Drug & supplement interaction

Trendione + Tapinarof

Tapinarof brand name: Vtama.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Trendione and Tapinarof in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Trendione and Tapinarof

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tapinarof and Trendione in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Trendione at all — not against Tapinarof, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Trendione safety at a glance

Trendione overall Avoid This is a synthetic anabolic steroid with serious safety concerns and no established safe use.
Pregnancy Possibly Unsafe When used orally. Prohormones can be converted to active hormones in the body and cause adverse effects such as menstrual irregularities, infertility, hair loss... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally. Prohormones can be converted to active hormones in the body and cause adverse effects such as menstrual irregularities, infertility, hair loss... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tapinarof and Trendione? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Tapinarof’s Own FDA Label Lists

This is not an interaction — none of it involves Trendione. These are the most notable effects listed in the ADVERSE REACTIONS section of Tapinarof’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 3 of them are worth acting on rather than waiting out — marked below.

  • Wheezing Worth acting on
  • Hives Worth acting on
  • A higher chance of infection Worth acting on
  • Migraine
  • Pain in an arm or leg
  • A stuffy or runny nose
  • Sore throat
  • Cough
  • Joint pain
  • Itching

Showing the 10 most notable of 14 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Tapinarof. Read the label on DailyMed › Trendione’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Trendione side to compare — that is a limit of the record, not a statement that Trendione has no side effects.

Special populations

Trendione in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally. Prohormones can be converted to active hormones in the body and cause adverse effects such as menstrual irregularities, infertility, hair loss, and acne. Prohormones have also been associated with hepatotoxicity and increased risk of cardiovascular disease. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing prohormones are dangerous. Avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Tapinarof

This page covers Trendione only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tapinarof page lists 3 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Dimethylsulfoxide (dmso) (moderate), Turpentine Oil (moderate) and Alchemilla (minor).

By severity: 2 moderate · 1 minor.

From our pharmacist’s overview on the Tapinarof page

“Tapinarof (Vtama) is a cream you apply to psoriasis plaques, so every supplement interaction on record involves other things you put on your skin, three in total, and none rates major. The two moderate entries, DMSO and turpentine oil, may pull more of the cream through the skin than intended, which could amplify both its effect and it…”

Reviewed by 2 · Jul 18, 2026

Open the Tapinarof interaction page

How much people look this up

Where Trendione and Tapinarof Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Trendione
Steady interest

#1,249 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tapinarof
Steady interest

#1,738 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Trendione reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Trendione and Tapinarof records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Trendione

What is Trendione?

  • Muscle building
  • Strength gains
  • Body recomposition
  • Athletic performance

Trendione (also marketed as estra-4,9,11-trien-3,17-dione) is a synthetic anabolic steroid sold as a so-called "prohormone" or "designer steroid," not a natural herb or vitamin. It is not a legitimate dietary supplement, has not been proven safe in humans, and is linked to potentially serious side effects, including liver harm. We strongly advise against using it and recommend talking with your doctor or pharmacist.

Not applicable; Trendione is a synthetic steroid compound, not a plant part · Capsules, tablets, oral powders (sold as a bodybuilding supplement)

An interaction check asks whether these two react with each other — it does not ask whether Trendione is a good idea for someone in your situation. Here is what our Trendione record says about it on its own.

Trendione: dosing

There is no established safe or effective dose for Trendione. Because it is a synthetic steroid rather than a studied medicine, no health authority has set a recommended amount.We do not provide dosing for this product because we do not recommend using it.

From our Trendione monograph — the full record covers uses, side effects and every documented interaction.

Read the full Trendione monograph & all interactions
Medication

About Tapinarof Topical

What Is Tapinarof Topical Used For?

Brand name: Vtama

Vtama cream, 1% is approved to treat plaque psoriasis in adults and atopic dermatitis (eczema) in adults and children 2 years of age and older. It is applied directly to affected skin.

For plaque psoriasis, Vtama cream is approved for adult use only. For atopic dermatitis, Vtama cream is approved for both adults and children as young as 2 years old. It has not been studied or approved for atopic dermatitis in children under 2, or for plaque psoriasis in children of any age.

See full Tapinarof Topical drug information
Keep checking

Other Drugs & Trendione

Browse every other medication we’ve checked against Trendione — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Trendione against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Trendione list.

See the full Trendione interactions page
See every supplement checked against Tapinarof, ranked by severity
Evidence & sources

Trendione References

The 1 references that drive our Trendione monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Trendione and Tapinarof Together: Common Questions

Is it safe to take Trendione with Tapinarof?
We do not list a known interaction between Trendione and Tapinarof. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Tapinarof interact with any supplements?
Yes. Tapinarof has documented interactions with 3 supplements in our database — Trendione is not one of them. The Tapinarof interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Trendione monograph Uses, safety profile, and every drug interaction in one place Tapinarof Topical drug information The full plain-English guide to this medication Tapinarof supplement interactions Every supplement checked against Tapinarof, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tapinarof and Trendione?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.