Tin Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Tin interacts with medications. The heart of this page is the interaction list — every drug Tin is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Tin is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Tin against your medication
Add one medicationDrugs that interact with Tin
0 medications have a known interaction with Tin, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Tin. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Tin combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Tin: Uses, Safety & Side Effects
Tin is a metallic element found in tiny amounts in the diet, but it is not considered an essential nutrient for humans and there is no proven health benefit to taking it as a supplement. Because some tin compounds can be toxic, there is little reason to take tin on purpose, and you should talk to a pharmacist or doctor before using any product that contains it.
- Part used
- Tin is a chemical element (Sn); the form used in supplements is the trace mineral, not a plant part
- Common forms
- Trace amounts in some multivitamin/mineral products; stannous salts are used in some toothpastes (not as a supplement)
- Marketed as a trace mineral supplement
- Claimed support for general 'mineral balance'
- Sometimes promoted for skin or hair (unproven)
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Tin is not an essential nutrient and some tin compounds can be harmful, so supplementing is not recommended without medical advice.
Insufficient reliable information available; avoid using.
Read the full pregnancy detailInsufficient reliable information available; avoid using.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Tin is a soft, silvery metal and a chemical element (symbol Sn). It is not a plant or herb. People take in very small amounts of tin every day through food, water, and sometimes from canned foods, where tin can leach from the can lining.
Unlike minerals such as iron, zinc, or calcium, tin is not known to be an essential nutrient for humans. That means your body does not appear to need it to stay healthy. Even so, tin sometimes appears in trace-mineral blends or is marketed as a supplement.
Tin comes in different chemical forms. Inorganic tin (the kind found in food and cans) is poorly absorbed and is generally considered low in toxicity at normal dietary levels. Organic tin compounds (organotins), used in industry, are much more toxic and are not meant to be eaten.
How it works
Researchers have not identified a clear, necessary role for tin in human health, so there is no well-established mechanism for any benefit. Some laboratory and animal studies have looked at how tin behaves in the body, but these do not prove it helps people.
What is better understood is the opposite: high amounts of tin, especially organic tin compounds, can interfere with normal cell function and may affect the nervous system and immune system. This is why the focus with tin is usually on avoiding too much, not on getting more.
Does Tin work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
Likely Effective Gingivitis
Dentifrices containing various forms of tin have shown some benefit for improving symptoms of gingivitis; most research has evaluated the use of stannous fluoride.
Possibly Effective Dental hypersensitivity
Most research shows that tin is beneficial for reducing dental hypersensitivity, although it may not be as effective as other ingredients.
Also studied for 3 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Dental plaque
Overall, using a dentifrice containing tin in the form of stannous fluoride seems to modestly reduce plaque; however, the improvement might not be clinically meaningful.
Insufficient Reliable Evidence To Rate Dry mouth
Preliminary clinical research shows that using a specific gel (Enamelon Preventive Treatment Gel, Premier Dental products Co.) containing tin as stannous fluoride 0.4% each evening for 14 days reduces symptoms of dry mouth, with 70% of patients rating the product at least 'good' for improving symptoms such as discomfort, as well as for improving lubrication and moisturization. However, it seems to be less effective than Biotene Oral Balance moisturizing gel, which was rated at least 'good' for the relief of these symptoms by 84% of patients.
Insufficient Reliable Evidence To Rate Halitosis
A meta-analysis of four clinical studies including 100 patients shows that using a dentifrice containing tin as stannous fluoride 0.4% (Crest Pro-Health) three times over a 28-hour period improves bad breath by 7.7% at 3-4 hours after a single use, 10.6% after two uses and a sleep (morning breath), and 24.5% after a third use that morning, when compared to a control fluoride toothpaste in individuals with halitosis. The long-term effects of this dentifrice on halitosis are unknown.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
Small amounts of inorganic tin from food are generally considered low risk for most people. However, taking tin on purpose as a supplement offers no proven benefit and carries possible risks, so it is not recommended without guidance from a healthcare professional.
People who should be especially careful include children, older adults, people with kidney or liver problems, and anyone with a known sensitivity to metals. Organic (organotin) compounds are toxic and should never be consumed.
Pregnancy: There is no proven benefit and the safety of tin supplements is unknown, so it is best to avoid them during pregnancy. Breastfeeding: Safety has not been established, so avoid tin supplements while breastfeeding. Always check with your pharmacist or doctor before using any product containing tin.
Side effects
Eating foods high in tin, such as some highly acidic canned products, can sometimes cause stomach upset, nausea, cramping, or diarrhea. These effects are usually temporary.
Larger or repeated exposures to tin compounds may, in rare cases, affect the nervous system, immune function, or other organs. Toxic effects are mostly linked to industrial organotin compounds rather than normal dietary tin. If you feel unwell after taking a tin-containing product, stop using it and contact a healthcare professional.
Tin: Reported Adverse Effects
Documented safety reports on Tin from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Orally, intake of food contaminated with large amounts of tin may cause gastrointestinal effects, including diarrhea, stomach pain, nausea, and anemia.
Topically, dentifrices and mouthwashes containing tin as stannous fluoride or stannous chloride may cause teeth staining or tongue discoloration.
When inhaled long-term, tin may cause stannosis.
- US Department of Health and Human Services. Toxicological profile for tin and tin compounds. Available at: http://www.atsdr.cdc.gov/toxprofiles/tp55.pdf
- Paraskevas, S. and van der Weijden, G. A. A review of the effects of stannous fluoride on gingivitis. J Clin Periodontol 2006;33(1):1-13.
