Medication interaction hub

What Supplements Interact with Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine?

Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine brand names: Histalet Forte, Poly Hist Forte, Vanex Forte. Every interaction below applies to the brands too.

229 Interactions 10 Major 175 Moderate 44 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Ephedra is the first thing I would take off the shelf for anyone using chlorpheniramine, phenylephrine, phenylpropanolamine, and pyrilamine (Histalet Forte, Poly Hist Forte, Vanex Forte). This cold and allergy combination contains two decongestants that already raise blood pressure and heart rate, and 44 ingredients on this list, ephedra included, add stimulant effects on top of that. Ten of the 229 entries carry a major rating, enough that I would treat this list as a genuine warning rather than fine print.

The antihistamine side matters too. Thirty ingredients pile on the same drying, sedating effects: drowsiness, dry mouth, confusion. The largest cluster, 121 ingredients, involves the CYP3A4 enzyme that clears this medicine, where grapefruit can push drug levels up and St. John's wort can pull them down. Most of the 175 moderate and 44 minor entries echo these same themes; the ten majors are the ones to know cold.

— , Clinical Pharmacist · July 18, 2026

Major 10 Moderate 175 Minor 44 No known interaction 1,223

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine: Top Interactions at a Glance

The most significant Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 229 interacting ingredients — plus 1,223 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Grapefruit + Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilaminei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Probable Activated Charcoal + Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilaminei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Ephedra + Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilaminei

Theoretically, concomitant use might increase the risk for serious adverse effects.

Read the full interaction Major Likelihood Probable Henbane + Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilaminei

Concomitant use of henbane can have additive anticholinergic effects and adverse effects with amantadine, antihistamines, atropine, belladonna alkaloids, hyoscy...

Read the full interaction Major Likelihood Probable Lithium + Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilaminei

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Read the full interaction Major Likelihood Probable Peyote + Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilaminei

Concomitant use of peyote with stimulant drugs may increase the risk of adverse CNS effects.

Read the full interaction
The complete list

Every Supplement Checked Against Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine

All 1,452 ingredients in our database, ranked by severity — 229 with a Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine interaction on file and 1,223 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Angelica Archangelica with Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Full Angelica Archangelica + Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine answer

Can you take Arrach with Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of arrach can increase risk of adverse effects, as unspecified Chenopodium species are associated with photos...

Full Arrach + Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine answer

Can you take Astaxanthin with Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.

Full Astaxanthin + Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine answer

Can you take Ayahuasca with Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ayahuasca might increase levels of serotonin, which may have additive effects with serotonergic drugs.

Full Ayahuasca + Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine answer

Can you take Bacopa with Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.

Full Bacopa + Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine answer

Can you take Beet with Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, beet might increase the levels of CYP3A4 substrates.

Full Beet + Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine answer

Can you take Berberine with Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.

Full Berberine + Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine answer

Can you take Beta-methylphenethylamine (bmpea) with Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, BMPEA might increase the levels and clinical effects of CYP3A4 substrates.

Full Beta-methylphenethylamine (bmpea) + Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine answer

Can you take Biofeedback with Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that electroencephalogram (EEG) biofeedback might lower the seizure threshold in some patients.

Full Biofeedback + Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine answer

Can you take Bishop's Weed with Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bishop's weed constituents seem to cause photosensitivity.

Full Bishop's Weed + Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine answer

Can you take Bitter Orange with Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bitter orange might increase levels of drugs metabolized by CYP3A4.

Full Bitter Orange + Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine answer

Can you take Black Cohosh with Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Combining serotonergic drugs with black cohosh might cause additive serotonergic effects.

Full Black Cohosh + Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine answer

Can you take Black Pepper with Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Full Black Pepper + Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine answer

Can you take Black Seed with Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndro...

Full Black Seed + Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine answer

Can you take Bog Labrador Tea with Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that aqueous and ethanolic extracts of Bog Labrador tea leaves can increase the concentration of cytochrome P450 3A4...

Full Bog Labrador Tea + Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine answer

Can you take Boswellia Serrata with Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.

Full Boswellia Serrata + Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine answer

Can you take Boxwood with Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that boxwood extract can inhibit acetylcholinesterase activity.

Full Boxwood + Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine answer

Can you take Bulbine Natalensis with Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Bulbine natalensis stem might reduce the levels and clinical effects of CYP3A4 substrates.

Full Bulbine Natalensis + Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine answer

Can you take Butcher's Broom with Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.

Full Butcher's Broom + Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine answer

Can you take Calamus with Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking calamus with drugs metabolized by CYP3A4 might increase drug levels and potentially increase the risk of adverse effec...

Full Calamus + Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine sits in 11 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine through this category.

Phenylpropanolamine 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine through this category.

Cytochrome P450 2D6 (Cyp2D6) Inhibitors 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine through this category.

Alpha-Adrenergic Agonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Pharmacist Counseling Corner

Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine & Supplements: Common Questions

What supplements interact with Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine?
Our database currently documents 229 ingredients with a known Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine interaction (10 major, 175 moderate, 44 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 229. The highest-ranked right now: Grapefruit, Activated Charcoal, Ephedra.
Which Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine supplement interactions are the most serious?
The 10 major-rated combinations — led by Grapefruit, Activated Charcoal, Ephedra, Henbane and Lithium — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine?
Plenty of supplements coexist fine with Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Histalet Forte have the same supplement interactions as Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine?
Yes — Histalet Forte, Poly Hist Forte, Vanex Forte all contain Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine and my other medications?
This page covers Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine against supplements and herbal ingredients. Checking Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.