Sweet Gale + Acetaminophen, Diphenhydramine
Acetaminophen, Diphenhydramine brand names: Tylenol PM, Tylenol PM Ex Strength.
We found no known interaction between Sweet Gale and Acetaminophen, Diphenhydramine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Sweet Gale and Acetaminophen, Diphenhydramine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Acetaminophen, Diphenhydramine and Sweet Gale in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Sweet Gale at all — not against Acetaminophen, Diphenhydramine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Sweet Gale safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
See Every Supplement That Interacts With Acetaminophen, Diphenhydramine
This page covers Sweet Gale only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetaminophen, Diphenhydramine page lists 254 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Gamma-hydroxybutyrate (ghb) (major).
By severity: 11 major · 204 moderate · 39 minor.
Where Sweet Gale and Acetaminophen, Diphenhydramine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,437 of 1,452 supplements looked up here in the last 7 days
#183 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources.
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Sweet Gale and Acetaminophen, Diphenhydramine records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Sweet Gale
What is Sweet Gale?
- Insect repellent
- Digestive complaints
- Flavoring for food and beverages
- Skin and itch relief (traditional)
- Aromatic and fragrance use
Sweet gale is an aromatic shrub long used as an insect repellent and a flavoring herb, but there is very little solid human research supporting any health benefit. Its essential oil is considered potentially toxic, so internal use should be approached with great caution and avoided in pregnancy. Talk to a pharmacist or doctor before using it.
Myrica gale · Myricaceae · Leaves, branches, fruit (catkins), and wax/essential oil · Tea, dried leaves, essential oil, flavoring agent
An interaction check asks whether these two react with each other — it does not ask whether Sweet Gale is a good idea for someone in your situation. Here is what our Sweet Gale record says about it on its own.
Sweet Gale: dosing
There is no established or standardized dose for sweet gale. Because reliable human research is lacking, no safe and effective amount has been defined for any health condition.If you choose to use a sweet gale product, follow the directions on the label and do not exceed them. Avoid swallowing the essential oil.
From our Sweet Gale monograph — the full record covers uses, side effects and every documented interaction.
Other Drugs & Sweet Gale
Browse every other medication we’ve checked against Sweet Gale — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Sweet Gale against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Sweet Gale list.
Sources & How We Checked
We checked Sweet Gale against Acetaminophen, Diphenhydramine in the Natural Medicines interaction database and found no documented interaction on file. The medication overview comes from MedlinePlus, and supplement label details from the NIH Dietary Supplement Label Database.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Acetaminophen, Diphenhydramine Is Linked to Lower Levels of One Nutrient
Natural Medicines records Acetaminophen, Diphenhydramine as a medicine that can lower these. This is not an interaction with Sweet Gale — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Acetaminophen, Diphenhydramine nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Sweet Gale and Acetaminophen, Diphenhydramine Together: Common Questions
Is it safe to take Sweet Gale with Acetaminophen, Diphenhydramine?
Does Acetaminophen, Diphenhydramine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Still Have a Question About Acetaminophen, Diphenhydramine and Sweet Gale?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.