Drug & supplement interaction

Stone Root + Epirubicin

Epirubicin brand name: Ellence.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Stone Root and Epirubicin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Stone Root and Epirubicin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Epirubicin and Stone Root in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Stone Root at all — not against Epirubicin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Stone Root safety at a glance

Stone Root overall Use caution Little safety data exists, so use with care and under professional guidance.
Pregnancy Avoid Not enough safety information is available, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety during breastfeeding is unknown, so avoid use to be safe.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Epirubicin and Stone Root? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Stone Root and Epirubicin May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Nausea Additional detail

    Stone Root

    “Orally, large amounts of stone root can cause intestinal tract irritation and colic-like pain dizziness, and nausea (18).”

    Stone Root · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Epirubicin

    Listed in the ADVERSE REACTIONS section of the FDA label for Epirubicin. Read the label on DailyMed ›

Reported for Stone Root but not commonly for Epirubicin: dizziness.

Effects for Epirubicin come from the ADVERSE REACTIONS section of its FDA label; effects for Stone Root come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Epirubicin

This page covers Stone Root only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Epirubicin page lists 24 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Acerola (moderate), Alpha-lipoic Acid (moderate), Coffee Charcoal (moderate) and European Mandrake (moderate).

By severity: 1 major · 14 moderate · 9 minor.

From our pharmacist’s overview on the Epirubicin page

“Epirubicin (Ellence) is chemotherapy, most often used for breast cancer, and when a supplement can weaken the treatment itself, the 24 ingredients on this list deserve real caution. The lone major entry is activated charcoal, which can pull the drug back out of the body even though epirubicin is given by IV, since the medicine recircul…”

Reviewed by 2 · Jul 18, 2026

Open the Epirubicin interaction page

One more smart check

Taking Stone Root as Part of a Dietary Supplement Product? Check It for Interactions

We hold 18 real supplement products containing Stone Root, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Stone Root. Even though Stone Root itself has no known interaction with Epirubicin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Stone Root and Epirubicin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Stone Root
Steady interest

#815 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Epirubicin
Steady interest

#1,431 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Stone Root reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Stone Root and Epirubicin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Stone Root

What is Stone Root?

Stone Root
  • Hemorrhoids
  • Urinary and bladder discomfort
  • Digestive upset
  • Sore throat and hoarseness
  • Kidney stones (traditional)

Stone root is a North American herb traditionally used for hemorrhoids, urinary complaints, and digestive issues. There is very little modern scientific evidence to confirm it works for any of these uses, so it should be viewed as a traditional remedy rather than a proven treatment. Talk with your pharmacist or doctor before trying it, especially if you are pregnant, breastfeeding, or take other medicines.

Collinsonia canadensis · Lamiaceae · Root and rhizome · Tincture, capsules, dried root for tea, liquid extract

An interaction check asks whether these two react with each other — it does not ask whether Stone Root is a good idea for someone in your situation. Here is what our Stone Root record says about it on its own.

Stone Root: dosing

There is no established standard dose for stone root. Traditional preparations include teas made from the dried root and alcohol-based tinctures, but reliable dosing guidelines from clinical studies do not exist.The safest approach is to follow the directions on the product label and not exceed them.

From our Stone Root monograph — the full record covers uses, side effects and every documented interaction.

Read the full Stone Root monograph & all interactions
Medication

About Epirubicin

What Is Epirubicin Used For?

Brand name: Ellence

Ellence (epirubicin), given as an intravenous injection, is used as part of adjuvant (post-surgery) combination chemotherapy in patients with breast cancer who have evidence of tumor involvement in the axillary lymph nodes (lymph nodes under the arm) following surgical removal of the primary tumor.

It is not used alone — Ellence is always given as part of a multi-drug regimen alongside other chemotherapy agents.

See full Epirubicin drug information
Keep checking

Other Drugs & Stone Root

Browse every other medication we’ve checked against Stone Root — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Stone Root against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Stone Root list.

See the full Stone Root interactions page
See every supplement checked against Epirubicin, ranked by severity
Evidence & sources

Stone Root References

The 1 references that drive our Stone Root monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Stone Root and Epirubicin Together: Common Questions

Is it safe to take Stone Root with Epirubicin?
We do not list a known interaction between Stone Root and Epirubicin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Stone Root and Epirubicin have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Epirubicin interact with any supplements?
Yes. Epirubicin has documented interactions with 24 supplements in our database — Stone Root is not one of them. The Epirubicin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Stone Root monograph Uses, safety profile, and every drug interaction in one place Epirubicin drug information The full plain-English guide to this medication Epirubicin supplement interactions Every supplement checked against Epirubicin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Epirubicin and Stone Root?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.