Drug & supplement interaction

Riboflavin + Mepolizumab

Mepolizumab brand name: Nucala.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Riboflavin and Mepolizumab in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Riboflavin and Mepolizumab

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Mepolizumab and Riboflavin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Riboflavin safety at a glance

Riboflavin overall Generally safe Riboflavin is considered very safe; excess is removed in the urine.
Pregnancy Likely Safe When used orally and appropriately in dietary amounts. A tolerable upper intake level (UL) has not been established. Read the full pregnancy detail
Breastfeeding Likely Safe When used orally and appropriately in dietary amounts. A tolerable upper intake level (UL) has not been established. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Mepolizumab and Riboflavin? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Keep it in perspective

Riboflavin Does Interact With Other Medications

Riboflavin has 20 moderate known drug interactions in our database — Mepolizumab isn’t one of them. If you take anything else, check it against the full list below.

Moderate 20 No known interaction 2,810 (incl. Mepolizumab)
Taking anything else?

Check Another of Your Medications Against Riboflavin

Covers the 2,830 medications we’ve checked against Riboflavin. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Riboflavin and Mepolizumab May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Diarrhea Additional detail

    Riboflavin

    “Orally, riboflavin has been associated with rare diarrhea and dose-related nausea. In one clinical study, one subject out of 28 reported having diarrhea two weeks after starting riboflavin 400 mg daily.”

    Riboflavin · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 1398. Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 1998;50:466-70. PubMed
    2. 71483. MacLennan, S. C., Wade, F. M., Forrest, K. M., Ratanayake, P. D., Fagan, E., and Antony, J. High-dose riboflavin for migraine prophylaxis in children: a double-blind, randomized, placebo-controlled trial. J Child Neurol. 2008;23(11):1300-1304.

    Mepolizumab

    Listed in the ADVERSE REACTIONS section of the FDA label for Mepolizumab. Read the label on DailyMed ›

Reported for Riboflavin but not commonly for Mepolizumab: passing urine more often and nausea.

Effects for Mepolizumab come from the ADVERSE REACTIONS section of its FDA label; effects for Riboflavin come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 49,399 voluntary FDA FAERS reports for Mepolizumab that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Riboflavin in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally and appropriately in dietary amounts. A tolerable upper intake level (UL) has not been established.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

One more smart check

Taking Riboflavin as Part of a Dietary Supplement Product? Check It for Interactions

We hold 18,014 real supplement products containing Riboflavin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Riboflavin. Even though Riboflavin itself has no known interaction with Mepolizumab, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Riboflavin and Mepolizumab Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Riboflavin
Top 1%

#12 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Mepolizumab
Steady interest

#1,677 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Riboflavin reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Riboflavin and Mepolizumab records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Riboflavin

What is Riboflavin?

  • Riboflavin deficiency
  • Migraine prevention
  • General energy and metabolism support
  • Healthy skin and eyes

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally very safe at typical doses, and the strongest evidence supports its use for treating deficiency, with some supportive (but not definitive) evidence for preventing migraines.

Vitamin (water-soluble B vitamin) · Tablets, capsules, softgels, multivitamins, B-complex products, fortified foods

An interaction check asks whether these two react with each other — it does not ask whether Riboflavin is a good idea for someone in your situation. Here is what our Riboflavin record says about it on its own.

Riboflavin: dosing

There is a recommended daily intake for riboflavin as a nutrient, and most people meet it through a normal diet. Do not assume that more is better.

From our Riboflavin monograph — the full record covers uses, side effects and every documented interaction.

Read the full Riboflavin monograph & all interactions
Medication

About Mepolizumab Injection

What Is Mepolizumab Injection Used For?

Brand name: Nucala

Nucala is used as an add-on maintenance treatment — meaning it works alongside other medications, not instead of them. It is approved for severe asthma (in patients 6 years and older with high eosinophil levels), chronic rhinosinusitis with nasal polyps (CRSwNP) in adults 18 and older whose symptoms aren't controlled by nasal corticosteroids alone, and COPD in adults with an eosinophilic phenotype whose disease isn't adequately controlled.

Nucala is also approved to treat eosinophilic granulomatosis with polyangiitis (EGPA), a rare form of blood vessel inflammation, and hypereosinophilic syndrome (HES), a condition involving dangerously elevated eosinophil counts, in adults and adolescents 12 and older. It is not meant to relieve sudden asthma attacks or acute COPD flares.

Most-Reported Side Effects for Mepolizumab

From FAERS, the FDA’s public side-effect reporting system (49,399 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Asthma 12,767 reports
Dyspnea 10,576 reports
Wheezing 7,131 reports
Cough 5,100 reports
Therapeutic product effect incomplete 5,051 reports
See full Mepolizumab Injection drug information
Keep checking

Other Drugs & Riboflavin

Browse every other medication we’ve checked against Riboflavin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
20Moderate
0Minor
2,809No known interaction
20 Moderate 2,809 No interaction
Moderate

20 interactions

No interaction 2,809 drugs checked — show the list

We also checked Riboflavin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,809 medications checked with no known interaction — see the full Riboflavin list.

See the full Riboflavin interactions page
See every supplement checked against Mepolizumab, ranked by severity
Evidence & sources

Riboflavin References

The 5 references that drive our Riboflavin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 1998;50:466-70. PubMed
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Leeson LJ, Weidenheimer JF. Stability of tetracycline and riboflavin. J Pharm Sci. 1969;58(3):355-7. PubMed
  4. MacLennan, S. C., Wade, F. M., Forrest, K. M., Ratanayake, P. D., Fagan, E., and Antony, J. High-dose riboflavin for migraine prophylaxis in children: a double-blind, randomized, placebo-controlled trial. J Child Neurol. 2008;23(11):1300-1304.
  5. Dietary reference intakes (DRIs): estimated average requirements. Food and Nutrition Board, Institute of Medicine, National Academics. https://www.nal.usda.gov/sites/default/files/fnic_uploads//recommended_intakes_individuals.pdf Accessed July 24, 2017.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Riboflavin and Mepolizumab Together: Common Questions

Is it safe to take Riboflavin with Mepolizumab?
We do not list a known interaction between Riboflavin and Mepolizumab. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Riboflavin and Mepolizumab have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Riboflavin interact with any other medications?
Yes. Riboflavin has 20 documented drug interactions in our database — Mepolizumab is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Riboflavin monograph Uses, safety profile, and every drug interaction in one place Mepolizumab Injection drug information The full plain-English guide to this medication Mepolizumab supplement interactions Every supplement checked against Mepolizumab, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Mepolizumab and Riboflavin?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.