Drug & supplement interaction

Tannic Acid + Meclofenamate

Meclofenamate brand name: Meclomen.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Tannic Acid and Meclofenamate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Meclofenamate states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Tannic Acid and Meclofenamate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Meclofenamate and Tannic Acid in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Tannic Acid at all — not against Meclofenamate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Tannic Acid safety at a glance

Tannic Acid overall Use caution Generally used topically in small amounts, but absorption through broken skin or large burns can harm the liver.
Pregnancy Possibly Unsafe When used topically on damaged or broken skin. There is insufficient reliable information available about the safety of tannic acid when used orally during preg... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used topically on damaged or broken skin. There is insufficient reliable information available about the safety of tannic acid when used orally during preg... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Meclofenamate and Tannic Acid? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Tannic Acid and Meclofenamate May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Vomiting / Nausea Additional detail

    Tannic Acid

    “Orally, large amounts of tannic acid can cause gastric irritation, nausea, and vomiting (11). Extensive use of tannins on burns or in enemas has been associated with fatal liver damage (11). However, this toxicity may be due to digallic acid, an impurity that is sometimes found in tannic acid (11).”

    Tannic Acid · Natural Medicines adverse-effect record, reported in burns.

    1 source cited
    1. 11. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.

    “Orally, large amounts of tannic acid can cause gastric irritation, nausea, and vomiting (11).”

    Tannic Acid · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 11. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.

    Meclofenamate

    Listed in the ADVERSE REACTIONS section of the FDA label for Meclofenamate. Read the label on DailyMed ›

Reported for Tannic Acid but not commonly for Meclofenamate: stomach upset and liver problems.

Effects for Meclofenamate come from the ADVERSE REACTIONS section of its FDA label; effects for Tannic Acid come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Tannic Acid in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used topically on damaged or broken skin. There is insufficient reliable information available about the safety of tannic acid when used orally during pregnancy and lactation; avoid using amounts greater than those found in foods.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Meclofenamate Products Have a Food Rule — Tannic Acid Should Not Break It

At least one FDA label for a product containing Meclofenamate says to take it with food. If you take Tannic Acid on an empty stomach out of habit, keep them separate — and take Meclofenamate with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Meclofenamate products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

If gastrointestinal complaints occur (see WARNINGS and PRECAUTIONS ), meclofenamate sodium may be administered with meals or with milk (see CLINICAL PHARMACOLOGY for a description of food effects).

From the Dosage and Administration section of the FDA label we read for Meclofenamate — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Overlapping uses

What Meclofenamate Is Prescribed For, and What Tannic Acid Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Meclofenamate is a prescription medicine with approved uses on its FDA label. Tannic Acid is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Meclofenamate is prescribed for: Meclofenamate sodium capsules are used in adults to relieve mild to moderate pain, reduce fever, and treat the signs and symptoms of rheumatoid arthritis, osteoarthritis, juvenile arthritis, and ankylosing spondylitis (a type of spinal arthritis). They are also used for acute painful shoulder, acute gouty arthritis, primary dysmenorrhea (painful periods), and idiopathic heavy menstrual bleeding. This medication is not recommended for use in children, as adequate safety and effectiveness studies have not been carried out in that age group.

Tannic Acid has been studied for:

  • Osteoarthritis studied, not established Tannic Acid has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Tannic Acid for osteoarthritis

    Some clinical research in patients with knee osteoarthritis shows that applying a specific cream containing tannic acid, comfrey extract, aloe vera gel, eucalyptus oil, and frankincense oil (4Jointz, Arthritis Relief Plus Ltd) about 3.5 grams three times daily for 6-12 weeks decreases pain and stiffness and improves physical function when compared with placebo.

    2 sources cited
    1. 44919. Laslett, L. L., Quinn, S. J., Darian-Smith, E., Kwok, M., Fedorova, T., Korner, H., Steels, E., March, L., and Jones, G. Treatment with 4Jointz reduces knee pain over 12 weeks of treatment in patients with clinical knee osteoarthritis: a randomised contr
    2. 92571. Smith DB, Jacobson BH. Effect of a blend of comfrey root extract (Symphytum officinale L.) and tannic acid creams in the treatment of osteoarthritis of the knee: randomized, placebo-controlled, double-blind, multiclinical trials. J Chiropr Med. 2011;10(3) PubMed

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Meclofenamate on your own; if you are taking Tannic Acid for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Meclofenamate

This page covers Tannic Acid only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Meclofenamate page lists 32 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Siberian Cocklebur (major) and Wine (major).

By severity: 5 major · 16 moderate · 11 minor.

