Medication interaction hub

What Supplements Interact with Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)?

Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) brand name: Mylanta. Every interaction below applies to the brands too.

35 Interactions 1 Major 14 Moderate 20 Minor
Curated & coded by · Clinical Pharmacist · Updated September 21, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Mylanta (aluminum hydroxide, magnesium hydroxide, and simethicone) is an everyday antacid, but its interaction list deserves genuine attention. Of the 35 supplements and herbs on record, activated charcoal is the one rated major; it soaks up medicines in the gut, so keep it well away from any Mylanta dose. Most of the rest are absorption stories, with thick fibers and gels such as glucomannan slowing or reducing what the body takes in from anything swallowed at the same time.

The quieter theme is aluminum. Vitamin C can increase how much aluminum the body absorbs from the aluminum hydroxide, a concern mainly for people with reduced kidney function. A few herbs work against the antacid effect itself, and the antacid can lower what you absorb from certain minerals. Beyond the charcoal, 14 entries are moderate and 20 minor, and spacing supplements well apart from a dose defuses most of them.

— , Clinical Pharmacist · July 18, 2026

Major 1 Moderate 14 Minor 20 No known interaction 1,417

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug): Top Interactions at a Glance

The Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 35 interacting ingredients — plus 1,417 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) Combinations Today

The Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Calcium + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)i

Calcium citrate might increase aluminum absorption and toxicity.

Read the full interaction Moderate Likelihood Probable Vitamin D + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)i

Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.

Read the full interaction Moderate Likelihood Possible Magnesium + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)i

Use of acid reducers may reduce the laxative effect of magnesium oxide.

Read the full interaction Minor Likelihood Possible Acerola + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)i

Theoretically, concomitant use of acerola with aluminum salts might increase the amount of aluminum absorbed.

Read the full interaction Moderate Likelihood Probable Vitamin C + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)i

Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.

Read the full interaction Minor Likelihood Possible Betaine Hydrochloride + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)i

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.

Read the full interaction
The complete list

Every Supplement Checked Against Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)

All 1,452 ingredients in our database, ranked by severity — 35 with a Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) interaction on file and 1,417 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Calcium with Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Calcium citrate might increase aluminum absorption and toxicity.

Full Calcium + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) answer

Can you take Vitamin D with Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.

Full Vitamin D + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) answer

Can you take Magnesium with Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Use of acid reducers may reduce the laxative effect of magnesium oxide.

Full Magnesium + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) answer

Can you take Acerola with Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use of acerola with aluminum salts might increase the amount of aluminum absorbed.

Full Acerola + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) answer

Can you take Vitamin C with Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.

Full Vitamin C + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) answer

Can you take Alpinia with Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, alpinia might decrease the effectiveness of antacids.

Full Alpinia + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) answer

Can you take Betaine Hydrochloride with Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.

Full Betaine Hydrochloride + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) answer

Can you take Black Psyllium with Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) answer

Can you take Blessed Thistle with Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, blessed thistle might decrease the effectiveness of antacids.

Full Blessed Thistle + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) answer

Can you take Blond Psyllium with Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) answer

Can you take Calamus with Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking calamus might reduce the effectiveness of antacids.

Full Calamus + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) answer

Can you take Calumba with Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, calumba might decrease the effectiveness of antacids.

Full Calumba + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) answer

Can you take Carob with Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) answer

Can you take Cubebs with Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, due to reports that cubebs increases stomach acid, cubebs might decrease the effectiveness of antacids.

Full Cubebs + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) answer

Can you take Hercules Club with Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Hercules club may decrease the clinical effects of antacids.

Full Hercules Club + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) answer

Can you take Karaya Gum with Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) answer

Can you take Marshmallow with Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) answer

Can you take Northern Prickly Ash with Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, northern prickly ash might decrease the effectiveness of antacids.

Full Northern Prickly Ash + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) answer

Can you take Quassia with Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, due to reports that quassia increases stomach acid, quassia might decrease the effectiveness of antacids.

Full Quassia + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) answer

Can you take Xanthan Gum with Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.

Full Xanthan Gum + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug), and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) sits in 3 interaction categories. Open any one to see what the group means:

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) through this category.

Antacids 13 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

13 of the supplement ingredients on this page reach Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) through this category.

Aluminum 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) through this category.

Related: does Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) deplete any nutrients?

Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) has 5 reported nutrient associations in the research literature — see the Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug).

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Products that contain Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug).

Super Greens Natural Berry Flavor by NutraChamps contains Rose Hip Special Two Multi Vitamin by Baar Nature's Blessing contains Rose Hip Cleanse Rite Advanced Colon Cleanse by NewtonEverett contains Rose Hip Calm Pressure by Dr. Gumman’s Integrative contains Rose Hip
Pharmacist Counseling Corner

Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) & Supplements: Common Questions

What supplements interact with Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)?
In our interaction database, 35 supplement and herbal ingredients have an interaction with Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) on file — 1 rated major, 14 moderate, and 20 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Activated Charcoal, Coffee Charcoal, European Mandrake.
Which Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) supplement interactions are the most serious?
Focus on the major group: Activated Charcoal. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)?
That depends entirely on which supplement. The honest answer for Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Mylanta have the same supplement interactions as Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)?
Yes — Mylanta all contain Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug), so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) deplete any vitamins or nutrients?
It might — Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) has 5 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) and my other medications?
This page covers Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) against supplements and herbal ingredients. Checking Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 21, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.