What Supplements Interact with Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride?
Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride brand name: Qternmet XR. Every interaction below applies to the brands too.
Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy
What is this page for?
One answer, for one medication: what supplements and herbal products interact with Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.
This page covers supplement interactions only — to check Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy
335 supplements and herbal ingredients have interactions with Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride on file in the HelloPharmacist interaction database — 4 rated major, 277 moderate, and 54 minor. The most serious involve Grapefruit, Siberian Cocklebur, Activated Charcoal and St. John's Wort.
Our assessment: with 4 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride.
Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.
This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓
Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride: Top Interactions at a Glance
The most significant Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.
Showing the 12 highest-ranked of 335 interacting ingredients — plus 1,117 more checked with no known interaction. See the complete ranked list.
The Major Interactions to Know About
The most clinically significant Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride + supplement combinations in our database, best-documented first. Open any card for the full report.
Grapefruit juice can increase levels of drugs metabolized by CYP3A4.
Read the full interaction Major Likelihood Likely Siberian Cocklebur + Dapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideiSiberian cocklebur seedlings and seeds have caused severe hypoglycemia in humans.
Read the full interaction Major Likelihood Probable Activated Charcoal + Dapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideiActivated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.
Read the full interaction Major Likelihood Probable St. John's Wort + Dapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideiSt.
Read the full interactionEvery Supplement Checked Against Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride
All 1,452 ingredients in our database, ranked by severity — 335 with a Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interaction on file and 1,117 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.
Looking for an interaction with a specific supplement product? Search products instead ↓
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GrapefruitCitrus Paradisi Likely
What it is: Grapefruit is a nutritious citrus fruit rich in vitamin C and other nutrients, and it is generally safe to eat.
Grapefruit juice can increase levels of drugs metabolized by CYP3A4.
Read the full Grapefruit + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionSiberian Cocklebur Likely
What it is: Siberian cocklebur is a fruit used in traditional Chinese and other Asian herbal medicine, mainly for nasal congestion, sinus issues, and al...
Siberian cocklebur seedlings and seeds have caused severe hypoglycemia in humans.
Read the full Siberian Cocklebur + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionActivated CharcoalActivated Carbon, animal Charcoal, carbo Vegetabilis, +13 more Probable
What it is: Activated charcoal is a highly porous form of carbon that can bind certain substances in the gut, and it is used in hospitals to treat some...
Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.
Read the full Activated Charcoal + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionSt. John's WortHypericum Perforatum, amber Touch-and-heal, barbe De Saint-jean, +13 more Probable
American GinsengPanax Quinquefolius, anchi Ginseng, baie Rouge, +14 more Probable
What it is: American ginseng is an herbal root used as an 'adaptogen' to support energy, stress, immune function, and blood sugar.
Theoretically, taking American ginseng with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full American Ginseng + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionAstragalusAstragale, astragale à Feuilles De Réglisse, astragale Queue-de-renard, +15 more Probable
What it is: Astragalus is a root used for centuries in traditional Chinese medicine, mainly to support the immune system and help the body cope with str...
Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Astragalus + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBanabaLagerstroemia Speciosa, banaba Extract, banabalean, +8 more Probable
What it is: Banaba is a leaf extract most often used to help support healthy blood sugar, and small early studies suggest its active compound corosolic...
Theoretically, concomitant use of banaba and hypoglycemic drugs might have additive effects.
Read the full Banaba + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBeer Probable
What it is: Beer is an alcoholic beverage that contains some minerals, B vitamins, and plant compounds from hops and grain, but it is not a health suppl...
Concomitant use may interfere with blood glucose control.
Read the full Beer + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBitter MelonMomordica Charantia, african Cucumber, ampalaya, +20 more Probable
What it is: Bitter melon is a tropical fruit eaten as food and used in traditional medicine, most often for blood sugar control.
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBranched-chain Amino Acids (bcaa) Probable
What it is: Branched-chain amino acids (leucine, isoleucine, and valine) are essential nutrients commonly taken by athletes for muscle support and recov...
Theoretically, BCAAs might alter the effects of antidiabetes medications.
Read the full Branched-chain Amino Acids (bcaa) + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCannabidiol (cbd) Probable
What it is: CBD is a compound from the cannabis (hemp) plant that does not cause a 'high.' It has strong evidence only for certain rare seizure disorder...
Cannabidiol may increase levels of drugs that are metabolized by CYP3A4.
Read the full Cannabidiol (cbd) + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCoffee CharcoalCafé Arabica, café Carbonisé, café Robusta, +5 more Probable
What it is: Coffee charcoal is made by roasting green coffee beans until they turn black, creating a charcoal-like material used traditionally for diarr...
Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two hours.
Read the full Coffee Charcoal + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCuminCuminum Cyminum, anis Âcre, comino, +6 more Probable
What it is: Cumin is a common cooking spice that has a long history in traditional medicine for digestion and other complaints.
Theoretically, cumin might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Cumin + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionEphedraEphedra Distachya, belcho, cao Mahuang, +13 more Probable
What it is: Ephedra (ma huang) contains powerful stimulants like ephedrine that affect the heart and nervous system.
Theoretically, taking ephedra with antidiabetes drugs might interfere with blood glucose control.
Read the full Ephedra + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionEuropean MandrakeMandragora Officinarum, alraunwurzel, mandragora, +7 more Probable
What it is: European mandrake is a highly toxic plant from the nightshade family that was used in ancient and medieval times as a sedative and pain reli...
Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European mandrake.
Read the full European Mandrake + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionFenugreekTrigonella Foenum-graecum, alholva, bird's Foot, +14 more Probable
What it is: Fenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk prod...
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionFig Probable
What it is: Fig (Ficus carica) is a common fruit that has long been used as a gentle food remedy for constipation, and its leaves are used traditionally...
Theoretically, fig leaf might enhance the blood glucose lowering effects of hypoglycemic drugs.
Read the full Fig + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionFlaxseedLinum Usitatissimum, alasi, aliviraaii, +20 more Probable
What it is: Flaxseed is a nutritious food rich in fiber, omega-3 fats (ALA), and plant compounds called lignans.
Theoretically, flaxseed might have additive effects when used with antidiabetes drugs and increase the risk for hypoglycemia.
Read the full Flaxseed + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionGlucomannanGlucomanano, glucomannane, konjac, +1 more Probable
What it is: Glucomannan is a soluble fiber from the konjac root that swells into a gel in your stomach, which may help with mild weight loss, constipati...
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Glucomannan + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionGuar GumDietary Fiber, farine De Guar, fibre Alimentaire, +10 more Probable
What it is: Guar gum is a soluble, gel-forming fiber from the guar bean that may modestly help with cholesterol, blood sugar, and bowel regularity.
Guar gum might reduce the absorption of metformin, potentially decreasing its effectiveness.
Read the full Guar Gum + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionGuggulCommiphora Wightii, devadhupa, gomme Guggul, +17 more Probable
What it is: Guggul is a gum resin from the Commiphora wightii tree, long used in Ayurvedic medicine for cholesterol, joint, and skin problems.
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionGymnemaGymnema Sylvestre, gimnema, gur-mar, +14 more Probable
What it is: Gymnema is an Ayurvedic herb best known for possibly helping lower blood sugar and reducing the taste of sweetness on the tongue.
Theoretically, taking gymnema with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Gymnema + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionInositol NicotinateHexaniacinate D'inositol, hexanicotinoyl Inositol, inositol Hexaniacinate, +5 more Probable
What it is: Inositol nicotinate is a 'no-flush' form of niacin marketed for cholesterol and circulation.
Theoretically, inositol nicotinate might increase blood glucose levels and may diminish the effects of antidiabetes drugs.
Read the full Inositol Nicotinate + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionIvy Gourd Probable
What it is: Ivy gourd is a tropical vine widely eaten as a vegetable and used in traditional medicine, most often for blood sugar support.
Ivy gourd may lower blood glucose levels and might have additive effects when used with antidiabetes drugs.
Read the full Ivy Gourd + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionNiacin3-pyridinecarboxylic Acid, vitamin B3 Probable
What it is: Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countri...
Niacin can increase blood glucose levels and may diminish the effects of antidiabetes drugs.
Read the full Niacin + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionPanax GinsengAsian Ginseng, asiatic Ginseng, chinese Ginseng, +12 more Probable
What it is: Panax ginseng is a popular traditional herb used to boost energy, ease stress, and support overall wellness, though scientific evidence is m...
Theoretically, taking Panax ginseng with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Panax Ginseng + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionPapayaCarica Papaya, banane De Prairie, caricae Papayae Folium, +16 more Probable
What it is: Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive...
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionPrickly Pear Cactus Probable
What it is: Prickly pear cactus is a desert plant whose pads and fruit are eaten as food and taken as a supplement, mainly for blood sugar, cholesterol,...
Combining prickly pear cactus with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Prickly Pear Cactus + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionRibose Probable
What it is: Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP.
Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Ribose + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionSalaciaSalacia Oblonga, chundan, kothala Himbutu, +3 more Probable
What it is: Salacia is a plant used in Ayurvedic medicine, mostly studied for lowering blood sugar after meals.
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionSchisandraSchisandra Chinensis, bac Ngu Vi Tu, baie De Schisandra, +10 more Probable
What it is: Schisandra is a traditional Chinese medicine berry used as an adaptogen for stress, fatigue, and liver support.
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Schisandra + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionSida CordifoliaAbutilon En Épi, bala, bariar, +15 more Probable
What it is: Sida cordifolia (bala or country mallow) is a traditional Ayurvedic plant that naturally contains ephedrine, a powerful stimulant.
Theoretically, Sida cordifolia might reduce the effectiveness of antidiabetes drugs.
Read the full Sida Cordifolia + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionTree Turmeric Probable
What it is: Tree turmeric (Berberis aristata) is a shrub used in traditional Indian (Ayurvedic) medicine, valued mainly for its berberine content.
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Tree Turmeric + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionVanadium Probable
What it is: Vanadium is a trace mineral found in tiny amounts in food, and people get plenty from a normal diet.
Theoretically, vanadium might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Vanadium + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionWine Probable
What it is: Wine is an alcoholic beverage made from fermented grapes and is not a true dietary supplement or medicine.
Concomitant use may interfere with blood glucose control.
Read the full Wine + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionAcacia RigidulaVachellia Rigidula, acacia Rigidula, acaciopsis Rigidula, +3 more Possible
What it is: Acacia rigidula is a shrub from Texas and Mexico that is marketed in weight-loss and energy supplements.
Theoretically, Acacia rigidula products that are adulterated with beta-methylphenylethylamine (BMPEA) might increase the levels of CYP3A4 substrates.
Read the full Acacia Rigidula + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionAcaiEuterpe Oleracea, euterpe Badiocarpa Possible
What it is: Acai is a nutritious Amazonian berry rich in antioxidants and healthy fats, and it is fine to enjoy as a food.
Theoretically, taking acai with antidiabetes drugs might interfere with glycemic control.
Read the full Acai + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionAdrafinilAdrafinilum, benzhydryl Sulfinyl Acetyl Hydroxamic Acid, crl-40028, +1 more Possible
What it is: Adrafinil is a synthetic compound that the body converts into modafinil, a prescription wakefulness-promoting drug.
Theoretically, adrafanil might reduce levels and clinical effects of CYP3A4 substrates.
Read the full Adrafinil + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionAfrican Wild Potato Possible
What it is: African Wild Potato (Hypoxis hemerocallidea) is a southern African plant traditionally used as a tonic and for immune, prostate, and inflamm...
In vitro evidence shows that African wild potato extract can inhibit cytochrome P450 3A4 (CYP3A4) enzyme activity by up to 86%.
