Medication interaction hub

What Supplements Interact with Empagliflozin, Linagliptin, Metformin Hydrochloride?

Empagliflozin, Linagliptin, Metformin Hydrochloride brand name: Trijardy XR. Every interaction below applies to the brands too.

285 Interactions 3 Major 243 Moderate 39 Minor
Curated & coded by · Clinical Pharmacist · Updated October 8, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Empagliflozin, Linagliptin, Metformin Hydrochloride? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Empagliflozin, Linagliptin, Metformin Hydrochloride against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Trijardy XR combines three diabetes medicines, empagliflozin, linagliptin, and metformin, in one pill, so anything else that lowers blood sugar can push it too far. Most of this list does exactly that: 239 of the 285 ingredients on file add their own glucose-lowering effect and raise the risk of hypoglycemia, dangerously low blood sugar. Three entries rate major and deserve your attention first. Siberian cocklebur has caused severe hypoglycemia in people, activated charcoal can pull the medicine out before it absorbs, and St. John's wort speeds drug clearance through a transporter called P-glycoprotein.

Nearly everything else rates moderate, 243 entries, with 39 minor, and most repeat the blood sugar theme at gentler strength. A smaller cluster works differently, blunting how well the pills absorb, mainly bulky fiber supplements and charcoal-type products. Space those well apart from your dose, and check your glucose more often whenever you add a supplement with sugar-lowering claims.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 243 Minor 39 No known interaction 1,167

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Empagliflozin, Linagliptin, Metformin Hydrochloride: Top Interactions at a Glance

The Empagliflozin, Linagliptin, Metformin Hydrochloride supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 285 interacting ingredients — plus 1,167 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Empagliflozin, Linagliptin, Metformin Hydrochloride Combinations Today

The Empagliflozin, Linagliptin, Metformin Hydrochloride + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Berberine + Empagliflozin, Linagliptin, Metformin Hydrochloridei

Theoretically, berberine may increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full interaction Moderate Likelihood Possible Slippery Elm + Empagliflozin, Linagliptin, Metformin Hydrochloridei

Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Read the full interaction Moderate Likelihood Possible Sesame + Empagliflozin, Linagliptin, Metformin Hydrochloridei

Taking sesame oil with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Policosanol + Empagliflozin, Linagliptin, Metformin Hydrochloridei

Theoretically, policosanol might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Purple Nut Sedge + Empagliflozin, Linagliptin, Metformin Hydrochloridei

Evidence from animal research suggests that purple nut sedge can reduce blood glucose levels.

Read the full interaction Minor Likelihood Possible Black Tea + Empagliflozin, Linagliptin, Metformin Hydrochloridei

Theoretically, metformin might increase the levels and adverse effects of caffeine.

Read the full interaction
The complete list

Every Supplement Checked Against Empagliflozin, Linagliptin, Metformin Hydrochloride

All 1,452 ingredients in our database, ranked by severity — 285 with a Empagliflozin, Linagliptin, Metformin Hydrochloride interaction on file and 1,167 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Empagliflozin, Linagliptin, Metformin Hydrochloride?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Berberine with Empagliflozin, Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine may increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Berberine + Empagliflozin, Linagliptin, Metformin Hydrochloride answer

Can you take Slippery Elm with Empagliflozin, Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Empagliflozin, Linagliptin, Metformin Hydrochloride answer

Can you take Sesame with Empagliflozin, Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking sesame oil with antidiabetes drugs might increase the risk of hypoglycemia.

Full Sesame + Empagliflozin, Linagliptin, Metformin Hydrochloride answer

Can you take Policosanol with Empagliflozin, Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, policosanol might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.

Full Policosanol + Empagliflozin, Linagliptin, Metformin Hydrochloride answer

Can you take Purple Nut Sedge with Empagliflozin, Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that purple nut sedge can reduce blood glucose levels.

Full Purple Nut Sedge + Empagliflozin, Linagliptin, Metformin Hydrochloride answer

Can you take Siberian Cocklebur with Empagliflozin, Linagliptin, Metformin Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Siberian cocklebur seedlings and seeds have caused severe hypoglycemia in humans.

Full Siberian Cocklebur + Empagliflozin, Linagliptin, Metformin Hydrochloride answer

Can you take Activated Charcoal with Empagliflozin, Linagliptin, Metformin Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Empagliflozin, Linagliptin, Metformin Hydrochloride answer

Can you take St. John's Wort with Empagliflozin, Linagliptin, Metformin Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. St.

Full St. John's Wort + Empagliflozin, Linagliptin, Metformin Hydrochloride answer

Can you take American Ginseng with Empagliflozin, Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking American ginseng with antidiabetes drugs might increase the risk of hypoglycemia.

Full American Ginseng + Empagliflozin, Linagliptin, Metformin Hydrochloride answer

Can you take Astragalus with Empagliflozin, Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.

