Medication interaction hub

What Supplements Interact with Bictegravir, Emtricitabine, Tenofovir Alafenamide?

Bictegravir, Emtricitabine, Tenofovir Alafenamide brand name: Biktarvy. Every interaction below applies to the brands too.

148 Interactions 3 Major 107 Moderate 38 Minor
Curated & coded by · Clinical Pharmacist · Updated October 1, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Bictegravir, Emtricitabine, Tenofovir Alafenamide? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Bictegravir, Emtricitabine, Tenofovir Alafenamide against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

148 supplements and herbal ingredients have interactions with Bictegravir, Emtricitabine, Tenofovir Alafenamide on file in the HelloPharmacist interaction database — 3 rated major, 107 moderate, and 38 minor. The most serious involve Grapefruit, Activated Charcoal and St. John's Wort.

Our assessment: with 3 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Bictegravir, Emtricitabine, Tenofovir Alafenamide.

Major 3 Moderate 107 Minor 38 No known interaction 1,304

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Bictegravir, Emtricitabine, Tenofovir Alafenamide: Top Interactions at a Glance

The Bictegravir, Emtricitabine, Tenofovir Alafenamide supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 148 interacting ingredients — plus 1,304 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Bictegravir, Emtricitabine, Tenofovir Alafenamide Combinations Today

The Bictegravir, Emtricitabine, Tenofovir Alafenamide + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Ginger + Bictegravir, Emtricitabine, Tenofovir Alafenamidei

Ginger might increase or decrease the levels of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Probable Iron + Bictegravir, Emtricitabine, Tenofovir Alafenamidei

Iron might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.

Read the full interaction Moderate Likelihood Possible Goldthread + Bictegravir, Emtricitabine, Tenofovir Alafenamidei

There's very preliminary evidence that berberine, a constituent of goldthread, might inhibit cytochrome P450 3A4 (CYP3A4) enzyme.

Read the full interaction Moderate Likelihood Possible Fennel + Bictegravir, Emtricitabine, Tenofovir Alafenamidei

Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Goji + Bictegravir, Emtricitabine, Tenofovir Alafenamidei

Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.

Read the full interaction Major Likelihood Likely Grapefruit + Bictegravir, Emtricitabine, Tenofovir Alafenamidei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction
The complete list

Every Supplement Checked Against Bictegravir, Emtricitabine, Tenofovir Alafenamide

All 1,452 ingredients in our database, ranked by severity — 148 with a Bictegravir, Emtricitabine, Tenofovir Alafenamide interaction on file and 1,304 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Bictegravir, Emtricitabine, Tenofovir Alafenamide?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Ginger with Bictegravir, Emtricitabine, Tenofovir Alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ginger might increase or decrease the levels of CYP3A4 substrates.

Full Ginger + Bictegravir, Emtricitabine, Tenofovir Alafenamide answer

Can you take Iron with Bictegravir, Emtricitabine, Tenofovir Alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Iron might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.

Full Iron + Bictegravir, Emtricitabine, Tenofovir Alafenamide answer

Can you take Goldthread with Bictegravir, Emtricitabine, Tenofovir Alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There's very preliminary evidence that berberine, a constituent of goldthread, might inhibit cytochrome P450 3A4 (CYP3A4) enzyme.

Full Goldthread + Bictegravir, Emtricitabine, Tenofovir Alafenamide answer

Can you take Fennel with Bictegravir, Emtricitabine, Tenofovir Alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

Full Fennel + Bictegravir, Emtricitabine, Tenofovir Alafenamide answer

Can you take Goji with Bictegravir, Emtricitabine, Tenofovir Alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.

Full Goji + Bictegravir, Emtricitabine, Tenofovir Alafenamide answer

Can you take Strawberry with Bictegravir, Emtricitabine, Tenofovir Alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that strawberry extract can inhibit p-glycoprotein efflux.

Full Strawberry + Bictegravir, Emtricitabine, Tenofovir Alafenamide answer

Can you take Sulforaphane with Bictegravir, Emtricitabine, Tenofovir Alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sulforaphane might increase the levels and effects of CYP3A4 substrates.

Full Sulforaphane + Bictegravir, Emtricitabine, Tenofovir Alafenamide answer

Can you take Sweet Annie with Bictegravir, Emtricitabine, Tenofovir Alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.

Full Sweet Annie + Bictegravir, Emtricitabine, Tenofovir Alafenamide answer

Can you take Sweet Orange with Bictegravir, Emtricitabine, Tenofovir Alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.

Full Sweet Orange + Bictegravir, Emtricitabine, Tenofovir Alafenamide answer

Can you take Syrian Rue with Bictegravir, Emtricitabine, Tenofovir Alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Syrian rue might increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Syrian Rue + Bictegravir, Emtricitabine, Tenofovir Alafenamide answer

Can you take Terminalia with Bictegravir, Emtricitabine, Tenofovir Alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.