Read the full African Wild Potato + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionAgaricus MushroomAgaricus Blazei, agaric, agaricus, +13 more Possible
What it is: Agaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxida...
Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Agaricus Mushroom + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionAgmatineAgmatin, agmatine Sulfate, decarboxylated Arginine Possible
What it is: Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement.
Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Agmatine + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionAgrimonyAgrimonia Eupatoria, agrimone, agrimonia, +11 more Possible
What it is: Agrimony is a traditional European herb rich in tannins that has long been used for sore throats, mild diarrhea, and minor skin problems.
Theoretically, taking agrimony with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Agrimony + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionAlfalfaMedicago Sativa, feuille De Luzerne, grand Trèfle, +9 more Possible
What it is: Alfalfa is a nutrient-rich legume that people use for high cholesterol, menopause symptoms, and general wellness, but solid human evidence f...
Theoretically, alfalfa might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Alfalfa + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionAlgal OilDha-s Oil, dha-t Oil, dhasco Oil, +7 more Possible
What it is: Algal oil is a plant-based source of the omega-3 fats DHA and (in some products) EPA, making it a popular alternative to fish oil for vegeta...
Theoretically, taking algal oil with antidiabetes drugs might interfere with the effects of antidiabetes drugs and reduce their effects.
Read the full Algal Oil + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionAloeAloe Vera, aloe Capensis, aloe Gel, +18 more Possible
What it is: Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help.
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Aloe + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionAmbretteAbelmoschus Moschatus, abelmosco, abelmosk, +15 more Possible
What it is: Ambrette (Abelmoschus moschatus) is a fragrant plant best known for its musky seed oil used in perfumes and food flavoring.
Theoretically, concomitant use of ambrette with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Ambrette + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionAmerican ElderSambucus Canadensis, american Elderberry, common Elderberry, +9 more Possible
What it is: American elder is a North American plant whose cooked, ripe berries and flowers are used mainly for colds, flu, and general immune support.
Theoretically, taking American elder might increase levels of CYP3A4 substrates.
Read the full American Elder + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionAnisePimpinella Anisum, anis, anís, +14 more Possible
What it is: Anise is a fragrant, licorice-flavored seed used for centuries to ease digestion and soothe coughs.
Theoretically, anise seed might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Anise + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionAnnattoBixa Orellana, acafrao, acafroa, +25 more Possible
What it is: Annatto is a plant-based coloring made from the seeds of the achiote tree and is widely used as a safe food dye.
Animal studies suggest that certain annatto extracts may have hypoglycemic or hyperglycemic effects.
Read the full Annatto + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionAppleMalus Domestica, abilde, almindelig Aeble, +25 more Possible
What it is: Apples are a nutritious whole food that provides fiber, vitamins, and antioxidant plant compounds, and eating them regularly fits well into...
Theoretically, consuming apple juice with antidiabetes drugs might interfere with blood glucose control.
Read the full Apple + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionArabinoxylanArabinoxilano, arabinoxylane, pentosan Possible
What it is: Arabinoxylan is a type of dietary fiber found in cereal grains that acts as a prebiotic and may modestly affect blood sugar and blood fats.
Evidence from human research suggests that an arabinoxylan-rich fiber can reduce postprandial glucose levels.
Read the full Arabinoxylan + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionArtemisia Herba-albaAhae, ahe, artemisia, +7 more Possible
What it is: Artemisia herba-alba is a desert shrub used in North African and Middle Eastern folk medicine, most often for digestion, diabetes, and paras...
Theoretically, concomitant use with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Artemisia Herba-alba + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionArtichokeCynara Cardunculus, alcachofa, alcaucil, +17 more Possible
What it is: Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indig...
Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Artichoke + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionAshFraxinus Americana, fraxinus Excelsior, bird's Tongue, +15 more Possible
What it is: Ash (Fraxinus excelsior and related species) is a tree whose leaves, bark, and seeds have a long history in folk medicine for arthritis, fev...
Theoretically, concomitant use with antidiabetes drugs might affect glucose control and increase the risk of hypoglycemia.
Read the full Ash + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionAshwagandhaWithania Somnifera, ajagandha, amangura, +17 more Possible
What it is: Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, thoug...
Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Ashwagandha + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionAstaxanthinAstaxanthine, astaxantina, dihydroxy-3, +6 more Possible
What it is: Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and...
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionAvocado Sugar ExtractD-mannoheptulose Possible
What it is: Avocado sugar extract is a source of D-mannoheptulose, an unusual sugar studied mainly in laboratory and animal research for its possible ef...
Theoretically, avocado sugar extract might increase blood glucose levels, and decrease the effects of antidiabetic agents.
Read the full Avocado Sugar Extract + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionAyahuascaAppane, ayahoasca, caapi, +19 more Possible
What it is: Ayahuasca is a powerful psychoactive brew that combines a DMT-containing plant with a vine that allows the DMT to take effect, causing inten...
Theoretically, ayahuasca might increase plasma concentrations of CYP3A4 substrates.
Read the full Ayahuasca + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBa Ji TianMorinda Officinalis, ba Ji, bajitian, +7 more Possible
What it is: Ba Ji Tian is a root used in Traditional Chinese Medicine, mostly to 'tonify the kidneys' and support energy, sexual function, and bone heal...
Animal research shows that taking ba ji tian extracts might increase or decrease blood glucose levels.
Read the full Ba Ji Tian + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBacopaBacopa Monnieri, andri, brahmi, +11 more Possible
What it is: Bacopa is an Ayurvedic herb most often used for memory and thinking.
Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Bacopa + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBaelAegle Marmelos, arbre De Bael, bael Tree, +16 more Possible
What it is: Bael is a fruit-bearing tree long used in traditional Indian (Ayurvedic) medicine, mostly for digestive problems like diarrhea and indigesti...
Evidence from animal research suggests that extracts of bael seed and leaf can reduce blood glucose levels.
Read the full Bael + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBaikal SkullcapScutellaria Baicalensis, baikal Scullcap, baikal Skullcap Root, +16 more Possible
What it is: Baikal skullcap is a traditional Chinese herb (Huang Qin) used for inflammation, allergies, and infections, with active compounds like baica...
Theoretically, concomitant use of Baikal skullcap with antidiabetes drugs might enhance blood glucose lowering effects.
Read the full Baikal Skullcap + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBay LeafLaurus Nobilis, bay, bay Laurel, +17 more Possible
What it is: Bay leaf is a common culinary herb that is safe in the small amounts used in cooking.
Concomitant use of bay leaf with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bay Leaf + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBeetBeta Vulgaris, beet Greens, beet Juice, +19 more Possible
What it is: Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in...
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beet + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBerberineAlcaloïde De Berbérine, berberina, berbérine, +5 more Possible
What it is: Berberine is a yellow plant compound that has shown promise for lowering blood sugar and cholesterol in some studies, but the quality of res...
Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.
Read the full Berberine + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBergamotCitrus Bergamia, aceite De Bergamota, bergamot, +8 more Possible
What it is: Bergamot is a Mediterranean citrus fruit, and its standardized extract is most often used to support cholesterol and heart health, with some...
Theoretically, taking bergamot with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bergamot + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBeta-methylphenethylamine (bmpea) Possible
What it is: Beta-methylphenethylamine (BMPEA) is a synthetic stimulant chemically similar to amphetamine that has been found in some weight-loss and spo...
Theoretically, BMPEA might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Beta-methylphenethylamine (bmpea) + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBilberryVaccinium Myrtillus, airelle, arándano, +16 more Possible
What it is: Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for...
Theoretically, bilberry leaf or fruit extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Bilberry + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBishop's WeedAmmi Majus, Élevé, ammi Inodore, +12 more Possible
What it is: Bishop's Weed (Ammi majus) is a flowering plant whose seeds contain natural light-sensitizing compounds called psoralens, which have been st...
Bergapten, a constituent of bishop's weed, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.
Read the full Bishop's Weed + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBitter OrangeCitrus Aurantium, aurantii Fructus, aurantium, +17 more Possible
What it is: Bitter orange is a citrus fruit whose extracts contain synephrine, a mild stimulant often added to weight-loss and energy supplements.
Bitter orange might increase levels of drugs metabolized by CYP3A4.
Read the full Bitter Orange + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBlack MulberryMorus Nigra, morera Negra, mulberry, +2 more Possible
What it is: Black mulberry is a nutritious fruit rich in antioxidants and vitamins, and it is generally safe to enjoy as a food.
Theoretically, black mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Black Mulberry + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBlack MustardBrassica Nigra Possible
What it is: Black mustard is best known as a pungent culinary spice and a traditional topical remedy for muscle aches and congestion.
Theoretically, black mustard seed might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full Black Mustard + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBlack PepperPiper Nigrum, black Peppercorn, extrait De Poivre, +23 more Possible
What it is: Black pepper is a common kitchen spice that is generally safe in the amounts used in food.
Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
Read the full Black Pepper + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBlack PsylliumAfrican Plantain, brown Psyllium, dietary Fiber, +16 more Possible
What it is: Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive...
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Read the full Black Psyllium + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBlack SeedNigella Sativa, black Caraway, black Cumin, +18 more Possible
What it is: Black seed (Nigella sativa) is a traditional spice and remedy that has been studied for asthma, blood sugar, cholesterol, and blood pressure...
Theoretically, taking black seed with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Black Seed + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBlond PsylliumPlantago Ovata, balle De Psyllium, blond Plantago, +14 more Possible
What it is: Blond psyllium is a soluble fiber from the seed husks of Plantago ovata, and it is one of the better-studied fiber supplements.
Theoretically, blond psyllium might increase the therapeutic and adverse effects of metformin.
Read the full Blond Psyllium + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBlood Irradiation Therapy Possible
What it is: Blood Irradiation Therapy is a medical procedure—not a dietary supplement or herb—in which blood is exposed to ultraviolet or laser light, e...
Preliminary clinical research and one case report suggest that blood irradiation therapy may lower blood glucose levels.
Read the full Blood Irradiation Therapy + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBlue Cohosh Possible
What it is: Blue cohosh is a traditional herb historically used by Native Americans and midwives to bring on labor or menstruation, but it carries serio...
There is some concern that blue cohosh might increase blood glucose levels.
Read the full Blue Cohosh + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBlue-green AlgaeAfa, algae, algues Bleu-vert Du Lac Klamath, +16 more Possible
What it is: Blue-green algae are nutrient-rich aquatic microorganisms (such as spirulina and Klamath Lake algae) taken as a supplement for energy, nutri...
Theoretically, taking blue-green algae with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Blue-green Algae + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBog Labrador TeaRhododendron Groenlandicum, bog Tea, continental Tea, +12 more Possible
What it is: Bog Labrador tea is a wetland shrub whose leaves have long been brewed as a traditional beverage and folk remedy, especially among Indigenou...
In vitro research shows that aqueous and ethanolic extracts of Bog Labrador tea leaves can increase the concentration of cytochrome P450 3A4 (CYP3A4) enzymes.
Read the full Bog Labrador Tea + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBoswellia SerrataBoswellia Serrata, arbre à Oliban Indien, boswella, +10 more Possible
What it is: Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation.
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Boswellia Serrata + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBrewer's YeastBaker's Yeast, dried Yeast Fermentate, faex, +7 more Possible
What it is: Brewer's yeast is a nutrient-rich fungus that provides B vitamins, protein, and minerals, and a related yeast product (S.
Taking brewer's yeast with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Brewer's Yeast + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBrickellia Possible
What it is: Brickellia, often sold under names like 'prodigiosa' or as a Mexican folk remedy for diabetes, is a plant in the daisy family traditionally...
Preliminary research in animal models shows that brickellia and its constituents have hypoglycemic effects.
Read the full Brickellia + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBulbine Natalensis Possible
What it is: Bulbine natalensis is a South African plant marketed mainly as a testosterone-boosting and libido supplement, but the human evidence is esse...
