Drug & supplement interaction

Savin Tops + nitisinone

nitisinone brand names: Orfadin, Nityr.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Savin Tops and nitisinone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Savin Tops and nitisinone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between nitisinone and Savin Tops in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Savin Tops at all — not against nitisinone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Savin Tops safety at a glance

Savin Tops overall Avoid Savin is a poisonous plant linked to severe toxicity and death, especially when taken internally.
Pregnancy Avoid It can cause abortion and severe harm to mother and baby and must never be used in pregnancy.
Breastfeeding Unsafe When used orally or topically. Savin tops are contraindicated in pregnancy because they can induce abortion, and fatal poisoning has occurred with as little as... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining nitisinone and Savin Tops? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Savin Tops Itself Has Been Linked To

This is not an interaction — nothing below involves nitisinone. It is the side-effect record for Savin Tops on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Savin Tops, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

  • Kidney problems Worth acting on Additional detail

    “Savin tops are generally regarded as unsafe for use. Any benefits of therapy may not outweigh the risk of toxicity. Orally, symptoms of savin tops poisoning include nausea, nervousness, cardiac rhythm disorders, spasm, kidney damage, hematuria, central paralysis, unconsciousness, and death (18).”

    Savin Tops · Natural Medicines adverse-effect record, reported in hepatitis.

    2 sources cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    2. 19. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  • Liver problems Worth acting on Additional detail

    “Orally, savin tops can cause toxicity. Hepatic symptoms of savin tops toxicity include hepatitis (19).”

    Savin Tops · Natural Medicines adverse-effect record, reported in hepatitis.

    1 source cited
    1. 19. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  • Anxiety or restlessness Additional detail

    Recorded for Savin Tops in the same Natural Medicines adverse-effect record shown under Kidney problems above.

  • Nausea Additional detail

    “Orally, savin tops can cause toxicity. Gastrointestinal symptoms of savin tops toxicity include nausea and gastroenteritis (18,19).”

    Savin Tops · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    2 sources cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    2. 19. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Everything above comes from the Natural Medicines adverse-effect record for Savin Tops — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of nitisinone’s FDA label too, and the two lists don’t meaningfully overlap — which is why no nitisinone column appears here.

Special populations

Savin Tops in Pregnancy & Breastfeeding

Lactation Unsafe

When used orally or topically. Savin tops are contraindicated in pregnancy because they can induce abortion, and fatal poisoning has occurred with as little as 6 drops of the essential oil.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With nitisinone

This page covers Savin Tops only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the nitisinone page lists 21 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Cannabinol (cbn) (moderate), Cannabis (moderate), Coffee Charcoal (moderate) and Delta-9-tetrahydrocannabinol (thc) (moderate).

By severity: 1 major · 11 moderate · 9 minor.

From our pharmacist’s overview on the nitisinone page

“For a child or adult with hereditary tyrosinemia type 1, nitisinone (Orfadin, Nityr) is the medication holding a dangerous metabolic disease in check, which is why the 21 supplements on this page warrant genuine care rather than a shrug. Activated charcoal is the single major-rated entry and the one to understand first, since it can so…”

Reviewed by 2 · Jul 18, 2026

Open the nitisinone interaction page

How much people look this up

Where Savin Tops and nitisinone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Savin Tops
Steady interest

#1,240 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication nitisinone
Top 25%

#689 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Savin Tops reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Savin Tops and nitisinone records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Savin Tops

What is Savin Tops?

  • Inducing menstruation
  • Attempting abortion (historical)
  • Skin warts and growths
  • Intestinal worms
  • Joint and muscle aches (topical)

Savin Tops comes from the savin juniper, a shrub whose oil is highly toxic and was historically misused to bring on menstruation or end pregnancy. It is considered dangerous and is not recommended for any use; serious poisonings and deaths have been reported. Do not take it internally.

Juniperus sabina · Cupressaceae · Young leafy branch tips (tops) and essential oil · Dried herb, essential oil, tinctures, and topical preparations (all rarely used today)

An interaction check asks whether these two react with each other — it does not ask whether Savin Tops is a good idea for someone in your situation. Here is what our Savin Tops record says about it on its own.

Savin Tops: dosing

There is no established or safe dose of Savin Tops. Because the plant is highly toxic and the harmful dose is very close to any traditionally used amount, no responsible dosing recommendation can be given.This herb is not recommended for self-treatment in any form.

From our Savin Tops monograph — the full record covers uses, side effects and every documented interaction.

Read the full Savin Tops monograph & all interactions
Medication

About Nitisinone

What Is Nitisinone Used For?

Brand names: Orfadin, Nityr

Nitisinone (as Orfadin capsules, Orfadin oral suspension, Nityr tablets, and generic Nitisinone capsules) is used to treat hereditary tyrosinemia type 1 (HT-1) — a rare inherited disease in which the body cannot properly break down the amino acid tyrosine, leading to toxic buildup that damages the liver and kidneys. It is used in both adults and children, always together with a strict low-tyrosine, low-phenylalanine diet.

Harliku tablets are approved for a different rare inherited condition: alkaptonuria (AKU). In adults with AKU, Harliku reduces the level of homogentisic acid (HGA) — a harmful substance that builds up in the urine and body tissues. Harliku is not approved for HT-1, and the other nitisinone products are not approved for AKU.

Most-Reported Side Effects for nitisinone

From FAERS, the FDA’s public side-effect reporting system (948 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Amino acid level increased 133 reports
Liver transplant 118 reports
Hepatocellular carcinoma 61 reports
Alpha 1 foetoprotein increased 52 reports
Treatment noncompliance 51 reports
See full Nitisinone drug information
Keep checking

Other Drugs & Savin Tops

Browse every other medication we’ve checked against Savin Tops — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Savin Tops against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Savin Tops list.

See the full Savin Tops interactions page
See every supplement checked against nitisinone, ranked by severity
Evidence & sources

Savin Tops References

The 2 references that drive our Savin Tops monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Savin Tops and nitisinone Together: Common Questions

Is it safe to take Savin Tops with nitisinone?
We do not list a known interaction between Savin Tops and nitisinone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does nitisinone interact with any supplements?
Yes. nitisinone has documented interactions with 21 supplements in our database — Savin Tops is not one of them. The nitisinone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Savin Tops monograph Uses, safety profile, and every drug interaction in one place Nitisinone drug information The full plain-English guide to this medication nitisinone supplement interactions Every supplement checked against nitisinone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About nitisinone and Savin Tops?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.