Drug & supplement interaction

Wood Anemone + Cladribine

Cladribine brand names: Leustatin, Mavenclad.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Wood Anemone and Cladribine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Wood Anemone and Cladribine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Cladribine and Wood Anemone in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Wood Anemone at all — not against Cladribine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Wood Anemone safety at a glance

Wood Anemone overall Avoid The fresh plant is toxic and irritating, so it is not recommended for general use.
Pregnancy Likely Unsafe When the fresh plant is used orally or topically. There is insufficient reliable information available about the safety of the oral or topical use of the dried,... Read the full pregnancy detail
Breastfeeding Likely Unsafe When the fresh plant is used orally or topically. There is insufficient reliable information available about the safety of the oral or topical use of the dried,... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Cladribine and Wood Anemone? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Wood Anemone and Cladribine May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Diarrhea Additional detail

    Wood Anemone

    “Orally, the ingestion of freshly harvested wood anemone can cause colic, diarrhea, and severe irritation to the gastrointestinal tract and the urinary drainage passages (18).”

    Wood Anemone · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Cladribine

    Listed in the ADVERSE REACTIONS section of the FDA label for Cladribine. Read the label on DailyMed ›

Effects for Cladribine come from the ADVERSE REACTIONS section of its FDA label; effects for Wood Anemone come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 9,555 voluntary FDA FAERS reports for Cladribine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Wood Anemone in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When the fresh plant is used orally or topically. There is insufficient reliable information available about the safety of the oral or topical use of the dried, cut plant during pregnancy and lactation; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Cladribine

This page covers Wood Anemone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cladribine page lists 70 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Active Hexose Correlated Compound (ahcc) (moderate), Alfalfa (moderate), American Ginseng (moderate) and Andrographis (moderate).

By severity: 1 major · 59 moderate · 10 minor.

From our pharmacist’s overview on the Cladribine page

“Cladribine (Leustatin, Mavenclad) treats hairy cell leukemia and relapsing multiple sclerosis by deliberately knocking down part of the immune system, so this list calls for real vigilance. Of the 70 supplements and herbs on file, 53 are immune stimulators, herbs like astragalus, ashwagandha, and ginseng that could push immunity back u…”

Reviewed by 2 · Jul 18, 2026

Open the Cladribine interaction page

How much people look this up

Where Wood Anemone and Cladribine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Wood Anemone
Steady interest

#1,269 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Cladribine
Steady interest

#1,831 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Wood Anemone reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Wood Anemone and Cladribine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Wood Anemone

What is Wood Anemone?

  • Headache and migraine (traditional)
  • Joint and muscle aches (traditional)
  • Skin conditions (traditional/topical)
  • Menstrual complaints (folk use)
  • Homeopathic remedy (Pulsatilla-type uses)

Wood Anemone is a spring woodland flower in the buttercup family that contains an irritant compound and is considered toxic when fresh. It has a history of folk and homeopathic use, but there is no good scientific evidence that it works for any condition, and it is not recommended as a self-care supplement.

Anemone nemorosa · Ranunculaceae · Aerial parts (leaves and flowers); historically the whole fresh plant · Rarely used today; historically as a fresh-plant tincture or homeopathic preparation

An interaction check asks whether these two react with each other — it does not ask whether Wood Anemone is a good idea for someone in your situation. Here is what our Wood Anemone record says about it on its own.

Wood Anemone: dosing

There is no established or recommended safe dose of Wood Anemone as a supplement. Do not prepare or take homemade products from the wild plant.

From our Wood Anemone monograph — the full record covers uses, side effects and every documented interaction.

Read the full Wood Anemone monograph & all interactions
Medication

About Cladribine

What Is Cladribine Used For?

Brand names: Leustatin, Mavenclad

Cladribine tablets (brand name Mavenclad) are used to treat relapsing forms of multiple sclerosis (MS) in adults — specifically relapsing-remitting MS and active secondary progressive MS. Because of its significant safety profile, it is generally reserved for patients who haven't responded well to, or can't tolerate, other MS medicines. It is not recommended for clinically isolated syndrome (CIS), a first episode that may or may not lead to MS.

Cladribine injection (given intravenously) is a separate product used to treat active hairy cell leukemia — a rare blood cancer — in patients who have clinically significant anemia, low white blood cell counts, low platelets, or disease-related symptoms.

Most-Reported Side Effects for Cladribine

From FAERS, the FDA’s public side-effect reporting system (9,555 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 814 reports
Headache 681 reports
Lymphocyte count decreased 488 reports
Multiple sclerosis relapse 474 reports
Nausea 423 reports
See full Cladribine drug information
Keep checking

Other Drugs & Wood Anemone

Browse every other medication we’ve checked against Wood Anemone — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Wood Anemone against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Wood Anemone list.

See the full Wood Anemone interactions page
See every supplement checked against Cladribine, ranked by severity
Evidence & sources

Wood Anemone References

The 1 references that drive our Wood Anemone monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Wood Anemone and Cladribine Together: Common Questions

Is it safe to take Wood Anemone with Cladribine?
We do not list a known interaction between Wood Anemone and Cladribine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Wood Anemone and Cladribine have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Cladribine interact with any supplements?
Yes. Cladribine has documented interactions with 70 supplements in our database — Wood Anemone is not one of them. The Cladribine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Wood Anemone monograph Uses, safety profile, and every drug interaction in one place Cladribine drug information The full plain-English guide to this medication Cladribine supplement interactions Every supplement checked against Cladribine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Cladribine and Wood Anemone?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.