Theoretically, Bulbine natalensis stem might reduce the levels and clinical effects of CYP3A4 substrates.
Read the full Bulbine Natalensis + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBupleurumBei Chai Hu, bupleuri, bupleurum Chinese, +12 more Possible
What it is: Bupleurum (Chai Hu) is a root used in traditional Chinese medicine, usually as part of multi-herb formulas, for liver, digestive, and fever-...
Theoretically, bupleurum might decrease the effects of antidiabetes drugs.
Read the full Bupleurum + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCabbageBrassica Oleracea, cabbage Leaf, chou, +13 more Possible
What it is: Cabbage is a nutritious, low-calorie vegetable that is safe to eat as food and is sometimes applied to the skin as a leaf wrap for breast en...
Theoretically, cabbage might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Cabbage + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCajeput OilMelaleuca Leucadendra, aceite De Cajeput, cajeputi Aetheroleum, +10 more Possible
What it is: Cajeput oil is an aromatic essential oil traditionally used for aches, congestion, and minor skin complaints, but solid human evidence for t...
Animal studies suggest that cajeput oil might have hypoglycemic effects.
Read the full Cajeput Oil + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCalamusAcorus Calamus, acore Calame, acore Odorant, +20 more Possible
What it is: Calamus is a swamp plant with a long history in Ayurvedic and traditional Chinese medicine, mostly for digestive and nervous-system complain...
Theoretically, taking calamus with drugs metabolized by CYP3A4 might increase drug levels and potentially increase the risk of adverse effects.
Read the full Calamus + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCannabisCannabis Sativa, anashca, banji, +25 more Possible
What it is: Cannabis contains many active compounds, mainly THC (which causes a 'high') and CBD (which does not).
Theoretically, cannabis may increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cannabis + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCapers Possible
What it is: Capers are the edible pickled flower buds of the Capparis spinosa shrub, used widely as food and in traditional medicine.
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCapsicum Possible
What it is: Capsicum (chili pepper) contains capsaicin, which is best known and best studied as a topical treatment for certain types of pain.
Theoretically, taking capsicum with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Capsicum + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCarawayCarum Carvi, alcaravea, anis Canadien, +20 more Possible
What it is: Caraway is a common cooking spice that has long been used to ease gas, bloating, and indigestion.
Theoretically, caraway might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full Caraway + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCarnosine Possible
What it is: Carnosine is a naturally occurring dipeptide (made of beta-alanine and histidine) that acts as an antioxidant and buffer in muscle and brain...
Theoretically, taking carnosine with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Carnosine + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCarqueja Possible
What it is: Carqueja is a South American herb traditionally used as a bitter tea for digestion, liver complaints, and blood sugar.
Theoretically, carqueja might lower blood glucose levels and might have additive effects when used with antidiabetes drugs.
Read the full Carqueja + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCashewAnacardium Occidentale, acajou Oil, anacarde, +13 more Possible
What it is: Cashews are a nutritious tree nut that provides protein, healthy fats, fiber, and minerals like magnesium and copper.
Eating a diet that consists of high amounts of cashew might increase fasting blood glucose levels.
Read the full Cashew + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCassia Auriculata Possible
What it is: Cassia auriculata (often called Tanner's cassia or Avaram) is a flowering shrub used in traditional Indian medicine, especially for blood su...
Theoretically, Cassia auriculata may reduce blood glucose levels and might have additive effects on glucose levels when used with antidiabetes drugs.
Read the full Cassia Auriculata + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCassia CinnamonCinnamomum Aromaticum, bastard Cinnamon, chinese Cinnamon, +1 more Possible
What it is: Cassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar suppor...
Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Read the full Cassia Cinnamon + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCat's ClawGriffe Du Chat, hawk's Claw, liane Du Pérou, +4 more Possible
What it is: Cat's claw is a South American vine traditionally used for inflammation, joint pain, and immune support.
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Cat's Claw + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCeylon CinnamonCinnamomum Verum, batavia Cassia, batavia Cinnamon, +13 more Possible
What it is: Ceylon cinnamon is the so-called 'true' cinnamon, valued as a spice and used in traditional medicine for blood sugar, cholesterol, and diges...
Theoretically, Ceylon cinnamon may have additive effects with antidiabetes drugs.
Read the full Ceylon Cinnamon + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCeylon Leadwort Possible
What it is: Ceylon Leadwort (Plumbago zeylanica) is a plant long used in Ayurvedic and other traditional medicine systems, mainly for digestion, skin pr...
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.
Read the full Ceylon Leadwort + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionChaga Possible
What it is: Chaga is a fungus that grows mostly on birch trees and is used as a tea or supplement, mainly for immune and antioxidant support.
Theoretically, taking chaga with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Chaga + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionChanca PiedraPhyllanthus Niruri, amli, arranca-pedras, +16 more Possible
What it is: Chanca piedra is a tropical herb traditionally used as a 'stone breaker' for kidney and gallstones, and for liver and urinary health.
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Chanca Piedra + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionChicoryCichorium Intybus, achicoria, barbe De Capucin, +14 more Possible
What it is: Chicory is best known as a caffeine-free coffee substitute and as a source of inulin, a soluble prebiotic fiber that may support digestion a...
Theoretically, chicory might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Chicory + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionChinese CucumberChinese Cucumber Fruit, chinese Cucumber Root, chinese Cucumber Seed, +11 more Possible
What it is: Chinese cucumber (Trichosanthes kirilowii) is a plant used in traditional Chinese medicine, and a protein from its root called trichosanthin...
Theoretically, concomitant use of Chinese cucumber with antidiabetic drugs may have additive effects and adverse effects.
Read the full Chinese Cucumber + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionChinese Mallow Possible
What it is: Chinese Mallow (Malva verticillata) is a leafy plant used in traditional Chinese and Asian medicine, mostly for constipation, urinary compla...
Theoretically, concomitant use with Chinese mallow might increase the risk for hypoglycemia.
Read the full Chinese Mallow + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionChirata Possible
What it is: Chirata is a very bitter herb used in traditional Ayurvedic and South Asian medicine, mainly for digestion, fever, and as a general tonic.
Theoretically, taking chirata concomitantly with antidiabetes drugs may increase the risk of hypoglycemia.
Read the full Chirata + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionChokeberryAronia Arbutifolia, aronia Melanocarpa, aronia Nigra, +1 more Possible
What it is: Chokeberry (aronia) is a dark berry rich in antioxidants called polyphenols, and it's widely eaten as juice, jam, and supplements.
Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.
Read the full Chokeberry + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionChromium Possible
What it is: Chromium is an essential trace mineral involved in how the body handles sugar and fat.
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCissus QuadrangularisVitis Quadrangularis, veldt Grape, adamant Creeper Possible
What it is: Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management.
Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Cissus Quadrangularis + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCloveSyzygium Aromaticum, bourgeon Floral De Clou De Girofle, bouton Floral De Clou De Girofle, +12 more Possible
What it is: Clove is a common cooking spice that is also used in traditional medicine, especially as a topical numbing agent for tooth pain thanks to it...
Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.
Read the full Clove + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCocaErythroxylum Coca, bolivian Coca, coca De Java, +11 more Possible
What it is: Coca is a South American plant best known as the natural source of cocaine.
Theoretically, coca might reduce the effects of antidiabetes drugs.
Read the full Coca + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCod Liver Oil Possible
What it is: Cod liver oil supplies omega-3 fatty acids (EPA and DHA) along with vitamins A and D, and is popular for heart, joint, and general health su...
Theoretically, taking cod liver oil with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Cod Liver Oil + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCodonopsis Possible
What it is: Codonopsis (often called 'dang shen') is a root long used in Traditional Chinese Medicine as a gentle energy and digestive tonic, frequently...
Theoretically, codonopsis might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Codonopsis + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionColeus6beta, 17beta-acetoxy-8, 13-epoxy-1alpha, +15 more Possible
What it is: Coleus is a plant from the mint family whose root contains a compound called forskolin, often marketed for weight loss, asthma, and heart he...
Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.
Read the full Coleus + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCollard Possible
What it is: Collard is a leafy green vegetable in the cabbage family that is rich in vitamins, minerals, and fiber, and is best thought of as a nutritio...
In an animal study, an aqueous extract of collard leaves and stems has been shown to reduce glucose levels.
Read the full Collard + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionColocynth Possible
What it is: Colocynth is a bitter desert gourd used in traditional medicine mainly as a powerful laxative, but it is highly toxic and can cause severe,...
Theoretically, colocynth might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Colocynth + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCombretum MicranthumAntidote à L'opium, antidote D'opium, antídoto De Opio, +8 more Possible
What it is: Combretum micranthum (kinkeliba) is a West African shrub whose leaves are brewed into a traditional tea for digestion, liver complaints, and...
Theoretically, taking Combretum micranthum leaf with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Combretum Micranthum + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCorianderCoriandrum Sativum, coriander Essential Oil, coriandre, +5 more Possible
What it is: Coriander (also called cilantro) is a common cooking herb and spice that has long been used in traditional medicine for digestive complaints...
Theoretically, coriander might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Coriander + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCorn SilkZea Mays, barbe De Maïs, blé D'inde, +13 more Possible
What it is: Corn silk is a traditional herbal remedy taken as a tea or extract, mostly for urinary and mild fluid-related complaints.
Theoretically, taking corn silk with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Corn Silk + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCorydalis Yanhusuo Possible
What it is: Corydalis yanhusuo is a traditional Chinese herb used mainly for pain.
Theoretically, Corydalis yanhusuo might increase serum levels of drugs metabolized by CYP3A4.
Read the full Corydalis Yanhusuo + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCowhage Possible
What it is: Cowhage (Mucuna pruriens) is a tropical legume best known as a natural source of L-dopa, the compound the body turns into dopamine.
Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Cowhage + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCranberryVaccinium Macrocarpon, agrio, american Cranberry, +16 more Possible
What it is: Cranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate bu...
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCubebsPiper Cubeba, cubeb, cubeb Berries, +14 more Possible
What it is: Cubebs are spicy, peppery berries from a vine in the pepper family that have long been used in traditional medicine for coughs, digestion, a...
Several compounds isolated from cubebs can inhibit cytochrome P450 3A4 (CYP3A4) in vitro.
Read the full Cubebs + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCucumber Possible
What it is: Cucumber is a common food vegetable that is mostly water and is generally safe to eat.
Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Read the full Cucumber + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCudweed Possible
What it is: Cudweed is a small, woolly-leaved plant used in traditional herbal medicine, mainly as a tea or gargle for sore throats, digestive upset, an...
Preliminary research in rats shows that cudweed might lower blood glucose levels.
Read the full Cudweed + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDamianaTurnera Diffusa, turnera Aphrodisiaca, turnera Diffusa Var. Aphrodisiaca, +1 more Possible
What it is: Damiana is a traditional herb most famous as an aphrodisiac and mild mood-lifter, but solid human evidence for any of its uses is very limit...
Theoretically, taking damiana with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Damiana + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDandelionTaraxacum Officinale, blowball, cankerwort, +17 more Possible
What it is: Dandelion is a common plant used in food and traditional medicine, often promoted as a natural 'water pill' and digestive aid.
Theoretically, dandelion might increase the risk for hypoglycemia when used with antidiabetes drugs.
Read the full Dandelion + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDanshenSalvia Bowleyana, ch'ih Shen, chinese Red Sage, +15 more Possible
What it is: Danshen is a root used in traditional Chinese medicine, mainly for heart and circulation problems.
Danshen might alter the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Danshen + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDevil's ClawHarpagophytum Procumbens, devils Claw, devil's Claw Root, +9 more Possible
What it is: Devil's claw is a southern African plant used mainly for arthritis and back pain, and some studies suggest it may help ease these types of d...
