Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Savage Grow Ingredients & Drug Interactions

by Justified Laboratories

Savage Grow label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Savage Grow against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Savage Grow is a dietary supplement by Justified Laboratories with 8 active ingredients. Its ingredients are commonly taken for menopausal symptoms, menstrual cramps, hormone balance (popular belief).Based on those ingredients, 1,076 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Horny Goat Weed leaf extract, Tongkat Ali root extract, Saw Palmetto fruit extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Savage Grow by Justified Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Savage Grow by Justified Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Savage Grow by Justified Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 8 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (742 mg) without saying how much of each component you get.

Savage Grow contains 8 active ingredients, most of them in a proprietary blend: wild yam root extract, boron amino acid chelate, orchic substance, tongkat ali root extract, horny goat weed leaf extract, saw palmetto fruit extract, sarsaparilla root extract, and nettle root extract. Wild yam, tongkat ali, horny goat weed, saw palmetto, and nettle are all herbal plant extracts traditionally used to support sexual function and male vitality.

Boron is a mineral; orchic substance is derived from bovine testes. The product also contains inactive ingredients—silica, magnesium stearate, and gelatin—that serve as fillers and capsule material.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: male sexual performance and vitality.
  • We looked for evidence on: Erectile dysfunction (ED), Sexual desire, Sexual dysfunction, Age-related testosterone deficiency, Athletic performance, Fatigue — and 3 related terms.
  • The strongest evidence on file: Eurycoma Longifolia is rated "Possibly Effective" for Sexual desire (Natural Medicines).
  • Also on file: Boron is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Eurycoma Longifolia is rated "Possibly Ineffective" for Athletic performance.

Evidence for most of Savage Grow's ingredients is limited or insufficient to establish they work for sexual dysfunction or sexual desire. Tongkat ali is rated possibly effective for sexual desire based on some clinical data, and nettle root is possibly effective for diabetes, though that's not this product's stated purpose.

Wild yam is possibly ineffective for menopausal symptoms. The rest—horny goat weed, saw palmetto, sarsaparilla, and orchic substance—all carry insufficient reliable evidence ratings for the conditions they're often marketed to address.

Boron is likely effective for boron deficiency itself, but whether it contributes meaningfully to this product's claims is not established in our data.

The evidence, ingredient by ingredient Wild Yam Boron Orchic Extract Eurycoma Longifolia Horny Goat Weed Saw Palmetto Sarsaparilla Stinging Nettle

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 8 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most ingredients in Savage Grow are generally well tolerated at typical supplement doses in the short term, but long-term safety is not well studied for any of them. Wild yam commonly causes fever, headache, upset stomach, and vomiting—especially at higher doses—and rarely can trigger anaphylaxis.

Horny goat weed commonly causes dizziness, dry mouth, nosebleed, thirst, and vomiting; respiratory arrest has been reported rarely. Saw palmetto is generally mild but can cause abdominal pain, constipation, nausea, diarrhea, and dizziness; rare reports include heart rhythm problems and severe drops in heart rate.

Nettle root is well tolerated in most people but constipation and diarrhea occur; one case of liver injury was reported after a month of use in a herbal blend. Orchic substance carries quality concerns because it comes from raw bovine testes from slaughterhouses and may include diseased animals; there is theoretical risk of contamination from BSE-infected tissue, though no human cases have been documented.

During pregnancy, avoid wild yam, orchic substance, tongkat ali, horny goat weed, saw palmetto, sarsaparilla, and nettle root extract—the safety data advises against use because there isn't enough information and some carry theoretical hormonal effects. During breastfeeding, the same ingredients should be avoided due to insufficient safety information.

Talk with your doctor or pharmacist before taking this product if you are pregnant or nursing.

Side effects, ingredient by ingredient Wild Yam Boron Orchic Extract Eurycoma Longifolia Horny Goat Weed Saw Palmetto Sarsaparilla Stinging Nettle

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 6 of the 8 matched ingredients can interact with medications — Sarsaparilla, Stinging Nettle, Horny Goat Weed, Wild Yam, Saw Palmetto, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 1,077 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Savage Grow, check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (Moderate risk via horny goat weed and saw palmetto); blood pressure medications (Moderate via horny goat weed); estrogens or hormonal contraceptives (Moderate via wild yam, horny goat weed, and saw palmetto); lithium or diuretics (Moderate via sarsaparilla and nettle root); digoxin/Lanoxin (Moderate via sarsaparilla); warfarin/Coumadin (Moderate via nettle root); propranolol/Inderal (Moderate via tongkat ali); or drugs metabolized by liver enzymes CYP1A2, CYP2B6, CYP2C19, CYP2A6, or CYP3A4 (Minor to Moderate). No interactions are documented in our data for boron amino acid chelate or orchic substance.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Savage Grow is marketed for sexual function and male vitality, but the evidence supporting most of its ingredients for those purposes is either insufficient or rated possibly effective at best. More importantly, this product carries multiple moderate-severity interactions with common medications—especially blood thinners, blood pressure drugs, estrogens and hormonal contraceptives, lithium, digoxin, and warfarin—and several minor interactions affecting how your liver processes other drugs.

