Drug & supplement interaction

Thyme + Neostigmine Bromide

Neostigmine Bromide brand names: Prostigmin, Prostigmin Injection.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Thyme has a moderate interaction with Neostigmine Bromide. Theoretically, concurrent use of cholinergic drugs and thyme essential oil might cause additive cholinergic effects.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Thyme and Neostigmine Bromide

Here is the interaction we found between these two, with the evidence behind it.

Moderate

CHOLINERGIC DRUGS

Why this applies to Neostigmine Bromide

Neostigmine Bromide falls under CHOLINERGIC DRUGS — the group Thyme interacts with.

Theoretically, concurrent use of cholinergic drugs and thyme essential oil might cause additive cholinergic effects.
In vitro evidence suggests that thyme essential oil and specific essential oil constituents like thymohydroquinone and carvacrol can inhibit acetylcholinesterase (AChE). However, this effect has not been observed in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the basic idea. Neostigmine works by blocking an enzyme called acetylcholinesterase, which lets your body's natural acetylcholine build up and boost things like muscle strength and gut movement. In lab dishes, certain concentrated thyme oil compounds (like thymol-related chemicals and carvacrol) seem to block that same enzyme. If both push in the same direction, you could in theory get extra cholinergic activity, meaning more watery eyes, drooling, sweating, stomach cramps, diarrhea, or a slow heartbeat.

I want to be honest about how weak this is. It's only test-tube data and has not been seen in people, and ordinary cooking with thyme is not a concern. Concentrated thyme essential oil is the only realistic question mark, so just run it past your pharmacist or doctor before using it.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Jukic, M., Politeo, O., Maksimovic, M., Milos, M., and Milos, M. In vitro acetylcholinesterase inhibitory properties of thymol, carvacrol and their derivatives thymoquinone and thymohydroquinone. Phytother.Res 2007;21(3):259-261.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Thyme Also Interacts With Other Medications

Thyme has 378 moderate known drug interactions in our database — the Neostigmine Bromide one above is one of them. If you take anything else, check it against the full list below.

Moderate 378 No known interaction 2,452 (incl. Neostigmine Bromide)
Taking anything else?

Check Another of Your Medications Against Thyme

Covers the 2,830 medications we’ve checked against Thyme. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Neostigmine Bromide

This page covers Thyme only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Neostigmine Bromide page lists 39 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Arenaria Rubra (moderate), Bacopa (moderate), Bael (moderate) and Betel Nut (moderate).

By severity: 1 major · 28 moderate · 10 minor.

From our pharmacist’s overview on the Neostigmine Bromide page

“Neostigmine bromide (Prostigmin) keeps muscle signals firing, most often for the muscle weakness of myasthenia gravis, so this is a list that deserves careful reading, not a skim. Of the 39 supplement and herbal ingredients on file, 21 act on the same acetylcholine system the drug does, herbs like huperzine A and bacopa, and stacking t…”

Reviewed by 2 · Jul 18, 2026

Open the Neostigmine Bromide interaction page

One more smart check

Taking Thyme as Part of a Dietary Supplement Product? Check It for Interactions

We hold 708 real supplement products containing Thyme, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Thyme. Your product may carry other ingredients that interact with Neostigmine Bromide too, on top of Thyme — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Thyme and Neostigmine Bromide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Thyme
Top 25%

#227 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Neostigmine Bromide
Top half

#1,142 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Thyme

What is Thyme?

Thyme
  • Cough and respiratory congestion
  • Sore throat
  • Digestive upset
  • Antimicrobial and antiseptic uses
  • Flavoring in cooking

Thyme is a common kitchen herb that has long been used for coughs, sore throats, and digestive complaints. It is generally safe in the amounts found in food, and some cough products that combine thyme with other herbs have modest supporting evidence, but high-quality research on thyme alone is limited. The concentrated essential oil should never be swallowed undiluted.

Read the full Thyme monograph & all interactions
Keep checking

Other Drugs & Thyme

Browse every other medication we’ve checked against Thyme — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
378Moderate
0Minor
2,451No known interaction
378 Moderate 2,451 No interaction
Moderate

378 interactions

Showing 60 of 378 moderate interactions — see all 378 on the Thyme page.

No interaction 2,451 drugs checked — show the list

We also checked Thyme against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,451 medications checked with no known interaction — see the full Thyme list.

See the full Thyme interactions page
See every supplement checked against Neostigmine Bromide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Thyme monograph › Uses, safety, and every drug interaction in one place Neostigmine Bromide supplement interactions › Every supplement checked against Neostigmine Bromide, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Thyme and Neostigmine Bromide Together: Common Questions

Can you take Thyme with Neostigmine Bromide?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Thyme and Neostigmine Bromide interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Neostigmine Bromide and Thyme?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.