Drug & supplement interaction

Podophyllum + Eslicarbazepine Acetate

Eslicarbazepine Acetate brand name: Aptiom.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Podophyllum and Eslicarbazepine Acetate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Podophyllum and Eslicarbazepine Acetate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Eslicarbazepine Acetate and Podophyllum in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Podophyllum at all — not against Eslicarbazepine Acetate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Podophyllum safety at a glance

Podophyllum overall Avoid The plant and its crude resin are toxic; only standardized prescription topical products should be used under supervision.
Pregnancy Likely Unsafe When used orally or topically for self-medication; avoid using. Podophyllum is potentially embryotoxic and teratogenic. Oral and topical use can result in birth... Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally or topically for self-medication; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Eslicarbazepine Acetate and Podophyllum? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Podophyllum and Eslicarbazepine Acetate May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Liver problems Worth acting on Additional detail

    Podophyllum

    “Orally and topically, podophyllum and its resin (podophyllin) can cause serious adverse effects and is generally regarded as unsafe for use.

    Serious Adverse Effects:

    Orally and topically: Abdominal pain, bone marrow depression, cardiotoxicity, coma, diarrhea, dyspnea, hallucinations, hepatotoxicity, hypertension or hypotension, kidney failure, metabolic acidosis, paralysis, polyneuropathy, tachycardia, and vomiting.”

    Podophyllum · Natural Medicines adverse-effect record, reported in depression.

    Eslicarbazepine Acetate

    Listed in the ADVERSE REACTIONS section of the FDA label for Eslicarbazepine Acetate. Read the label on DailyMed ›

  • Vomiting Additional detail

    Podophyllum

    “Orally and topically, podophyllum resin can cause nausea, severe vomiting, diarrhea, abdominal pain, and ileus.

    Topically, podophyllum resin applied to the tongue or oral mucosa can cause transient loss of taste and local irritation.”

    Podophyllum · Natural Medicines adverse-effect record, reported in diarrhea.

    6 sources cited
    1. 5617. Cassidy DE, Drewry J, Fanning JP. Podophyllum toxicity: a report of a fatal case and a review of the literature. J Toxicol Clin Toxicol 1982;19:35-44. PubMed
    2. 12898. Frasca T, Brett AS, Yoo SD. Mandrake toxicity. A case of mistaken identity. Arch Intern Med 1997;157:2007-9.
    3. 12900. Mack RB. Living mortals run mad. Mandrake (podophyllum) poisoning. N C Med J 1992;53:98-9.
    4. 12897. Lozada-Nur F, Costa C. Retrospective findings of the clinical benefits of podophyllum resin 25% sol on hairy leukoplakia. Clinical results in nine patients. Oral Surg Oral Med Oral Pathol 1992;73:555-8. PubMed
    5. 68895. Moura, M. D., Guimaraes, T. R., Fonseca, L. M., de, Almeida Pordeus, I, and Mesquita, R. A. A random clinical trial study to assess the efficiency of topical applications of podophyllin resin (25%) versus podophyllin resin (25%) together with acyclovir c
    6. 68942. Gowdey, G., Lee, R. K., and Carpenter, W. M. Treatment of HIV-related hairy leukoplakia with podophyllum resin 25% solution. Oral Surg.Oral Med.Oral Pathol.Oral Radiol.Endod. 1995;79(1):64-67. PubMed

    Eslicarbazepine Acetate

    Listed in the ADVERSE REACTIONS section of the FDA label for Eslicarbazepine Acetate. Read the label on DailyMed ›

  • Nausea Additional detail

    Podophyllum

    Recorded for Podophyllum in the same Natural Medicines adverse-effect record shown under Vomiting above.

    Eslicarbazepine Acetate

    Listed in the ADVERSE REACTIONS section of the FDA label for Eslicarbazepine Acetate. Read the label on DailyMed ›

Reported for Podophyllum but not commonly for Eslicarbazepine Acetate: stomach pain, hallucinations, kidney problems and a change in taste.

Effects for Eslicarbazepine Acetate come from the ADVERSE REACTIONS section of its FDA label; effects for Podophyllum come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Podophyllum in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally or topically for self-medication; avoid using. Podophyllum is potentially embryotoxic and teratogenic. Oral and topical use can result in birth defects and fetal death.

Lactation Likely Unsafe

When used orally or topically for self-medication; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Eslicarbazepine Acetate

This page covers Podophyllum only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Eslicarbazepine Acetate page lists 37 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Alkanna (moderate), Alpine Ragwort (moderate), Boneset (moderate) and Borage (moderate).

By severity: 1 major · 27 moderate · 9 minor.

From our pharmacist’s overview on the Eslicarbazepine Acetate page

“Missing even part of a dose of Aptiom (eslicarbazepine acetate) can mean a breakthrough seizure, which is why I read this list with real care. Of the 37 supplement ingredients on file, only activated charcoal rates major; it binds the medicine in your gut and can sharply cut what reaches your blood.”

Reviewed by 2 · Jul 18, 2026

Open the Eslicarbazepine Acetate interaction page

One more smart check

Taking Podophyllum as Part of a Dietary Supplement Product? Check It for Interactions

We hold 9 real supplement products containing Podophyllum, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Podophyllum. Even though Podophyllum itself has no known interaction with Eslicarbazepine Acetate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Podophyllum and Eslicarbazepine Acetate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Podophyllum
Steady interest

#1,198 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Eslicarbazepine Acetate
Steady interest

#2,201 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Podophyllum reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Podophyllum and Eslicarbazepine Acetate records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Podophyllum

What is Podophyllum?

