Medication interaction hub

What Supplements Interact with Atropine, Hyoscyamine, Phenobarbital?

Atropine, Hyoscyamine, Phenobarbital brand name: Hypnaldyne. Every interaction below applies to the brands too.

165 Interactions 10 Major 134 Moderate 21 Minor
Curated & coded by · Clinical Pharmacist · Updated September 18, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Atropine, Hyoscyamine, Phenobarbital? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Atropine, Hyoscyamine, Phenobarbital against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Hypnaldyne combines atropine and hyoscyamine, both drying anticholinergic drugs, with phenobarbital, a sedating barbiturate that also controls seizures, so the 165 supplements on this list deserve real attention before you add one. Nearly half, 78 ingredients, deepen the sedation phenobarbital already causes; alcohol and kava sit among the ten rated major, where the concern reaches dangerously slowed breathing. Another 30 pile on the anticholinergic side, adding dry mouth, blurred vision, and confusion, and St. John's wort can drop phenobarbital levels far enough to threaten seizure control.

Beyond those, 134 entries rate moderate and 21 minor, and their trouble is quieter: some speed up how the liver clears phenobarbital, while bulky fibers and charcoal products can blunt absorption in the gut, so space those well apart from your dose. If a supplement makes you drowsy on its own, assume it will hit harder, and run your full list past a pharmacist.

— , Clinical Pharmacist · July 18, 2026

Major 10 Moderate 134 Minor 21 No known interaction 1,287

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Atropine, Hyoscyamine, Phenobarbital: Top Interactions at a Glance

The Atropine, Hyoscyamine, Phenobarbital supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 165 interacting ingredients — plus 1,287 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Atropine, Hyoscyamine, Phenobarbital Combinations Today

The Atropine, Hyoscyamine, Phenobarbital + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Choline + Atropine, Hyoscyamine, Phenobarbitali

Theoretically, choline might decrease the effects of atropine in the brain.

Read the full interaction Moderate Likelihood Possible Phosphatidylserine + Atropine, Hyoscyamine, Phenobarbitali

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.

Read the full interaction Moderate Likelihood Possible Caffeine + Atropine, Hyoscyamine, Phenobarbitali

Theoretically, caffeine might reduce the effects of phenobarbital and increase the risk for convulsions.

Read the full interaction Minor Likelihood Possible Ginger + Atropine, Hyoscyamine, Phenobarbitali

Theoretically, ginger might increase the levels of CYP2B6 substrates.

Read the full interaction Moderate Likelihood Possible Vitamin B6 + Atropine, Hyoscyamine, Phenobarbitali

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.

Read the full interaction Moderate Likelihood Possible Boneset + Atropine, Hyoscyamine, Phenobarbitali

Boneset belongs to the genus Eupatorium, and many species of this genus contain hepatotoxic pyrrolizidine alkaloids (PAs).

Read the full interaction
The complete list

Every Supplement Checked Against Atropine, Hyoscyamine, Phenobarbital

All 1,452 ingredients in our database, ranked by severity — 165 with a Atropine, Hyoscyamine, Phenobarbital interaction on file and 1,287 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Atropine, Hyoscyamine, Phenobarbital?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Choline with Atropine, Hyoscyamine, Phenobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, choline might decrease the effects of atropine in the brain.

Full Choline + Atropine, Hyoscyamine, Phenobarbital answer

Can you take Phosphatidylserine with Atropine, Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.

Full Phosphatidylserine + Atropine, Hyoscyamine, Phenobarbital answer

Can you take Caffeine with Atropine, Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, caffeine might reduce the effects of phenobarbital and increase the risk for convulsions.

Full Caffeine + Atropine, Hyoscyamine, Phenobarbital answer

Can you take Ginger with Atropine, Hyoscyamine, Phenobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, ginger might increase the levels of CYP2B6 substrates.

Full Ginger + Atropine, Hyoscyamine, Phenobarbital answer

Can you take Vitamin B6 with Atropine, Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.

Full Vitamin B6 + Atropine, Hyoscyamine, Phenobarbital answer

Can you take Corydalis Yanhusuo with Atropine, Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Corydalis yanhusuo might increase the sedative effects of CNS depressants.

Full Corydalis Yanhusuo + Atropine, Hyoscyamine, Phenobarbital answer

Can you take Delta-9-tetrahydrocannabinol (thc) with Atropine, Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, THC might have additive effects if used with other CNS depressants.

Full Delta-9-tetrahydrocannabinol (thc) + Atropine, Hyoscyamine, Phenobarbital answer

Can you take Dusty Miller with Atropine, Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers might increase the risk of adverse effects from the pyrrolizidine alkaloid (PA) constituents in dusty miller.

Full Dusty Miller + Atropine, Hyoscyamine, Phenobarbital answer

Can you take Elecampane with Atropine, Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, elecampane may cause additive sedative effects when taken with CNS depressants.

Full Elecampane + Atropine, Hyoscyamine, Phenobarbital answer

Can you take European Barberry with Atropine, Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.

Full European Barberry + Atropine, Hyoscyamine, Phenobarbital answer

Can you take Evodia with Atropine, Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking CYP3A4 inducers might decrease the levels and clinical effects of evodia.

Full Evodia + Atropine, Hyoscyamine, Phenobarbital answer

Can you take Fo-ti with Atropine, Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP2B6.

