Medication interaction hub

What Supplements Interact with Pseudoephedrine Sulfate?

Pseudoephedrine Sulfate brand names: Drixoral N.D., Afrinol. Every interaction below applies to the brands too.

62 Interactions 5 Major 44 Moderate 13 Minor
Curated & coded by · Clinical Pharmacist · Updated September 25, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Pseudoephedrine Sulfate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Pseudoephedrine Sulfate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Most people reach for pseudoephedrine (Afrinol, Drixoral N.D.) for a stuffy nose without much thought, often with their usual coffee, tea, or a weight-loss supplement nearby, and that casual pairing is where the trouble sits. Pseudoephedrine already pushes heart rate and blood pressure up, and 44 of the 62 supplements on file act as stimulants themselves, stacking that same effect. Everyday caffeine sources fill most of the moderate entries, but ephedra and other ephedrine-containing herbs like Sida cordifolia rate major and deserve genuine hesitation, not a shrug.

Five entries rate major overall, with 44 moderates and 13 minors behind them. Activated charcoal is a different kind of problem, one of 17 ingredients that can change how much of an oral dose the body actually absorbs, so space products like that well apart from your dose. If you use pseudoephedrine regularly for allergies rather than one short cold, ask your pharmacist to walk through the five majors with you first.

— , Clinical Pharmacist · July 18, 2026

Major 5 Moderate 44 Minor 13 No known interaction 1,390

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Pseudoephedrine Sulfate: Top Interactions at a Glance

The Pseudoephedrine Sulfate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 62 interacting ingredients — plus 1,390 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Pseudoephedrine Sulfate Combinations Today

The Pseudoephedrine Sulfate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Marshmallow + Pseudoephedrine Sulfatei

Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Read the full interaction Moderate Likelihood Possible Butcher's Broom + Pseudoephedrine Sulfatei

Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.

Read the full interaction Moderate Likelihood Possible 1,4-dmaa + Pseudoephedrine Sulfatei

1,4-DMAA is thought to have stimulant and vasoconstrictive effects, which have been demonstrated in animal studies.

Read the full interaction Minor Likelihood Likely Thyroid Extract + Pseudoephedrine Sulfatei

Food and medications can interfere with thyroid hormone absorption.

Read the full interaction Major Likelihood Probable Activated Charcoal + Pseudoephedrine Sulfatei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Ephedra + Pseudoephedrine Sulfatei

Theoretically, concomitant use might increase the risk for serious adverse effects.

Read the full interaction
The complete list

Every Supplement Checked Against Pseudoephedrine Sulfate

All 1,452 ingredients in our database, ranked by severity — 62 with a Pseudoephedrine Sulfate interaction on file and 1,390 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Pseudoephedrine Sulfate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Marshmallow with Pseudoephedrine Sulfate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Pseudoephedrine Sulfate answer

Can you take Butcher's Broom with Pseudoephedrine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.

Full Butcher's Broom + Pseudoephedrine Sulfate answer

Can you take 1,4-dmaa with Pseudoephedrine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. 1,4-DMAA is thought to have stimulant and vasoconstrictive effects, which have been demonstrated in animal studies.

Full 1,4-dmaa + Pseudoephedrine Sulfate answer

Can you take Thyroid Extract with Pseudoephedrine Sulfate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Pseudoephedrine Sulfate answer

Can you take Methylsynephrine with Pseudoephedrine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Methylsynephrine has cardiac stimulant effects.

Full Methylsynephrine + Pseudoephedrine Sulfate answer

Can you take Panax Ginseng with Pseudoephedrine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Panax ginseng with stimulant drugs might increase the risk of adverse stimulant effects.

Full Panax Ginseng + Pseudoephedrine Sulfate answer

Can you take Phenpromethamine with Pseudoephedrine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking phenpromethamine with stimulant drugs might have additive effects and increase the risk of adverse cardiovascular effe...

Full Phenpromethamine + Pseudoephedrine Sulfate answer

Can you take Raspberry Ketone with Pseudoephedrine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.

Full Raspberry Ketone + Pseudoephedrine Sulfate answer

Can you take Rauwolscine with Pseudoephedrine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rauwolscine with stimulant drugs might increase the risk of adverse stimulant effects.

Full Rauwolscine + Pseudoephedrine Sulfate answer

Can you take Securinega Suffruticosa with Pseudoephedrine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Securinega suffruticosa with stimulant drugs might increase the risk of serious adverse effects.

Full Securinega Suffruticosa + Pseudoephedrine Sulfate answer

Can you take Slippery Elm with Pseudoephedrine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Pseudoephedrine Sulfate answer

Can you take Tragacanth with Pseudoephedrine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Pseudoephedrine Sulfate answer

Can you take Yohimbe with Pseudoephedrine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking yohimbe with stimulant drugs can have additive effects.

Full Yohimbe + Pseudoephedrine Sulfate answer

Can you take Agar with Pseudoephedrine Sulfate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Pseudoephedrine Sulfate answer

Can you take Algin with Pseudoephedrine Sulfate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Pseudoephedrine Sulfate answer

Can you take Black Psyllium with Pseudoephedrine Sulfate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Pseudoephedrine Sulfate answer

Can you take Blond Psyllium with Pseudoephedrine Sulfate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Pseudoephedrine Sulfate answer

Can you take Carob with Pseudoephedrine Sulfate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Pseudoephedrine Sulfate answer

Can you take Karaya Gum with Pseudoephedrine Sulfate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Pseudoephedrine Sulfate answer

Can you take N-methyltyramine with Pseudoephedrine Sulfate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. N-methyltyramine is thought to have stimulant effects.

Full N-methyltyramine + Pseudoephedrine Sulfate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Pseudoephedrine Sulfate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Pseudoephedrine Sulfate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Pseudoephedrine Sulfate sits in 3 interaction categories. Open any one to see what the group means:

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Pseudoephedrine Sulfate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Pseudoephedrine Sulfate through this category.

Alpha-Adrenergic Agonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Pseudoephedrine Sulfate through this category.

About Pseudoephedrine Sulfate

Pseudoephedrine is a nasal decongestant used to relieve nasal and sinus congestion from colds, allergies, and hay fever.

Generic name: Pseudoephedrine Sulfate  ·  Brand names: Drixoral N.D., Afrinol.

See the full Pseudoephedrine drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Pseudoephedrine Sulfate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Pseudoephedrine Sulfate.

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Pharmacist Counseling Corner

Pseudoephedrine Sulfate & Supplements: Common Questions

What supplements interact with Pseudoephedrine Sulfate?
In our interaction database, 62 supplement and herbal ingredients have an interaction with Pseudoephedrine Sulfate on file — 5 rated major, 44 moderate, and 13 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Activated Charcoal, Ephedra, Peyote.
Which Pseudoephedrine Sulfate supplement interactions are the most serious?
The 5 major-rated combinations — led by Activated Charcoal, Ephedra, Peyote, Rauvolfia Vomitoria and Sida Cordifolia — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Pseudoephedrine Sulfate?
That depends entirely on which supplement. The honest answer for Pseudoephedrine Sulfate is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Drixoral N.D. have the same supplement interactions as Pseudoephedrine Sulfate?
Yes — Drixoral N.D., Afrinol all contain Pseudoephedrine Sulfate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Pseudoephedrine Sulfate and my other medications?
This page covers Pseudoephedrine Sulfate against supplements and herbal ingredients. Checking Pseudoephedrine Sulfate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Pseudoephedrine drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 25, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.