Drug & supplement interaction

Poplar + Sofosbuvir, Velpatasvir, Voxilaprevir

Sofosbuvir, Velpatasvir, Voxilaprevir brand name: Vosevi.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Poplar and Sofosbuvir, Velpatasvir, Voxilaprevir in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Sofosbuvir, Velpatasvir, Voxilaprevir states a food rule worth keeping to.

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Interaction report

Poplar and Sofosbuvir, Velpatasvir, Voxilaprevir

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sofosbuvir, Velpatasvir, Voxilaprevir and Poplar in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Poplar at all — not against Sofosbuvir, Velpatasvir, Voxilaprevir, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Poplar safety at a glance

Poplar overall Use caution Generally used in folk medicine, but human safety data are limited and it contains aspirin-like compounds.
Pregnancy Avoid Not enough safety data and its salicylate content makes it best avoided during pregnancy.
Breastfeeding Avoid Safety during breastfeeding is unknown, so it is best avoided.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sofosbuvir, Velpatasvir, Voxilaprevir and Poplar? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Sofosbuvir, Velpatasvir, Voxilaprevir’s Own FDA Label Lists

This is not an interaction — none of it involves Poplar. These are the most notable effects listed in the ADVERSE REACTIONS section of Sofosbuvir, Velpatasvir, Voxilaprevir’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 5 of them are worth acting on rather than waiting out — marked below.

  • A slow heartbeat Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • Low mood Worth acting on
  • A severe allergic reaction Worth acting on
  • Liver problems Worth acting on
  • Trouble sleeping
  • Swelling
  • Tiredness
  • Diarrhea
  • A skin rash

Showing the 10 most notable of 12 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Sofosbuvir, Velpatasvir, Voxilaprevir. Read the label on DailyMed › Poplar’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Poplar side to compare — that is a limit of the record, not a statement that Poplar has no side effects.

How to take them

Some Sofosbuvir, Velpatasvir, Voxilaprevir Products Have a Food Rule — Poplar Should Not Break It

At least one FDA label for a product containing Sofosbuvir, Velpatasvir, Voxilaprevir says to take it with food. If you take Poplar on an empty stomach out of habit, keep them separate — and take Sofosbuvir, Velpatasvir, Voxilaprevir with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Sofosbuvir, Velpatasvir, Voxilaprevir products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.1 ) Recommended dosage: One tablet (400 mg of sofosbuvir, 100 mg of velpatasvir, and 100 mg of voxilaprevir) taken orally once daily with food.

From the Dosage and Administration section of the FDA label we read for Sofosbuvir, Velpatasvir, Voxilaprevir — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Sofosbuvir, Velpatasvir, Voxilaprevir

This page covers Poplar only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sofosbuvir, Velpatasvir, Voxilaprevir page lists 173 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 130 moderate · 40 minor.

From our pharmacist’s overview on the Sofosbuvir, Velpatasvir, Voxilaprevir page

“Vosevi (sofosbuvir, velpatasvir, and voxilaprevir) cures hepatitis C over a single short course, and that is exactly why I would be genuinely careful with supplements while taking it. Anything that drags its blood levels down can cost you the cure itself.”

Reviewed by 2 · Jul 18, 2026

Open the Sofosbuvir, Velpatasvir, Voxilaprevir interaction page

One more smart check

Taking Poplar as Part of a Dietary Supplement Product? Check It for Interactions

We hold 4 real supplement products containing Poplar, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Poplar. Even though Poplar itself has no known interaction with Sofosbuvir, Velpatasvir, Voxilaprevir, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Poplar and Sofosbuvir, Velpatasvir, Voxilaprevir Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Poplar
Steady interest

#731 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sofosbuvir, Velpatasvir, Voxilaprevir
Top half

#792 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Poplar is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Poplar reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Poplar and Sofosbuvir, Velpatasvir, Voxilaprevir records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Poplar

What is Poplar?

  • Minor pain and fever
  • Arthritis and joint discomfort
  • Minor skin wounds and irritation (topical)
  • Coughs and sore throat
  • Inflammation

Poplar comes from trees in the Populus genus and has a long history in folk medicine for pain, inflammation, and minor wounds, partly because its bark and buds contain salicin (a salicylate similar to the building block of aspirin). High-quality human studies are limited, so its true effectiveness is uncertain. Talk with your pharmacist or doctor before using it, especially if you are sensitive to aspirin.

Populus spp. · Salicaceae · Bark, leaf buds (leaf bud resin), and leaves · Tea, tincture, capsules, topical salves and ointments, dried bark or buds

An interaction check asks whether these two react with each other — it does not ask whether Poplar is a good idea for someone in your situation. Here is what our Poplar record says about it on its own.

Poplar: dosing

There is no well-established standard dose for poplar. The right amount depends on the product, the part of the plant used, and how it is prepared (tea, tincture, capsule, or topical).The safest approach is to follow the directions on the product label and not exceed them.

From our Poplar monograph — the full record covers uses, side effects and every documented interaction.

Read the full Poplar monograph & all interactions
Medication

About Sofosbuvir, Velpatasvir, and Voxilaprevir

What Is Sofosbuvir, Velpatasvir, and Voxilaprevir Used For?

Brand name: Vosevi

Vosevi is used to treat chronic hepatitis C virus (HCV) infection in adults who do not have cirrhosis or who have compensated cirrhosis (mild liver scarring that is still functioning). It is specifically for people who have already been treated with an HCV regimen before and need a different option.

Vosevi is approved for adults with HCV genotype 1, 2, 3, 4, 5, or 6 who previously took a medicine that included an NS5A inhibitor. It is also approved for adults with genotype 1a or 3 who previously took sofosbuvir without an NS5A inhibitor.

See full Sofosbuvir, Velpatasvir, and Voxilaprevir drug information
Keep checking

Other Drugs & Poplar

Browse every other medication we’ve checked against Poplar — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Poplar against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Poplar list.

See the full Poplar interactions page
See every supplement checked against Sofosbuvir, Velpatasvir, Voxilaprevir, ranked by severity
Evidence & sources

Poplar References

The 2 sources that drive our Poplar monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Poplar is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Salicylate Sensitivity — MedlinePlus Source
  2. Herbs at a Glance — NIH NCCIH Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Poplar and Sofosbuvir, Velpatasvir, Voxilaprevir Together: Common Questions

Is it safe to take Poplar with Sofosbuvir, Velpatasvir, Voxilaprevir?
We do not list a known interaction between Poplar and Sofosbuvir, Velpatasvir, Voxilaprevir. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Poplar and Sofosbuvir, Velpatasvir, Voxilaprevir at the same time of day?
At least one FDA label for a product containing Sofosbuvir, Velpatasvir, Voxilaprevir says to take it with food. If you take Poplar on an empty stomach out of habit, keep them separate and take Sofosbuvir, Velpatasvir, Voxilaprevir with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Sofosbuvir, Velpatasvir, Voxilaprevir products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Sofosbuvir, Velpatasvir, Voxilaprevir interact with any supplements?
Yes. Sofosbuvir, Velpatasvir, Voxilaprevir has documented interactions with 173 supplements in our database — Poplar is not one of them. The Sofosbuvir, Velpatasvir, Voxilaprevir interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Poplar monograph Uses, safety profile, and every drug interaction in one place Sofosbuvir, Velpatasvir, and Voxilaprevir drug information The full plain-English guide to this medication Sofosbuvir, Velpatasvir, Voxilaprevir supplement interactions Every supplement checked against Sofosbuvir, Velpatasvir, Voxilaprevir, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Sofosbuvir, Velpatasvir, Voxilaprevir and Poplar?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.