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDhea3b-hydroxy-androst-5-ene-17-one, 3betahydroxy-androst-5-ene-17-one, androstenolone, +4 more Possible
What it is: DHEA is a natural hormone that the body makes and that declines with age, and it is sold as a supplement claiming many benefits.
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dhea + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDill Possible
What it is: Dill is a common culinary herb that has long been used in traditional medicine for digestive complaints, but solid human evidence for any me...
Theoretically, dill extract might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
Read the full Dill + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDiosmin Possible
What it is: Diosmin is a citrus-derived flavonoid most often used for vein-related problems such as chronic venous insufficiency and hemorrhoids, and it...
Theoretically, diosmin might inhibit the metabolism of CYP3A4 substrates.
Read the full Diosmin + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDocosahexaenoic Acid (dha)Adh, dha, fish Oil Fatty Acid, +7 more Possible
What it is: DHA is an omega-3 fatty acid found in fatty fish and algae that is a building block for the brain, nervous system, and eyes.
Theoretically, taking DHA with antidiabetes drugs might reduce the effects of these medications.
Read the full Docosahexaenoic Acid (dha) + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDragon Fruit Possible
What it is: Dragon fruit is a colorful tropical fruit that is a nutritious, low-calorie source of fiber, vitamin C, and antioxidants.
Dragon fruit might lower blood glucose levels.
Read the full Dragon Fruit + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionEchinaceaAmerican Cone Flower, black Sampson, black Susans, +7 more Possible
What it is: Echinacea is a popular herb taken to help prevent or shorten the common cold, but study results are mixed and the overall benefit appears sm...
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionElderflower Possible
What it is: Elderflower comes from the elder plant (Sambucus nigra) and is traditionally used as a tea or extract for colds, sinus congestion, and fever...
Theoretically, elderflower might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Elderflower + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionEleutheroEleutherococcus Senticosus, acanthopanax Obovatus, ciwujia Root, +13 more Possible
What it is: Eleuthero is an herb traditionally used as an 'adaptogen' to fight fatigue, boost energy, and help the body handle stress.
Theoretically, eleuthero might have additive effects when used with antidiabetes drugs.
Read the full Eleuthero + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionEllagic Acid Possible
What it is: Ellagic acid is a natural plant compound (a polyphenol) found in foods like pomegranates, raspberries, strawberries, and walnuts.
Some clinical research shows that ellagic acid reduces fasting and postprandial glucose levels in patients with type 2 diabetes who are on stable doses of hypoglycemic agents such as metformin.
Read the full Ellagic Acid + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionEucalyptusEucalyptus Globulus, blue Gum, blue Mallee, +13 more Possible
What it is: Eucalyptus is best known for its strong-smelling oil used in vapor rubs, inhalants, and lozenges to ease coughs and congestion.
Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.
Read the full Eucalyptus + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionEuropean BarberryBerberis Vulgaris, agracejo, barberry, +15 more Possible
What it is: European barberry is a shrub whose root, bark, and berries contain berberine, a bitter plant alkaloid that has been studied mostly in isolat...
Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.
Read the full European Barberry + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionEvodia Possible
What it is: Evodia is a fruit used in traditional Chinese medicine, most often for digestive complaints, headaches, and menstrual pain.
Theoretically, evodia might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Evodia + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionEyebrightEuphrasia Rostkoviana, euphrasia Officinalis, euphrasia Stricta, +13 more Possible
What it is: Eyebright is a traditional herb long used for minor eye irritation, redness, and allergy symptoms, but high-quality human studies are very l...
Theoretically, eyebright might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Eyebright + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionFalse UnicornChamaelirium Luteum, alétris, blazing Star, +9 more Possible
What it is: False Unicorn is a North American plant whose root has long been used in traditional medicine for women's reproductive and menstrual concern...
In vitro, false unicorn extract inhibits cytochrome P450 3A4 (CYP3A4) activity.
Read the full False Unicorn + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionFasting Possible
What it is: Fasting means voluntarily going without food (and sometimes drink) for set periods.
Fasting might increase the risk of hypoglycemia if used with antidiabetes drugs.
Read the full Fasting + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionFennelFoeniculum Vulgare, adas, almindelig Fennikel, +20 more Possible
What it is: Fennel is a Mediterranean herb widely used as a food and spice, and traditionally taken for digestive complaints, colic, and menstrual cramp...
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionFeverfewTanacetum Parthenium, altamisa, bachelor's Buttons, +13 more Possible
What it is: Feverfew is a daisy-family herb best known for migraine prevention, where some studies suggest it may modestly lower how often migraines occ...
Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.
Read the full Feverfew + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionFo-ti Possible
What it is: Fo-ti (He Shou Wu) is a root used in traditional Chinese medicine, often promoted for healthy aging and hair.
Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Fo-ti + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionGalbanum Possible
What it is: Galbanum is an aromatic gum resin from a Ferula plant, used mostly in perfumes, incense, and traditional remedies.
Theoretically, taking galbanum with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Galbanum + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionGarciniaGarcinia Gummi-gutta, acide Hydroxycitrique, ahc, +11 more Possible
What it is: Garcinia is a tropical fruit whose rind contains hydroxycitric acid (HCA), widely marketed for weight loss and appetite control.
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
Read the full Garcinia + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionGarden CressLepidium Sativum, berro Hortelano, cresson Alénois, +3 more Possible
What it is: Garden cress is a nutritious leafy herb and seed used widely in cooking and traditional medicine, providing vitamins, minerals, and fiber.
Theoretically, taking garden cress with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Garden Cress + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionGarlicAllium Sativum, aged Black Garlic Extract, aged Garlic Extract, +16 more Possible
What it is: Garlic is a common food and supplement that may modestly help with blood pressure and cholesterol, though the evidence is mixed and effects...
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionGerman ChamomileMatricaria Recutita, blue Chamomile, camomèle, +12 more Possible
What it is: German chamomile is a widely used herbal remedy taken mainly as a tea for calming, sleep, and digestive complaints.
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full German Chamomile + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionGingerZingiber Officinale, african Ginger, ardraka, +21 more Possible
What it is: Ginger is a widely used culinary spice with a long history in traditional medicine, and it has the strongest evidence for helping with nause...
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionGinkgoGinkgo Biloba, abricot Argenté Japonais, adiantifolia, +13 more Possible
What it is: Ginkgo is one of the world's most popular herbal supplements, mostly taken to support memory and circulation.
Theoretically, ginkgo might decrease levels of drugs metabolized by CYP3A4.
Read the full Ginkgo + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionGojiLycium Chinense, lycium Barbarum, barberry Matrimony Vine, +15 more Possible
What it is: Goji berries are a nutritious fruit rich in antioxidants, vitamins, and plant polysaccharides, and they are safe for most people as a food.
Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
Read the full Goji + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionGoldensealHydrastis Canadensis, chinese Goldenseal, eye Balm, +14 more Possible
What it is: Goldenseal is a popular North American herb that contains berberine, a compound studied for antimicrobial effects.
Goldenseal might increase serum levels of drugs metabolized by CYP3A4.
Read the full Goldenseal + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionGoldthreadCoptis Chinensis, cankerroot, chinese Coptis, +13 more Possible
What it is: Goldthread is a traditional Chinese and East Asian herb whose root is rich in berberine, a compound being studied for blood sugar, cholester...
There's very preliminary evidence that berberine, a constituent of goldthread, might inhibit cytochrome P450 3A4 (CYP3A4) enzyme.
Read the full Goldthread + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionGrapeVitis Vinifera, activin, black Grape Raisins, +10 more Possible
What it is: Grapes and grape products like grape seed extract contain antioxidant compounds such as resveratrol and proanthocyanidins that may support h...
It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
Read the full Grape + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionGuarumoCecropia Obtusifolia, chancarro, grayumbo, +9 more Possible
What it is: Guarumo (Cecropia obtusifolia) is a tropical tree used in Latin American traditional medicine, most often as a leaf tea for diabetes and hig...
Some clinical evidence suggests that drinking tea prepared with guarumo leaf might lower blood glucose levels in people with type 2 diabetes.
Read the full Guarumo + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionGuava Possible
What it is: Guava is a tropical fruit tree whose leaves and fruit have a long history of folk use for diarrhea, blood sugar, and general wellness.
Theoretically, concomitant use with antidiabetes drugs might have additive effects and increase the risk of hypoglycemia.
Read the full Guava + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionGum ArabicAcacia, acacia Gum, arabic Gum, +16 more Possible
What it is: Gum arabic is a soluble dietary fiber from the acacia tree that is widely used as a safe food additive and is sometimes taken as a supplemen...
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Gum Arabic + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionHibiscus SabdariffaHibiscus Sabdariffa, agua De Jamaica, ambashthaki, +16 more Possible
What it is: Hibiscus sabdariffa is a tart, cranberry-flavored plant most often consumed as a tea, and its best-studied use is for mildly lowering blood...
Theoretically, taking Hibiscus sabdariffa with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Hibiscus Sabdariffa + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionHigenamine Possible
What it is: Higenamine is a plant-based stimulant compound added to many weight-loss and pre-workout supplements, but there is very little human evidenc...
Theoretically, higenamine might increase the levels and clinical effects drugs metabolized by CYP3A4.
Read the full Higenamine + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionHollyhock Possible
What it is: Hollyhock is a flowering plant in the mallow family that has been used in traditional medicine, mainly as a soothing (demulcent) remedy for...
Animal and in vitro research shows that hollyhock flower extracts might lower blood glucose levels.
Read the full Hollyhock + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionHoly BasilOcimum Tenuiflorum, ocimum Sanctum Possible
What it is: Holy basil (tulsi) is a traditional Ayurvedic herb most often used today for stress and general wellness, but the human evidence is mostly s...
Theoretically, holy basil might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Holy Basil + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionHoodiaHoodia Gordonii, cactus, cactus Hoodia, +6 more Possible
What it is: Hoodia is a succulent plant from southern Africa that is marketed as an appetite suppressant for weight loss, but solid human evidence that...
Animal research shows that a steroid glycoside of hoodia, gordonoside F, increases glucose-stimulated insulin secretion by activating GPR119.
Read the full Hoodia + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionHorny Goat WeedEpimedium Grandiflorum, barrenwort, Épimède, +10 more Possible
What it is: Horny goat weed (Epimedium) is a traditional Chinese herb most often marketed for low libido and erectile problems, but solid human evidence...
Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
Read the full Horny Goat Weed + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionHorsetailEquisetum Arvense, alligator Cane, asprêle, +15 more Possible
What it is: Horsetail is a traditional herb most often used as a mild diuretic and for hair, nail, and bone support, but high-quality human evidence is...
Theoretically, taking horsetail with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Horsetail + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionHu Zhang Possible
What it is: Hu Zhang (Japanese knotweed root) is a traditional Chinese herb that is one of the richest natural sources of resveratrol and emodin.
Theoretically, hu zhang might increase levels of drugs metabolized by CYP3A4.
Read the full Hu Zhang + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionHydrazine Sulfate Possible
What it is: Hydrazine sulfate is a synthetic industrial chemical that was promoted as an alternative cancer treatment, but well-designed clinical trials...
Theoretically, taking hydrazine sulfate concomitantly with antidiabetes drugs could increase the risk for hypoglycemia.
Read the full Hydrazine Sulfate + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionIndian Cassia Possible
What it is: Indian Cassia (Cinnamomum tamala), also known as Indian bay leaf or tejpat, is an aromatic leaf used widely as a cooking spice and in tradit...
Theoretically, Indian cassia might have additive effects with antidiabetes drugs.
