Drug & supplement interaction

Pyrethrum + Gamma Hydroxybutyrate (prescription drug)

Gamma Hydroxybutyrate (prescription drug) brand name: GHB.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Pyrethrum and Gamma Hydroxybutyrate (prescription drug) in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Pyrethrum and Gamma Hydroxybutyrate (prescription drug)

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Gamma Hydroxybutyrate (prescription drug) and Pyrethrum in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Pyrethrum at all — not against Gamma Hydroxybutyrate (prescription drug), and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Pyrethrum safety at a glance

Pyrethrum overall Use caution Pyrethrum is an insecticide, not a dietary supplement, and should not be taken internally.
Pregnancy Avoid Avoid internal use and limit exposure to insecticide products during pregnancy due to lack of safety data.
Breastfeeding Avoid Avoid internal use while breastfeeding because safety has not been established.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Gamma Hydroxybutyrate (prescription drug) and Pyrethrum? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Pyrethrum Itself Has Been Linked To

This is not an interaction — nothing below involves Gamma Hydroxybutyrate (prescription drug). It is the side-effect record for Pyrethrum on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Pyrethrum, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • An allergic reaction Worth acting on Additional detail

    “Pyrethrum has limited toxicity. The symptoms of overdose include headache, tinnitus, nausea, tingling of fingers and toes, respiratory disturbances, and other symptoms of neurotoxicity (18). The pyrethrum flower or derivatives of it might cause an allergic reaction in individuals sensitive to the Asteraceae/Compositae family.”

    Pyrethrum · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  • Ringing in the ears / Numbness or tingling / Headache / Nausea Additional detail

    Recorded for Pyrethrum in the same Natural Medicines adverse-effect record shown under An allergic reaction above.

Everything above comes from the Natural Medicines adverse-effect record for Pyrethrum — expand a row for the licensed statement it rests on. We haven’t matched Gamma Hydroxybutyrate (prescription drug) to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Gamma Hydroxybutyrate (prescription drug).

Everything else you take

See Every Supplement That Interacts With Gamma Hydroxybutyrate (prescription drug)

This page covers Pyrethrum only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Gamma Hydroxybutyrate (prescription drug) page lists 100 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).

By severity: 7 major · 78 moderate · 15 minor.

From our pharmacist’s overview on the Gamma Hydroxybutyrate (prescription drug) page

“Someone taking prescription gamma hydroxybutyrate (GHB) for narcolepsy is already on one of the strongest sedatives in medicine, a drug that can slow breathing all by itself, so I read this supplement list with real vigilance. Of the 100 ingredients on file, 78 pile extra sedation on top of what GHB does, and the seven rated major sit…”

Reviewed by 2 · Jul 18, 2026

Open the Gamma Hydroxybutyrate (prescription drug) interaction page

How much people look this up

Where Pyrethrum and Gamma Hydroxybutyrate (prescription drug) Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pyrethrum
Top half

#635 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Gamma Hydroxybutyrate (prescription drug)
Steady interest

#2,361 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pyrethrum reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Pyrethrum and Gamma Hydroxybutyrate (prescription drug) records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Pyrethrum

What is Pyrethrum?

  • Natural insect repellent
  • Killing fleas, lice, and other pests
  • Garden and household insecticide
  • Traditional use against parasites

Pyrethrum is a daisy-like flower whose extracts (called pyrethrins) are widely used as a natural insecticide for plants, pets, and lice. It is not a supplement meant to be taken by mouth, and there is no good evidence supporting any internal health use. If you use pyrethrum products, treat them as pesticides and follow label directions carefully.

Tanacetum cinerariifolium · Asteraceae · Dried flower heads · Insecticide powders, sprays, and extracts (pyrethrins); rarely used internally

An interaction check asks whether these two react with each other — it does not ask whether Pyrethrum is a good idea for someone in your situation. Here is what our Pyrethrum record says about it on its own.

Pyrethrum: dosing

There is no established or recommended internal dose for pyrethrum, and it should not be taken as a supplement. For insecticide, lice, or flea products, the correct amount depends entirely on the specific product.Always follow the directions on the product label exactly, and do not use more or more often than directed.

From our Pyrethrum monograph — the full record covers uses, side effects and every documented interaction.

Read the full Pyrethrum monograph & all interactions
Keep checking

Other Drugs & Pyrethrum

Browse every other medication we’ve checked against Pyrethrum — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Pyrethrum against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Pyrethrum list.

See the full Pyrethrum interactions page
See every supplement checked against Gamma Hydroxybutyrate (prescription drug), ranked by severity
Evidence & sources

Pyrethrum References

The 3 references that drive our Pyrethrum monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  3. Drugs in Pregnancy and Lactation. 4th ed. Baltimore, MD: Williams & Wilkins, 1994.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Pyrethrum and Gamma Hydroxybutyrate (prescription drug) Together: Common Questions

Is it safe to take Pyrethrum with Gamma Hydroxybutyrate (prescription drug)?
We do not list a known interaction between Pyrethrum and Gamma Hydroxybutyrate (prescription drug). That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Gamma Hydroxybutyrate (prescription drug) interact with any supplements?
Yes. Gamma Hydroxybutyrate (prescription drug) has documented interactions with 100 supplements in our database — Pyrethrum is not one of them. The Gamma Hydroxybutyrate (prescription drug) interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Pyrethrum monograph Uses, safety profile, and every drug interaction in one place Gamma Hydroxybutyrate (prescription drug) supplement interactions Every supplement checked against Gamma Hydroxybutyrate (prescription drug), ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Gamma Hydroxybutyrate (prescription drug) and Pyrethrum?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.