Medication interaction hub

What Supplements Interact with Caffeine, Diphenhydramine, Ergotamine (prescription drug)?

Caffeine, Diphenhydramine, Ergotamine (prescription drug) brand name: Ergodryl. Every interaction below applies to the brands too.

297 Interactions 15 Major 236 Moderate 46 Minor
Curated & coded by · Clinical Pharmacist · Updated October 5, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Caffeine, Diphenhydramine, Ergotamine (prescription drug)? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Caffeine, Diphenhydramine, Ergotamine (prescription drug) against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Because Ergodryl packs caffeine, diphenhydramine, and ergotamine into one migraine capsule, its supplement interactions pull in several directions at once, and I would treat this list with genuine care. Sedating herbs and alcohol deepen the drowsiness diphenhydramine already causes, stimulant botanicals stack onto the caffeine and can strain the heart, and grapefruit blocks the enzyme that clears ergotamine, letting a drug with real toxicity build up.

St. John's wort works that same enzyme in reverse, speeding ergotamine's breakdown so the migraine relief may fade. Dozens of other entries add anticholinergic effects, meaning dry mouth, blurred vision, and constipation, to what diphenhydramine already produces, and a few can blunt absorption of the dose itself. Of the 297 ingredients on file, 236 rate moderate and 46 minor, while the 15 rated major cover every one of those fronts, sedation, stimulation, and ergotamine levels alike.

— , Clinical Pharmacist · July 18, 2026

Major 15 Moderate 236 Minor 46 No known interaction 1,155

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Caffeine, Diphenhydramine, Ergotamine (prescription drug): Top Interactions at a Glance

The most significant Caffeine, Diphenhydramine, Ergotamine (prescription drug) supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 297 interacting ingredients — plus 1,155 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Caffeine, Diphenhydramine, Ergotamine (prescription drug) + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Beer + Caffeine, Diphenhydramine, Ergotamine (prescription drug)i

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Likely Grapefruit + Caffeine, Diphenhydramine, Ergotamine (prescription drug)i

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Likely Wine + Caffeine, Diphenhydramine, Ergotamine (prescription drug)i

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Probable 1,4-butanediol + Caffeine, Diphenhydramine, Ergotamine (prescription drug)i

Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Read the full interaction Major Likelihood Probable Activated Charcoal + Caffeine, Diphenhydramine, Ergotamine (prescription drug)i

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Ephedra + Caffeine, Diphenhydramine, Ergotamine (prescription drug)i

Theoretically, concomitant use might increase the risk for serious adverse effects.

Read the full interaction
The complete list

Every Supplement Checked Against Caffeine, Diphenhydramine, Ergotamine (prescription drug)

All 1,452 ingredients in our database, ranked by severity — 297 with a Caffeine, Diphenhydramine, Ergotamine (prescription drug) interaction on file and 1,155 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Caffeine, Diphenhydramine, Ergotamine (prescription drug)?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Parsley with Caffeine, Diphenhydramine, Ergotamine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, parsley might increase serum levels of CYP1A2 substrates.

Full Parsley + Caffeine, Diphenhydramine, Ergotamine (prescription drug) answer

Can you take Passion Flower with Caffeine, Diphenhydramine, Ergotamine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.

Full Passion Flower + Caffeine, Diphenhydramine, Ergotamine (prescription drug) answer

Can you take Peony with Caffeine, Diphenhydramine, Ergotamine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP1A2.

Full Peony + Caffeine, Diphenhydramine, Ergotamine (prescription drug) answer

Can you take Peppermint with Caffeine, Diphenhydramine, Ergotamine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Full Peppermint + Caffeine, Diphenhydramine, Ergotamine (prescription drug) answer

Can you take Phellodendron with Caffeine, Diphenhydramine, Ergotamine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phellodendron might increase the sedative effects of CNS depressants.

Full Phellodendron + Caffeine, Diphenhydramine, Ergotamine (prescription drug) answer

Can you take Phenibut with Caffeine, Diphenhydramine, Ergotamine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phenibut might increase the risk of sedation and respiratory depression when taken with CNS depressants.

Full Phenibut + Caffeine, Diphenhydramine, Ergotamine (prescription drug) answer

Can you take Phenpromethamine with Caffeine, Diphenhydramine, Ergotamine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking phenpromethamine with stimulant drugs might have additive effects and increase the risk of adverse cardiovascular effe...

Full Phenpromethamine + Caffeine, Diphenhydramine, Ergotamine (prescription drug) answer

Can you take Phosphatidylserine with Caffeine, Diphenhydramine, Ergotamine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.

Full Phosphatidylserine + Caffeine, Diphenhydramine, Ergotamine (prescription drug) answer

Can you take Pinellia Ternata with Caffeine, Diphenhydramine, Ergotamine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research shows that a Pinellia ternata preparation decreases activity and increases sleeping time.

Full Pinellia Ternata + Caffeine, Diphenhydramine, Ergotamine (prescription drug) answer

Can you take Poria Mushroom with Caffeine, Diphenhydramine, Ergotamine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.

Full Poria Mushroom + Caffeine, Diphenhydramine, Ergotamine (prescription drug) answer

Can you take Propolis with Caffeine, Diphenhydramine, Ergotamine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.

Full Propolis + Caffeine, Diphenhydramine, Ergotamine (prescription drug) answer

Can you take Purple Nut Sedge with Caffeine, Diphenhydramine, Ergotamine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro, purple nut sedge dose-dependently inhibits acetylcholinesterase (AChE).

Full Purple Nut Sedge + Caffeine, Diphenhydramine, Ergotamine (prescription drug) answer

Can you take Quercetin with Caffeine, Diphenhydramine, Ergotamine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might alter the effects and adverse effects of CYP3A4 substrates.