Read the full Indian Cassia + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionIndian GooseberryPhyllanthus Emblica, aamalaki, amalaki, +14 more Possible
What it is: Indian gooseberry (amla) is a vitamin C-rich fruit used in Ayurvedic medicine for many purposes, from antioxidant support to cholesterol and...
Taking Indian gooseberry with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Indian Gooseberry + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionIndian Long PepperPiper Longum, bi Ba, bi Bo, +17 more Possible
What it is: Indian long pepper (pippali) is a spice long used in Ayurvedic medicine and is best known for its piperine content, which may increase how w...
Theoretically, Indian long pepper might increase the effects and adverse effects of CYP3A4 substrates.
Read the full Indian Long Pepper + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionIndian SnakerootRauvolfia Serpentina, ajmaline, alseroxylon, +16 more Possible
What it is: Indian snakeroot is a traditional Ayurvedic plant that contains reserpine, a compound with real blood-pressure-lowering and sedative effects...
Theoretically, concomitant use of Indian snakeroot with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Indian Snakeroot + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionIndigo Pulchra Possible
What it is: Indigo Pulchra is not a plant or supplement that we can find in any reliable scientific or herbal reference.
Theoretically, indigo pulchra might lower blood glucose levels and might have additive effects when used with antidiabetes drugs.
Read the full Indigo Pulchra + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionInositolHexahydroxycyclohexane, antialopecia Factor, cyclohexitol, +10 more Possible
What it is: Inositol is a sugar alcohol made naturally in the body and found in many foods, and it is sold as a supplement (often myo-inositol) mainly f...
Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Inositol + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionIrvingia GabonensisIrvingia Gabonensis, synonyms Irvingia Barteri, mangifera Gabonensis Possible
What it is: Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health.
Theoretically, taking Irvingia gabonensis with antidiabetes drugs might increase the risk of hypoglycemia in some patients.
Read the full Irvingia Gabonensis + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionJackfruitArtocarpus Heterophyllus, arbol Del Pan, baramil, +21 more Possible
What it is: Jackfruit is a large tropical fruit that is nutritious and safe to eat as a food, offering fiber, vitamin C, potassium, and antioxidants.
Theoretically, jackfruit might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Jackfruit + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionJambolan Possible
What it is: Jambolan (Syzygium cumini), also called Java plum or black plum, is a tropical fruit tree traditionally used for blood sugar and digestive c...
Animal research shows that jambolan seed and bark extracts can lower blood glucose levels.
Read the full Jambolan + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionJapanese Apricot Possible
What it is: Japanese Apricot (Prunus mume) is a tart fruit used widely in East Asian foods and traditional medicine, often as pickled umeboshi or a conc...
Theoretically, taking Japanese apricot in combination with antidiabetes drugs might lower blood glucose and increase the risk of hypoglycemia.
Read the full Japanese Apricot + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionJequirityAbrus Precatorius, bead Vine, black-eyed Susan, +19 more Possible
What it is: Jequirity (Abrus precatorius) is a tropical plant whose bright red, black-tipped seeds contain abrin, one of the most toxic plant proteins k...
Evidence from animal research suggests that an extract of jequirity can reduce blood glucose levels.
Read the full Jequirity + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionJiaogulanGynostemma Pentaphyllum, adaptogen, adaptogène, +13 more Possible
What it is: Jiaogulan is a climbing vine used in traditional Chinese medicine as an adaptogen and for heart, blood sugar, and cholesterol support.
Theoretically, jiaogulan might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Jiaogulan + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionJob's Tears Possible
What it is: Job's Tears is a grain-like seed long used as a food and in traditional medicine, especially in East Asia.
Preliminary evidence shows that constituents of Job's tears might have hypoglycemic effects.
Read the full Job's Tears + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionJuniper Possible
What it is: Juniper berry is a traditional herb best known for flavoring gin and for its folk use as a diuretic and digestive aid.
Theoretically, taking juniper berry with antidiabetes medications might cause additive hypoglycemia.
Read the full Juniper + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionKetogenic Diet Possible
What it is: The ketogenic diet is a very low-carbohydrate, high-fat eating plan that shifts the body to burn fat for fuel.
Theoretically, following the ketogenic diet while using antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Ketogenic Diet + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionKombucha Possible
What it is: Kombucha is a fermented tea that many people enjoy as a probiotic-rich beverage, but solid human research proving specific health benefits i...
Theoretically, kombucha might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Kombucha + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionKousso Possible
What it is: Kousso is the dried flower of the African tree Hagenia abyssinica, used traditionally—especially in Ethiopia—to expel tapeworms.
Theoretically, kousso might have an additive effect with antidiabetes drugs and cause hypoglycemia.
Read the full Kousso + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionKratomMitragyna Speciosa, biak-biak, cratom, +16 more Possible
What it is: Kratom is a Southeast Asian plant whose leaves act on the brain's opioid receptors and can produce both stimulant-like and opioid-like effec...
Kratom might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Kratom + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionKrill Oil Possible
What it is: Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption.
Theoretically, taking krill oil with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Krill Oil + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionL-arginine2-amino-5-guanidinopentanoic Acid Possible
What it is: L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen.
Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Read the full L-arginine + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionL-cysteine Possible
What it is: L-cysteine is a sulfur-containing amino acid your body uses to make proteins and the antioxidant glutathione.
Theoretically, taking L-cysteine supplements with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full L-cysteine + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionLemongrassCymbopogon Citratus, abafado, cana Santa, +17 more Possible
What it is: Lemongrass is a fragrant tropical grass widely used as a cooking herb, a tea, and an aromatherapy oil.
Theoretically, lemongrass might decrease the metabolism of CYP3A4 substrates.
Read the full Lemongrass + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionLentinanBeta-glucan Lentinan, lentinane, lentinus Edodes Polysaccharide, +4 more Possible
What it is: Lentinan is a beta-glucan polysaccharide from shiitake mushrooms that is studied mainly as an immune-modulating add-on to cancer chemotherap...
Laboratory research suggests that lentinan might increase the activity of cytochrome P450 3A4 (CYP3A4).
Read the full Lentinan + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionLicoriceGlycyrrhiza Echinate, alcacuz, bois Doux, +17 more Possible
What it is: Licorice root is a traditional remedy used for sore throats, coughs, and digestive complaints, but solid human evidence is limited for most...
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Licorice + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionLimeCitrus Aurantifolia, adam's Apple, bara Nimbu, +11 more Possible
What it is: Lime is a common citrus fruit and a good natural source of vitamin C and plant antioxidants.
Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4.
Read the full Lime + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionLion's Mane MushroomBearded Tooth, crinière De Lion, hedgehog Fungus, +9 more Possible
What it is: Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still li...
Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Read the full Lion's Mane Mushroom + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionLotusNelumbo Nucifera, bean Of India, blue Lotus, +20 more Possible
What it is: Lotus is an edible aquatic plant used in food and traditional medicine across Asia, with parts like the seeds, leaves, and flowers taken for...
Theoretically, lotus might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
Read the full Lotus + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionLychee Possible
What it is: Lychee is a sweet tropical fruit that is nutritious and a source of vitamin C and antioxidant plant compounds.
Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full Lychee + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionMadagascar Periwinkle Possible
What it is: Madagascar periwinkle is a flowering plant famous as the natural source of important chemotherapy drugs (vincristine and vinblastine), but t...
Animal research shows that Madagascar periwinkle lowers blood glucose levels in diabetic rats.
Read the full Madagascar Periwinkle + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionMaitake MushroomGrifola Frondosa, champignon Dansant, champignon Des Fous Dansants, +13 more Possible
What it is: Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sug...
Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Maitake Mushroom + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionManchurian Thorn Possible
What it is: Manchurian Thorn (Aralia elata) is a thorny shrub or small tree used in traditional East Asian medicine, mainly for blood sugar, joint pain,...
Animal research suggests that saponins isolated from Manchurian thorn can lower plasma glucose levels.
Read the full Manchurian Thorn + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionMaritime PinePinus Pinaster, condensed Tannins, french Marine Pine Bark Extract, +13 more Possible
What it is: Maritime pine bark extract (often sold as Pycnogenol) is a plant-based antioxidant most studied for circulation, vein, and skin health.
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full Maritime Pine + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionMelatoninN-acetyl-5-methoxytryptamine Possible
What it is: Melatonin is a hormone your body makes naturally to help control your sleep-wake cycle, and the supplement form is widely used to help with...
Theoretically, taking melatonin with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Melatonin + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionMethoxylated Flavones Possible
What it is: Methoxylated flavones (often called polymethoxyflavones) are a group of plant compounds, found mainly in citrus peel, that include substance...
In vitro evidence suggests that methoxylated flavones might inhibit cytochrome P450 3A4 (CYP3A4).
Read the full Methoxylated Flavones + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionMilk ThistleSilybum Marianum, artichaut Sauvage, blessed Milk Thistle, +12 more Possible
What it is: Milk thistle is a popular herbal supplement most often used for liver health, and its main active component is a group of compounds called s...
Taking milk thistle with antidiabetes drugs may increase the risk of hypoglycemia.
Read the full Milk Thistle + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionMiracle FruitSynsepalum Dulcificum, bumelia Dulcifica, richadellla Dulcifica, +8 more Possible
What it is: Miracle fruit contains a protein called miraculin that temporarily makes sour and acidic foods taste sweet for up to about an hour.
Theoretically, miracle fruit leaf might have an additive effect with antidiabetes drugs and increase the risk of hypoglycemia.
Read the full Miracle Fruit + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionMoringaMoringa Oleifera Possible
What it is: Moringa is a nutrient-rich plant whose leaves are widely used as a food and supplement, especially in parts of the world where malnutrition...
Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.
Read the full Moringa + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionMyrrhCommiphora Myrrha, abyssinian Myrrh, african Myrrh, +21 more Possible
What it is: Myrrh is a fragrant gum resin from Commiphora trees that has long been used in mouthwashes, throat remedies, and skin care.
Theoretically, myrrh might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Myrrh + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionNeemAzadirachta Indica, arishta, arishtha, +18 more Possible
What it is: Neem is a tree from India used for centuries in traditional medicine, especially for skin, dental, and antimicrobial purposes.
Theoretically, neem leaf extract might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Neem + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionOats Possible
What it is: Oats are a well-studied whole grain whose soluble fiber (beta-glucan) can help lower cholesterol and support heart health when eaten regular...
Theoretically, oats may have additive effects with antidiabetic agents and might increase the risk of hypoglycemia.
Read the full Oats + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionOctacosanol Possible
What it is: Octacosanol is a waxy long-chain alcohol from plant sources that is most often promoted for exercise endurance and cholesterol support, but...
Theoretically, octacosanol might have additive effects when used in combination with antidiabetes drugs.
Read the full Octacosanol + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionOleic Acid Possible
What it is: Oleic acid is a heart-healthy monounsaturated fat found mainly in olive oil, canola oil, avocados, and nuts.
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionOnionAllium Cepa, allii Cepae Bulbus, cebolla, +9 more Possible
What it is: Onion is a common food with a long history in traditional medicine, and it contains antioxidants like quercetin and sulfur compounds.
Concomitant use of antidiabetes drugs with onion may increase the risk of hypoglycemia.
Read the full Onion + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionOreganoOriganum Vulgare, carvacrol, european Oregano, +13 more Possible
What it is: Oregano is a common Mediterranean cooking herb that is also sold as a concentrated oil or supplement, often standardized for a compound call...
Theoretically, oregano might increase the risk for hypoglycemia when taken with antidiabetes drugs.
Read the full Oregano + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionOregon GrapeMahonia Aquifolium, barberry, berberis, +13 more Possible
What it is: Oregon grape is a shrub whose root contains berberine and related compounds.
Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP3A4.
