Riboflavin + Mesalamine
Mesalamine brand names: Pentasa, Asacol, Canasa, Rowasa, Lialda, and others.
We found no known interaction between Riboflavin and Mesalamine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Mesalamine states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Riboflavin and Mesalamine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Mesalamine and Riboflavin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Riboflavin safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Mesalamine
Interactions in our licensed database are recorded against drug classes, not just single drug names. Mesalamine is filed under a single classification — oral drugs. Riboflavin has documented interactions with 1 drug class — the most serious being tetracycline antibiotics (moderate) — and none of Mesalamine’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Riboflavin Does Interact With Other Medications
Riboflavin has 20 moderate known drug interactions in our database — Mesalamine isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Riboflavin
We haven’t checked that one against Riboflavin yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Riboflavin. Pick one to open its full report.
Riboflavin in Pregnancy & Breastfeeding
When used orally and appropriately in dietary amounts. A tolerable upper intake level (UL) has not been established.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Mesalamine Products Have a Food Rule — Riboflavin Should Not Break It
At least one FDA label for a product containing Mesalamine says to take it with food. If you take Riboflavin on an empty stomach out of habit, keep them separate — and take Mesalamine with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Mesalamine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
( 2 ) Administer mesalamine delayed-release tablets with food.
From the Dosage and Administration section of the FDA label we read for Mesalamine — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
Questions About Riboflavin or Mesalamine
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Riboflavin or Mesalamine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Mesalamine
This page covers Riboflavin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Mesalamine page lists 17 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).
By severity: 1 major · 7 moderate · 9 minor.
From our pharmacist’s overview on the Mesalamine page
“Activated charcoal is the one entry here I would treat as a genuine problem for anyone taking mesalamine (Asacol, Lialda, Pentasa, and others). It is the lone major-rated interaction among the 17 on file, because charcoal soaks up drugs in the gut and can pull mesalamine out of the picture before it does its job.”
Reviewed by 2 · Jul 18, 2026
Taking Riboflavin as Part of a Dietary Supplement Product? Check It for Interactions
We hold 18,014 real supplement products containing Riboflavin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Riboflavin. Even though Riboflavin itself has no known interaction with Mesalamine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Riboflavin and Mesalamine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#12 of 1,452 supplements looked up here in the last 7 days
#277 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Riboflavin reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Riboflavin and Mesalamine records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Riboflavin
What is Riboflavin?
- Riboflavin deficiency
- Migraine prevention
- General energy and metabolism support
- Healthy skin and eyes
Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally very safe at typical doses, and the strongest evidence supports its use for treating deficiency, with some supportive (but not definitive) evidence for preventing migraines.
Vitamin (water-soluble B vitamin) · Tablets, capsules, softgels, multivitamins, B-complex products, fortified foods
An interaction check asks whether these two react with each other — it does not ask whether Riboflavin is a good idea for someone in your situation. Here is what our Riboflavin record says about it on its own.
Riboflavin: dosing
There is a recommended daily intake for riboflavin as a nutrient, and most people meet it through a normal diet. Do not assume that more is better.
From our Riboflavin monograph — the full record covers uses, side effects and every documented interaction.
About Mesalamine
What Is Mesalamine Used For?
Brand names: Pentasa, Asacol, Canasa, Rowasa, Lialda, Delzicol
Mesalamine is used to treat mildly to moderately active ulcerative colitis — a condition where the lining of the large intestine becomes inflamed and ulcerated. Depending on the product and formulation, it can be used to bring the disease under control (induction of remission) and/or to keep it from coming back (maintenance of remission).
Different products target different parts of the lower digestive tract. Oral forms (tablets and capsules) treat the colon more broadly. Rectal forms — including enemas (ROWASA, sfROWASA, mesalamine rectal suspension) — are used for distal ulcerative colitis, proctosigmoiditis, or proctitis (inflammation limited to the lower end of the colon or rectum). Rectal suppositories (CANASA, mesalamine rectal suppositories) are specifically for ulcerative proctitis (inflammation of the rectum only).
Other Drugs & Riboflavin
Browse every other medication we’ve checked against Riboflavin — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
20 interactions
- Doxycycline ›
- Minocycline ›
- Tetracycline ›
- Doxycycline Hyclate ›
- Minocycline Hydrochloride ›
- Retapamulin ›
- Chlortetracycline ›
- Demeclocycline ›
- Doripenem ›
- Doxycycline Monohydrate ›
- Doxycyline ›
- Eravacycline ›
- Omadacycline (iv) ›
- Omadacycline (oral) ›
- Oxytetracycline ›
- Tigecycline ›
- Amphotericin, Tetracycline ›
- Bismuth Subsalicylate, Metronidazole, Tetracycline ›
- Metronidazole, Tetracyline, Bismuth Subcitrate Potassium ›
- Oxytetracycline, Phenazopyridine, Sulfamethizole ›
No interaction 2,809 drugs checked — show the list
We also checked Riboflavin against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Abemaciclib ›
- Aspirin ›
- Metoprolol ›
- Acetaminophen ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Warfarin Sodium ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Methotrexate ›
- Amlodipine Besylate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Fluoxetine ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,809 medications checked with no known interaction — see the full Riboflavin list.
Riboflavin References
The 5 references that drive our Riboflavin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 1998;50:466-70. PubMed
- Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
- Leeson LJ, Weidenheimer JF. Stability of tetracycline and riboflavin. J Pharm Sci. 1969;58(3):355-7. PubMed
- MacLennan, S. C., Wade, F. M., Forrest, K. M., Ratanayake, P. D., Fagan, E., and Antony, J. High-dose riboflavin for migraine prophylaxis in children: a double-blind, randomized, placebo-controlled trial. J Child Neurol. 2008;23(11):1300-1304.
- Dietary reference intakes (DRIs): estimated average requirements. Food and Nutrition Board, Institute of Medicine, National Academics. https://www.nal.usda.gov/sites/default/files/fnic_uploads//recommended_intakes_individuals.pdf Accessed July 24, 2017.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Riboflavin and Mesalamine Together: Common Questions
Is it safe to take Riboflavin with Mesalamine?
Do Riboflavin and Mesalamine have any of the same side effects?
Should I take Riboflavin and Mesalamine at the same time of day?
How was the Riboflavin and Mesalamine combination checked?
Does Riboflavin interact with any other medications?
Does Mesalamine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Mesalamine and Riboflavin?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.