Drug & supplement interaction

Yellow Toadflax + Procarbazine

Procarbazine brand name: Matulane.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Yellow Toadflax and Procarbazine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Yellow Toadflax and Procarbazine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Procarbazine and Yellow Toadflax in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Yellow Toadflax at all — not against Procarbazine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Yellow Toadflax safety at a glance

Yellow Toadflax overall Use caution Modern safety data are very limited, so use cautiously and only short-term.
Pregnancy Avoid Not enough safety information; avoid use during pregnancy.
Breastfeeding Avoid No reliable safety data, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Procarbazine and Yellow Toadflax? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Procarbazine’s Own FDA Label Lists

This is not an interaction — none of it involves Yellow Toadflax. These are the most notable effects listed in the ADVERSE REACTIONS section of Procarbazine’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Hearing loss Worth acting on
  • Trouble swallowing Worth acting on
  • Unsteadiness Worth acting on
  • Hallucinations Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • Fainting Worth acting on
  • Confusion Worth acting on
  • Seizures Worth acting on
  • Low mood Worth acting on
  • Anemia Worth acting on

Showing the 10 most notable of 46 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Procarbazine. Read the label on DailyMed › Yellow Toadflax’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Yellow Toadflax side to compare — that is a limit of the record, not a statement that Yellow Toadflax has no side effects.

Everything else you take

See Every Supplement That Interacts With Procarbazine

This page covers Yellow Toadflax only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Procarbazine page lists 24 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Acerola (moderate), Alpha-lipoic Acid (moderate), Coenzyme Q10 (moderate) and Coffee Charcoal (moderate).

By severity: 1 major · 14 moderate · 9 minor.

From our pharmacist’s overview on the Procarbazine page

“Procarbazine (Matulane) is chemotherapy, taken by mouth for Hodgkin lymphoma, and that raises the stakes of every entry on this page. Anything that keeps a full dose from reaching the tumor deserves serious attention, and the one interaction rated major, activated charcoal, does exactly that by binding the drug in the gut.”

Reviewed by 2 · Jul 18, 2026

Open the Procarbazine interaction page

How much people look this up

Where Yellow Toadflax and Procarbazine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Yellow Toadflax
Steady interest

#1,236 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Procarbazine
Steady interest

#2,226 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Yellow Toadflax is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Yellow Toadflax reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Yellow Toadflax and Procarbazine records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Yellow Toadflax

What is Yellow Toadflax?

  • Hemorrhoids and skin irritation
  • Mild constipation
  • Fluid retention (as a folk diuretic)
  • Liver and gallbladder complaints (traditional)
  • Minor wounds and inflammation (topical)

Yellow toadflax is a traditional folk remedy used mostly for hemorrhoids, skin problems, and as a mild laxative or diuretic, but there is very little modern human research to confirm any of these uses. Because its safety has not been well studied, it is best used cautiously, avoided in pregnancy and breastfeeding, and discussed with a pharmacist or doctor first.

Linaria vulgaris · Plantaginaceae · Aerial parts (flowering tops, leaves, and stems) · Tea, tincture, dried herb, ointment or salve, poultice

An interaction check asks whether these two react with each other — it does not ask whether Yellow Toadflax is a good idea for someone in your situation. Here is what our Yellow Toadflax record says about it on its own.

Yellow Toadflax: dosing

There is no well-established or standardized dose for yellow toadflax. Traditional preparations vary widely, and modern guidelines for safe amounts do not exist.If you choose to use a commercial product, follow the directions on the label and do not exceed them.

From our Yellow Toadflax monograph — the full record covers uses, side effects and every documented interaction.

Read the full Yellow Toadflax monograph & all interactions
Medication

About Procarbazine

What Is Procarbazine Used For?

Brand name: Matulane

Matulane (procarbazine) is used to treat Stage III and IV Hodgkin's disease — advanced forms of a cancer that affects the lymphatic system. It is not used alone; it is always given as part of a combination chemotherapy regimen.

Matulane is a key component of the MOPP regimen, which combines nitrogen mustard, vincristine, procarbazine, and prednisone.

See full Procarbazine drug information
Keep checking

Other Drugs & Yellow Toadflax

Browse every other medication we’ve checked against Yellow Toadflax — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Yellow Toadflax against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Yellow Toadflax list.

See the full Yellow Toadflax interactions page
See every supplement checked against Procarbazine, ranked by severity
Evidence & sources

Yellow Toadflax References

The 1 sources that drive our Yellow Toadflax monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Yellow Toadflax is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Dietary and Herbal Supplements — NIH NCCIH Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Yellow Toadflax and Procarbazine Together: Common Questions

Is it safe to take Yellow Toadflax with Procarbazine?
We do not list a known interaction between Yellow Toadflax and Procarbazine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Procarbazine interact with any supplements?
Yes. Procarbazine has documented interactions with 24 supplements in our database — Yellow Toadflax is not one of them. The Procarbazine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Yellow Toadflax monograph Uses, safety profile, and every drug interaction in one place Procarbazine drug information The full plain-English guide to this medication Procarbazine supplement interactions Every supplement checked against Procarbazine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Procarbazine and Yellow Toadflax?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.