- Sälzer S, Slot DE, Dörfer CE, Van der Weijden GA. Comparison of triclosan and stannous fluoride dentifrices on parameters of gingival inflammation and plaque scores: a systematic review and meta-analysis. Int J Dent Hyg. 2015 Feb;13(1):1-17.
- Lorenz K, Hoffmann T, Heumann C, Noack B. Effect of toothpaste containing amine fluoride and stannous chloride on the reduction of dental plaque and gingival inflammation. A randomized controlled 12-week home-use study. Int J Dent Hyg. 2019;17(3):237-243.
- Frese C, Wohlrab T, Sheng L, Kieser M, Krisam J, Wolff D. Clinical effect of stannous fluoride and amine fluoride containing oral hygiene products: A 4-year randomized controlled pilot study. Sci Rep 2019;9(1):7681.
Anemia Hematologic
Orally, intake of food contaminated with large amounts of tin has caused anemia.
- US Department of Health and Human Services. Toxicological profile for tin and tin compounds. Available at: http://www.atsdr.cdc.gov/toxprofiles/tp55.pdf
Diarrhea Gastrointestinal
Orally, intake of food contaminated with large amounts of tin may cause gastrointestinal effects. Several cases of gastrointestinal events, including diarrhea, stomach pain, nausea, and/or gastroenteritis have been reported for patients who ingested foods contaminated with tin from tin cans. The dose of tin contained in these foods ranged from 250-1000 mg/kg body weight. Consumption of food containing lower amounts of inorganic tin (100-200 ppm) has not been associated with adverse gastrointestinal effects.
- US Department of Health and Human Services. Toxicological profile for tin and tin compounds. Available at: http://www.atsdr.cdc.gov/toxprofiles/tp55.pdf
- Blunden, S. and Wallace, T. Tin in canned food: a review and understanding of occurrence and effect. Food Chem Toxicol 2003;41(12):1651-1662.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no established or recommended dose of tin as a supplement, because it is not known to be an essential nutrient. No official daily requirement has been set for humans.
If a product you are considering lists tin, follow the label and keep the amount low, but understand there is no proven reason to take it. The safest approach is to talk with a pharmacist or doctor before using any supplement that contains tin.
Tin & Pregnancy
Tin & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 8 references that drive our Tin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- US Department of Health and Human Services. Toxicological profile for tin and tin compounds. Available at: http://www.atsdr.cdc.gov/toxprofiles/tp55.pdf
- Paraskevas, S. and van der Weijden, G. A. A review of the effects of stannous fluoride on gingivitis. J Clin Periodontol 2006;33(1):1-13. PubMed
- Blunden, S. and Wallace, T. Tin in canned food: a review and understanding of occurrence and effect. Food Chem Toxicol 2003;41(12):1651-1662. PubMed
- Sälzer S, Slot DE, Dörfer CE, Van der Weijden GA. Comparison of triclosan and stannous fluoride dentifrices on parameters of gingival inflammation and plaque scores: a systematic review and meta-analysis. Int J Dent Hyg. 2015 Feb;13(1):1-17.
- Feng X, Chen X, Cheng R, Sun L, Zhang Y, He T. Breath malodor reduction with use of a stannous-containing sodium fluoride dentifrice: a meta-analysis of four randomized and controlled clinical trials. Am J Dent. 2010;23 Spec No B:27B-31B.
- Milleman JL, Milleman KR, Santos SL, Proskin HM, Battershell KK, DiMarino JC. Subjective assessment of Enamelon® preventive treatment gel in a self-reported dry-mouth population. Compend Contin Educ Dent. 2016;37(8):e5-8.
- Lorenz K, Hoffmann T, Heumann C, Noack B. Effect of toothpaste containing amine fluoride and stannous chloride on the reduction of dental plaque and gingival inflammation. A randomized controlled 12-week home-use study. Int J Dent Hyg. 2019;17(3):237-243. PubMed
- Frese C, Wohlrab T, Sheng L, Kieser M, Krisam J, Wolff D. Clinical effect of stannous fluoride and amine fluoride containing oral hygiene products: A 4-year randomized controlled pilot study. Sci Rep 2019;9(1):7681. PubMed
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with Tin
100 brands in our database make a supplement containing Tin.
Supplement products with Tin
385 products in our database contain Tin. Open any to see its full ingredient list and every drug interaction we check.
Tin: Common Questions
What is Tin used for, and does it work?
Does Tin interact with prescription medications?
How are Tin interactions rated?
Is it safe to take Tin with my medications?
Where does this Tin interaction information come from?
Is Tin a vitamin or essential mineral?
Should I take a Tin supplement?
Is Tin in canned food dangerous?
Is Tin safe during pregnancy or breastfeeding?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Tin
A rotating sample of real supplements in our database that list Tin — open any to see its full ingredients and every drug interaction we check.
- Fulvic Trace Minerals by Good State
- Vita-Lea without Iron Formula by Shaklee
- Silver Strength +Gold by Sunwarrior
- Vita-Lea Men's Multi+ by Shaklee
- intraMIN Organic Trace Minerals Unflavored by Drucker Labs
- Men's Daily Multivitamin by CVS Health
- One Daily Maximum by 21st Century
- Century Adults by Signature Care
- Liver Cleanse by True Botanica
- Advanced Formula SunVite With Biotin by Sundown Naturals
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