If you take any prescription medications, review them against the interaction checker on this page before starting. Anyone pregnant, nursing, or managing a medical condition should talk with their doctor or pharmacist to see if this product is right for them.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Savage Grow, straight from the product label.

Brand Justified Laboratories
Barcode (UPC) 745051434267
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Oct 24, 2022
DSLD ID 276801
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Savage Grow by Justified Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
745051434267
IngredientAmount% DV
Proprietary Blend742 mg--
Wild Yam root extract0 NP--
Boron Amino Acid Chelate0 NP--
Orchic Substance0 NP--
Tongkat Ali root extract0 NP--
Horny Goat Weed leaf extract0 NP--
Saw Palmetto fruit extract0 NP--
Sarsaparilla root extract0 NP--
Nettle root extract0 NP--

Other ingredients: Silica, Magnesium Stearate, Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take (1) capsule twice daily. Take an additional capsule 30 mins prior to activity if desired, or as directed by a healthcare professional.

General Statements

Fast Flow - America's Choice for Vim, Vigor and Vitality!"

742 mg

Precautions

Caution: Do not exceed recommended dose.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement. Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

Storage

Store at room temperature.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Strength Endurance Recovery time

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Savage Grow by Justified Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Savage Grow label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Savage Grow by Justified Laboratories

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Other (inactive) ingredients: Silica, Magnesium Stearate, Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Savage Grow by Justified Laboratories Drug Interactions

Want to check YOUR meds against Savage Grow?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,076Drugs
1,052 Moderate 24 Minor

Ingredients driving the most interactions

Horny Goat Weed leaf extract 963
Tongkat Ali root extract 248
Saw Palmetto fruit extract 174
Nettle root extract 164
Wild Yam root extract 41

Individual Drug Interactions

The ingredients in Savage Grow interact with 1,076 drugs. Click any drug to see the details.

6 of the 8 ingredients in Savage Grow interact with drugs. Each result below shows which ingredient is responsible. Horny Goat Weed leaf extract Tongkat Ali root extract Saw Palmetto fruit extract Nettle root extract Wild Yam root extract Sarsaparilla root extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Savage Grow with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Horny Goat Weed leaf extract6 drug types · 963 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, horny goat weed might increase the risk of bleeding.
In vitro research and animal research shows that horny goat weed can inhibit platelet aggregation and thrombus formation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, horny goat weed might increase the risk of hypotension.
Laboratory research suggests that horny goat weed might have hypotensive effects. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
In vitro, horny goat weed leaf extract inhibits CYP1A2. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP2B6 substrates.
In vitro, horny goat weed leaf extract inhibits CYP2B6. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
In vitro, horny goat weed extract inhibits CYP3A4 and suppresses CYP3A4 mRNA expression. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of horny goat weed with estrogens might increase their therapeutic and adverse effects.
In vitro evidence suggests that horny goat weed has estrogenic activity. In clinical research, horny goat weed has been shown to increase blood levels of estrogen in some females.

Likelihood Possible Evidence D
Horny Goat Weed leaf extract full monograph & interactions

Tongkat Ali root extract5 drug types · 248 drugs

Propranolol (Inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.

Likelihood Probable Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Testosterone

Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.

Likelihood Possible Evidence D
Tongkat Ali root extract full monograph & interactions

Saw Palmetto fruit extract3 drug types · 174 drugs

Anticoagulant/Antiplatelet Drugs

Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Saw palmetto is reported to prolong bleeding time. Theoretically, it might increase the risk of bleeding when used concomitantly with anticoagulant or antiplatelet drugs.

Likelihood Possible Evidence D
Contraceptive Drugs

Saw palmetto might reduce the effectiveness of contraceptive drugs.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with contraceptive drugs taken concomitantly.

Likelihood Possible Evidence B
Estrogens

Saw palmetto might reduce the effectiveness of estrogens.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with estrogens taken concomitantly.

Likelihood Possible Evidence B
Saw Palmetto fruit extract full monograph & interactions

Nettle root extract4 drug types · 164 drugs

Antidiabetes Drugs

Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Clinical research shows that stinging nettle might decrease blood glucose levels in patients with diabetes.

