Medication interaction hub

What Supplements Interact with Ephedrine Hydrochloride (prescription drug)?

Ephedrine Hydrochloride (prescription drug) brand name: Rezipres. Every interaction below applies to the brands too.

53 Interactions 8 Major 42 Moderate 3 Minor
Curated & coded by · Clinical Pharmacist · Updated September 19, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Ephedrine Hydrochloride (prescription drug)? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Ephedrine Hydrochloride (prescription drug) against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

53 supplements and herbal ingredients have interactions with Ephedrine Hydrochloride (prescription drug) on file in the HelloPharmacist interaction database — 8 rated major, 42 moderate, and 3 minor. The most serious involve Arsenic, Cesium, Ephedra, Grapefruit and Peyote.

Our assessment: with 8 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Ephedrine Hydrochloride (prescription drug).

Major 8 Moderate 42 Minor 3 No known interaction 1,399

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Ephedrine Hydrochloride (prescription drug): Top Interactions at a Glance

The most significant Ephedrine Hydrochloride (prescription drug) supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 53 interacting ingredients — plus 1,399 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Ephedrine Hydrochloride (prescription drug) + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Arsenic + Ephedrine Hydrochloride (prescription drug)i

Arsenic trioxide can prolong the QT interval.

Read the full interaction Major Likelihood Probable Cesium + Ephedrine Hydrochloride (prescription drug)i

Theoretically, taking cesium concomitantly with other drugs that prolong the QT interval may increase the risk of ventricular arrhythmias and death.

Read the full interaction Major Likelihood Probable Ephedra + Ephedrine Hydrochloride (prescription drug)i

Theoretically, ephedra might have an additive effect with drugs that prolong the QT interval.

Read the full interaction Major Likelihood Probable Grapefruit + Ephedrine Hydrochloride (prescription drug)i

Grapefruit or grapefruit juice, especially if consumed in large amounts, can cause additive QT interval prolongation when taken with QT interval-prolonging drug...

Read the full interaction Major Likelihood Probable Peyote + Ephedrine Hydrochloride (prescription drug)i

Concomitant use of peyote with stimulant drugs may increase the risk of adverse CNS effects.

Read the full interaction Major Likelihood Probable Rauvolfia Vomitoria + Ephedrine Hydrochloride (prescription drug)i

Theoretically, concomitant use might cause additive effects.

Read the full interaction
The complete list

Every Supplement Checked Against Ephedrine Hydrochloride (prescription drug)

All 1,452 ingredients in our database, ranked by severity — 53 with a Ephedrine Hydrochloride (prescription drug) interaction on file and 1,399 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Ephedrine Hydrochloride (prescription drug)?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Adrafinil with Ephedrine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking adrafinil with stimulant drugs might have additive stimulant effects.

Full Adrafinil + Ephedrine Hydrochloride (prescription drug) answer

Can you take Beta-methylphenethylamine (bmpea) with Ephedrine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking BMPEA with other stimulant drugs might increase the risk of adverse cardiovascular effects.

Full Beta-methylphenethylamine (bmpea) + Ephedrine Hydrochloride (prescription drug) answer

Can you take Bitter Orange with Ephedrine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bitter orange might have an additive effect when combined with drugs that prolong the QT interval, potentially increasing the...

Full Bitter Orange + Ephedrine Hydrochloride (prescription drug) answer

Can you take Butcher's Broom with Ephedrine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.

Full Butcher's Broom + Ephedrine Hydrochloride (prescription drug) answer

Can you take Cinchona with Ephedrine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cinchona with other QT interval-prolonging drugs might cause an additive effect and increase the risk of ventricular a...

Full Cinchona + Ephedrine Hydrochloride (prescription drug) answer

Can you take Dimethylhexylamine (dmha) with Ephedrine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining DMHA with stimulant drugs might increase the risk of adverse cardiovascular effects.

Full Dimethylhexylamine (dmha) + Ephedrine Hydrochloride (prescription drug) answer

Can you take Ergot with Ephedrine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Co-administration of stimulant drugs with ergot may increase the risk of vasoconstriction.

Full Ergot + Ephedrine Hydrochloride (prescription drug) answer

Can you take Evodia with Ephedrine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, evodia might have an additive effect with drugs that prolong the QT interval, potentially increasing the risk of ventricular...