Read the full Oregon Grape + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionPadang Cassia Possible
What it is: Padang Cassia is a type of cinnamon (Indonesian or Korintje cinnamon) grown mainly in Indonesia and used widely as a kitchen spice.
In vitro research shows that a methanol extract of Padang cassia inhibits cytochrome P450 3A4 (CYP3A4) activity.
Read the full Padang Cassia + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionParsleyPetroselinum Crispum, common Parsley, garden Parsley, +16 more Possible
What it is: Parsley is a popular culinary herb that is safe to eat in normal food amounts and is a good source of vitamins K and C.
Theoretically, parsley might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Parsley + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionPata De Vaca Possible
What it is: Pata de Vaca is a South American plant whose leaves are traditionally brewed as a tea to help support blood sugar, earning it the nickname '...
Animal research suggests that pata de vaca may have hypoglycemic effects.
Read the full Pata De Vaca + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionPeonyPaeonia Lactiflora, bai Shao, chi Shao, +17 more Possible
What it is: Peony root is a traditional Chinese medicine herb often used for menstrual problems, cramps, and inflammation, frequently as part of combina...
Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Peony + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionPeppermintMentha X Piperita, black Peppermint, brandy Mint, +12 more Possible
What it is: Peppermint is a popular herb with the best evidence supporting enteric-coated peppermint oil for easing IBS symptoms.
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionPhaseolus Vulgaris Possible
What it is: Phaseolus vulgaris, the common bean, is widely eaten as food, and a concentrated white bean extract is marketed as a 'carb blocker' for weig...
Theoretically, Phaseolus vulgaris might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Phaseolus Vulgaris + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionPhellodendronPhellodendron Amurense, amur Cork Bark, amur Cork Tree, +7 more Possible
What it is: Phellodendron is a traditional Chinese medicine bark (Huang Bai) that contains berberine and other plant compounds with antimicrobial and an...
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.
Read the full Phellodendron + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionPhlorizin Possible
What it is: Phlorizin is a natural plant compound (a dihydrochalcone) found in apple tree bark and other plants that has been studied mostly in the labo...
Phlorizin is a potent, nonselective inhibitor of SGLT1 and SGLT2.
Read the full Phlorizin + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionPicrorhiza Possible
What it is: Picrorhiza (Picrorhiza kurroa) is a bitter Himalayan herb used in Ayurvedic medicine, mainly for liver and digestive complaints.
Evidence from animal research suggests that an extract of picrorhiza can reduce fasting and non-fasting blood sugar levels.
Read the full Picrorhiza + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionPolicosanol32c, dotriacontanol, heptacosanol, +8 more Possible
What it is: Policosanol is a mix of waxy alcohols (mostly octacosanol) made from sugar cane or other plant waxes, and it is often marketed as a natural...
Theoretically, policosanol might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
Read the full Policosanol + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionPropolisAcide De Cire D'abeille, baume De Propolis, bee Glue, +12 more Possible
What it is: Propolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies.
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Propolis + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionPurple Nut Sedge Possible
What it is: Purple nut sedge (Cyperus rotundus) is a common weed whose tubers have a long history in Ayurvedic, Chinese, and other traditional medicine...
Evidence from animal research suggests that purple nut sedge can reduce blood glucose levels.
Read the full Purple Nut Sedge + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionQuassia Possible
What it is: Quassia is a tropical wood known for its very bitter taste, traditionally used as a digestive bitter and as a folk remedy for parasites and...
In animals, quassia extract reduced levels of fasting glucose.
Read the full Quassia + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionQuercetin7-pentahydroxyflavone, bioflavonoid, bioflavonoid Complex, +9 more Possible
What it is: Quercetin is a plant flavonoid with antioxidant and anti-inflammatory properties found in many common foods and sold as a supplement.
Theoretically, concomitant use might alter the effects and adverse effects of CYP3A4 substrates.
Read the full Quercetin + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionRabdosia RubescensRabdosia Rubescens, bing Ling Cao, blushred Rabdosia, +5 more Possible
What it is: Rabdosia rubescens is a Chinese herb traditionally used for sore throats, inflammation, and infections, and its compound oridonin has drawn...
In vitro research shows that oridonin, a constituent of Rabdosia rubescens, induces cytochrome P450 3A4 (CYP3A4) enzyme.
Read the full Rabdosia Rubescens + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionRadish Possible
What it is: Radish is a common edible root vegetable that is nutritious and generally safe to eat as food.
Theoretically, radish might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Radish + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionRauvolfia Vomitoria Possible
What it is: Rauvolfia vomitoria is an African shrub whose root contains powerful alkaloids, including reserpine, that have historically been used for hi...
Theoretically, taking Rauvolfia vomitoria with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rauvolfia Vomitoria + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionRed Sandalwood Possible
What it is: Red Sandalwood (Pterocarpus santalinus) is a hardwood used in traditional medicine and in skin and cosmetic preparations, valued for its red...
Animal research shows that an aqueous extra of red sandalwood bark reduces blood glucose levels.
Read the full Red Sandalwood + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionRehmannia Possible
What it is: Rehmannia is a root used for centuries in Traditional Chinese Medicine, often to 'tonify' the kidneys and support energy or blood health.
Theoretically, rehmannia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Rehmannia + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionReishi MushroomGanoderma Lucidum, basidiomycetes Mushroom, champignon Reishi, +15 more Possible
What it is: Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness.
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Read the full Reishi Mushroom + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionResveratrolExtrait De Vin, extrait De Vin Rouge, kojo-kon, +16 more Possible
What it is: Resveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant supp...
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Resveratrol + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionRhodiolaRhodiola Rosea, arctic Root, golden Root, +12 more Possible
What it is: Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress.
Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rhodiola + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionRooibosAspalathus Linearis, green Red Bush, infusion Rooibos, +9 more Possible
What it is: Rooibos is a caffeine-free herbal tea from South Africa that is rich in antioxidants and generally considered safe as a beverage.
Theoretically, taking rooibos with CYP3A4 substrates may increase the effects of CYP3A4 substrates.
Read the full Rooibos + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionRosemaryRosmarinus Officinalis, alecrim, compass Plant, +14 more Possible
What it is: Rosemary is a fragrant Mediterranean herb that is safe and flavorful in normal food amounts.
Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rosemary + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionRutin Possible
What it is: Rutin is a plant flavonoid (often taken from buckwheat or citrus) that people use mainly for blood vessel and circulation problems like vari...
Theoretically, taking rutin with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rutin + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionSafflowerCarthamus Tinctorius, alazor, american Saffron, +10 more Possible
What it is: Safflower is a thistle-like plant used mainly for its seed oil (a common cooking oil) and its colorful flowers.
Theoretically, safflower oil might alter the effects of antidiabetes drugs.
Read the full Safflower + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionSaffronCrocus Sativus, autumn Crocus, azafrán, +16 more Possible
What it is: Saffron is a costly spice that has shown promise in early studies for mild-to-moderate depression and some mood and PMS symptoms, but most r...
Theoretically, concomitant use of saffron with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Saffron + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionSageSalvia Officinalis, broadleaf Sage, common Sage, +14 more Possible
What it is: Sage is a common kitchen herb that is generally safe in food amounts and is traditionally used for sore throats, digestion, sweating, and me...
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Sage + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionSchizonepeta Possible
What it is: Schizonepeta is a mint-family herb long used in traditional Chinese medicine, usually as part of combination formulas for colds, fevers, and...
Animal research suggests that schizonepetin, a monoterpene constituent of schizonepeta, induces cytochrome P450 (CYP) 3A4.
Read the full Schizonepeta + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionSesame Possible
What it is: Sesame is a nutritious seed and oil widely used in cooking and traditional medicine, and it provides healthy fats, fiber, and antioxidant co...
Taking sesame oil with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Sesame + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionShilajit Possible
What it is: Shilajit is a sticky, tar-like substance found in rocks of mountain ranges like the Himalayas, used in traditional Ayurvedic medicine for en...
Taking shilajit with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Shilajit + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionSlippery ElmIndian Elm, moose Elm, olmo Americano, +7 more Possible
What it is: Slippery elm is a traditional herbal remedy made from the inner bark of a North American elm tree, used mainly to soothe sore throats and ir...
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionSolomon's SealPolygonatum Multiflorum Possible
What it is: Solomon's Seal is a traditional herb whose root has long been used for joint, tendon, and muscle complaints, but high-quality human studies...
Theoretically, concomitant use may enhance hypoglycemic drug effects and alter blood glucose control.
Read the full Solomon's Seal + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionSoy Possible
What it is: Soy is a nutritious bean that is a staple food and a popular source of plant protein and isoflavones.
Soy can lower blood glucose and have additive effects with antidiabetes drugs.
Read the full Soy + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionSpinach Possible
What it is: Spinach is a nutrient-dense leafy green that is a healthy part of a balanced diet, providing vitamins, minerals, fiber, and antioxidants.
There are claims that spinach leaves have hypoglycemic effects.
Read the full Spinach + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionStereospermum Possible
What it is: Stereospermum is a tree used in traditional Ayurvedic medicine, most notably as one of the herbs in the classic 'Dashamula' (ten-root) formu...
Animal research suggests that stereospermum can have hypoglycemic effects.
Read the full Stereospermum + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionStinging NettleUrtica Dioica, urtica Urens, bichu, +12 more Possible
What it is: Stinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain.
Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Read the full Stinging Nettle + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionSulforaphane Possible
What it is: Sulforaphane is a natural compound found in broccoli and other cruciferous vegetables that has shown promising antioxidant and anti-inflamma...
Theoretically, sulforaphane might increase the levels and effects of CYP3A4 substrates.
Read the full Sulforaphane + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionSunflower OilHelianthus Annuus Possible
What it is: Sunflower oil is a common edible vegetable oil rich in unsaturated fats and vitamin E that most people can use safely as part of a normal di...
Theoretically, sunflower oil might decrease the effectiveness of antidiabetes medications.
Read the full Sunflower Oil + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionSweet AnnieArtemisia Annua, absinthe Sauvage, ajenjo Silvestre, +11 more Possible
What it is: Sweet Annie (Artemisia annua) is the source of artemisinin, a compound used in prescription antimalarial drugs.
Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Sweet Annie + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionSyrian Rue Possible
What it is: Syrian Rue (Peganum harmala) is a traditional plant whose seeds contain potent compounds called harmala alkaloids, including MAO-inhibiting...
Theoretically, Syrian rue might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Syrian Rue + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionTamarind Possible
What it is: Tamarind is a tangy tropical fruit widely used in cooking and traditional medicine, mainly for digestion and as a mild laxative.
Theoretically, tamarind seed extract might have additive effects when used with antidiabetes drugs.
Read the full Tamarind + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionTerminaliaTerminalia Arjuna, abhaya, amandier Indien, +19 more Possible
What it is: Terminalia is a group of traditional Ayurvedic tree species (most notably Terminalia arjuna) used for heart, digestive, and general wellness...
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Terminalia + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionTerminalia Bellirica Possible
What it is: Terminalia bellirica, often called 'Bibhitaki,' is a fruit long used in Ayurvedic medicine and is one of the three ingredients in the popula...
Theoretically, concomitant use of Terminalia bellirica with antidiabetes drugs could affect blood sugar control and increase the risk of hypoglycemia.
Read the full Terminalia Bellirica + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionTerminalia Chebula Possible
What it is: Terminalia chebula, often called haritaki, is a fruit widely used in Ayurvedic medicine, most commonly for digestion and as a key part of th...
Theoretically, concomitant use of Terminalia chebula with antidiabetes drugs could affect blood sugar control and increase the risk of hypoglycemia.