Likelihood Possible Evidence B
Diuretic Drugs

Theoretically, combining stinging nettle with diuretic drugs may have additive effects.
Animal research suggests that the above ground parts and roots of stinging nettle may have a diuretic effect.

Likelihood Possible Evidence D
Lithium

Theoretically, stinging nettle might reduce excretion and increase levels of lithium.
Animal research suggests that stinging nettle has diuretic and natriuretic properties, which could alter the excretion of lithium. The dose of lithium might need to be decreased.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is some concern that stinging nettle might decrease the effects of anticoagulant drugs such as warfarin.
Stinging nettle contains a significant amount of vitamin K. When taken in large quantities, this might interfere with the activity of warfarin.

Likelihood Possible Evidence D
Nettle root extract full monograph & interactions

Wild Yam root extract1 drug type · 41 drugs

Estrogens

Theoretically, wild yam might increase or decrease the effects of estrogen.
Wild yam root shows estrogenic and anti-estrogenic effects in vitro. Theoretically, wild yam might interfere with hormone therapy.

Likelihood Possible Evidence D
Wild Yam root extract full monograph & interactions

Sarsaparilla root extract2 drug types · 2 drugs

Digoxin (Lanoxin)

Theoretically, concomitant use of sarsaparilla with digoxin might increase the risk of cardiac toxicity.
Sarsaparilla is thought to have diuretic properties, which could potentially cause potassium loss. Overuse or misuse of sarsaparilla with cardiac glycoside therapy might increase the risk of cardiac toxicity due to potassium loss.

Likelihood Possible Evidence D
Lithium

Theoretically, sarsaparilla might increase the effects and adverse effects of lithium.
Sarsaparilla is thought to have diuretic properties. Due to these effects, sarsaparilla might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Sarsaparilla root extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Savage Grow, from the product label.

Justified Laboratories

See all Justified Laboratories products
Name
Justified Laboratories
City
Arlington
State
TX
ZipCode
76011
Phone Number
1-888-645-9404
Web Address
www.justifiedlaboratories.com
Pharmacist Counseling Corner

Savage Grow by Justified Laboratories: Common Questions

Does Savage Grow by Justified Laboratories interact with any medications?
Yes. Based on its ingredients, Savage Grow has a known interaction with 1,076 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Savage Grow contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product actually work for sexual performance or desire?
The evidence is weak. Tongkat ali is rated possibly effective for sexual desire based on some clinical studies, but most other ingredients here—wild yam, horny goat weed, saw palmetto, sarsaparilla, and orchic substance—have insufficient reliable evidence to know if they work for sexual dysfunction. Wild yam is actually rated possibly ineffective for menopausal symptoms. Talk with your doctor about whether a supplement makes sense for you.
Are there any side effects I should know about?
Wild yam commonly causes fever, headache, upset stomach, and vomiting. Horny goat weed can cause dizziness, dry mouth, nosebleed, thirst, and vomiting. Saw palmetto may cause abdominal pain, nausea, diarrhea, constipation, or dizziness. Nettle root is usually tolerated well but can cause constipation or diarrhea. Most of these are mild, but stop and contact your doctor if you experience chest pain, heart rhythm changes, or any severe reaction.
Is this safe to take while pregnant or breastfeeding?
No. The safety data advises against all the main ingredients in this product during pregnancy and breastfeeding because there isn't enough information to be sure they're safe, and some carry theoretical effects on hormones. Talk with your doctor or pharmacist before taking this product if you are pregnant, nursing, or planning to become pregnant.
What is orchic substance and should I be concerned about it?
Orchic substance is derived from raw bovine testes from slaughterhouses. There's very limited human safety data for it, and there's a theoretical risk of contamination from diseased animals or BSE-infected tissue, though no human cases have been documented. Quality control and safety for animal-tissue products vary widely between manufacturers.
Will this interact with my blood pressure or heart medications?
Possibly. Horny goat weed may lower blood pressure further (Moderate risk with blood pressure drugs). Sarsaparilla may increase the risk of heart toxicity if you take digoxin/Lanoxin. Tongkat ali may reduce the effectiveness of propranolol/Inderal by about 29%. Use the interaction checker on this page with your exact medications and talk with your pharmacist before starting.
What if I take birth control or hormone therapy?
Be careful. Wild yam, horny goat weed, and saw palmetto all interact with estrogens and hormonal contraceptives at Moderate severity. Wild yam might increase or decrease estrogen effects; horny goat weed might increase both effects and side effects; saw palmetto might reduce effectiveness. Talk with your doctor before combining this product with any hormone-based medication.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Savage Grow label
Go deeper

The Full Monographs Behind Savage Grow’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Wild Yam

Interacts with 41 drugs

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for these uses is lacking. Despite popular cl...

