Testolone - Interferon Alfa-2b Interaction

Interaction Details

Interferon Alfa-2b is classified as belonging to the following category: Hepatotoxic Drugs

Theoretically, concomitant use might have additive hepatotoxic effects.
In a case report, a 52-year-old male was diagnosed with liver injury thought to be related to the use of products containing testolone. Also, elevated liver enzymes were commonly reported in a dose escalation study of testolone.

Interaction Rating

Likelihood of Occurrence

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists

References

• LoRusso P, Hamilton E, Ma C, et al. A first-in-human phase 1 study of a novel selective androgen receptor modulator (SARM), RAD140, in ER+/HER2- metastatic breast cancer. Clin Breast Cancer 2022;22(1):67-77.
• Barbara M, Dhingra S, Mindikoglu AL. Drug-induced liver injury associated with alpha bolic (RAD-140) and alpha elite (RAD-140 and LGD-4033). ACG Case Rep J 2020;7(6):e00409.

Interferon Alfa-2b Overview

• Interferon alfa-2b injection is used to treat a number of conditions.

• Interferon alfa-2b injection is used

  • alone or in combination with ribavirin (Copegus, Rebetol, Ribasphere) to treat chronic (long-term) hepatitis C infection (swelling of the liver caused by a virus) in people who show signs of liver damage,

  • to treat chronic hepatitis B infection (swelling of the liver caused by a virus) in people who show signs of liver damage,

  • to treat hairy cell leukemia (a white blood cell cancer),

  • to treat genital warts,

  • to treat Kaposi's sarcoma (a type of cancer that causes abnormal tissue to grow on different parts of the body) related to acquired immunodeficiency syndrome (AIDS),

  • to treat malignant melanoma (a cancer that begins in certain skin cells) in certain people who have had surgery to remove the cancer,

  • along with another medication to treat follicular non-Hodgkin's lymphoma (NHL; a slow-growing blood cancer).

• Interferon alfa-2b is in a class of medications called immunomodulators. Interferon alfa-2b works to treat hepatitis C virus (HCV) and hepatitis B virus (HBV) by decreasing the amount virus in the body. Interferon alfa-2b may not cure hepatitis B or hepatitis C or prevent you from developing complications from these infections such as cirrhosis (scarring) of the liver, liver failure, or liver cancer. It also may not prevent the spread of hepatitis B or C to other people. It is not known exactly how interferon alfa-2b works to treat cancer or genital warts.

Testolone - More Interactions

Testolone interacts with 344 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.