Read the full Terminalia Chebula + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionTheaflavin Possible
What it is: Theaflavins are antioxidant compounds formed when tea leaves are oxidized to make black tea.
In an animal diabetic model, giving theaflavin reduced fasting blood glucose, with an effect comparable to metformin.
Read the full Theaflavin + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionThunder God VineTripterygium Wilfordii, huang-t'eng Ken, lei Gong Teng, +8 more Possible
What it is: Thunder God Vine is a Chinese herb studied mainly for rheumatoid arthritis and other autoimmune conditions, with some promising but limited...
Theoretically, thunder god vine might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Thunder God Vine + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionTinospora Cordifolia Possible
What it is: Tinospora cordifolia, known as Guduchi or Giloy in Ayurvedic medicine, is a climbing plant traditionally used to support immunity and treat...
Theoretically, Tinospora cordifolia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Tinospora Cordifolia + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionTiratricol Possible
What it is: Tiratricol (also called TRIAC) is a powerful synthetic thyroid hormone metabolite, not a natural herb, and it has been illegally added to so...
Theoretically, tiratricol might interfere with blood glucose control.
Read the full Tiratricol + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionTragacanthAdragante, astragale Adragant, astragale De Marseille, +14 more Possible
What it is: Tragacanth is a plant gum used mainly as a thickener and emulsifier in foods, cosmetics, and medicines, and traditionally to soothe the thro...
Theoretically, tragacanth might alter absorption of oral drugs.
Read the full Tragacanth + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionTribulusTribulus Terrestris, abrojo, abrojos, +17 more Possible
What it is: Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind th...
Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Tribulus + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionTronadora Possible
What it is: Tronadora (Tecoma stans) is a flowering shrub used in Mexican and Latin American folk medicine, most often as a tea for diabetes and digesti...
Theoretically, concomitant use of tronadora and antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Tronadora + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionTurkey Tail MushroomCoriolus Versicolor, cloud Mushroom Possible
What it is: Turkey tail is a woodland mushroom rich in polysaccharides like beta-glucans, and it is mainly used to support the immune system.
Theoretically, taking turkey tail mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Turkey Tail Mushroom + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionTurmericCurcuma Longa, curcuma, curcumae Longa, +17 more Possible
What it is: Turmeric is a popular spice whose main active compounds, curcuminoids, are studied mostly for inflammation and joint pain.
Turmeric might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Turmeric + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionUva UrsiArctostaphylos Uva-ursi, arberry, arbousier, +16 more Possible
What it is: Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have anti...
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Uva Ursi + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionVitamin EAlpha-tocopherol, beta-tocopherol, delta-tocopherol, +1 more Possible
What it is: Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet.
Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Read the full Vitamin E + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionWeight Watchers Diet Possible
What it is: Weight Watchers (now called WW) is a commercial weight-loss program built around a points system, food tracking, and group or online support...
Following the Weight Watchers diet while taking antidiabetes drugs may increase the risk of hypoglycemia.
Read the full Weight Watchers Diet + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionWheatgrassTriticum Aestivum, agropyre, blé En Herbe, +7 more Possible
What it is: Wheatgrass is the young grass of the wheat plant, taken as a juice or powder, and is mainly used as a concentrated source of vitamins and pl...
Theoretically, taking wheatgrass with antidiabetes drugs might lower blood glucose levels and increase the risk of hypoglycemia.
Read the full Wheatgrass + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionWhite HorehoundMarrubium Vulgare, bonhomme, grand Bonhomme, +8 more Possible
What it is: White horehound is a traditional bitter herb used mainly for coughs, sore throats, and mild digestive complaints, and it is a common flavori...
Evidence from animal research suggests that white horehound might lower blood glucose.
Read the full White Horehound + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionWhite MulberryMorus Alba, chinese White Mulberry, chin Sang, +8 more Possible
What it is: White mulberry leaf is most studied for helping blunt the rise in blood sugar after meals, but the human evidence is limited and not strong.
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionWhite Pepper Possible
What it is: White pepper comes from the same plant as black pepper and is mostly used as a kitchen spice.
In vitro evidence suggests that piperine, a constituent of white pepper, inhibits cytochrome P450 3A4 (CYP3A4).
Read the full White Pepper + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionWild CherryPrunus Serotine, american Black Cherry, bird Cherry, +12 more Possible
What it is: Wild cherry bark is a traditional cough remedy found in many old-fashioned cough syrups and lozenges, but there is little modern scientific...
In vitro research suggests that wild cherry can inhibit cytochrome P450 3A4 (CYP3A4) enzymes.
Read the full Wild Cherry + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionWinter Cherry Possible
What it is: Winter Cherry is another name for ashwagandha (Withania somnifera), an herb long used in Ayurvedic medicine, most often for stress, sleep, a...
In animal diabetic models, winter cherry extract decreases blood glucose.
Read the full Winter Cherry + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionZeaxanthin Possible
What it is: Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health.
Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Zeaxanthin + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionZedoary Possible
What it is: Zedoary is a ginger-family root used in traditional Asian and Indian medicine, mostly for digestion and as a spice.
Theoretically, zedoary might increase levels of drugs metabolized by CYP3A4.
Read the full Zedoary + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionZizyphusZiziphus Jujuba, anèbe, annab, +20 more Possible
What it is: Zizyphus (jujube) is an edible fruit and traditional remedy used mainly for sleep, anxiety, and digestion.
Theoretically, zizyphus might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Zizyphus + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionThyroid Extract Likely
What it is: Thyroid extract supplements are made from dried animal thyroid gland and may contain real thyroid hormones (T3 and T4), but the amounts in o...
Food and medications can interfere with thyroid hormone absorption.
Read the full Thyroid Extract + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionAnhydrous Crystalline MaltoseMalt Sugar Probable
What it is: Anhydrous crystalline maltose is a starch-derived sugar (also called malt sugar) studied mainly as a slow-dissolving lozenge to ease dry mou...
Maltose, a disaccharide composed of two glucose molecules, has the potential to affect blood sugar levels similarly to table sugar (sucrose).
Read the full Anhydrous Crystalline Maltose + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionAegeline Possible
What it is: Aegeline is a compound originally identified in the bael tree (Aegle marmelos) that gained attention because it was added to some weight-los...
Aegeline inhibits cytochrome P450 3A4 (CYP3A4) activity in vitro.
Read the full Aegeline + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionAgarAgar-agar, agarose, agarose Gel, +17 more Possible
What it is: Agar is a plant-based gel made from red seaweed that is widely used as a vegetarian alternative to gelatin and as a source of dietary fiber.
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionAlginAlginate, alginate De Calcium, alginate De Magnésium, +12 more Possible
What it is: Algin (alginate) is a fiber-like substance from brown seaweed that is widely used as a thickener, gel, and binder in foods and medicines.
Theoretically, algin can alter the absorption of oral drugs.
Read the full Algin + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionApple Cider VinegarAcv, cider Vinegar, vinagre De Manzana, +2 more Possible
What it is: Apple cider vinegar is a fermented apple product that many people use hoping to help with blood sugar, weight, or digestion.
Theoretically, taking apple cider vinegar with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Apple Cider Vinegar + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionAtractylodesAtractylodes Lancea, amk, atr, +9 more Possible
What it is: Atractylodes is a root used for centuries in traditional Chinese, Japanese, and Thai medicine, mostly for digestive complaints and fatigue,...
Theoretically, atractylodes might increase the levels of CYP3A4 substrates.
Read the full Atractylodes + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBlack Tea Possible
What it is: Black tea is a popular caffeinated drink made from the fully oxidized leaves of the Camellia sinensis plant, and it contains caffeine and an...
Theoretically, metformin might increase the levels and adverse effects of caffeine.
Read the full Black Tea + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBreadfruit Possible
What it is: Breadfruit is a starchy tropical fruit eaten as a staple food, and its leaves are used in traditional medicine for conditions like high bloo...
Theoretically, breadfruit might inhibit cytochrome P450 3A4 (CYP3A4) and increase levels of drugs metabolized by these enzymes; until more is known, use with caution.
Read the full Breadfruit + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCaffeine Possible
What it is: Caffeine is a natural stimulant found in coffee, tea, and many other plants and products.
Theoretically, metformin might increase the levels and adverse effects of caffeine.
Read the full Caffeine + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCalea Zacatechichi Possible
What it is: Calea zacatechichi, often called 'dream herb,' is a Mexican plant traditionally used to encourage vivid dreams and to treat digestive compla...
Theoretically, taking Calea zacatechichi with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Calea Zacatechichi + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCarobCeratonia Siliqua, algarrobo, carob Flour, +16 more Possible
What it is: Carob is a Mediterranean tree whose pods are widely used as a caffeine-free, naturally sweet cocoa alternative and as a thickener (carob gum...
Theoretically, carob might also impair the absorption of oral drugs.
Read the full Carob + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCascara SagradaFrangula Purshiana, rhamnus Purshiana, bitter Bark, +13 more Possible
What it is: Cascara sagrada is a stimulant laxative made from the aged bark of a Pacific Northwest tree, used mainly for short-term relief of constipati...
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Cascara Sagrada + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCola NutCola Acuminata, bissey Nut, bissy Nut, +10 more Possible
What it is: Cola nut is a caffeine-containing seed from West Africa used mainly as a natural stimulant for energy and alertness.
Theoretically, metformin might increase the levels and adverse effects of the caffeine in cola nut.
Read the full Cola Nut + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionFucus VesiculosusBlack Tang, bladder Fucus, bladder Wrack, +14 more Possible
What it is: Fucus vesiculosus (bladderwrack) is a brown seaweed rich in iodine that has been used traditionally for thyroid concerns, weight, and skin.
Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.
Read the full Fucus Vesiculosus + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionGoli Apple Cider Vinegar GummiesApple Cider Vinegar, acv Possible
What it is: Goli Apple Cider Vinegar Gummies are a flavored supplement that delivers a small amount of apple cider vinegar along with added ingredients...
Theoretically, taking apple cider vinegar, which is contained in Goli ACV, with antidiabetes drugs might increase the risk of hypoglycemia (i.e., low blood sugar).
Read the full Goli Apple Cider Vinegar Gummies + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionGreen TeaCamellia Sinensis, green Sencha Tea, green Tea Extract, +17 more Possible
What it is: Green tea is a popular beverage rich in antioxidants called catechins, and drinking it in normal amounts is considered safe for most people.
Theoretically, metformin might increase the levels and adverse effects of caffeine.
Read the full Green Tea + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionGuaranaPaullinia Cupana, brazilian Cocoa, cacao Brésilien, +3 more Possible
What it is: Guarana is an Amazonian seed that is naturally high in caffeine, which explains most of its stimulant and energy effects.
Theoretically, metformin might increase the levels and adverse effects of caffeine.
Read the full Guarana + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionHempCannabis Sativa, cheungsam, fiber Hemp, +14 more Possible
What it is: Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generall...
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Hemp + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionHoneyBeri Honey, blossom Honey, buckwheat Honey, +13 more Possible
What it is: Honey is a natural food with some real, modest evidence for easing coughs and helping certain wounds, especially when special medical-grade...
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionHopsHumulus Lupulus, asperge Sauvage, common Hops, +13 more Possible
What it is: Hops are most often used for sleep and mild anxiety, frequently combined with valerian, but the human evidence is limited and not very stron...
Theoretically, hops extract might alter metabolism of CYP3A4 substrates; however, this effect may not be clinically significant.
Read the full Hops + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionIlex Guayusa Possible
What it is: Ilex guayusa is a caffeine-containing holly leaf from the Amazon, traditionally brewed as a tea for energy and alertness, much like yerba ma...
Theoretically, metformin might increase the levels and adverse effects of caffeine.
