea reported in 31.1% of FDA reports for Tenapanor Hydrochloride Additional detail
Plum
“Orally, plum has been reported to cause gastrointestinal issues, including flatulence and diarrhea.

In one case report, small bowel obstruction with impaction in the terminal ileum occurred in a 10-month old infant who consumed a dried plum. This was likely due to the infant being unable to properly chew the plum.

Consumption of plum pits has also caused serious gastrointestinal adverse effects.”

Plum · Natural Medicines adverse-effect record, reported in diarrhea.
6 sources cited

95272. Lever E, Cole J, Scott SM, Emery PW, Whelan K. Systematic review: the effect of prunes on gastrointestinal function. Aliment Pharmacol Ther. 2014;40(7):750-8. PubMed

95276. Hooshmand S, Chai SC, Saadat RL, et al. Comparative effects of dried plum and dried apple on bone in postmenopausal women. Br J Nutr. 2011;106(6):923-30. PubMed

95285. Ibrahim N, Chauhan I, Nikkar-Esfahani A. 'A problematic plum pit in the piping': a case of traumatic oesophageal perforation. BMJ Case Rep. 2016;2016. pii: bcr2015213807. PubMed

95293. Piirainen L, Peuhkuri K, Bäckström K, Korpela R, Salminen S. Prune juice has a mild laxative effect in adults with certain gastrointestinal symptoms. Nutr. Res. 2007;27(8):511-3. DOI

95300. Arjmandi BH, Khalil DA, Lucas EA, et al. Dried plums improve indices of bone formation in postmenopausal women. J Womens Health Gend Based Med. 2002;11(1):61-8. PubMed

95296. Kong MS, Wang KL. A prune-induced small intestinal obstruction: sonographic appearance. J Clin Ultrasound. 1995;23(9):558-60. PubMed
Tenapanor Hydrochloride

Listed in the ADVERSE REACTIONS section of the FDA label for Tenapanor Hydrochloride, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Plum but not commonly for Tenapanor Hydrochloride: an allergic reaction and a bowel blockage.

Effects for Tenapanor Hydrochloride come from the ADVERSE REACTIONS section of its FDA label; effects for Plum come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 1,216 voluntary FDA FAERS reports for Tenapanor Hydrochloride that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Tenapanor Hydrochloride Is Prescribed For, and What Plum Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Tenapanor Hydrochloride is a prescription medicine with approved uses on its FDA label. Plum is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Tenapanor Hydrochloride is prescribed for: Tenapanor is approved for two distinct conditions, each under a separate brand. Ibsrela is used to treat irritable bowel syndrome with constipation (IBS-C) in adults. XPHOZAH is used to reduce high phosphorus levels (hyperphosphatemia) in adults with chronic kidney disease (CKD) who are on dialysis — specifically as an add-on when phosphate binders haven't worked well enough or aren't tolerated.

Plum has been studied for:

Constipation Natural Medicines rates the evidence for Plum: Possibly Effective Read what the research shows

Plum for constipation

Consuming whole dried plums (prunes), plum juice, or plum puree seems to improve symptoms of constipation at least as effectively as psyllium.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Tenapanor Hydrochloride on your own; if you are taking Plum for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Tenapanor Hydrochloride

This page covers Plum only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tenapanor Hydrochloride page lists 138 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 94 moderate · 41 minor.

From our pharmacist’s overview on the Tenapanor Hydrochloride page

“Tenapanor hydrochloride (Ibsrela) works in the gut to relieve irritable bowel syndrome with constipation, and its supplement interaction list deserves genuine care rather than a quick skim. Three of the 138 ingredients on file rate major: grapefruit, St.”

Reviewed by 2 · Jul 18, 2026

Open the Tenapanor Hydrochloride interaction page

One more smart check

Taking Plum as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,682 real supplement products containing Plum, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Plum. Even though Plum itself has no known interaction with Tenapanor Hydrochloride, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Plum and Tenapanor Hydrochloride Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Plum

Top 25%

#204 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Tenapanor Hydrochloride

Top 10%

#172 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Plum reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Plum and Tenapanor Hydrochloride records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Plum

What is Plum?

Constipation
Digestive health
Bone health support
Antioxidant source
General nutrition

Plums and their dried form (prunes) are common, nutritious foods that are best known for helping relieve constipation thanks to their fiber and sorbitol content. They are generally safe as food, but eating large amounts can cause gas, bloating, or loose stools. Talk to your pharmacist or doctor before using concentrated supplements, especially if you have a medical condition.

Prunus domestica · Rosaceae · Fruit (fresh and dried, also called prunes); juice · Fresh fruit, dried plums (prunes), juice, powder, capsules

An interaction check asks whether these two react with each other — it does not ask whether Plum is a good idea for someone in your situation. Here is what our Plum record says about it on its own.