Full Fo-ti + Atropine, Hyoscyamine, Phenobarbital answer

Can you take Galphimia Glauca with Atropine, Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Galphimia glauca with CNS depressants may increase the risk of sedation.

Full Galphimia Glauca + Atropine, Hyoscyamine, Phenobarbital answer

Can you take Gamma Butyrolactone (gbl) with Atropine, Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of GBL with CNS depressants may potentiate respiratory and CNS depression.

Full Gamma Butyrolactone (gbl) + Atropine, Hyoscyamine, Phenobarbital answer

Can you take German Chamomile with Atropine, Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, German chamomile might have additive effects when used with CNS depressants.

Full German Chamomile + Atropine, Hyoscyamine, Phenobarbital answer

Can you take Golden Ragwort with Atropine, Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers might increase the risk of adverse effects from the pyrrolizidine alkaloid (PA) constituents in golden ragwor...

Full Golden Ragwort + Atropine, Hyoscyamine, Phenobarbital answer

Can you take Goldenseal with Atropine, Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goldenseal might increase the sedative effects of CNS depressants.

Full Goldenseal + Atropine, Hyoscyamine, Phenobarbital answer

Can you take Gotu Kola with Atropine, Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking gotu kola might increase the sedative effects of CNS depressants.

Full Gotu Kola + Atropine, Hyoscyamine, Phenobarbital answer

Can you take Gravel Root with Atropine, Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hepatotoxic pyrrolizidine alkaloids (PA) are substrates of cytochrome P450 3A4 (CYP3A4).

Full Gravel Root + Atropine, Hyoscyamine, Phenobarbital answer

Can you take Green Tea with Atropine, Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, green tea might reduce the effects of phenobarbital and increase the risk for convulsions.

Full Green Tea + Atropine, Hyoscyamine, Phenobarbital answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Atropine, Hyoscyamine, Phenobarbital is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Atropine, Hyoscyamine, Phenobarbital, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Atropine, Hyoscyamine, Phenobarbital sits in 11 interaction categories. Open any one to see what the group means:

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Atropine, Hyoscyamine, Phenobarbital through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Atropine, Hyoscyamine, Phenobarbital through this category.

Cytochrome P450 3A4 (Cyp3A4) Inducers 19 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

19 of the supplement ingredients on this page reach Atropine, Hyoscyamine, Phenobarbital through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Atropine, Hyoscyamine, Phenobarbital through this category.

Phenobarbital (Luminal) 16 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

16 of the supplement ingredients on this page reach Atropine, Hyoscyamine, Phenobarbital through this category.

Cytochrome P450 2B6 (Cyp2B6) Substrates 15 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

15 of the supplement ingredients on this page reach Atropine, Hyoscyamine, Phenobarbital through this category.

Barbiturates 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Atropine, Hyoscyamine, Phenobarbital through this category.

Cytochrome P450 2C9 (Cyp2C9) Inducers 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Atropine, Hyoscyamine, Phenobarbital through this category.

Cytochrome P450 2C19 (Cyp2C19) Inducers 2 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

2 of the supplement ingredients on this page reach Atropine, Hyoscyamine, Phenobarbital through this category.

Atropine 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Atropine, Hyoscyamine, Phenobarbital through this category.

Cytochrome P450 1A2 (Cyp1A2) Inducers 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Atropine, Hyoscyamine, Phenobarbital through this category.

Related: does Atropine, Hyoscyamine, Phenobarbital deplete any nutrients?

Atropine, Hyoscyamine, Phenobarbital has 7 reported nutrient associations in the research literature — see the Atropine, Hyoscyamine, Phenobarbital nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Atropine, Hyoscyamine, Phenobarbital

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Atropine, Hyoscyamine, Phenobarbital.

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Products that contain Atropine, Hyoscyamine, Phenobarbital-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Atropine, Hyoscyamine, Phenobarbital.

Standardized St. John's Wort 600 mg by Nature's Truth contains St. John's Wort St. John's Wort-IMT by SP Standard Process contains St. John's Wort St John's Wort Extract by SuperSmart contains St. John's Wort St John's Wort 400 mg by Signature Supplements contains St. John's Wort
Pharmacist Counseling Corner

Atropine, Hyoscyamine, Phenobarbital & Supplements: Common Questions

What supplements interact with Atropine, Hyoscyamine, Phenobarbital?
More than you might expect — 165 in total, though they are far from equal: 10 are rated major, 134 moderate, and 21 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Beer, St. John's Wort, Wine.
Which Atropine, Hyoscyamine, Phenobarbital supplement interactions are the most serious?
The 10 major-rated combinations — led by Beer, St. John's Wort, Wine, 1,4-butanediol and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Atropine, Hyoscyamine, Phenobarbital?
Usually yes — most people on Atropine, Hyoscyamine, Phenobarbital can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Hypnaldyne have the same supplement interactions as Atropine, Hyoscyamine, Phenobarbital?
Yes — Hypnaldyne all contain Atropine, Hyoscyamine, Phenobarbital, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Atropine, Hyoscyamine, Phenobarbital deplete any vitamins or nutrients?
It might — Atropine, Hyoscyamine, Phenobarbital has 7 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Atropine, Hyoscyamine, Phenobarbital nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Atropine, Hyoscyamine, Phenobarbital and my other medications?
This page covers Atropine, Hyoscyamine, Phenobarbital against supplements and herbal ingredients. Checking Atropine, Hyoscyamine, Phenobarbital against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 18, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.