Drug & supplement interaction

Simaruba + Talbutal

Talbutal brand name: Lotusate.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Simaruba and Talbutal in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Simaruba and Talbutal

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Talbutal and Simaruba in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Simaruba at all — not against Talbutal, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Simaruba safety at a glance

Simaruba overall Use caution Human safety data are limited, so use cautiously and under professional guidance.
Pregnancy Likely Unsafe When used orally during pregnancy due to apparent abortifacient effects; avoid using. There is insufficient reliable information available about the safety of s... Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally during pregnancy due to apparent abortifacient effects; avoid using. There is insufficient reliable information available about the safety of s... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Talbutal and Simaruba? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Simaruba Itself Has Been Linked To

This is not an interaction — nothing below involves Talbutal. It is the side-effect record for Simaruba on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Simaruba, this list is the first place to look.

  • Vomiting Additional detail

    “Orally, ingesting large amounts of simaruba can cause vomiting (18).”

    Simaruba · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Everything above comes from the Natural Medicines adverse-effect record for Simaruba — expand a row for the licensed statement it rests on. We haven’t matched Talbutal to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Talbutal.

Special populations

Simaruba in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally during pregnancy due to apparent abortifacient effects; avoid using. There is insufficient reliable information available about the safety of simaruba during lactation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Talbutal

This page covers Simaruba only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Talbutal page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Talbutal page

“Every one of the 17 supplements that interacts with Talbutal (Lotusate) works through your gut, changing how much of this barbiturate sleep aid actually reaches your bloodstream. That deserves genuine caution, because barbiturates leave little room for error.”

Reviewed by 2 · Jul 18, 2026

Open the Talbutal interaction page

One more smart check

Taking Simaruba as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2 real supplement products containing Simaruba, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Simaruba. Even though Simaruba itself has no known interaction with Talbutal, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Simaruba and Talbutal Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Simaruba
Top half

#624 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Talbutal
Steady interest

#2,752 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Simaruba reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Simaruba and Talbutal records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Simaruba

What is Simaruba?

  • Diarrhea and dysentery
  • Digestive upset
  • Malaria and fevers (traditional)
  • Intestinal parasites
  • General antimicrobial use

Simaruba (Simarouba amara) is a tropical tree whose bark has long been used in folk medicine for diarrhea, dysentery, and fevers. Modern, high-quality human studies are very limited, so its benefits and safety are not well proven. Talk to a pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Simarouba amara · Simaroubaceae · Bark (especially root and stem bark), sometimes leaves · Dried bark for tea or decoction, tincture, capsules, liquid extract

An interaction check asks whether these two react with each other — it does not ask whether Simaruba is a good idea for someone in your situation. Here is what our Simaruba record says about it on its own.

Simaruba: dosing

There is no standardized, well-established dose for Simaruba. Traditional preparations were usually water-based extracts (decoctions) of the bark, but these vary widely in strength.If you choose to use a commercial product, follow the directions on the label and do not exceed the recommended amount.

From our Simaruba monograph — the full record covers uses, side effects and every documented interaction.

Read the full Simaruba monograph & all interactions
Keep checking

Other Drugs & Simaruba

Browse every other medication we’ve checked against Simaruba — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Simaruba against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Simaruba list.

See the full Simaruba interactions page
See every supplement checked against Talbutal, ranked by severity
Evidence & sources

Simaruba References

The 2 references that drive our Simaruba monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Hocking GM. A dictionary of natural products. 2nd ed. Medford, OR: Plexus Publishing, 1997.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Simaruba and Talbutal Together: Common Questions

Is it safe to take Simaruba with Talbutal?
We do not list a known interaction between Simaruba and Talbutal. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Talbutal interact with any supplements?
Yes. Talbutal has documented interactions with 17 supplements in our database — Simaruba is not one of them. The Talbutal interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Simaruba monograph Uses, safety profile, and every drug interaction in one place Talbutal supplement interactions Every supplement checked against Talbutal, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Talbutal and Simaruba?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.