From our pharmacist’s overview on the Meclofenamate page

“Meclofenamate (Meclomen) is a prescription NSAID for pain and arthritis, a class of drug that is already hard on the stomach and kidneys, so this list deserves real care rather than a quick skim. Five of its 32 supplement and herbal interactions rate major, clustered around two dangers: alcohol (beer and wine both raise the risk of sto…”

Reviewed by 2 · Jul 18, 2026

Open the Meclofenamate interaction page

How much people look this up

Where Tannic Acid and Meclofenamate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Tannic Acid
Steady interest

#1,270 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Meclofenamate
Steady interest

#2,579 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Tannic Acid reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Tannic Acid and Meclofenamate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Tannic Acid

What is Tannic Acid?

  • Minor skin irritation and weeping rashes
  • Sore throat and mouth sores
  • Minor burns and blisters
  • Astringent for skin
  • Hemorrhoids

Tannic acid is a plant-derived astringent used mostly on the skin and in the mouth to dry out and tighten tissue. There is some traditional and topical use, but high-quality evidence for most uses is limited, and it can be harmful if too much is absorbed, especially on broken skin or burns.

Tannins extracted from plant sources such as oak galls, bark, and certain seeds and leaves · Topical powders and solutions, throat lozenges, gargles, suppositories, and some over-the-counter skin products

An interaction check asks whether these two react with each other — it does not ask whether Tannic Acid is a good idea for someone in your situation. Here is what our Tannic Acid record says about it on its own.

Tannic Acid: dosing

There is no well-established standard dose of tannic acid for supplement use. The amount varies widely depending on the product and how it is used (for example, a skin solution versus a lozenge).The safest approach is to follow the directions on the product label and not apply it to large areas of broken or burned skin.

From our Tannic Acid monograph — the full record covers uses, side effects and every documented interaction.

Read the full Tannic Acid monograph & all interactions
Medication

About Meclofenamate

What Is Meclofenamate Used For?

Brand name: Meclomen

Meclofenamate sodium capsules are used in adults to relieve mild to moderate pain, reduce fever, and treat the signs and symptoms of rheumatoid arthritis, osteoarthritis, juvenile arthritis, and ankylosing spondylitis (a type of spinal arthritis). They are also used for acute painful shoulder, acute gouty arthritis, primary dysmenorrhea (painful periods), and idiopathic heavy menstrual bleeding.

This medication is not recommended for use in children, as adequate safety and effectiveness studies have not been carried out in that age group.

See full Meclofenamate drug information
Keep checking

Other Drugs & Tannic Acid

Browse every other medication we’ve checked against Tannic Acid — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Tannic Acid against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Tannic Acid list.

See the full Tannic Acid interactions page
See every supplement checked against Meclofenamate, ranked by severity
Evidence & sources

Tannic Acid References

The 8 references that drive our Tannic Acid monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  4. Laslett, L. L., Quinn, S. J., Darian-Smith, E., Kwok, M., Fedorova, T., Korner, H., Steels, E., March, L., and Jones, G. Treatment with 4Jointz reduces knee pain over 12 weeks of treatment in patients with clinical knee osteoarthritis: a randomised contr
  5. Smith DB, Jacobson BH. Effect of a blend of comfrey root extract (Symphytum officinale L.) and tannic acid creams in the treatment of osteoarthritis of the knee: randomized, placebo-controlled, double-blind, multiclinical trials. J Chiropr Med. 2011;10(3) PubMed
  6. Goh CL, Yoyong K. A comparison of topical tannic acid versus iontophoresis in the medical treatment of palmar hyperhidrosis. Singapore Med J. 1996;37(5):466-8.
  7. Kołodziej M, Bebenek D, Konarska Z, Szajewska H. Gelatine tannate in the management of acute gastroenteritis in children: a randomised controlled trial. BMJ Open. 2018;8(5):e020205. PubMed
  8. Mennini M, Tolone C, Frassanito A, Midulla F, Cucchiara S, Aloi M. Gelatin tannate for acute childhood gastroenteritis: a randomized, single-blind controlled trial. Paediatr Drugs. 2017 Apr;19(2):131-137. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Tannic Acid and Meclofenamate Together: Common Questions

Is it safe to take Tannic Acid with Meclofenamate?
We do not list a known interaction between Tannic Acid and Meclofenamate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Tannic Acid and Meclofenamate have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Tannic Acid and Meclofenamate at the same time of day?
At least one FDA label for a product containing Meclofenamate says to take it with food. If you take Tannic Acid on an empty stomach out of habit, keep them separate and take Meclofenamate with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Meclofenamate products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Are Tannic Acid and Meclofenamate used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Tannic Acid in each. That is a conversation for your prescriber, especially if Meclofenamate is being adjusted to a target.
Does Meclofenamate interact with any supplements?
Yes. Meclofenamate has documented interactions with 32 supplements in our database — Tannic Acid is not one of them. The Meclofenamate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Tannic Acid monograph Uses, safety profile, and every drug interaction in one place Meclofenamate drug information The full plain-English guide to this medication Meclofenamate supplement interactions Every supplement checked against Meclofenamate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Meclofenamate and Tannic Acid?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.