Plum: dosing

There is no official standardized dose for plum. As a food, people often eat a small serving of dried plums or drink a small glass of plum juice to help with constipation, then adjust based on how their body responds.For supplements, powders, or capsules, follow the directions on the product label, since strength varies between products.

From our Plum monograph — the full record covers uses, side effects and every documented interaction.

Read the full Plum monograph & all interactions

Medication

About Tenapanor

What Is Tenapanor Used For?

Brand name: Ibsrela

Tenapanor is approved for two distinct conditions, each under a separate brand. Ibsrela is used to treat irritable bowel syndrome with constipation (IBS-C) in adults. XPHOZAH is used to reduce high phosphorus levels (hyperphosphatemia) in adults with chronic kidney disease (CKD) who are on dialysis — specifically as an add-on when phosphate binders haven't worked well enough or aren't tolerated.

Most-Reported Side Effects for Tenapanor Hydrochloride

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Diarrhea 1,239 reports

Therapy interrupted 292 reports

Abdominal distension 234 reports

Insurance issue 184 reports

Intentional underdose 167 reports

See full Tenapanor drug information

Keep checking

Other Drugs & Plum

Browse every other medication we’ve checked against Plum — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

122Moderate

0Minor

2,707No known interaction

122 Moderate 2,707 No interaction

Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Plum page.

No interaction 2,707 drugs checked — show the list

We also checked Plum against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Plum list.

See the full Plum interactions page

See every supplement checked against Tenapanor Hydrochloride, ranked by severity

Evidence & sources

Plum References

The 10 references that drive our Plum monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Lever E, Cole J, Scott SM, Emery PW, Whelan K. Systematic review: the effect of prunes on gastrointestinal function. Aliment Pharmacol Ther. 2014;40(7):750-8. PubMed
Hooshmand S, Chai SC, Saadat RL, et al. Comparative effects of dried plum and dried apple on bone in postmenopausal women. Br J Nutr. 2011;106(6):923-30. PubMed
Ibrahim N, Chauhan I, Nikkar-Esfahani A. 'A problematic plum pit in the piping': a case of traumatic oesophageal perforation. BMJ Case Rep. 2016;2016. pii: bcr2015213807. PubMed
Piirainen L, Peuhkuri K, Bäckström K, Korpela R, Salminen S. Prune juice has a mild laxative effect in adults with certain gastrointestinal symptoms. Nutr. Res. 2007;27(8):511-3. DOI
Kong MS, Wang KL. A prune-induced small intestinal obstruction: sonographic appearance. J Clin Ultrasound. 1995;23(9):558-60. PubMed
Jain M, Pielage P, De-Ryke R. Plum stones: an unusual cause of ileostomy obstruction demonstrated by sonography. J Clin Ultrasound. 1998;26(8):416-7. DOI
Arjmandi BH, Khalil DA, Lucas EA, et al. Dried plums improve indices of bone formation in postmenopausal women. J Womens Health Gend Based Med. 2002;11(1):61-8. PubMed
Santhakumar AB, Kundur AR, Fanning K, Netzel M, Stanley R, Singh I. Consumption of anthocyanin-rich Queen Garnet plum juice reduces platelet activation related thrombogenesis in healthy volunteers. J. Functional Foods. 2015;12:11-22. DOI
Santhakumar AB, Kundur AR, Sabapathy S, Stanley R, Singh I. The potential of anthocyanin-rich Queen Garnet plum juice supplementation in alleviating thrombotic risk under induced oxidative stress conditions. J. Functional Foods. 2015;14:747-57. DOI
Johnson MC, Fisher JK. Plum pit ileus: a case report. Mo Med. 1991;88(10):696-8.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Plum and Tenapanor Hydrochloride Together: Common Questions

Is it safe to take Plum with Tenapanor Hydrochloride?

We do not list a known interaction between Plum and Tenapanor Hydrochloride. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Plum and Tenapanor Hydrochloride have any of the same side effects?

Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

Are Plum and Tenapanor Hydrochloride used for the same thing?

They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Plum in each. That is a conversation for your prescriber, especially if Tenapanor Hydrochloride is being adjusted to a target.

How was the Plum and Tenapanor Hydrochloride combination checked?

Interactions in our licensed database are recorded against drug classes. Tenapanor Hydrochloride is filed under 2 classifications, and Plum has documented interactions with 1 drug class — none of Tenapanor Hydrochloride's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Plum interact with any other medications?

Yes. Plum has 122 documented drug interactions in our database — Tenapanor Hydrochloride is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Tenapanor Hydrochloride interact with any supplements?

Yes. Tenapanor Hydrochloride has documented interactions with 138 supplements in our database — Plum is not one of them. The Tenapanor Hydrochloride interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Plum monograph Uses, safety profile, and every drug interaction in one place Tenapanor drug information The full plain-English guide to this medication Tenapanor Hydrochloride supplement interactions Every supplement checked against Tenapanor Hydrochloride, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 10 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tenapanor Hydrochloride and Plum?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.