Read the full Ilex Guayusa + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionKaraya GumBassora Tragacanth, goma Karaya, gomme Karaya, +14 more Possible
What it is: Karaya gum is a natural plant gum from the Sterculia tree that is mostly used as a bulk-forming laxative and as a thickener or adhesive in f...
Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption of drugs.
Read the full Karaya Gum + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionMaqui Possible
What it is: Maqui is a dark purple berry from Chile that is very rich in antioxidant plant pigments called anthocyanins.
Theoretically, maqui fruit extract may increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full Maqui + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionMarshmallowAlthaea Officinalis, altea, alteia, +16 more Possible
What it is: Marshmallow root is a traditional herb rich in soothing, gel-like fibers called mucilage, which is why it has long been used for coughs, sor...
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionPassion FlowerPassiflora Incarnata, apricot Vine, burucuya, +18 more Possible
What it is: Passion flower is a traditional calming herb that many people use for anxiety and sleep.
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passion Flower + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionPu-erh Tea Possible
What it is: Pu-erh tea is a fermented, aged form of tea made from the same plant as green and black tea.
Theoretically, metformin might increase the levels and adverse effects of caffeine.
Read the full Pu-erh Tea + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionPuravive Possible
What it is: Puravive is a branded, multi-ingredient capsule marketed mainly for weight loss by claiming to boost brown fat activity, but there is no pub...
Puravive contains Panax ginseng.
Read the full Puravive + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionStevia Possible
What it is: Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by...
Theoretically, stevia might increase the risk for hypoglycemia when combined with antidiabetes drugs.
Read the full Stevia + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionValerianValeriana Officinalis, all-heal, amantilla, +10 more Possible
What it is: Valerian is an herb whose root is widely used as a natural sleep aid and for calming nerves.
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionVitamin B12B-12, b12, b Complex, +16 more Possible
What it is: Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA.
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionVitamin DErgocalciferol, cholecalciferol Possible
What it is: Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function.
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionXanthan GumBacterial Polysaccharide, corn Sugar Gum, goma Xantana, +7 more Possible
What it is: Xanthan gum is a fermentation-made fiber widely used to thicken and stabilize foods and to thicken liquids for people with swallowing diffic...
Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.
Read the full Xanthan Gum + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionYerba MateIlex Paraguariensis, chimarrao, green Mate, +14 more Possible
What it is: Yerba mate is a caffeine-containing herbal beverage from South America that is widely enjoyed for its stimulating, coffee-like effects.
Theoretically, yerba mate might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Yerba Mate + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionYohimbePausinystalia Yohimbe, 11-hydroxy Yohimbine, coryanthe Yohimbe, +7 more Possible
What it is: Yohimbe is a West African tree bark that contains yohimbine, a compound mainly promoted for erectile dysfunction and as an aphrodisiac.
Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Yohimbe + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionAlpha-lipoic AcidThioctacid, thioctan, thioctic Acid Unlikely
What it is: Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods.
Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Alpha-lipoic Acid + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionAtkins Diet Unlikely
What it is: The Atkins Diet is a low-carbohydrate eating plan that can help some people lose weight and improve blood sugar in the short term.
Theoretically, following the Atkins diet might have additive hypoglycemic effects.
Read the full Atkins Diet + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBlueberry Unlikely
What it is: Blueberries are a nutritious fruit rich in antioxidants called anthocyanins, and eating them as part of a balanced diet is healthy and safe...
Theoretically, blueberries or blueberry leaf extracts might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Blueberry + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCoconut Unlikely
What it is: Coconut is a nutritious tropical food enjoyed as oil, water, milk, and flesh, and it is generally safe to eat in normal food amounts.
Theoretically, taking coconut with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Coconut + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCoconut WaterCocos Nucifera Unlikely
What it is: Coconut water is a natural drink rich in potassium and other electrolytes that many people use for hydration, especially around exercise.
Theoretically, taking coconut water with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Coconut Water + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCoffee Unlikely
What it is: Coffee is a widely consumed beverage made from roasted coffee beans, valued mainly for its caffeine, which boosts alertness and energy.
Theoretically, concomitant use of coffee and antidiabetes drugs might interfere with blood glucose control.
Read the full Coffee + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDelta-9-tetrahydrocannabinol (thc)Bho, black Glass, budder, +9 more Unlikely
What it is: THC is the main mind-altering compound in cannabis and is best known for causing a 'high.' A prescription form (dronabinol) is approved for...
Theoretically, THC may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Delta-9-tetrahydrocannabinol (thc) + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionGlucosamine Unlikely
What it is: Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, espe...
Despite initial concerns, it is unlikely that glucosamine will interfere with the effects of antidiabetes drugs.
Read the full Glucosamine + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionGreen CoffeeCoffea Arabica, coffea Canephora, coffea Bukobensis, +2 more Unlikely
What it is: Green coffee is the unroasted bean of the coffee plant, prized for its high chlorogenic acid content.
Theoretically, taking green coffee and antidiabetes drugs might interfere with blood glucose control.
Read the full Green Coffee + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionHumann Superbeets Heart Chews Unlikely
What it is: SuperBeets Heart Chews are a beetroot- and grape-seed-based supplement marketed to support healthy blood flow, blood pressure, and nitric ox...
Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).
Read the full Humann Superbeets Heart Chews + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionInulin Unlikely
What it is: Inulin is a type of plant fiber (a prebiotic) found naturally in foods like chicory root, onions, and garlic, and it is widely added to supp...
Theoretically, inulin might increase the risk of hypoglycemia with antidiabetes drugs.
Read the full Inulin + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionKavaPiper Methysticum, ava Pepper, ava Root, +20 more Unlikely
What it is: Kava is a Pacific Island plant traditionally used to promote relaxation and ease anxiety, and some studies suggest it may help mild anxiety.
It is unclear if kava inhibits CYP3AA; research is conflicting.
Read the full Kava + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionKudzuPueraria Montana, bidarikand, bilaikanda, +18 more Unlikely
What it is: Kudzu is a fast-growing vine whose root has long been used in traditional Chinese medicine and is now studied mostly for reducing alcohol in...
Theoretically, taking kudzu with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Kudzu + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionMommy's Bliss Gripe Water Unlikely
What it is: Mommy's Bliss Gripe Water is a sugar-free, alcohol-free liquid made with fennel and ginger that parents use to soothe gassy, colicky, or fus...
Mommy's Bliss Gripe Water contains fennel seed.
Read the full Mommy's Bliss Gripe Water + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionOolong Tea Unlikely
What it is: Oolong tea is a traditional partially oxidized tea made from the same plant as green and black tea, and it provides caffeine and plant antio...
Theoretically, taking oolong tea with antidiabetes drugs might interfere with blood glucose control.
Read the full Oolong Tea + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionPolypodium Leucotomos Unlikely
What it is: Polypodium leucotomos is a fern extract taken by mouth, mostly studied as an add-on to (not a replacement for) sunscreen and for certain lig...
Theoretically, Polypodium leucotomos might increase levels of drugs metabolized by CYP3A4.
Read the full Polypodium Leucotomos + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionPomegranatePunica Granatum, anardana, dadim, +14 more Unlikely
What it is: Pomegranate is a nutrient-rich fruit that is high in antioxidants and is widely enjoyed as food and juice.
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Pomegranate + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionRed CloverTrifolium Pratense, beebread, clovone, +17 more Unlikely
What it is: Red clover is a plant rich in isoflavones (plant compounds with weak estrogen-like activity) that is most often used for menopause symptoms...
Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.
Read the full Red Clover + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionTangerine Unlikely
What it is: Tangerine is a sweet citrus fruit that is a good source of vitamin C and other nutrients, and is widely enjoyed as food.
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionCan You Take It With Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride?
One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.
Can you take Theaflavin with Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In an animal diabetic model, giving theaflavin reduced fasting blood glucose, with an effect comparable to metformin.
Full Theaflavin + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride answerCan you take Thunder God Vine with Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, thunder god vine might increase the levels and clinical effects of CYP3A4 substrates.
Full Thunder God Vine + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride answerCan you take Tinospora Cordifolia with Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Tinospora cordifolia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Full Tinospora Cordifolia + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride answerCan you take Tiratricol with Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tiratricol might interfere with blood glucose control.
Full Tiratricol + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride answerCan you take Tragacanth with Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.
Full Tragacanth + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride answerCan you take Tribulus with Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Full Tribulus + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride answerCan you take Tronadora with Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of tronadora and antidiabetes drugs might increase the risk of hypoglycemia.
Full Tronadora + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride answerCan you take Turkey Tail Mushroom with Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking turkey tail mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Full Turkey Tail Mushroom + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride answerCan you take Turmeric with Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Turmeric might increase or decrease levels of drugs metabolized by CYP3A4.
Full Turmeric + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride answerCan you take Uva Ursi with Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Full Uva Ursi + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride answerCan you take Vitamin E with Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Full Vitamin E + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride answerCan you take Weight Watchers Diet with Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Following the Weight Watchers diet while taking antidiabetes drugs may increase the risk of hypoglycemia.
Full Weight Watchers Diet + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride answerCan you take Wheatgrass with Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking wheatgrass with antidiabetes drugs might lower blood glucose levels and increase the risk of hypoglycemia.
Full Wheatgrass + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride answerCan you take White Horehound with Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that white horehound might lower blood glucose.
Full White Horehound + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride answerCan you take White Mulberry with Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Full White Mulberry + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride answerCan you take White Pepper with Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence suggests that piperine, a constituent of white pepper, inhibits cytochrome P450 3A4 (CYP3A4).
Full White Pepper + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride answerCan you take Wild Cherry with Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that wild cherry can inhibit cytochrome P450 3A4 (CYP3A4) enzymes.
Full Wild Cherry + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride answerCan you take Winter Cherry with Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In animal diabetic models, winter cherry extract decreases blood glucose.
Full Winter Cherry + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride answerCan you take Zeaxanthin with Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
Full Zeaxanthin + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride answerCan you take Zedoary with Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, zedoary might increase levels of drugs metabolized by CYP3A4.
Full Zedoary + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride answerWhat Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
How Does Our Interaction Checker Work?
Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).
So the check works in three steps: (1) Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.
Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride sits in 5 interaction categories. Open any one to see what the group means:
Antidiabetes Drugs 239 ingredients
Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.
239 of the supplement ingredients on this page reach Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride through this category.
Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients
A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.
121 of the supplement ingredients on this page reach Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride through this category.
Metformin (Glucophage) 18 ingredients
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
18 of the supplement ingredients on this page reach Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride through this category.
Oral Drugs 17 ingredients
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
17 of the supplement ingredients on this page reach Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride through this category.
Organic Cation Transporter 2 (Oct2) Substrates 1 ingredient
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
1 of the supplement ingredient on this page reaches Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride through this category.
Related: does Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride deplete any nutrients?
Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride has 4 reported nutrient associations in the research literature — see the Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride nutrient depletion report.
Take a Supplement Product? Check the Whole Bottle Against Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride
Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride.
Search a supplement product
Type a product name, brand, or UPC — smart search across our full catalog.
Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI
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Products that contain Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride-interacting ingredients
Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride.
Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride & Supplements: Common Questions
What supplements interact with Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride?
Which Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride supplement interactions are the most serious?
Can I take vitamins or supplements while on Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride?
Do brands like Qternmet XR have the same supplement interactions as Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride?
Where do these interaction ratings come from?
Does Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride deplete any vitamins or nutrients?
What about Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride and my other medications?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Where This Data Comes From — and Why You Can Trust It
🧪 Licensed clinical database
Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.
🧑⚕️ Pharmacist review
This page is curated and coded by Dr. Brian Staiger, PharmD, BCPS, Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.
🔄 Kept current
Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 9, 2026.
🔍 Full transparency
How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.
Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.