Threonine + Methol/Benzocaine
Methol/Benzocaine brand name: Vicks Formula 44 Sore Throat Lozenges.
We found no known interaction between Threonine and Methol/Benzocaine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Threonine and Methol/Benzocaine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Methol/Benzocaine and Threonine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Threonine safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Methol/Benzocaine
Interactions in our licensed database are recorded against drug classes, not just single drug names. Methol/Benzocaine is filed under a single classification — topical drugs. Threonine has documented interactions with 1 drug class — the most serious being nmda antagonists (major) — and none of Methol/Benzocaine’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Threonine Does Interact With Other Medications
Threonine has 3 major, known drug interactions in our database — Methol/Benzocaine isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Threonine
We haven’t checked that one against Threonine yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Threonine. Pick one to open its full report.
See Every Supplement That Interacts With Methol/Benzocaine
This page covers Threonine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Methol/Benzocaine page lists 3 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Dimethylsulfoxide (dmso) (moderate), Turpentine Oil (moderate) and Alchemilla (minor).
By severity: 2 moderate · 1 minor.
From our pharmacist’s overview on the Methol/Benzocaine page
“A sore throat bad enough for Methol/Benzocaine lozenges (Vicks Formula 44) often sends the same person to the supplement aisle, and the good news is that this pairing is manageable for nearly everyone. Just three ingredients have interactions on file, none rated major, and all three affect topical drugs like the numbing benzocaine in t…”
Reviewed by 2 · Jul 18, 2026
Taking Threonine as Part of a Dietary Supplement Product? Check It for Interactions
We hold 1,803 real supplement products containing Threonine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Threonine. Even though Threonine itself has no known interaction with Methol/Benzocaine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Threonine and Methol/Benzocaine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#127 of 1,452 supplements looked up here in the last 7 days
#822 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Threonine reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Threonine and Methol/Benzocaine records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Threonine
What is Threonine?
- General amino acid/protein support
- Muscle and tissue health
- Immune support
- Nervous system support (as a precursor)
- Liver health (proposed)
Threonine is an essential amino acid your body needs but cannot make, so you must get it from food or supplements. Most people get plenty from a normal diet, and high-quality evidence for taking it as a separate supplement is limited. If you are considering threonine supplements, talk with your pharmacist or doctor first.
Amino acid (obtained from dietary protein or made synthetically) · Capsules, tablets, powder, and part of amino acid blends; also found in protein-rich foods
An interaction check asks whether these two react with each other — it does not ask whether Threonine is a good idea for someone in your situation. Here is what our Threonine record says about it on its own.
Threonine: dosing
There is no well-established standard supplement dose of threonine for general health. Studies that have used it for specific medical conditions used different amounts, and those doses were given under medical supervision.If you choose to use a threonine product, follow the directions on the label and do not exceed the recommended amount.
From our Threonine monograph — the full record covers uses, side effects and every documented interaction.
Other Drugs & Threonine
Browse every other medication we’ve checked against Threonine — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
3 interactions
No interaction 2,826 drugs checked — show the list
We also checked Threonine against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Metoprolol ›
- Rivaroxaban ›
- Aspirin ›
- Rosuvastatin ›
- Acetaminophen ›
- Escitalopram ›
- Abemaciclib ›
- Clopidogrel ›
- Tadalafil ›
- Atorvastatin ›
- Docusate ›
- Tirzepatide ›
- Valacyclovir ›
- Ibuprofen ›
- Hydroxyurea ›
- Methamphetamine ›
- Warfarin Sodium ›
- Semaglutide ›
- Sumatriptan ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bupropion ›
- Amitriptyline ›
- Bendamustine ›
- Methotrexate ›
- Acyclovir ›
- Doxycycline ›
- Amphetamine ›
- Isotretinoin ›
- Fluoxetine ›
- Lamotrigine ›
- Pregabalin ›
- Azithromycin ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amlodipine Besylate ›
- Dextroamphetamine ›
- Clonazepam ›
- Methylene Blue ›
- Quetiapine ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Naproxen ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,826 medications checked with no known interaction — see the full Threonine list.
Threonine References
The 4 references that drive our Threonine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Tandan R, Bromberg MB, Forshew D, et al. A controlled trial of amino acid therapy in amyotrophic lateral sclerosis: I. Clinical, functional, and maximum isometric torque data. Neurology 1996;47:1220-6. PubMed
- Lee A, Patterson V. A double blind study of L-threonine in patients with spinal spasticity. Acta Neurol Scand 1993;88:334-8. PubMed
- Blin O, Pouget J, Aubrespy G, et al. A double-blind placebo controlled trial of L-threonine in amyotrophic lateral sclerosis. J Neurol 1992;239:79-81.
- Roufs JB. L-threonine as a symptomatic treatment for amyotrophic lateral sclerosis (ALS). Med Hypotheses 1991;34:20-3. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Threonine and Methol/Benzocaine Together: Common Questions
Is it safe to take Threonine with Methol/Benzocaine?
How was the Threonine and Methol/Benzocaine combination checked?
Does Threonine interact with any other medications?
Does Methol/Benzocaine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.