Full Terminalia + Bictegravir, Emtricitabine, Tenofovir Alafenamide answer

Can you take Thunder God Vine with Bictegravir, Emtricitabine, Tenofovir Alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, thunder god vine might increase the levels and clinical effects of CYP3A4 substrates.

Full Thunder God Vine + Bictegravir, Emtricitabine, Tenofovir Alafenamide answer

Can you take Tragacanth with Bictegravir, Emtricitabine, Tenofovir Alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Bictegravir, Emtricitabine, Tenofovir Alafenamide answer

Can you take Turmeric with Bictegravir, Emtricitabine, Tenofovir Alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Turmeric might increase or decrease levels of drugs metabolized by CYP3A4.

Full Turmeric + Bictegravir, Emtricitabine, Tenofovir Alafenamide answer

Can you take Uva Ursi with Bictegravir, Emtricitabine, Tenofovir Alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.

Full Uva Ursi + Bictegravir, Emtricitabine, Tenofovir Alafenamide answer

Can you take Vitamin E with Bictegravir, Emtricitabine, Tenofovir Alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.

Full Vitamin E + Bictegravir, Emtricitabine, Tenofovir Alafenamide answer

Can you take White Pepper with Bictegravir, Emtricitabine, Tenofovir Alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence suggests that piperine, a constituent of white pepper, inhibits cytochrome P450 3A4 (CYP3A4).

Full White Pepper + Bictegravir, Emtricitabine, Tenofovir Alafenamide answer

Can you take Wild Cherry with Bictegravir, Emtricitabine, Tenofovir Alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that wild cherry can inhibit cytochrome P450 3A4 (CYP3A4) enzymes.

Full Wild Cherry + Bictegravir, Emtricitabine, Tenofovir Alafenamide answer

Can you take Zedoary with Bictegravir, Emtricitabine, Tenofovir Alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, zedoary might increase levels of drugs metabolized by CYP3A4.

Full Zedoary + Bictegravir, Emtricitabine, Tenofovir Alafenamide answer

Can you take Thyroid Extract with Bictegravir, Emtricitabine, Tenofovir Alafenamide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Bictegravir, Emtricitabine, Tenofovir Alafenamide answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Bictegravir, Emtricitabine, Tenofovir Alafenamide is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Bictegravir, Emtricitabine, Tenofovir Alafenamide, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Bictegravir, Emtricitabine, Tenofovir Alafenamide sits in 4 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Bictegravir, Emtricitabine, Tenofovir Alafenamide through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Bictegravir, Emtricitabine, Tenofovir Alafenamide through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Bictegravir, Emtricitabine, Tenofovir Alafenamide through this category.

Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy) 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Bictegravir, Emtricitabine, Tenofovir Alafenamide through this category.

About Bictegravir, Emtricitabine, Tenofovir Alafenamide

Bictegravir, emtricitabine, and tenofovir alafenamide is a three-drug combination antiretroviral used to treat HIV-1 infection in adults and eligible pediatric patients.

Generic name: Bictegravir, Emtricitabine, Tenofovir Alafenamide  ·  Brand name: Biktarvy.

See the full Bictegravir, Emtricitabine, and Tenofovir Alafenamide drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Bictegravir, Emtricitabine, Tenofovir Alafenamide

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Bictegravir, Emtricitabine, Tenofovir Alafenamide.

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Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

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Pharmacist Counseling Corner

Bictegravir, Emtricitabine, Tenofovir Alafenamide & Supplements: Common Questions

What supplements interact with Bictegravir, Emtricitabine, Tenofovir Alafenamide?
More than you might expect — 148 in total, though they are far from equal: 3 are rated major, 107 moderate, and 38 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Grapefruit, Activated Charcoal, St. John's Wort.
Which Bictegravir, Emtricitabine, Tenofovir Alafenamide supplement interactions are the most serious?
The 3 major-rated combinations — led by Grapefruit, Activated Charcoal and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Bictegravir, Emtricitabine, Tenofovir Alafenamide?
Usually yes — most people on Bictegravir, Emtricitabine, Tenofovir Alafenamide can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Biktarvy have the same supplement interactions as Bictegravir, Emtricitabine, Tenofovir Alafenamide?
Yes — Biktarvy all contain Bictegravir, Emtricitabine, Tenofovir Alafenamide, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Bictegravir, Emtricitabine, Tenofovir Alafenamide and my other medications?
This page covers Bictegravir, Emtricitabine, Tenofovir Alafenamide against supplements and herbal ingredients. Checking Bictegravir, Emtricitabine, Tenofovir Alafenamide against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Bictegravir, Emtricitabine, and Tenofovir Alafenamide drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 1, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.