Full Astragalus + Empagliflozin, Linagliptin, Metformin Hydrochloride answer

Can you take Banaba with Empagliflozin, Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of banaba and hypoglycemic drugs might have additive effects.

Full Banaba + Empagliflozin, Linagliptin, Metformin Hydrochloride answer

Can you take Beer with Empagliflozin, Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use may interfere with blood glucose control.

Full Beer + Empagliflozin, Linagliptin, Metformin Hydrochloride answer

Can you take Bitter Melon with Empagliflozin, Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.

Full Bitter Melon + Empagliflozin, Linagliptin, Metformin Hydrochloride answer

Can you take Branched-chain Amino Acids (bcaa) with Empagliflozin, Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, BCAAs might alter the effects of antidiabetes medications.

Full Branched-chain Amino Acids (bcaa) + Empagliflozin, Linagliptin, Metformin Hydrochloride answer

Can you take Coffee Charcoal with Empagliflozin, Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Empagliflozin, Linagliptin, Metformin Hydrochloride answer

Can you take Cumin with Empagliflozin, Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cumin might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Cumin + Empagliflozin, Linagliptin, Metformin Hydrochloride answer

Can you take Ephedra with Empagliflozin, Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ephedra with antidiabetes drugs might interfere with blood glucose control.

Full Ephedra + Empagliflozin, Linagliptin, Metformin Hydrochloride answer

Can you take European Mandrake with Empagliflozin, Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Empagliflozin, Linagliptin, Metformin Hydrochloride answer

Can you take Fenugreek with Empagliflozin, Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.

Full Fenugreek + Empagliflozin, Linagliptin, Metformin Hydrochloride answer

Can you take Fig with Empagliflozin, Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fig leaf might enhance the blood glucose lowering effects of hypoglycemic drugs.

Full Fig + Empagliflozin, Linagliptin, Metformin Hydrochloride answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Empagliflozin, Linagliptin, Metformin Hydrochloride is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Empagliflozin, Linagliptin, Metformin Hydrochloride, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Empagliflozin, Linagliptin, Metformin Hydrochloride sits in 7 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Empagliflozin, Linagliptin, Metformin Hydrochloride through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Empagliflozin, Linagliptin, Metformin Hydrochloride through this category.

Metformin (Glucophage) 18 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

18 of the supplement ingredients on this page reach Empagliflozin, Linagliptin, Metformin Hydrochloride through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Empagliflozin, Linagliptin, Metformin Hydrochloride through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Empagliflozin, Linagliptin, Metformin Hydrochloride through this category.

Empagliflozin (Jardiance) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Empagliflozin, Linagliptin, Metformin Hydrochloride through this category.

Organic Cation Transporter 2 (Oct2) Substrates 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Empagliflozin, Linagliptin, Metformin Hydrochloride through this category.

Related: does Empagliflozin, Linagliptin, Metformin Hydrochloride deplete any nutrients?

Empagliflozin, Linagliptin, Metformin Hydrochloride has 4 reported nutrient associations in the research literature — see the Empagliflozin, Linagliptin, Metformin Hydrochloride nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Empagliflozin, Linagliptin, Metformin Hydrochloride

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Empagliflozin, Linagliptin, Metformin Hydrochloride.

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Pharmacist Counseling Corner

Empagliflozin, Linagliptin, Metformin Hydrochloride & Supplements: Common Questions

What supplements interact with Empagliflozin, Linagliptin, Metformin Hydrochloride?
Our database currently documents 285 ingredients with a known Empagliflozin, Linagliptin, Metformin Hydrochloride interaction (3 major, 243 moderate, 39 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 285. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, St. John's Wort.
Which Empagliflozin, Linagliptin, Metformin Hydrochloride supplement interactions are the most serious?
The 3 major-rated combinations — led by Siberian Cocklebur, Activated Charcoal and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Empagliflozin, Linagliptin, Metformin Hydrochloride?
Plenty of supplements coexist fine with Empagliflozin, Linagliptin, Metformin Hydrochloride; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Trijardy XR have the same supplement interactions as Empagliflozin, Linagliptin, Metformin Hydrochloride?
Yes — Trijardy XR all contain Empagliflozin, Linagliptin, Metformin Hydrochloride, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Empagliflozin, Linagliptin, Metformin Hydrochloride deplete any vitamins or nutrients?
It might — Empagliflozin, Linagliptin, Metformin Hydrochloride has 4 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Empagliflozin, Linagliptin, Metformin Hydrochloride nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Empagliflozin, Linagliptin, Metformin Hydrochloride and my other medications?
This page covers Empagliflozin, Linagliptin, Metformin Hydrochloride against supplements and herbal ingredients. Checking Empagliflozin, Linagliptin, Metformin Hydrochloride against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 8, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.