Salatrim + Sodium Phenylbutyrate
Sodium Phenylbutyrate brand names: Buphenyl, Pheburane, Olpruva.
We found no known interaction between Salatrim and Sodium Phenylbutyrate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Sodium Phenylbutyrate states a food rule worth keeping to.
Salatrim and Sodium Phenylbutyrate
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Sodium Phenylbutyrate and Salatrim in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Salatrim at all — not against Sodium Phenylbutyrate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Salatrim safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Some Sodium Phenylbutyrate Products Have a Food Rule — Salatrim Should Not Break It
At least one FDA label for a product containing Sodium Phenylbutyrate says to take it with food. If you take Salatrim on an empty stomach out of habit, keep them separate — and take Sodium Phenylbutyrate with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Sodium Phenylbutyrate products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
The powder is to be mixed with food (solid or liquid) for immediate use; however, when dissolved in water, BUPHENYL Powder has been shown to be stable for up to one week at room temperature or refrigerated.
From the Dosage and Administration section of the FDA label we read for Sodium Phenylbutyrate — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Sodium Phenylbutyrate
This page covers Salatrim only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sodium Phenylbutyrate page lists 19 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).
By severity: 1 major · 9 moderate · 9 minor.
From our pharmacist’s overview on the Sodium Phenylbutyrate page
“Sodium phenylbutyrate (Buphenyl, Pheburane, Olpruva) keeps ammonia in check in people with urea cycle disorders, so a supplement that blunts its absorption is not a small problem, it is the difference between a controlled ammonia level and a dangerous one. Seventeen of the 19 ingredients on this page, mostly fibers, gums, and mucilages…”
Reviewed by 2 · Jul 18, 2026
Where Salatrim and Sodium Phenylbutyrate Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,108 of 1,452 supplements looked up here in the last 7 days
#1,280 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Salatrim is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Salatrim reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Salatrim and Sodium Phenylbutyrate records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Salatrim
What is Salatrim?
- Reduced-calorie fat replacement in foods
- Lower-calorie baked goods and confections
- Reducing dietary fat calories
- Food texture and mouthfeel similar to regular fat
Salatrim is a man-made, reduced-calorie fat used as an ingredient in processed foods, not a traditional herb or supplement you would take on its own. It is designed to provide fewer calories than ordinary fat, but eating large amounts may cause stomach and bowel discomfort. If you have questions about products containing it, check the food label and ask your pharmacist or doctor.
Not applicable (manufactured fat ingredient) · Reduced-fat or reduced-calorie processed foods such as baked goods, chocolate, confections, and dairy-type products
An interaction check asks whether these two react with each other — it does not ask whether Salatrim is a good idea for someone in your situation. Here is what our Salatrim record says about it on its own.
Salatrim: dosing
There is no established supplement dose for Salatrim, because it is a food ingredient rather than a pill or capsule you would take by itself. The amount you get depends on the food product and how much of it you eat.If you choose foods made with Salatrim, follow the serving sizes listed on the food label and avoid eating very large amounts at once to lower the chance of digestive upset.
From our Salatrim monograph — the full record covers uses, side effects and every documented interaction.
About Sodium Phenylbutyrate
Most-Reported Side Effects for Sodium Phenylbutyrate
From FAERS, the FDA’s public side-effect reporting system (420 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Salatrim
Browse every other medication we’ve checked against Salatrim — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Salatrim against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Ivermectin ›
- Abemaciclib ›
- Testosterone ›
- Sertraline ›
- Losartan Potassium ›
- Acetaminophen ›
- Rosuvastatin ›
- Aspirin ›
- Escitalopram ›
- Metoprolol ›
- Clopidogrel ›
- Atorvastatin ›
- Rivaroxaban ›
- Isotretinoin ›
- Tirzepatide ›
- Warfarin Sodium ›
- Ibuprofen ›
- Methamphetamine ›
- Amlodipine Besylate ›
- Docusate ›
- Valacyclovir ›
- Metformin ›
- Prednisone ›
- Sumatriptan ›
- Hydroxyurea ›
- Tadalafil ›
- Amitriptyline ›
- Levothyroxine, Liothyronine ›
- Semaglutide ›
- Lisdexamfetamine ›
- Propranolol ›
- Amphetamine ›
- Methotrexate ›
- Lisinopril ›
- Amoxicillin ›
- Bupropion ›
- Fluoxetine ›
- Azithromycin ›
- Doxycycline ›
- Pregabalin ›
- Bendamustine ›
- Gabapentin ›
- Dextroamphetamine ›
- Lamotrigine ›
- Naproxen ›
- Acetaminophen, Aspirin, Caffeine ›
- Acyclovir ›
- Quetiapine ›
- Clonazepam ›
- Buspirone ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Citalopram ›
- Methylene Blue ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Salatrim list.
Salatrim References
The 2 sources that drive our Salatrim monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Salatrim is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.
- Food Additives & Ingredients — U.S. Food and Drug Administration Source
- Fat Replacers — MedlinePlus Source
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Salatrim and Sodium Phenylbutyrate Together: Common Questions
Is it safe to take Salatrim with Sodium Phenylbutyrate?
Should I take Salatrim and Sodium Phenylbutyrate at the same time of day?
Does Sodium Phenylbutyrate interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.