Riboflavin + Doxycycline Hyclate
Doxycycline Hyclate brand names: Acticlate, Acticlate Cap, Lymepak.
Riboflavin has a moderate interaction with Doxycycline Hyclate. Theoretically, taking riboflavin with tetracycline antibiotics may decrease the potency of these antibiotics.
Read the full interaction reportRiboflavin and Doxycycline Hyclate
Here is the interaction we found between these two, with the evidence behind it.
TETRACYCLINE ANTIBIOTICS
Why this applies to Doxycycline Hyclate
Doxycycline Hyclate falls under TETRACYCLINE ANTIBIOTICS — the group Riboflavin interacts with.
In vitro research suggests that riboflavin may inhibit the potency of tetracycline antibiotics. It is not clear if this effect is clinically significant, as this interaction has not been reported in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the short version: there's a possible interaction where riboflavin (vitamin B2) might make doxycycline a little less effective at fighting your infection. But I want to be clear about how thin the evidence is. This idea comes only from lab dish (in vitro) studies, and it has never actually been reported in real people. So while it's worth knowing, it's not something I'd lose sleep over.
The everyday dose of riboflavin you'd get from a multivitamin or normal food is very unlikely to weaken your doxycycline or let an infection like an acne flare or a tick-borne illness slip through. If you're taking high-dose riboflavin (for example for migraines) alongside doxycycline, just mention it to your pharmacist or doctor so they can keep an eye on how well your treatment is working. Don't stop either one on your own.
- Leeson LJ, Weidenheimer JF. Stability of tetracycline and riboflavin. J Pharm Sci. 1969;58(3):355-7. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Riboflavin Also Interacts With Other Medications
Riboflavin has 19 moderate known drug interactions in our database — the Doxycycline Hyclate one above is one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Riboflavin
We haven’t checked that one against Riboflavin yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Riboflavin. Pick one to open its full report.
Questions About Riboflavin or Doxycycline Hyclate
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Riboflavin or Doxycycline Hyclate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Does Ginger Water Interfere With Amoxicillin-Clavulanate? ›
- How Can I Prevent Stomach Pain From Amoxicillin-Clavulanate? ›
- Help With Taking Vitamins After Clarithromycin ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Doxycycline Hyclate
This page covers Riboflavin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Doxycycline Hyclate page lists 166 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Oleander (major) and Siberian Cocklebur (major).
Taking Riboflavin as Part of a Dietary Supplement Product? Check It for Interactions
We hold 18,014 real supplement products containing Riboflavin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Riboflavin. Your product may carry other ingredients that interact with Doxycycline Hyclate too, on top of Riboflavin — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Riboflavin and Doxycycline Hyclate Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#12 of 1,452 supplements looked up here in the last 7 days
#780 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Riboflavin
What is Riboflavin?
- Riboflavin deficiency
- Migraine prevention
- General energy and metabolism support
- Healthy skin and eyes
Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally very safe at typical doses, and the strongest evidence supports its use for treating deficiency, with some supportive (but not definitive) evidence for preventing migraines.
About Doxycycline
What Is Doxycycline Used For?
Brand names: Acticlate, Acticlate Cap, Lymepak
Doxycycline belongs to the tetracycline family of antibiotics. It's prescribed for many types of bacterial infections, including respiratory tract infections, sexually transmitted infections (STIs), tick-borne illnesses like Rocky Mountain spotted fever, and eye infections. It's also used to help prevent malaria and, in some cases, as a helper treatment for severe acne.
In situations where penicillin-type antibiotics can't be used — due to allergy, for example — doxycycline can step in as an alternative. It should only be used for infections that are proven or strongly suspected to be caused by bacteria.
Other Drugs & Riboflavin
Browse every other medication we’ve checked against Riboflavin — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
19 interactions
- Doxycycline ›
- Minocycline ›
- Tetracycline ›
- Minocycline Hydrochloride ›
- Retapamulin ›
- Chlortetracycline ›
- Demeclocycline ›
- Doripenem ›
- Doxycycline Monohydrate ›
- Doxycyline ›
- Eravacycline ›
- Omadacycline (iv) ›
- Omadacycline (oral) ›
- Oxytetracycline ›
- Tigecycline ›
- Amphotericin, Tetracycline ›
- Bismuth Subsalicylate, Metronidazole, Tetracycline ›
- Metronidazole, Tetracyline, Bismuth Subcitrate Potassium ›
- Oxytetracycline, Phenazopyridine, Sulfamethizole ›
No interaction 2,810 drugs checked — show the list
We also checked Riboflavin against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Acetaminophen ›
- Tadalafil ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Valacyclovir ›
- Abemaciclib ›
- Hydroxyurea ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Warfarin Sodium ›
- Tirzepatide ›
- Prednisone ›
- Propranolol ›
- Bupropion ›
- Lisdexamfetamine ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Acyclovir ›
- Bendamustine ›
- Amitriptyline ›
- Methotrexate ›
- Lamotrigine ›
- Fluoxetine ›
- Acetaminophen, Codeine ›
- Amphetamine ›
- Gabapentin ›
- Pregabalin ›
- Azithromycin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Clonazepam ›
- Omeprazole ›
- Methylene Blue ›
- Quetiapine ›
- Amlodipine Besylate ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Naproxen ›
- Ciprofloxacin ›
- Bisoprolol ›
Showing the 60 most looked-up of 2,810 medications checked with no known interaction — see the full Riboflavin list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Doxycycline Hyclate Is Linked to Lower Levels of 7 Nutrients
Natural Medicines records Doxycycline Hyclate as a medicine that can lower these. This is not an interaction with Riboflavin — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Doxycycline Hyclate nutrient depletion report ›
Riboflavin is itself a nutrient we track — see which medications may deplete RIBOFLAVIN.
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Riboflavin and Doxycycline Hyclate Together: Common Questions
Can you take Riboflavin with Doxycycline Hyclate?
How serious is the Riboflavin and Doxycycline Hyclate interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Still Have a Question About Doxycycline Hyclate and Riboflavin?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.