  • Genital and skin warts (topical)
  • Constipation (historical/traditional laxative)
  • Digestive complaints (homeopathic)
  • Watery diarrhea (homeopathic)
  • Liver and gallbladder remedies (traditional)

Podophyllum (American mayapple) is a toxic plant whose resin contains podophyllotoxin, used in prescription topical products to treat warts. The raw plant and crude resin are poisonous if taken by mouth and should never be self-used. Only use FDA-approved wart products exactly as directed and under medical guidance.

Podophyllum peltatum · Berberidaceae · Dried root and rhizome (and the resin extracted from it, called podophyllin) · Topical resin/solution (prescription podophyllin and podofilox), homeopathic preparations; historically a crude purgative

An interaction check asks whether these two react with each other — it does not ask whether Podophyllum is a good idea for someone in your situation. Here is what our Podophyllum record says about it on its own.

Podophyllum: dosing

There is no safe self-care oral dose for podophyllum, and the whole plant should not be taken by mouth. For warts, dosing is determined entirely by the strength of the prescription product and your clinician's instructions.If you are prescribed a topical podophyllin or podofilox product, use only the amount directed, apply it only to the warts, and follow the schedule and wash-off instructions exactly. Never increase the amount or frequency on your own.

From our Podophyllum monograph — the full record covers uses, side effects and every documented interaction.

Read the full Podophyllum monograph & all interactions
Medication

About Eslicarbazepine

What Is Eslicarbazepine Used For?

Brand name: Aptiom

Eslicarbazepine acetate tablets — sold under the brand names Aptiom and Eslicarbazepine Acetate — are used to treat partial-onset seizures (seizures that start in one part of the brain) in patients 4 years of age and older. It can be used alone (monotherapy) or alongside other seizure medications (adjunctive therapy).

Both Aptiom and the generic eslicarbazepine acetate tablets are approved for this same use, in the same age range. The dose is adjusted based on age, body weight, and kidney function.

See full Eslicarbazepine drug information
Keep checking

Other Drugs & Podophyllum

Browse every other medication we’ve checked against Podophyllum — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Podophyllum against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Podophyllum list.

See the full Podophyllum interactions page
See every supplement checked against Eslicarbazepine Acetate, ranked by severity
Evidence & sources

Podophyllum References

The 13 references that drive our Podophyllum monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Cassidy DE, Drewry J, Fanning JP. Podophyllum toxicity: a report of a fatal case and a review of the literature. J Toxicol Clin Toxicol 1982;19:35-44. PubMed
  2. Rosenstein G, Rosenstein H, Freeman M, Weston N. Podophyllum-a dangerous laxative. Pediatrics 1976;57:419-21. DOI
  3. Lozada-Nur F, Costa C. Retrospective findings of the clinical benefits of podophyllum resin 25% sol on hairy leukoplakia. Clinical results in nine patients. Oral Surg Oral Med Oral Pathol 1992;73:555-8. PubMed
  4. Frasca T, Brett AS, Yoo SD. Mandrake toxicity. A case of mistaken identity. Arch Intern Med 1997;157:2007-9.
  5. Schwartz J, Norton SA. Useful plants of dermatology. VI. The mayapple (Podophyllum). J Am Acad Dermatol 2002;47:774-5. PubMed
  6. Mack RB. Living mortals run mad. Mandrake (podophyllum) poisoning. N C Med J 1992;53:98-9.
  7. Longstaff E, von Krogh G. Condyloma eradication: self-therapy with 0.15-0.5% podophyllotoxin versus 20-25% podophyllin preparations--an integrated safety assessment. Regul Toxicol Pharmacol 2001;33:117-37. PubMed
  8. Wiley DJ, Douglas J, Beutner K, et al. External genital warts: diagnosis, treatment, and prevention. Clin Infect Dis 2002;35:S210-24. PubMed
  9. Moura, M. D., Guimaraes, T. R., Fonseca, L. M., de, Almeida Pordeus, I, and Mesquita, R. A. A random clinical trial study to assess the efficiency of topical applications of podophyllin resin (25%) versus podophyllin resin (25%) together with acyclovir c
  10. Martin, L. K., Rubin, A. I., Theocharous, C., and Murrell, D. F. Podophyllin reaction mimicking Bowen's disease in a patient with delusions of verrucosis. Clin Exp.Dermatol 2008;33(4):443-445. PubMed
  11. Chamberlain, M. J., Reynolds, A. L., and Yeoman, W. B. Medical memoranda. Toxic effect of podophyllum application in pregnancy. Br.Med.J. 8-12-1972;3(823):391-392. PubMed
  12. Karol, M. D., Conner, C. S., Watanabe, A. S., and Murphrey, K. J. Podophyllum: suspected teratogenicity from topical application. Clin.Toxicol. 1980;16(3):283-286. PubMed
  13. Gowdey, G., Lee, R. K., and Carpenter, W. M. Treatment of HIV-related hairy leukoplakia with podophyllum resin 25% solution. Oral Surg.Oral Med.Oral Pathol.Oral Radiol.Endod. 1995;79(1):64-67. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Podophyllum and Eslicarbazepine Acetate Together: Common Questions

Is it safe to take Podophyllum with Eslicarbazepine Acetate?
We do not list a known interaction between Podophyllum and Eslicarbazepine Acetate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Podophyllum and Eslicarbazepine Acetate have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Eslicarbazepine Acetate interact with any supplements?
Yes. Eslicarbazepine Acetate has documented interactions with 37 supplements in our database — Podophyllum is not one of them. The Eslicarbazepine Acetate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Podophyllum monograph Uses, safety profile, and every drug interaction in one place Eslicarbazepine drug information The full plain-English guide to this medication Eslicarbazepine Acetate supplement interactions Every supplement checked against Eslicarbazepine Acetate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 13 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Eslicarbazepine Acetate and Podophyllum?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.