Herb & supplement monograph

Orchic Extract Drug Interactions, Uses, Safety & More

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Interaction report

Drugs that interact with Orchic Extract

0 medications have a known interaction with Orchic Extract, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Orchic Extract. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Orchic Extract combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Orchic Extract: Uses, Safety & Side Effects

The bottom line

Orchic extract is a glandular supplement made from the testicle tissue of animals, usually cattle. It is marketed for testosterone and male vitality, but there is essentially no reliable human evidence that it works, and quality and safety standards for animal-derived glandulars vary widely. Talk to your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Part used
Testicular tissue (testis) from cattle or other animals
Common forms
Capsules, tablets, powders (often in glandular supplement blends)
People commonly use it for
  • Low testosterone or male vitality
  • Sexual performance and libido support
  • Athletic performance and muscle building
  • General 'glandular' health support

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Human safety and effectiveness data are very limited, and animal-tissue products carry quality and contamination concerns.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Orchic extract is a type of supplement made from the testicular tissue (the testes, or "orchis") of animals, most often cattle. It belongs to a group of products called glandulars, which are made from the dried or processed glands and organs of animals.

The idea behind glandular supplements is an old one: that eating or taking an extract of a certain animal organ may support the matching organ or function in the human body. Because of this, orchic extract is mostly marketed to men for testosterone, energy, and sexual health.

It is usually sold as capsules, tablets, or powders, and is often combined with other ingredients in "male" or "testosterone support" formulas. It is not a plant or herb, so it has no botanical name.

Uses & effectiveness

People most commonly take orchic extract hoping to raise testosterone, boost libido and sexual performance, or improve energy and muscle gains. These uses come from tradition and marketing, not from solid science.

The evidence is very weak. There are essentially no good-quality human clinical trials showing that orchic extract raises testosterone or improves any of these outcomes. Most claims are based on the general theory behind glandular supplements rather than on tested results.

Because of this, orchic extract should be considered unproven for all of its marketed uses. If you have symptoms of low testosterone or sexual problems, a medical evaluation is far more useful than an unstudied supplement.

How it works

Supporters of glandular supplements suggest that animal testicular tissue may supply hormones, peptides, enzymes, or other building blocks that support human hormone production. This is a proposed idea and is not well supported by research.

Importantly, hormones like testosterone are largely broken down during digestion, so taking animal tissue by mouth is unlikely to deliver meaningful active hormone. Any specific active compounds and how the body actually uses them have not been clearly identified in modern studies.

In short, the mechanism is mostly theoretical, and there is little laboratory or human evidence to explain how — or whether — orchic extract has any real effect.

Safety & precautions

Because orchic extract has not been well studied in people, its safety is largely unknown. A specific concern with any animal-tissue product is the possibility of contamination with bacteria or, in theory, disease-causing agents found in animal tissue. Product quality and sourcing can vary a lot between brands.

People with hormone-sensitive conditions, prostate problems, or any chronic illness should be especially cautious and speak with a doctor first. Children and teenagers should not use it.

Pregnancy and breastfeeding: there is no reliable safety information, so orchic extract should be avoided if you are pregnant, trying to become pregnant, or breastfeeding.

As with all supplements, dietary products are not tightly regulated, so what is on the label may not match what is in the bottle. Always tell your pharmacist or doctor about any supplement you are taking.

Side effects

Because orchic extract has not been formally studied, its full side-effect profile is not known. Reported or possible effects with glandular supplements include digestive upset, nausea, and allergic reactions, especially in people sensitive to animal proteins.

Rare but more serious risks can come from contaminated or poorly made animal-tissue products, including infection. Stop using the product and seek medical care if you have signs of an allergic reaction such as rash, swelling, or trouble breathing.

Orchic Extract: Reported Adverse Effects

Documented safety reports on Orchic Extract from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Reports by condition
Encephalitis Other

Orchic extract is derived from raw bovine testes gathered from slaughterhouses, which may include sick or diseased animals. Products made from contaminated or diseased organs might present a human health hazard. There is also concern that orchic extracts produced from cows in countries where bovine spongiform encephalitis (BSE) has been reported might be contaminated with diseased tissue. However, there have been no reports of BSE transfer to humans from contaminated orchic extract products.

