Drug & supplement interaction

Tagetes + Dolutegravir, Rilpivirine

Dolutegravir, Rilpivirine brand name: Juluca.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Tagetes and Dolutegravir, Rilpivirine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Dolutegravir, Rilpivirine states a food rule worth keeping to.

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Interaction report

Tagetes and Dolutegravir, Rilpivirine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Dolutegravir, Rilpivirine and Tagetes in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Tagetes at all — not against Dolutegravir, Rilpivirine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Tagetes safety at a glance

Tagetes overall Use caution Generally considered low-risk in food amounts, but the essential oil and concentrated extracts can irritate skin and lack strong safety data.
Pregnancy Avoid Avoid medicinal or essential oil use during pregnancy because safety has not been established.
Breastfeeding Avoid Not enough safety information exists, so avoid medicinal use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Dolutegravir, Rilpivirine and Tagetes? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Tagetes Itself Has Been Linked To

This is not an interaction — nothing below involves Dolutegravir, Rilpivirine. It is the side-effect record for Tagetes on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Tagetes, this list is the first place to look.

  • A skin rash Additional detail

    “Topically, ornamental marigold has been reported to cause contact dermatitis (11).”

    Tagetes · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 11. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.

Everything above comes from the Natural Medicines adverse-effect record for Tagetes — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Dolutegravir, Rilpivirine’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Dolutegravir, Rilpivirine column appears here.

How to take them

Some Dolutegravir, Rilpivirine Products Have a Food Rule — Tagetes Should Not Break It

At least one FDA label for a product containing Dolutegravir, Rilpivirine says to take it with food. If you take Tagetes on an empty stomach out of habit, keep them separate — and take Dolutegravir, Rilpivirine with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Dolutegravir, Rilpivirine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.2 ) 2.1 Recommended Dosage The recommended dosage of JULUCA is one tablet taken orally once daily with a meal [see Clinical Pharmacology ( 12.3 )] .

From the Dosage and Administration section of the FDA label we read for Dolutegravir, Rilpivirine — where that label names a specific product, the instruction is that product's.

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Dolutegravir, Rilpivirine

This page covers Tagetes only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dolutegravir, Rilpivirine page lists 159 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Calcium (major) and Cesium (major).

By severity: 9 major · 115 moderate · 35 minor.

From our pharmacist’s overview on the Dolutegravir, Rilpivirine page

“Juluca combines dolutegravir and rilpivirine into a single daily HIV pill, and staying suppressed depends on that pill working at full strength every day, which is why this list calls for real vigilance. Most of the 159 interacting supplements and herbs change how the body handles the medication, some raising its levels and others lowe…”

Reviewed by 2 · Jul 18, 2026

Open the Dolutegravir, Rilpivirine interaction page

One more smart check

Taking Tagetes as Part of a Dietary Supplement Product? Check It for Interactions

We hold 100 real supplement products containing Tagetes, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Tagetes. Even though Tagetes itself has no known interaction with Dolutegravir, Rilpivirine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Tagetes and Dolutegravir, Rilpivirine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Tagetes
Top half

#583 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Dolutegravir, Rilpivirine
Steady interest

#1,922 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Tagetes reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Tagetes and Dolutegravir, Rilpivirine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Tagetes

What is Tagetes?

  • Digestive upset
  • Antimicrobial and antifungal
  • Skin and wound care
  • Insect repellent
  • Eye health (lutein source from petals)

Tagetes (marigold) is a group of flowering plants used in traditional medicine and as a source of plant pigments like lutein. Human evidence for most health benefits is very limited, and the essential oil can cause skin reactions and sun sensitivity. Talk to a pharmacist or doctor before using it, especially while pregnant or breastfeeding.

Asteraceae · Flowers, leaves, and essential oil · Essential oil, tea, dried flowers, topical preparations, tinctures

An interaction check asks whether these two react with each other — it does not ask whether Tagetes is a good idea for someone in your situation. Here is what our Tagetes record says about it on its own.

Tagetes: dosing

There is no well-established standard dose for Tagetes as a supplement or medicine. Products vary widely in strength, and the amount of active compounds depends on the species, plant part, and how it was prepared.If you choose to use a Tagetes product, follow the directions on the label and do not exceed them. Essential oils should be diluted before any skin use and kept away from the eyes and mouth.

From our Tagetes monograph — the full record covers uses, side effects and every documented interaction.

Read the full Tagetes monograph & all interactions
Keep checking

Other Drugs & Tagetes

Browse every other medication we’ve checked against Tagetes — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Tagetes References

The 1 references that drive our Tagetes monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Tagetes and Dolutegravir, Rilpivirine Together: Common Questions

Is it safe to take Tagetes with Dolutegravir, Rilpivirine?
We do not list a known interaction between Tagetes and Dolutegravir, Rilpivirine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Tagetes and Dolutegravir, Rilpivirine at the same time of day?
At least one FDA label for a product containing Dolutegravir, Rilpivirine says to take it with food. If you take Tagetes on an empty stomach out of habit, keep them separate and take Dolutegravir, Rilpivirine with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Dolutegravir, Rilpivirine products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Dolutegravir, Rilpivirine interact with any supplements?
Yes. Dolutegravir, Rilpivirine has documented interactions with 159 supplements in our database — Tagetes is not one of them. The Dolutegravir, Rilpivirine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Dolutegravir, Rilpivirine and Tagetes?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.