Drug & supplement interaction

Sweet Cicely + Ruxolitinib

Ruxolitinib brand names: Jakafi, Opzelura.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Sweet Cicely and Ruxolitinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Sweet Cicely and Ruxolitinib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ruxolitinib and Sweet Cicely in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Sweet Cicely at all — not against Ruxolitinib, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Sweet Cicely safety at a glance

Sweet Cicely overall Use caution Likely safe in small culinary amounts, but medicinal use is poorly studied.
Pregnancy Avoid Not enough safety data, so it is best avoided in medicinal amounts during pregnancy.
Breastfeeding Avoid Safety has not been studied, so avoid medicinal use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ruxolitinib and Sweet Cicely? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Ruxolitinib’s Own FDA Label Lists

This is not an interaction — none of it involves Sweet Cicely. These are the most notable effects listed in the ADVERSE REACTIONS section of Ruxolitinib’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Unsteadiness Worth acting on
  • Low blood sugar Worth acting on
  • Blood clots Worth acting on
  • Anemia Worth acting on mentioned in 8.6% of FDA reports for Ruxolitinib
  • A low platelet count Worth acting on mentioned in 3.9% of FDA reports for Ruxolitinib
  • A severe skin reaction Worth acting on
  • Raised blood pressure Worth acting on
  • Shortness of breath Worth acting on
  • A low white blood cell count Worth acting on
  • Bleeding or bruising Worth acting on

Showing the 10 most notable of 24 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Ruxolitinib. Read the label on DailyMed › Where a percentage is shown, it is the share of 69,262 voluntary FDA FAERS reports for Ruxolitinib that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Sweet Cicely’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Sweet Cicely side to compare — that is a limit of the record, not a statement that Sweet Cicely has no side effects.

Everything else you take

See Every Supplement That Interacts With Ruxolitinib

This page covers Sweet Cicely only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ruxolitinib page lists 141 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 96 moderate · 42 minor.

From our pharmacist’s overview on the Ruxolitinib page

“Ruxolitinib (Jakafi for myelofibrosis and other blood cancers, Opzelura as a skin cream) is cleared by one liver enzyme, CYP3A4, and that single fact explains nearly all 141 supplements here, which is why this list deserves real caution. Three entries are rated major.”

Reviewed by 2 · Jul 18, 2026

Open the Ruxolitinib interaction page

How much people look this up

Where Sweet Cicely and Ruxolitinib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Sweet Cicely
Steady interest

#1,377 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ruxolitinib
Top 25%

#676 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources.
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Sweet Cicely and Ruxolitinib records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Sweet Cicely

What is Sweet Cicely?

  • Digestive upset and gas
  • Mild cough and chest complaints
  • As a natural sweetener for tart foods
  • Loss of appetite
  • General tonic

Sweet Cicely is a mild, anise-flavored garden herb traditionally used in cooking and folk remedies for digestion and coughs. There is very little modern scientific research to confirm any health benefits, but it is generally considered safe in food amounts. Talk to a pharmacist or doctor before using it as a medicine, especially if you are pregnant or breastfeeding.

Myrrhis odorata · Apiaceae · Leaves, seeds, and roots · Fresh or dried herb, tea, culinary herb, occasionally tincture

An interaction check asks whether these two react with each other — it does not ask whether Sweet Cicely is a good idea for someone in your situation. Here is what our Sweet Cicely record says about it on its own.

Sweet Cicely: dosing

There is no established, standardized medicinal dose for Sweet Cicely. Most use is culinary, where the fresh or dried leaves and seeds are added to food or steeped as a mild tea.If you choose to use a commercial Sweet Cicely product, follow the directions on the product label and do not exceed the recommended amount.

From our Sweet Cicely monograph — the full record covers uses, side effects and every documented interaction.

Read the full Sweet Cicely monograph & all interactions
Medication

About Ruxolitinib

What Is Ruxolitinib Used For?

Brand names: Jakafi, Opzelura

Ruxolitinib is approved to treat several serious blood and immune conditions in adults, and some in patients as young as 12. It is used for myelofibrosis (a bone marrow disorder that disrupts normal blood cell production), polycythemia vera (a condition where the bone marrow makes too many red blood cells), and two forms of graft-versus-host disease (GVHD) — a complication that can occur after a stem cell transplant.

For polycythemia vera, it is specifically for patients who have not responded well to, or cannot tolerate, a medication called hydroxyurea. For chronic GVHD, it is used after at least one or two other treatments have failed.

Most-Reported Side Effects for Ruxolitinib

From FAERS, the FDA’s public side-effect reporting system (71,241 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 6,114 reports
Anemia 3,094 reports
Haemoglobin decreased 2,961 reports
Platelet count decreased 2,700 reports
Diarrhea 2,683 reports
See full Ruxolitinib drug information
Keep checking

Other Drugs & Sweet Cicely

Browse every other medication we’ve checked against Sweet Cicely — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Sweet Cicely against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Sweet Cicely list.

See the full Sweet Cicely interactions page
See every supplement checked against Ruxolitinib, ranked by severity
Sources

Sources & How We Checked

We checked Sweet Cicely against Ruxolitinib in the Natural Medicines interaction database and found no documented interaction on file. The medication overview comes from MedlinePlus, and supplement label details from the NIH Dietary Supplement Label Database.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Sweet Cicely monograph › Uses, safety, and every drug interaction in one place Ruxolitinib supplement interactions › Every supplement checked against Ruxolitinib, ranked by severity Ruxolitinib drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Sweet Cicely and Ruxolitinib Together: Common Questions

Is it safe to take Sweet Cicely with Ruxolitinib?
We do not list a known interaction between Sweet Cicely and Ruxolitinib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Ruxolitinib interact with any supplements?
Yes. Ruxolitinib has documented interactions with 141 supplements in our database — Sweet Cicely is not one of them. The Ruxolitinib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Ruxolitinib and Sweet Cicely?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.