Simaruba + Butenafine
Butenafine brand name: Mentax.
We found no known interaction between Simaruba and Butenafine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Simaruba and Butenafine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Butenafine and Simaruba in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Simaruba at all — not against Butenafine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Simaruba safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Simaruba in Pregnancy & Breastfeeding
When used orally during pregnancy due to apparent abortifacient effects; avoid using. There is insufficient reliable information available about the safety of simaruba during lactation.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
See Every Supplement That Interacts With Butenafine
This page covers Simaruba only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Butenafine page lists 20 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).
By severity: 1 major · 7 moderate · 12 minor.
From our pharmacist’s overview on the Butenafine page
“Butenafine (Mentax), an antifungal cream for athlete's foot, jock itch, and ringworm, carries a supplement list that deserves real vigilance, and most of that vigilance points at one entry. Activated charcoal, the only major-rated interaction of the 20 on file, can reduce the body's exposure to many drugs regardless of how they were gi…”
Reviewed by 2 · Jul 18, 2026
Taking Simaruba as Part of a Dietary Supplement Product? Check It for Interactions
We hold 2 real supplement products containing Simaruba, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Simaruba. Even though Simaruba itself has no known interaction with Butenafine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Simaruba and Butenafine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#632 of 1,452 supplements looked up here in the last 7 days
#1,453 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Simaruba reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Simaruba and Butenafine records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Simaruba
What is Simaruba?
- Diarrhea and dysentery
- Digestive upset
- Malaria and fevers (traditional)
- Intestinal parasites
- General antimicrobial use
Simaruba (Simarouba amara) is a tropical tree whose bark has long been used in folk medicine for diarrhea, dysentery, and fevers. Modern, high-quality human studies are very limited, so its benefits and safety are not well proven. Talk to a pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.
Simarouba amara · Simaroubaceae · Bark (especially root and stem bark), sometimes leaves · Dried bark for tea or decoction, tincture, capsules, liquid extract
An interaction check asks whether these two react with each other — it does not ask whether Simaruba is a good idea for someone in your situation. Here is what our Simaruba record says about it on its own.
Simaruba: dosing
There is no standardized, well-established dose for Simaruba. Traditional preparations were usually water-based extracts (decoctions) of the bark, but these vary widely in strength.If you choose to use a commercial product, follow the directions on the label and do not exceed the recommended amount.
From our Simaruba monograph — the full record covers uses, side effects and every documented interaction.
About Butenafine
What Is Butenafine Used For?
Brand name: Mentax
Butenafine treats common fungal skin infections. Products containing butenafine — including Athletes Foot, Athletes Foot Ultra, Butenafine Hydrochloride, Butenafine Hydrochloride 1%, Jock Itch, and Jock Itch Cream — cure most cases of athlete's foot (between the toes), jock itch, and ringworm. They also relieve the itching, burning, cracking, and scaling that come with these infections.
For athlete's foot, these products work between the toes. Effectiveness on the bottom or sides of the foot is not established. Jock Itch and Jock Itch Cream are specifically indicated for jock itch and its associated symptoms.
Other Drugs & Simaruba
Browse every other medication we’ve checked against Simaruba — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Simaruba against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Warfarin Sodium ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Simaruba list.
Simaruba References
The 2 references that drive our Simaruba monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Hocking GM. A dictionary of natural products. 2nd ed. Medford, OR: Plexus Publishing, 1997.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Simaruba and Butenafine Together: Common Questions
Is it safe to take Simaruba with Butenafine?
Does Butenafine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Butenafine and Simaruba?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.