Drug & supplement interaction

Sweet Sumac + Olsalazine Sodium

Olsalazine Sodium brand name: Dipentum.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Sweet Sumac and Olsalazine Sodium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Sweet Sumac and Olsalazine Sodium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Olsalazine Sodium and Sweet Sumac in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Sweet Sumac at all — not against Olsalazine Sodium, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Sweet Sumac safety at a glance

Sweet Sumac overall Use caution Limited safety data exist, and it is related to plants that can cause skin reactions.
Pregnancy Avoid There is not enough safety information, so avoid use during pregnancy.
Breastfeeding Avoid Safety is unknown while breastfeeding, so it is best to avoid it.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Olsalazine Sodium and Sweet Sumac? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Sweet Sumac and Olsalazine Sodium May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • A higher chance of infection Worth acting on Additional detail

    Sweet Sumac

    “Orally, infections of the urogenital tract have been reported in women with overactive bladder who were taking a combination product (Granu Fink femina, Omega Pharma) containing sweet sumac bark extract, pumpkin seed oil, and hops cone extract. It is unclear if these adverse effects were due to sweet sumac, other ingredients, or the combination.”

    Sweet Sumac · Natural Medicines adverse-effect record, reported in overactive bladder.

    1 source cited
    1. 103253. Gauruder-Burmester A, Heim S, Patz B, Seibt S. Cucurbita pepo-Rhus aromatica-Humulus lupulus combination reduces overactive bladder symptoms in women - a noninterventional study. Planta Med. 2019;85(13):1044-53. PubMed

    Olsalazine Sodium

    Listed in the ADVERSE REACTIONS section of the FDA label for Olsalazine Sodium. Read the label on DailyMed ›

Effects for Olsalazine Sodium come from the ADVERSE REACTIONS section of its FDA label; effects for Sweet Sumac come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Olsalazine Sodium

This page covers Sweet Sumac only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Olsalazine Sodium page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Olsalazine Sodium page

“Olsalazine sodium (Dipentum) treats ulcerative colitis, and it only works if enough of the drug travels intact to the colon, so anything that binds it or interferes with its passage through the gut deserves real attention. All 17 supplement interactions on file involve absorption, and one carries a major rating: activated charcoal, whi…”

Reviewed by 2 · Jul 18, 2026

Open the Olsalazine Sodium interaction page

How much people look this up

Where Sweet Sumac and Olsalazine Sodium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Sweet Sumac
Steady interest

#1,249 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Olsalazine Sodium
Steady interest

#1,841 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Sweet Sumac reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Sweet Sumac and Olsalazine Sodium records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Sweet Sumac

What is Sweet Sumac?

  • Urinary complaints
  • Diarrhea
  • Excessive urination or bedwetting
  • Sore throat and mouth rinse
  • Mild bleeding

Sweet Sumac (Rhus aromatica) is a North American shrub used in traditional and folk medicine, mostly for urinary and digestive complaints. There is very little modern human research to confirm that it works for any condition, so its benefits remain unproven. Because it belongs to the same plant family as poison ivy, talk with a pharmacist or doctor before using it.

Rhus aromatica · Anacardiaceae · Bark of the root, leaves, and berries · Dried bark, tea, tincture, liquid extract

An interaction check asks whether these two react with each other — it does not ask whether Sweet Sumac is a good idea for someone in your situation. Here is what our Sweet Sumac record says about it on its own.

Sweet Sumac: dosing

There is no established, standardized dose for Sweet Sumac. It has traditionally been taken as a tea, tincture, or liquid extract made from the root bark or leaves, but reliable dosing guidelines from clinical research are not available.If you choose to use a commercial product, follow the directions on the label and do not exceed the suggested amount.

From our Sweet Sumac monograph — the full record covers uses, side effects and every documented interaction.

Read the full Sweet Sumac monograph & all interactions
Medication

About Olsalazine

What Is Olsalazine Used For?

Brand name: Dipentum

Dipentum (olsalazine) is used to keep ulcerative colitis in remission — meaning it helps prevent the disease from flaring up after it has been brought under control. It is specifically approved for adults who are intolerant of sulfasalazine, another medication commonly used for ulcerative colitis.

Most-Reported Side Effects for Olsalazine Sodium

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Colitis ulcerative 19 reports
Diarrhea 14 reports
Fatigue 9 reports
Pain in extremity 7 reports
Pruritus 7 reports
See full Olsalazine drug information
Keep checking

Other Drugs & Sweet Sumac

Browse every other medication we’ve checked against Sweet Sumac — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Sweet Sumac against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Sweet Sumac list.

See the full Sweet Sumac interactions page
See every supplement checked against Olsalazine Sodium, ranked by severity
Evidence & sources

Sweet Sumac References

The 1 references that drive our Sweet Sumac monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gauruder-Burmester A, Heim S, Patz B, Seibt S. Cucurbita pepo-Rhus aromatica-Humulus lupulus combination reduces overactive bladder symptoms in women - a noninterventional study. Planta Med. 2019;85(13):1044-53. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Sweet Sumac and Olsalazine Sodium Together: Common Questions

Is it safe to take Sweet Sumac with Olsalazine Sodium?
We do not list a known interaction between Sweet Sumac and Olsalazine Sodium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Sweet Sumac and Olsalazine Sodium have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Olsalazine Sodium interact with any supplements?
Yes. Olsalazine Sodium has documented interactions with 17 supplements in our database — Sweet Sumac is not one of them. The Olsalazine Sodium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Sweet Sumac monograph Uses, safety profile, and every drug interaction in one place Olsalazine drug information The full plain-English guide to this medication Olsalazine Sodium supplement interactions Every supplement checked against Olsalazine Sodium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Olsalazine Sodium and Sweet Sumac?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.