Drug & supplement interaction

Tannic Acid + Omeprazole

Omeprazole brand names: Prilosec, Zegerid, Losec.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Tannic Acid and Omeprazole in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Tannic Acid and Omeprazole

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Omeprazole and Tannic Acid in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Tannic Acid at all — not against Omeprazole, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Tannic Acid safety at a glance

Tannic Acid overall Use caution Generally used topically in small amounts, but absorption through broken skin or large burns can harm the liver.
Pregnancy Possibly Unsafe When used topically on damaged or broken skin. There is insufficient reliable information available about the safety of tannic acid when used orally during preg... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used topically on damaged or broken skin. There is insufficient reliable information available about the safety of tannic acid when used orally during preg... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Omeprazole and Tannic Acid? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Tannic Acid and Omeprazole May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Nausea / Vomiting reported in 6.0% of FDA reports for Omeprazole Additional detail

    Tannic Acid

    “Orally, large amounts of tannic acid can cause gastric irritation, nausea, and vomiting (11). Extensive use of tannins on burns or in enemas has been associated with fatal liver damage (11). However, this toxicity may be due to digallic acid, an impurity that is sometimes found in tannic acid (11).”

    Tannic Acid · Natural Medicines adverse-effect record, reported in burns.

    1 source cited
    1. 11. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.

    “Orally, large amounts of tannic acid can cause gastric irritation, nausea, and vomiting (11).”

    Tannic Acid · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 11. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.

    Omeprazole

    Listed in the ADVERSE REACTIONS section of the FDA label for Omeprazole, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Tannic Acid but not commonly for Omeprazole: stomach upset and liver problems.

Effects for Omeprazole come from the ADVERSE REACTIONS section of its FDA label; effects for Tannic Acid come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 448,293 voluntary FDA FAERS reports for Omeprazole that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Tannic Acid in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used topically on damaged or broken skin. There is insufficient reliable information available about the safety of tannic acid when used orally during pregnancy and lactation; avoid using amounts greater than those found in foods.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Tannic Acid or Omeprazole

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Tannic Acid or Omeprazole, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Omeprazole

This page covers Tannic Acid only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Omeprazole page lists 174 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 121 moderate · 50 minor.

From our pharmacist’s overview on the Omeprazole page

“Omeprazole (Prilosec, Zegerid, Losec) is an acid reducer for heartburn, reflux, and ulcers, and because it sits on pharmacy shelves next to the vitamins, people tend to assume it mixes safely with anything. This list argues otherwise, and it warrants genuine care.”

Reviewed by 2 · Jul 18, 2026

Open the Omeprazole interaction page

How much people look this up

Where Tannic Acid and Omeprazole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Tannic Acid
Steady interest

#1,059 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Omeprazole
Top 5%

#43 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Tannic Acid reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Tannic Acid and Omeprazole records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Tannic Acid

What is Tannic Acid?

  • Minor skin irritation and weeping rashes
  • Sore throat and mouth sores
  • Minor burns and blisters
  • Astringent for skin
  • Hemorrhoids

Tannic acid is a plant-derived astringent used mostly on the skin and in the mouth to dry out and tighten tissue. There is some traditional and topical use, but high-quality evidence for most uses is limited, and it can be harmful if too much is absorbed, especially on broken skin or burns.

Tannins extracted from plant sources such as oak galls, bark, and certain seeds and leaves · Topical powders and solutions, throat lozenges, gargles, suppositories, and some over-the-counter skin products

An interaction check asks whether these two react with each other — it does not ask whether Tannic Acid is a good idea for someone in your situation. Here is what our Tannic Acid record says about it on its own.

Tannic Acid: dosing

There is no well-established standard dose of tannic acid for supplement use. The amount varies widely depending on the product and how it is used (for example, a skin solution versus a lozenge).The safest approach is to follow the directions on the product label and not apply it to large areas of broken or burned skin.

From our Tannic Acid monograph — the full record covers uses, side effects and every documented interaction.

Read the full Tannic Acid monograph & all interactions
Medication

About Omeprazole

What Is Omeprazole Used For?

Brand names: Prilosec, Zegerid, Losec

Omeprazole is used to treat a range of conditions where stomach acid causes problems. These include heartburn and acid reflux (GERD), erosive esophagitis (damage to the esophagus from acid), and stomach or duodenal ulcers. It can also be used alongside antibiotics to help get rid of an H. pylori infection — a bacteria that causes ulcers.

In more serious cases, omeprazole is used to manage conditions where the stomach produces far too much acid, such as pathologic hypersecretory conditions (rare medical disorders that cause extreme acid overproduction). It is approved for adults and children one year of age and older for GERD and erosive esophagitis.

Most-Reported Side Effects for Omeprazole

From FAERS, the FDA’s public side-effect reporting system (448,293 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Chronic kidney disease 36,807 reports
Nausea 27,095 reports
Fatigue 26,259 reports
Diarrhea 25,668 reports
Acute kidney injury 23,964 reports
See full Omeprazole drug information
Keep checking

Other Drugs & Tannic Acid

Browse every other medication we’ve checked against Tannic Acid — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Tannic Acid against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Tannic Acid list.

See the full Tannic Acid interactions page
See every supplement checked against Omeprazole, ranked by severity
Evidence & sources

Tannic Acid References

The 8 references that drive our Tannic Acid monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  4. Laslett, L. L., Quinn, S. J., Darian-Smith, E., Kwok, M., Fedorova, T., Korner, H., Steels, E., March, L., and Jones, G. Treatment with 4Jointz reduces knee pain over 12 weeks of treatment in patients with clinical knee osteoarthritis: a randomised contr
  5. Smith DB, Jacobson BH. Effect of a blend of comfrey root extract (Symphytum officinale L.) and tannic acid creams in the treatment of osteoarthritis of the knee: randomized, placebo-controlled, double-blind, multiclinical trials. J Chiropr Med. 2011;10(3) PubMed
  6. Goh CL, Yoyong K. A comparison of topical tannic acid versus iontophoresis in the medical treatment of palmar hyperhidrosis. Singapore Med J. 1996;37(5):466-8.
  7. Kołodziej M, Bebenek D, Konarska Z, Szajewska H. Gelatine tannate in the management of acute gastroenteritis in children: a randomised controlled trial. BMJ Open. 2018;8(5):e020205. PubMed
  8. Mennini M, Tolone C, Frassanito A, Midulla F, Cucchiara S, Aloi M. Gelatin tannate for acute childhood gastroenteritis: a randomized, single-blind controlled trial. Paediatr Drugs. 2017 Apr;19(2):131-137. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Tannic Acid and Omeprazole Together: Common Questions

Is it safe to take Tannic Acid with Omeprazole?
We do not list a known interaction between Tannic Acid and Omeprazole. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Tannic Acid and Omeprazole have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Omeprazole interact with any supplements?
Yes. Omeprazole has documented interactions with 174 supplements in our database — Tannic Acid is not one of them. The Omeprazole interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Tannic Acid monograph Uses, safety profile, and every drug interaction in one place Omeprazole drug information The full plain-English guide to this medication Omeprazole supplement interactions Every supplement checked against Omeprazole, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Omeprazole and Tannic Acid?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.