Drug & supplement interaction

Volumetrics Diet + Promethazine

Promethazine brand name: Phenergan.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Volumetrics Diet and Promethazine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Volumetrics Diet and Promethazine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Promethazine and Volumetrics Diet in our sources. This does not guarantee that the combination is completely free of risk — research on Volumetrics Diet alongside specific medications may be limited.

Worth understanding: our licensed dataset holds no drug-interaction record for Volumetrics Diet at all — not against Promethazine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

Volumetrics Diet is an eating pattern rather than something you take. Ask your pharmacist or doctor before changing how you eat while on a prescribed medicine: some medicines are dosed around meals, and a change in diet can change how they work. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Volumetrics Diet safety at a glance

Volumetrics Diet overall Generally safe As a balanced whole-food eating pattern, it is generally safe for most healthy adults.
Pregnancy Use caution Pregnancy is not a time for active weight loss; talk with your doctor before changing your diet.
Breastfeeding Use caution Nursing parents have higher calorie and nutrient needs, so check with your doctor before restricting intake.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Promethazine and Volumetrics Diet? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Promethazine’s Own FDA Label Lists

This is not an interaction — none of it involves Volumetrics Diet. These are the most notable effects listed in the ADVERSE REACTIONS section of Promethazine’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you follow Volumetrics Diet and take the medicine. 10 of them are worth acting on rather than waiting out — marked below.

  • A slow heartbeat Worth acting on
  • Hallucinations Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • Wheezing Worth acting on
  • Confusion Worth acting on
  • Seizures Worth acting on
  • A low platelet count Worth acting on
  • Hives Worth acting on
  • A low white blood cell count Worth acting on
  • Bleeding or bruising Worth acting on

Showing the 10 most notable of 26 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Promethazine. Read the label on DailyMed › Where a percentage is shown, it is the share of 22,361 voluntary FDA FAERS reports for Promethazine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Volumetrics Diet’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Volumetrics Diet side to compare — that is a limit of the record, not a statement that Volumetrics Diet has no side effects.

From our Q&A

Questions About Volumetrics Diet or Promethazine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Volumetrics Diet or Promethazine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Promethazine

This page covers Volumetrics Diet only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Promethazine page lists 83 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Henbane (major), Scopolia (major), Alfalfa (moderate) and Angel's Trumpet (moderate).

By severity: 3 major · 57 moderate · 23 minor.

From our pharmacist’s overview on the Promethazine page

“Promethazine (Phenergan) is a phenothiazine antihistamine used for allergies, nausea, and motion sickness, and it is strongly anticholinergic on its own, causing dry mouth, blurred vision, drowsiness, and constipation. That is why the 83 supplements and herbs on this list deserve real attention, starting with the three rated major.”

Reviewed by 2 · Jul 18, 2026

Open the Promethazine interaction page

How much people look this up

Where Volumetrics Diet and Promethazine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Volumetrics Diet
Steady interest

#1,299 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Promethazine
Top half

#1,207 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Volumetrics Diet is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Volumetrics Diet reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Volumetrics Diet and Promethazine records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Eating pattern

About Volumetrics Diet

What is Volumetrics Diet?

  • Weight loss
  • Weight management
  • Feeling fuller on fewer calories
  • Healthier eating habits
  • Reducing overeating

The Volumetrics Diet is an eating plan, not an herb or supplement. It focuses on choosing foods that are low in calories but high in volume—like vegetables, fruits, broth-based soups, and lean proteins—so you feel full while eating fewer calories. It is generally considered a balanced, safe approach to weight management, but results depend on consistency, and you should talk with a doctor or dietitian before starting any weight-loss plan.

Eating plan / dietary pattern (not a pill or supplement)

An interaction check asks whether these two react with each other — it does not ask whether Volumetrics Diet is a good idea for someone in your situation. Here is what our Volumetrics Diet record says about it on its own.

Volumetrics Diet: dosing

There is no pill, capsule, or standardized "dose" for the Volumetrics Diet because it is an eating pattern, not a supplement.Instead of a dose, the plan guides you to build meals around low-energy-density foods, fill about half your plate with vegetables and fruit, and limit high-calorie foods. They can help you follow the approach safely and realistically.

From our Volumetrics Diet monograph — the full record covers uses, side effects and every documented interaction.

Read the full Volumetrics Diet monograph & all interactions
Medication

About Promethazine

What Is Promethazine Used For?

Brand name: Phenergan

Promethazine is used for a wide range of conditions. Tablets, oral solution, and rectal suppositories (brands including Phenergan, Promethegan, and Phenadoz) are approved for seasonal and perennial allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis, hives (urticaria), angioedema, dermographism, and allergic reactions to blood or plasma. They are also used for motion sickness (both prevention and active treatment), nausea and vomiting related to anesthesia and surgery, sedation, and as a helper medication alongside pain relievers after surgery.

Promethazine hydrochloride injection (brands including Phenergan and Promethazine HCl injection) is used for many of the same purposes but is reserved for situations where oral treatment is not possible — including allergic emergencies as an adjunct to epinephrine, sedation during labor, and as an aid during certain surgical procedures such as bronchoscopy and eye surgery.

Most-Reported Side Effects for Promethazine

From FAERS, the FDA’s public side-effect reporting system (22,614 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dependence 3,586 reports
Nausea 2,646 reports
Vomiting 1,802 reports
Fatigue 1,496 reports
Diarrhea 1,341 reports
See full Promethazine drug information
Keep checking

Other Drugs & Volumetrics Diet

Browse every other medication we’ve checked against Volumetrics Diet — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Volumetrics Diet against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Volumetrics Diet list.

See the full Volumetrics Diet interactions page
See every supplement checked against Promethazine, ranked by severity
Evidence & sources

Volumetrics Diet References

The 2 sources that drive our Volumetrics Diet monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Volumetrics Diet is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Choosing a Safe and Successful Weight-Loss Program — NIH National Institute of Diabetes and Digestive and Kidney Diseases Source
  2. Healthy Weight, Nutrition, and Physical Activity — Centers for Disease Control and Prevention Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Following Volumetrics Diet While Taking Promethazine: Common Questions

Is it safe to follow Volumetrics Diet while taking Promethazine?
We do not list a known interaction between Volumetrics Diet and Promethazine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Promethazine interact with any supplements?
Yes. Promethazine has documented interactions with 83 supplements in our database — Volumetrics Diet is not one of them. The Promethazine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Volumetrics Diet monograph Uses, safety profile, and every drug interaction in one place Promethazine drug information The full plain-English guide to this medication Promethazine supplement interactions Every supplement checked against Promethazine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Promethazine and Volumetrics Diet?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.