Full Evodia + Ephedrine Hydrochloride (prescription drug) answer

Can you take Guarana with Ephedrine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Guarana + Ephedrine Hydrochloride (prescription drug) answer

Can you take Higenamine with Ephedrine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, higenamine might increase the risk of cardiovascular toxicity when taken with stimulant drugs.

Full Higenamine + Ephedrine Hydrochloride (prescription drug) answer

Can you take Hordenine with Ephedrine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hordenine is structurally similar to N-methyltyramine and synephrine, constituents in bitter orange known to have stimulant properties.

Full Hordenine + Ephedrine Hydrochloride (prescription drug) answer

Can you take Iboga with Ephedrine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, iboga may have an additive effect with drugs that prolong the QT interval.

Full Iboga + Ephedrine Hydrochloride (prescription drug) answer

Can you take Indian Snakeroot with Ephedrine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might cause additive effects.

Full Indian Snakeroot + Ephedrine Hydrochloride (prescription drug) answer

Can you take Isopropylnorsynephrine with Ephedrine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking isopropylnorsynephrine with stimulant drugs might have additive effects and increase the risk of adverse cardiovascula...

Full Isopropylnorsynephrine + Ephedrine Hydrochloride (prescription drug) answer

Can you take K2/spice with Ephedrine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, K2/spice might have an additive effect with drugs that prolong the QT interval and increase the risk of ventricular arrhythmi...

Full K2/spice + Ephedrine Hydrochloride (prescription drug) answer

Can you take Khat with Ephedrine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Cathinone, a constituent of khat, appears to have sympathomimetic effects and can increase blood pressure and heart rate.

Full Khat + Ephedrine Hydrochloride (prescription drug) answer

Can you take Methylsynephrine with Ephedrine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Methylsynephrine has cardiac stimulant effects.

Full Methylsynephrine + Ephedrine Hydrochloride (prescription drug) answer

Can you take Panax Ginseng with Ephedrine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Panax ginseng has an additive effect with drugs that prolong the QT interval and potentially increase the risk of ventricular...

Full Panax Ginseng + Ephedrine Hydrochloride (prescription drug) answer

Can you take Phenpromethamine with Ephedrine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking phenpromethamine with stimulant drugs might have additive effects and increase the risk of adverse cardiovascular effe...

Full Phenpromethamine + Ephedrine Hydrochloride (prescription drug) answer

Can you take Puravive with Ephedrine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Puravive contains Panax ginseng.

Full Puravive + Ephedrine Hydrochloride (prescription drug) answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Ephedrine Hydrochloride (prescription drug) is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Ephedrine Hydrochloride (prescription drug), and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Ephedrine Hydrochloride (prescription drug) sits in 3 interaction categories. Open any one to see what the group means:

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Ephedrine Hydrochloride (prescription drug) through this category.

Qt Interval-Prolonging Drugs 13 ingredients

Medications that can affect the heart's electrical rhythm (the QT interval). Supplements with similar effects can add to that risk.

13 of the supplement ingredients on this page reach Ephedrine Hydrochloride (prescription drug) through this category.

Alpha-Adrenergic Agonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Ephedrine Hydrochloride (prescription drug) through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Ephedrine Hydrochloride (prescription drug)

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Ephedrine Hydrochloride (prescription drug).

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Pharmacist Counseling Corner

Ephedrine Hydrochloride (prescription drug) & Supplements: Common Questions

What supplements interact with Ephedrine Hydrochloride (prescription drug)?
More than you might expect — 53 in total, though they are far from equal: 8 are rated major, 42 moderate, and 3 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Arsenic, Cesium, Ephedra.
Which Ephedrine Hydrochloride (prescription drug) supplement interactions are the most serious?
The 8 major-rated combinations — led by Arsenic, Cesium, Ephedra, Grapefruit and Peyote — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Ephedrine Hydrochloride (prescription drug)?
Usually yes — most people on Ephedrine Hydrochloride (prescription drug) can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Rezipres have the same supplement interactions as Ephedrine Hydrochloride (prescription drug)?
Yes — Rezipres all contain Ephedrine Hydrochloride (prescription drug), so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Ephedrine Hydrochloride (prescription drug) and my other medications?
This page covers Ephedrine Hydrochloride (prescription drug) against supplements and herbal ingredients. Checking Ephedrine Hydrochloride (prescription drug) against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 19, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.