Read the full Wild Yam monograph → Herb & supplement monograph

Boron

Boron is a trace mineral found in many plant foods and sold as a supplement, mainly promoted for bone, joint, and hormone health. The human evidence for most of these uses is limited or prel...

Read the full Boron monograph → Herb & supplement monograph

Orchic Extract

Orchic extract is a glandular supplement made from the testicle tissue of animals, usually cattle. It is marketed for testosterone and male vitality, but there is essentially no reliable hum...

Read the full Orchic Extract monograph → Herb & supplement monograph

Eurycoma Longifolia

Interacts with 248 drugs

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small human studies suggesting possible benefits....

Read the full Eurycoma Longifolia monograph → Herb & supplement monograph

Horny Goat Weed

Interacts with 963 drugs

Horny goat weed (Epimedium) is a traditional Chinese herb most often marketed for low libido and erectile problems, but solid human evidence for these uses is lacking. While short-term use s...

Read the full Horny Goat Weed monograph → Herb & supplement monograph

Saw Palmetto

Interacts with 174 drugs

Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no better than a placebo for most men, though i...

Read the full Saw Palmetto monograph → Herb & supplement monograph

Sarsaparilla

Interacts with 2 drugs

Sarsaparilla is a traditional root used in teas, tonics, and old-fashioned root beer flavoring. Modern evidence for its health claims is very limited and comes mostly from lab studies, so it...

Read the full Sarsaparilla monograph → Herb & supplement monograph

Stinging Nettle

Interacts with 164 drugs

Stinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain. The evidence is mixed and mostly preliminary, so it i...

Read the full Stinging Nettle monograph →
Sources

Sources & How We Checked

Savage Grow's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 78 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Wild Yam 7 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Eagon PK, Elm MS, Hunter DS, et al. Medicinal herbs: modulation of estrogen action. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11.
  3. Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
  4. Rosenberg Zand, R. S., Jenkins, D. J., and Diamandis, E. P. Effects of natural products and nutraceuticals on steroid hormone-regulated gene expression. Clin Chim.Acta 2001;312(1-2):213-219. PubMed
  5. Araghiniknam M, Chung S, Nelson-White T, and et al. Antioxidant activity of Dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sciences 1996;59:L147-L157.
  6. Zeng M, Zhang L, Li M, et al. Estrogenic effects of the extracts from the Chinese Yam (Dioscorea opposite Thunb.) and its effective compounds in vitro and in vivo. Molecules. 2018 Jan 23;23(2). Pii: E11. PubMed
  7. Lu J, Wong RN, Zhang L, et al. Comparative analysis of proteins with stimulating activity on ovarian estradiol biosynthesis from four different Dioscorea species in vitro using both phenotypic and target-based approaches: implication for treating menopaus

See these in context on the Wild Yam monograph →

Boron 6 references
  1. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  3. Thai L, Hart LL. Boric acid vaginal suppositories. Ann Pharmacother 1993;27:1355-7.
  4. Acs N, Banhidy F, Puho E, Czeizel AE. Teratogenic effects of vaginal boric acid treatment during pregnancy. Int J Gynaecol Obstet 2006;93:55-6. PubMed
  5. Garabrant, D. H., Bernstein, L., Peters, J. M., and Smith, T. J. Respiratory and eye irritation from boron oxide and boric acid dusts. J Occup Med 1984;26(8):584-586. PubMed
  6. Hjelm C, Harari F, Vahter M. Pre- and postnatal environmental boron exposure and infant growth: results from a mother-child cohort in northern Argentina. Environ Res 2019;171:60-8. PubMed

See these in context on the Boron monograph →

Orchic Extract 2 references
  1. ORCHIC PMG (Protomorphogen). Natural Health Cod. www.nbizz.com/naturalhealthdoc/listings/184.html (Accessed 9 November 2000).
  2. Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.

See these in context on the Orchic Extract monograph →

Eurycoma Longifolia 4 references
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Horny Goat Weed 11 references
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Saw Palmetto 22 references
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Sarsaparilla 3 references
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Stinging Nettle 23 references
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  23. Nnamani I, Tolu-Akinnawo O, Dufera RR, Akintunde A, Maliakkal B. Tinospora cordifolia (Guduchi/Giloy)-Induced Liver Injury: A Case Review. Cureus 2023;15(5):e39793. PubMed

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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