  1. ORCHIC PMG (Protomorphogen). Natural Health Cod. www.nbizz.com/naturalhealthdoc/listings/184.html (Accessed 9 November 2000).
  2. Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no established or standardized dose for orchic extract. Because it has not been properly studied, no amount has been shown to be safe or effective.

If you choose to use a product, follow the dose printed on the label and do not exceed it. It is best to check with your pharmacist or doctor first, especially if you take other medicines or have any health conditions.

Pregnancy & Breastfeeding

Orchic Extract & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Orchic Extract & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 2 references that drive our Orchic Extract monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. ORCHIC PMG (Protomorphogen). Natural Health Cod. www.nbizz.com/naturalhealthdoc/listings/184.html (Accessed 9 November 2000).
  2. Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Product directory

Supplement products with Orchic Extract

177 products in our database contain Orchic Extract. Open any to see its full ingredient list and every drug interaction we check.

Orchic Beef Natural Glandular by Allergy Research Group Capsule 100 Vegicap(s) View ingredients & interactions Orchic Beef Natural Glandular by NutriCology Capsule 100 Vegicap(s) View ingredients & interactions Performance Pack by SP Standard Process Other (e.g. Tea Bag) 60 Pack(s) · 252 Gram(s) · 9 Ounce(s) View ingredients & interactions Power V by Nature's Bounty Tablet Or Pill 30 Tablet(s) View ingredients & interactions Prime Test by Prime Labs Other (e.g. Tea Bag) 60 Caplet(s) View ingredients & interactions Prime Test by Prime Labs Other (e.g. Tea Bag) 60 Caplet(s) View ingredients & interactions Quick Flow Male by Justified Laboratories Capsule 60 Capsule(s) View ingredients & interactions Raging Bull by Healthy 'N Fit Capsule 120 Capsule(s) View ingredients & interactions Raw Orchic Glandular Testicular Substance 1 gram by Swanson Premium Brand Tablet Or Pill 30 Tablet(s) View ingredients & interactions Savage Grow by Justified Laboratories Capsule 60 Capsule(s) View ingredients & interactions Size by BioXgenic Capsule 60 Capsule(s) View ingredients & interactions SizeGenix Extreme Booster by Justified Laboratories Capsule 60 Capsule(s) View ingredients & interactions Sport by Mannatech Capsule 60 Capsule(s) View ingredients & interactions Stinagra RX by Justified Laboratories Capsule 60 Capsule(s) View ingredients & interactions Styphdxfirol by Justified Laboratories Capsule 60 Capsule(s) View ingredients & interactions SuccessFuel by APOPTOSIS Nutraceuticals Capsule 60 Vegetarian Capsule(s) View ingredients & interactions Super Maca Blend by Health Solution USA Tablet Or Pill 60 Tablet(s) View ingredients & interactions Super Macho by DLC Laboratories, Inc. Softgel Capsule 50 Softgel(s) View ingredients & interactions Super Male Plex With VirileMax by Vitamin World MPP Men's Performance Products Other (e.g. Tea Bag) 60 Coated Caplet(s) View ingredients & interactions T-Thrive by Just Ripe Nutrition Tablet Or Pill 60 Tablet(s) View ingredients & interactions Testo Booster by DrFormulas Tablet Or Pill 60 Tablet(s) View ingredients & interactions Testosterole Maximum Libido Complex by Maximum International Capsule 60 Veggie Cap(s) View ingredients & interactions Testrong by Dr. Venessa's Formulas Tablet Or Pill 60 Tablet(s) View ingredients & interactions Thyroid Mender by BioAnue Capsule 90 Capsule(s) · 350 mg View ingredients & interactions
Pharmacist Counseling Corner

Orchic Extract: Common Questions

Does Orchic Extract interact with prescription medications?
We do not currently list any known drug interactions for Orchic Extract. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Orchic Extract interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Orchic Extract with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Orchic Extract interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Orchic Extract made from?
It is a glandular supplement made from the testicular tissue of animals, usually cattle. It is not an herb or plant.
Does Orchic Extract really raise testosterone?
There is no reliable human evidence that it raises testosterone or improves sexual or athletic performance. Its marketed benefits are unproven.
Is Orchic Extract safe to take?
Its safety is largely unknown because it has not been well studied, and animal-tissue products can carry quality and contamination concerns. Check with your pharmacist or doctor before using it.
Can I take Orchic Extract while pregnant or breastfeeding?
No. There is no safety information for these situations, so it should be avoided during pregnancy and breastfeeding.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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