Full Quercetin + Caffeine, Diphenhydramine, Ergotamine (prescription drug) answer

Can you take Rabdosia Rubescens with Caffeine, Diphenhydramine, Ergotamine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that oridonin, a constituent of Rabdosia rubescens, induces cytochrome P450 3A4 (CYP3A4) enzyme.

Full Rabdosia Rubescens + Caffeine, Diphenhydramine, Ergotamine (prescription drug) answer

Can you take Raspberry Ketone with Caffeine, Diphenhydramine, Ergotamine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.

Full Raspberry Ketone + Caffeine, Diphenhydramine, Ergotamine (prescription drug) answer

Can you take Rauwolscine with Caffeine, Diphenhydramine, Ergotamine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rauwolscine with seizure threshold lowering drugs might increase the risk of adverse convulsant effects.

Full Rauwolscine + Caffeine, Diphenhydramine, Ergotamine (prescription drug) answer

Can you take Resveratrol with Caffeine, Diphenhydramine, Ergotamine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.

Full Resveratrol + Caffeine, Diphenhydramine, Ergotamine (prescription drug) answer

Can you take Rooibos with Caffeine, Diphenhydramine, Ergotamine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rooibos with CYP1A2 substrates may increase the effects of CYP1A2 substrates.

Full Rooibos + Caffeine, Diphenhydramine, Ergotamine (prescription drug) answer

Can you take Rue with Caffeine, Diphenhydramine, Ergotamine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rue might increase the risk for phototoxicity when used with photosensitizing drugs.

Full Rue + Caffeine, Diphenhydramine, Ergotamine (prescription drug) answer

Can you take Saffron with Caffeine, Diphenhydramine, Ergotamine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of saffron and CNS depressants might have additive sedative effects.

Full Saffron + Caffeine, Diphenhydramine, Ergotamine (prescription drug) answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Caffeine, Diphenhydramine, Ergotamine (prescription drug) is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Caffeine, Diphenhydramine, Ergotamine (prescription drug), and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Caffeine, Diphenhydramine, Ergotamine (prescription drug) sits in 13 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Caffeine, Diphenhydramine, Ergotamine (prescription drug) through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Caffeine, Diphenhydramine, Ergotamine (prescription drug) through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Caffeine, Diphenhydramine, Ergotamine (prescription drug) through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Caffeine, Diphenhydramine, Ergotamine (prescription drug) through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Caffeine, Diphenhydramine, Ergotamine (prescription drug) through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Caffeine, Diphenhydramine, Ergotamine (prescription drug) through this category.

Caffeine 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Caffeine, Diphenhydramine, Ergotamine (prescription drug) through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Caffeine, Diphenhydramine, Ergotamine (prescription drug) through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Caffeine, Diphenhydramine, Ergotamine (prescription drug) through this category.

Methylxanthines 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Caffeine, Diphenhydramine, Ergotamine (prescription drug) through this category.

Cytochrome P450 2D6 (Cyp2D6) Inhibitors 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Caffeine, Diphenhydramine, Ergotamine (prescription drug) through this category.

Ergot Derivatives 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Caffeine, Diphenhydramine, Ergotamine (prescription drug) through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Caffeine, Diphenhydramine, Ergotamine (prescription drug) through this category.

Related: does Caffeine, Diphenhydramine, Ergotamine (prescription drug) deplete any nutrients?

Caffeine, Diphenhydramine, Ergotamine (prescription drug) has 1 reported nutrient association in the research literature — see the Caffeine, Diphenhydramine, Ergotamine (prescription drug) nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Caffeine, Diphenhydramine, Ergotamine (prescription drug)

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Caffeine, Diphenhydramine, Ergotamine (prescription drug).

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

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Products that contain Caffeine, Diphenhydramine, Ergotamine (prescription drug)-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Caffeine, Diphenhydramine, Ergotamine (prescription drug).

Yeast-Cleanse by Solaray contains Grapefruit Ultimate GCB by M3 Supplement Company contains Grapefruit Neuro Health by Nature’s Craft contains Grapefruit NDF Happy Peach by Bioray Kids contains Grapefruit
Pharmacist Counseling Corner

Caffeine, Diphenhydramine, Ergotamine (prescription drug) & Supplements: Common Questions

What supplements interact with Caffeine, Diphenhydramine, Ergotamine (prescription drug)?
More than you might expect — 297 in total, though they are far from equal: 15 are rated major, 236 moderate, and 46 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Beer, Grapefruit, Wine.
Which Caffeine, Diphenhydramine, Ergotamine (prescription drug) supplement interactions are the most serious?
Focus on the major group: Beer, Grapefruit, Wine, 1,4-butanediol and Activated Charcoal, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Caffeine, Diphenhydramine, Ergotamine (prescription drug)?
Usually yes — most people on Caffeine, Diphenhydramine, Ergotamine (prescription drug) can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Ergodryl have the same supplement interactions as Caffeine, Diphenhydramine, Ergotamine (prescription drug)?
Yes — Ergodryl all contain Caffeine, Diphenhydramine, Ergotamine (prescription drug), so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Caffeine, Diphenhydramine, Ergotamine (prescription drug) deplete any vitamins or nutrients?
It might — Caffeine, Diphenhydramine, Ergotamine (prescription drug) has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Caffeine, Diphenhydramine, Ergotamine (prescription drug) nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Caffeine, Diphenhydramine, Ergotamine (prescription drug) and my other medications?
This page covers Caffeine, Diphenhydramine, Ergotamine (prescription drug) against supplements and herbal ingredients. Checking Caffeine, Diphenhydramine, Ergotamine (prescription drug) against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 5, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.